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Diffusion tensor tractography characteristics of axonal injury in concussion/mild traumatic brain injury

Neural Regeneration Research 2022年第5期17卷 978-982页

作者： sung Ho Jang You sung seo Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaeguRepublic of Korea

The main advantage of diffusion tensor tractography is that it allows the entire neural tract to be *** addition,configurational analysis of reconstructed neural tracts can indicate abnormalities such as tearing,narrowing,or discontinuations,which have been used to identify axonal injury of neural tracts in concussion *** review focuses on the characteristic features of axonal injury in concussion or mild traumatic brain injury(m TBI)patients through the use of diffusion tensor *** injury in concussion(m TBI)patients is characterized by their occurrence in long neural tracts and multiple injuries,and these characteristics are common in patients with diffuse axonal injury and in concussion(m TBI)patients with axonal ***,the discontinuation of the corticospinal tract is mostly observed in diffuse axonal injury,and partial tearing and narrowing in the subcortical white matter are frequently observed in concussion(m TBI)patients with axonal *** difference appears to be attributed to the observation that axonal injury in concussion(m TBI)patients is the result of weaker forces than those producing diffuse axonal *** addition,regarding the fornix,in diffuse axonal injury,discontinuation of the fornical crus has been frequently reported,but in concussion(m TBI)patients,many collateral branches form in the fornix in addition to these findings in many case *** is presumed that the impact on the brain in TBI is relatively weaker than that in diffuse axonal injury,and that the formation of collateral branches occurs during the fornix recovery *** the occurrence of axonal injury in multiple areas of the brain is an important feature of diffuse axonal injury,case studies in concussion(m TBI)have shown that axonal injury occurs in multiple neural *** axonal injury lesions in m TBI patients may persist for approximately 10 years after injury onset,the characteristics of axonal injury in co

关键词： axonal injury brain injury concussion diffusion tensor imaging diffusion tensor tractography mild traumatic brain injury neural tract

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Recovery of a degenerated corticospinal tract after injury in a patient with intracerebral hemorrhage:confirmed by diffusion tensor tractography imaging

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Neural Regeneration Research 2015年第5期10卷 829-831页

作者： You sung seo sung Ho Jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

The corticospinal tract （CST） is a major neuronal tract of motor function in the human brain （York, 1987; Davidoff, 1990; Jang, 2014）. Recovery of an injured CST is one of the motor recovery mechanisms in stroke patients （Hendricks et al., 2003; Jang et al., 2006, 2007; Swayne et al., 2008; Kwon et al., 2011, 2013; Kwon and Jang, 2012; Yeo and Jang, 2013; Rong et al., 2014）. Diffusion tensor tractography （DTT）, derived from diffusion tensor imaging （DTI）, and transcra- nial magnetic stimulation （TMS） have been widely used in demonstrating the recovery of an injured CST （Hendricks et al., 2003; Jang et al., 2006, 2007; Swayne et al., 2008; Pannek et al., 2009; Kwon et al., 2011, 2013; Kwon and Jang, 2012; Yeo and Jang, 2013; Rong et al., 2014）. DTT has the advan- tage of enabling visualization of the architecture and integ- rity of the CST at the subcortical level in three dimensions （Mori et al., 1999; Kunimatsu et al., 2004）.

关键词： Recovery of a degenerated corticospinal tract after injury in a patient with intracerebral hemorrhage CST DTT ICH TMS

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Recovery of gait and injured corticoreticulospinal tracts in a patient with diffuse axonal injury

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Neural Regeneration Research 2021年第5期16卷 924-925页

作者： sung Ho Jang You sung seo Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaeguRepublic of Korea

Diffuse axonal injury(DAI)is defined as the presence of microscopic axonal damage in the white matter of the brain produced by mechanical forces and is characterized histologically by widespread damage to axons(Maxwell et al.,1997).Diffusion tensor imaging(DTI)allows evaluation of the integrity of the white matter of brain to be determined by virtue of its ability to image water diffusion characteristics(Basser et al.,1994).

关键词： axonal al. damage

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Recovery of injured fornical crura following neurosurgical operation of a brain tumor: a case report

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Neural Regeneration Research 2016年第5期11卷 854-855页

作者： sung Ho Jang You sung seo Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

The fornix, which is involved in transfer of episodic memory, is an important structure of the Papez circuit between the medial diencephalon and the medial temporal lobe. Many studies using DTI have reported on injury of the fornix in patients with brain injury （Nakayama et al., 2006; Sugiyama et al., 2007; Wang et al., 2008; Chang et al., 2010）. However, only a few studies on recov- ery of an injured fornix in patients with brain injury, including traumatic brain injury and stroke, have been reported （Yeo et al., 2011; Yeo and Jang, 2013a, b）. In this study, using follow up DTT images, we reported on a patient who showed recovery of injured fornical crura following a neurosurgical operation for a brain tumor.

关键词： body a case report Recovery of injured fornical crura following neurosurgical operation of a brain tumor DTT DTI

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Flux Optimization During Tapping in BOF Process

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Journal of Iron and Steel Research International 2011年第S2期18卷 148-152页

作者： Hyun-seo PARK sung-Mo seo Ji-Tae KWON Joo CHOI Steelmaking Research Group POSCO Technical Research Laboratories 699 Gumho-dong Gwangyang-si Jeonnam 545-090 Korea Technology development team plate rolling department Gwangyang Steelworks POSCO Gumho-dong Gwangyang-si Jeonnam 545-711 Korea

An integrated Plate Mill has started it’s operation on July 7, 2010 in Gwangyang Steelworks, POSCO. The production capability is about 2.5 million tons per year and the main stream consists of Blast Furnace, Hot metal pretreatment (KR), Converter, Bubbling Station, RH/VTD and Continuous Casting. Particularly, it is possible to control sulfur concentration at excellent level in BOF without any further treatment in LF or VTD, which is attained by unique KR process and scrap usage strategy in BOF. In this paper, desulfurization efficiency and steel cleanliness was introduced by optimizing flux amount during tapping in BOF process. In addition, the effect of the flux addition on the refractory of ladle was investigated based on EPMA analyses with the viewpoint of phase diagram. The cleanliness of each sample was examined using optical emission spectrometry and oxygen nitrogen determinator.

关键词： plate mill steel cleanliness flux tapping

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The brain activation pattern of the medial temporal lobe during chewing gum: a functional MRI study

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Neural Regeneration Research 2017年第5期12卷 812-814页

作者： Youn-Hee Choi Woo Hyuk Jang Sang-Uk Im Keun-Bae Song Hee-Kyung Lee Han Do Lee You sung seo sung Ho Jang Department of Preventive Dentistry School of Dentistry Kyungpook National University Department of Occupational Therapy College of Health Science Kangwon National University Departments of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

The human brain is known to be influenced by environmental stimuli（Feeney et al.,1982;Kaplan,1988）.Therefore,research on the brain activation pattern by external stimuli has been an important topic in neuroscience（Kaplan,1988）.Chewing gum has been known to have a positive effect on cognition,including alertness,attention,cognitive processing speed,

关键词： MRI The brain activation pattern of the medial temporal lobe during chewing gum a functional MRI study

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In vitro,in vivo and in silico anti-hyperglycemic inhibition by sinigrin

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 352-358页

作者： Qamar Abbas Mubashir Hassan Hussain Raza Song Ja Kim Ki-Wha Chung Gwang-Hoon Kim sung-Yum seo Department of Biological Sciences College of Natural SciencesKongju National University56 Gongjudehak-Ro 56GongjuChungnam 32588Republic of Korea

Objective:To evaluate the anti-hyperglycemic potential of sinigrin using in *** silico and in riro streptozotocin(STZ) induced hyperglycemic zebrafish ***:The in vitro enzyme inhibition assay was carried out to determine the IC_(50) value against α-glucosidase and α-*** silico molecular docking was performed against both enzymes with PyRx tool and simulations were performed using GROMACS *** was induced in zebrafishes using three intraperitoneal injections on alternating days for one week at 350mg/kg of *** fishes were treated intraperitoncally with 50.100 and 150 mg of sinigrin/kg of body weight for 24 h and glucose levels were ***:The sinigrin showed very strong inhibition against α-glucosidase and α-amylase with 0.248 and0.00124 μM while reference drug acarbose showed IC_(50) value of 73.0700 and 0.0017 μM against α-glucosidase and α-amylase,*** analysis revealed that sinigrin has the mixed type mode of inhibition against α-*** docking results revealed its strong binding affinity with α-glucosidase(-10.00 Kcal/mol) and α-amylase(-8.10 Kcal/mol).Simulations graphs confirmed its stability against both *** hyperglycemic zebrafishes most significant(P<0.001) reduction of glucose was occurred at150 mg/*** significant reduction of glucose was observed at 100 mg/kg and no any significant reduction of glucose was measured at 50 mg/***:It can be evident from the present results that sinigrin has potent anti-hyperglycemic activity and it may prove to be effective treatment for the hyperglycemia.

关键词： Anti-hyperglycemia MD simulations Sinigrin Zebrafish α-amylase α-glucosidase

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Increased thalamocortical connectivity from the affected thalamus to the unaffected hemisphere in a stroke patient

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Neural Regeneration Research 2020年第8期15卷 1568-1568页

作者： sung Ho Jang You sung seo sung Jun Lee Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

Consciousness is controlled by complicated actions of various neural structures(Schiff,2010;Long et al.,2016).The thalamocortical connections between the central thalamus and cerebral cortex are considered an important neural structure for consciousness(Laureys et al.,2000;Schiff,2010;Jang and Lee,2015).Here,we report a patient who revealed increased thalamocortical connectivity from the affected thalamus to the unaffected hemisphere through interthalamic adhesion.

关键词： al. patient thalamus

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Long-term follow-ups of revascularized immature necrotic teeth:three case reports

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International Journal of Oral Science 2012年第2期4卷 109-113页

作者： Duck-Su Kim Hae-Jin Park Je-Ha Yeom Ji-sung seo Gil-Joo Ryu Ki-Ho Park Seung-Il Shin Sun-Young Kim Department of Conservative Dentistry School of DentistryKyung Hee UniversitySeoulKorea Good Will Dental Hospital BusanKorea Department of Orthodontics School of DentistryKyung Hee UniversitySeoulKorea Department of Periodontology School of DentistryKyung Hee UniversitySeoulKorea

Revascularization of immature necrotic teeth is a reliable treatment alternative to conventional apexogenesis or apexification. In case 1, a 12-year-old boy had his necrotic, immature mandibular left second premolar treated with a revascularization technique. At a 24-month follow-up, periapical radiolucency had disappeared and thickening of the root wall was observed. In cases 2 and 3, a lO-year-old boy had his necrotic, immature, bilateral mandibular second premolars treated with the same modality. At 48-month （in case 2） and 42-month （in case 3） follow-ups, loss of periapical radiolucencies and increases in the root wall thickness were also observed.

关键词： revascularization pulp necrosis mineral trioxide aggregate antibiotic mixture immature tooth

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Cytochrome b5 Reductase 1 Triggers Serial Reactions that Lead to Iron Uptake in Plants

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Molecular Plant 2016年第4期9卷 501-513页

作者： Young Jun Oh Hanul Kim sung Hee seo Bae Geun Hwang Yoon seok Chang Junho Lee Dong Wook Lee Eun Ju Sohn Sang Joon Lee Youngsook Lee Inhwan Hwang Division of Integrative Biosciences and Biotechnology Department Life Sciences Division of Environmental Science and Engineering Division of Mechanical Engineering Pohang University of Science and Technology Pohang 790-784 Korea

Rhizosphere acidification is essential for iron （Fe） uptake into plant roots. Plasma membrane （PM） H＊-ATPases play key roles in rhizosphere acidification. However, it is not fully understood how PM H＋-ATPase activity is regulated to enhance root Fe uptake under Fe-deficient conditions. Here, we present evidence that cytochrome b5 reductase 1 （CBR1） increases the levels of unsaturated fatty acids, which stimulate PM H＋-ATPase activity and thus lead to rhizosphere acidification. CBRl-overexpressing （CBRI-OX） Arabidopsis thaliana plants had higher levels of unsaturated fatty acids （18：2 and 18：3）, higher PM H＊-ATPase activity, and lower rhizosphere pH than wild-type plants. By contrast, cbrl loss-of-function mutant plants showed lower levels of unsaturated fatty acids and lower PM H＊-ATPase activity but higher rhizosphere pH. Reduced PM H＊-ATPase activity in cbrl could be restored in vitro by addition of unsatu- rated fatty acids. Transcript levels of CBR1, fatty acids desaturase 2 （FAD2）, and fatty acids desaturase 3 （FAD3） were increased under Fe-deficient conditions. We propose that CBR1 has a crucial role in increasing the levels of unsaturated fatty acids, which activate the PM H＊-ATPase and thus reduce rhizosphere pH. This reaction cascade ultimately promotes root Fe uptake.

关键词： cytochrome b5 reductase 1 (CBR1) unsaturated fatty acids iron (Fe) uptake H^+-ATPase

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