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Association between preoperative high sensitive troponin I levels and cardiovascular events after hip fracture surgery in the elderly

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Journal of Geriatric Cardiology 2018年第3期15卷 215-221页

作者： Bum sung kim Tae-Hoon kim Jeong-Hwan Oh Chang Hee Kwon sung hea kim Hyun-Joong kim Heung Kon Hwang Sang-Man Chung in-gu Seoul Republic of Korea Department of Orthopedic surgery Konkuk University Medical Center 120-1 Neungdong-ro Hwayang-dong Gwangjin-guSeoulRepublic of Korea

Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery （HFS）. We used high sensitive troponin I （hs-TnI） assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events （MACE） in elderly hip frac^u＇e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure （HF）, new-onset atrial fibrillation （AF）, myocardial infarction （MI） and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 （24.8%）. Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide （NT-proBNP） and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio （HR）： 1.79, 95% confident interval （CI）： 1.03-3.13, P = 0.04], left ventricular ejection fraction （LVEF）〈 50% （adjusted HR： 3.17, 95% CI： 1.47-5.82, P 〈 0.01） and hs-TnI 〉 6.5 ng/L （adjusted HR： 3.75, 95% CI： 2.09~5.17, P 〈 0.01）. Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.

关键词： Cardiovascular complication High sensitive troponin I Hip fracture surgery

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong kim Ruqayya Afridi Il-sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

Clinical characteristics of Helicobacter pylori-negative drugnegative peptic ulcer bleeding

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World Journal of Gastroenterology 2015年第28期21卷 8636-8643页

作者： Woo Chul Chung Eun Jung Jeon Dae Bum kim hea Jung sung Yeon-Ji kim Eun Sun Lim Min-ah kim Jung Hwan Oh Department of Internal Medicine St. Paul’s HospitalCollege of Medicine the Catholic University of Korea

AIM:To investigate the clinical characteristics and outcomes of idiopathic Helicobacter pylori(***)-negative and drug-negative]peptic ulcer bleeding(PUB).METHODS:A consecutive series of patients who experienced PUB between 2006 and 2012 was retrospectively analyzed.A total of 232 patients were enrolled in this *** patients were divided into four groups according to the etiologies of PUB:idiopathic,***-associated,drug-induced and combined(***-associated and drug-induced)*** compared the clinical characteristics and outcomes between the *** the silver stain or rapid urease tests were ***-negative,we obtained an additional biopsy specimen by endoscopic re-examination and performed an *** antibody test 6-8 wk after the initial endoscopic *** a diagnosis of idiopathic PUB,a negative result of an *** antibody test was *** all cases,re-bleeding was confirmed by endoscopic *** the risk assessment,the Blatchford and the Rockall scores were calculated for all ***:For PUB,the frequency of *** infection was 59.5%(138/232),whereas the frequency of idiopathic cases was 8.6%(20/232).When idiopathic PUB was compared to ***-associated PUB,the idiopathic PUB group showed a higher rate of rebleeding after initial hemostasis during the hospital stay(30%vs 7.4%,P = 0.02).When idiopathic PUB was compared to drug-induced PUB,the patients in the idiopathic PUB group showed a higher rate of rebleeding after initial hemostasis upon admission(30%vs 2.7%,P < 0.01).When drug-induced PUB was compared to ***-associated PUB,the patients in the drug-induced PUB were older(68.49 ± 14.76 years vs 47.83 ± 15.15 years,P< 0.01) and showed a higher proportion of gastric ulcer(77%vs 49%,P < 0.01).However,the Blatchford and the Rockall scores were not significantly different between the two *** the patients who experienced drug-induced PUB,no significant differences were found with respect

关键词： Peptic ulcer Gastrointestinal bleeding Helicobacter pylori Non-steroidal anti-inflammatorydrug

Electrodeposition behavior and characteristics of Ni-carbon nanotube composite coatings

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 68-72页

作者： sung-Kyu kim Tae-sung OH Department of Materials Science and Engineering Hongik University

Ni-CNT (carbon nanotube) composite coatings were processed by electrodeposition and their hardness and corrosion characteristics were investigated with variations of CNT concentration in an electrolyte solution and electrodeposition current density. With increasing the CNT concentration in the electrodeposition bath and the current density, more CNTs are incorporated into Ni matrix. Hardness values of the Ni-CNT coatings are irrelevant to the CNT concentration in the solution, the current density, and current mode, implying poor adhesion of CNTs to Ni matrix. With increasing the CNT content in the coating, the corrosion resistance of the Ni-CNT composite coating becomes inferior due to the porous microstructure.

关键词： composite coating carbon nanotube electrodeposition

SYNTHESIS AND CHARACTERIZATION OF HYDROPHOBIC-HYDROPHILIC MULTIBLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS

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Chinese Journal of Polymer Science 1999年第2期17卷 113-122页

作者： Yong Kiel sung Yong Joo kim sung Wan kim Department of Chemistry College of Natural Science Dongguk University 3Ga 26 PhildongJunggu Seoul 100-715 KoreaReliability Technology Division NITQ 2 Chungangdong Kwachoncity Kyunggido 427-010 KoreaCenter for Controlled Chemical Delivery University of Utah Salt Lake City Utah 84112 U. S. A.

The synthesis and characterization of amphiphilic copolymers of poly（dimethyl siloxane）(PDMS),poly（ethylene oxide）(PEO), and heparin（Hep） were investigated. These multiblock copolymers wereidentified using;H-NMR, FTIR, end group analysis, and sulfur elemental analysis. The multiblockcopolymers were characterized by using DSC and X-ray diffractometry. The glass transition temperature,crystalline melting characteristics, annealing effect, and cold crystallization of the block copolymers weredetermined by DSC. The crystallinity of the block copolymers was also determined by X-ray diffractionmethod.

关键词： Heparinized block copolymer Biomedical polymer Synthesis Characterization

Effect of reduction in area per pass on strain distribution and microstructure during caliber rolling in twinning-induced plasticity steel

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Journal of Iron and Steel Research International 2020年第1期27卷 62-74页

作者： Joong-ki Hwang sung Jin kim School of Mechanical Engineering Tongmyong UniversityBusan 48520Republic of Korea Department of Advanced Materials Engineering Sunchon National UniversitySuncheon 57922Republic of Korea

The effects of reduction in area(RA)per pass during caliber rolling on microstructure and strain distribution of twinninginduced plasticity steel have been investigated to find solutions to make a more homogeneous material along the radial direction for wire rod *** steel wires subjected to an average RA per pass of 2.5%(skin pass caliber rolling)and 10.0%(conventional caliber rolling)were *** skin pass caliber-rolled wire was characterized as a duplex fiber texture of majorand minor.and the textures were almost same at/between center and surface area,which is totally different from those of conventional caliber rolling and wire *** skin pass caliber rolling led to more homogeneous microstructure and mechanical properties along the radial direction in comparison with the conventional caliber rolling and wire drawing due to the more homogeneous Hall-Petch hardening,dislocation hardening,and texture behavior with area,resulting in higher formability.

关键词： Twinning-induced plasticity steel Caliber rolling Deformation twin Reduction in area Skin pass

Looping by RNA: Dynamic control of the chromatin loop by long non-coding RNAs in plants

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Molecular Plant 2021年第9期14卷 1430-1432页

作者： Junghyun kim Sibum sung Department of Molecular Biosciences The University of Texas at AustinAustinTX 78712USA

In eukaryotes,the three-dimensional(3D)structure of the genome plays a critical role in the transcriptional *** though the 3D structure of the genome is mainly determined by DNA and protein components,increasing evidenee has demonstrated that RNA also occupies a large portion of chromatin and in flue nces genomic architecture(Ramirez-Colmenero et al.,2020;Wierzbicki et al.,2021).Long non-coding RNA(IncRNA)is a class of non-coding RNAs longer than 200 nucleotides but that lacks protein-coding *** are key regulators of gene expression through their capacity to harbor regulatory proteins and to establish molecular interactions.

关键词： potential harbor

UV-assisted flash light welding process to fabricate silver nanowire/graphene on a PET substrate for transparent electrodes

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Nano Research 2018年第4期11卷 2190-2203页

作者： Wan-Ho Chung sung-Hyeon Park sung-Jun Joo Hak-sung kim Department of Mechanical Engineering Hanyang University 17 Haendang-Dong Seongdong-Gu Seoul 133-791 Republic of Korea Institute of Nano Science and Technology Hanyang University Seou1133-791 Republic of Korea

Graphene oxide and silver nanowires were bar coated onto polyethylene terephthalate （PET） substrates and then welded using an ultraviolet （UV）-assisted flash light irradiation process to achieve both high electrical conductivity and low haze. The irradiation process connected adjacent silver nanowires by welding, while simultaneously reducing the graphene oxide to graphene. This process was performed using a custom W-assisted flash light welding system at room temperature under ambient conditions and was extremely rapid, with processing time of several milliseconds. The effects of varying the weight fractions of the silver nanowires and graphene oxide and of varying the W-assisted flash light welding conditions （light energy and pulse duration） were investigated. The surface morphologies of the welded silver nanowire/graphene films were analyzed using scanning electron microscopy. Optical characterizations, including transmittance and haze measurements, were also conducted using a spectrophotometer. To test their resistance to oxidation, the welded silver nanowire/graphene films were subjected to high temperature in a furnace （100 ℃）, and their sheet resistances were measured every hour. The flash light welding process was found to yield silver nanowire/graphene films with high oxidation resistance, high conductivity （14.35 Ω·sq-1）, high transmittance （93.46%）, and low haze （0.9%）. This material showed uniform temperature distribution when applied as a resistive heating film.

关键词： silver nanowires graphene oxide transparent electrode flash light welding printed electronics