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Atypical causes of cholestasis

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World Journal of Gastroenterology 2014年第28期20卷 9418-9426页

作者： Ken D nguyen Vinay sundaram Walid S Ayoub Department of Internal Medicine Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Gastroenterology and Hepatology Multi Organ Transplant CenterCedars Sinai Medical CenterLos AngelesCA 90048United States

Cholestatic liver disease consists of a variety of *** sclerosing cholangitis and primary biliary cirrhosis are the most commonly recognized cholestatic liver disease in the adult population,while biliary atresia and Alagille syndrome are commonly recognized in the pediatric *** infants,the causes are usually congenital or *** though jaundice is a hallmark of cholestasis,it is not always seen in adult patients with chronic liver *** can have"silent"progressive cholestatic liver disease for years prior to development of symptoms such as jaundice and *** this review,we will discuss some of the atypical causes of cholestatic liver disease such as benign recurrent intrahepatic cholestasis,progressive familial intrahepatic cholestasis,Alagille Syndrome,biliary atresia,total parenteral nutrition induced cholestasis and cholestasis secondary to drug induced liver injury.

关键词： Cholestasis Benign recurrent intrahepatic cholesta

Advances in High Density Interconnect Substrate and Printed Wiring Board Technology

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Advances in High Density Interconnect Substrate and Printed ...

nondestructive Determination of Moisture Content in Dry Fruits by Impedance and Phase Angle Measurements

第六届电子封装技术国际学术会议

作者： Venky sundaram Boyd Wiedenman Rao Tummala Packaging Research Center Georgia Institute of technology Packaging Research Center Georgia Institute of technology Packaging Research Center Georgia Institute of technology

The substrate or printed wiring board (PWB), as the largest component in electronic packages and systems, is performing an increasingly critical role in advancedpackages, high performance electronic s

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Journal of Sensor Technology 2015年第4期5卷 73-80页

作者： Chari V. Kandala Ron Holser Jaya sundaram naveen Puppala national Peanut Research Laboratory USDA Dawson GA USA Russell Research Center USDA Athens GA USA Faculty of Engineering University of Georgia Athens GA USA Clovis Center New Mexico State University Clovis NM USA

An electronic method to estimate the moisture content (MC) of dry fruits by measuring the impedance (Z) and phase angle (θ) of a cylindrical parallel-plate capacitor with dry fruit sample between the plates, using a CI meter (Chari’s Impedance meter) at 1 and 9 MHz is described. Capacitance C was derived from Z and θ, and using the C, θ, and Z values of a set of dried cherries, whose MC values were later determined by the vacuum hot air-oven method, a calibration equation was developed. Using this equation, and their measured C, θ, and Z values, the MC of a group of cherries, not used in the calibration, was predicted. The predicted values were compared with their air-oven values. Similar predictions were done using the same method on dried blueberries. The method worked well with a good R2 value, and showed a low standard error of prediction (SEP) in the measured MC range between 5% and 30% for cherries, and 9% and 22% for blueberries.

关键词： Cherries Blueberries CI Meter Moisture Content Capacitance Impedance Dry Fruits

InTERFEREnCE EFFECTS OBSERVED In PHOTOREFLECTAnCE SPECTRA

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真空科学与技术学报 1992年第Z1期23卷 175-178页

作者： M.Kallergi J.Aubel S.sundaram Physics Department University of South Florida Florida 33620 U.S.A.Physics Department University of South Florida Florida 33620 U.S.A.Physics Department University of South Florida Florida 33620 U.S.A.

The nature of the interference observed in photoreflectance spectra from epitaxial multilayer structures is clarified.

关键词：公切目力改址

Sensing of Moisture Content of In-Shell Peanuts by nIR Reflectance Spectroscopy

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Journal of Sensor Technology 2012年第1期2卷 1-7页

作者： Jaya sundaram Chari V. Kandala Konda naganathan Govindarajan Jeyam Subbiah Bio-Systems Engineering University of Nebraska Lincoln USA United States Department of Agriculture Agricultural Research Service National Peanut Research Laboratory Dawson USA

It was found earlier that moisture content (MC) of intact kernels of grain and nuts could be determined by near Infra Red (nIR) reflectance spectrometry. However, if the MC values can be determined while the nuts are in their shells, it would save lot of labor and money spent in shelling and cleaning the nuts. Grain and nuts absorb low levels of nIR, and when nIR radiation is incident on them, a substantial portion of the radiation is reflected back. Thus, studying the nIR reflectance spectra emanating from in-shell peanuts, an attempt is made for the first time to determine the MC of in-shell peanuts. In-shell peanuts of two different market types, Virginia and Valencia, were conditioned to different moisture levels between 6% and 26% (wet basis), and separated into calibration and validation groups. nIR absorption spectral data from 1000 nm to 2500 nm in 1 nm intervals were collected from both groups. Measurements were obtained on 30 replicates within each moisture level. Reference MC values for each moisture level in these groups were obtained using standard air-oven method. Partial Least Square (PLS) analysis was performed on the calibration data, and prediction models were developed. The Standard Error of Calibration (SEC), and R2 of the calibration models were computed to select the best calibration model. The selected models were used to predict the moisture content of peanuts in the validation sets. Predicted MC values of the validation samples were compared with their standard air-oven moisture values. Goodness of fit was determined based on the lowest Standard Error of Prediction (SEP) and highest R2 value obtained for the prediction models. The model, with reflectance plus normalization spectral data with an SEP of 0.74 for Valencia and 1.57 for Virginia type in-shell peanuts was selected as the best model. The corresponding R2 values were 0.98 for both peanut types. This work establishes the possibility of sensing MC of intact in-shell peanuts by nIR ref

关键词： In-Shell Peanuts nIR Spectroscopy Pretreatments Partial Least Square Standard Error of Prediction Relative Percent Deviation

Changing paradigm in treatment of lung cancer

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 214-219页

作者： sundaram Viswanath Abhishek Pathak Amul Kapoor Anvesh Rathore Bhupendra nath Kapur Medical Oncology Army Hospital Research and ReferralNew Delhi 110010India

Lung cancer is one of the most common and deadliest forms of *** accounts for 13%of all new cancer cases and 19%of cancer-related *** India,lung cancer constitutes 6.9%of all new cancer cases and 9.3%of all cancer *** has also been a dramatic rise worldwide in both the absolute and relative frequencies of lung cancer *** 1953 it became the most common cause of cancer mortality in *** 1985,it became the leading cause of cancer deaths in women,causing almost twice as many deaths as breast *** demographic profile of lung cancer has changed greatly over the years;however,methods for diagnosing,screening,and managing lung cancer patients have *** is due to our growing understanding of the biology of lung *** is now possible to further define lung cancer types beyond small cell lung carcinoma and non-small cell lung ***,new histology-based therapeutic modalities have been developed,and more new lung cancer biomarkers have been ***,more detailed histological characterization of lung cancer samples is warranted in order to determine the best course of treatment for specific *** review article describes how these new molecular technologies are shaping the way lung cancer can be treated in future.

关键词： non-small cell lung carcinoma epidermal growth factor receptor anaplastic lymphoma kinase

Large cell neuroendocrine carcinoma of the ampulla of Vater

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 465-467页

作者： Eswaran Selvakumar Velayutham Vimalraj Shanmugasundaram Rajendran Tirupporur G.Balachandar Devy G.Kannan Satyanesan Jeswanth Palaniappan Ravichandran Arunachalam sundaram Rajagopal Surendran Departments of Pathology and Surgical Gastroenterology Center for G.I.Bleeding & Division of Hepatobiliary Pancreatic Diseases Government Stanley Medical College Hospitalthe Tamilnadu Dr.M.G.R.Medical UniversityChennaiTamilnaduIndia

BACKGROUnD: neuroendocrine tumors of the ampulla of Vater are extremely rare, and few cases of large cell neuroendocrine carcinoma (LCnEC) of the ampulla have been reported. METHODS: A 48-year-old male with obstructive jaundice was admitted to our hospital. On examination the patient was found to have a periampullary growth and subsequently underwent the Whipple's procedure. RESULTS: Histopathological examination and immunohistochemistry revealed features of LCnEC of the ampulla of Vater. The patient developed multiple liver metastases 6 months after Whipple's procedure. COnCLUSIOn: LCnEC of the ampulla of Vater is rare and highly aggressive, with a dismal prognosis.

关键词： large cell neuroendocrine carcinoma ampulla of Vater Whipple's procedure periampullary growth

葡萄糖调节蛋白前体GRP78和肿瘤排斥抗原GP96为仓鼠附睾头部精子特有

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Asian Journal of Andrology 2010年第3期12卷 344-355,I0009页

作者： Duvvuri Butchi Kameshwari Satish Bhande Curam Sreenivasacharlu sundaram Venkatesh Kota Archana B. Siva Sisinthy Shivaji Centre for Cellular and Molecular Biology Hyderabad 500007 India

The immotile testicular mammalian spermatozoon gets transformed into a motile spermatozoon during ＇epididymal maturation＇. During this process, the spermatozoa transit from the caput to the cauda epididymis and undergo a number of distinct morphological, biophysical and biochemical changes, including changes in protein composition and protein modifications, which may be relevant to the acquisition of motility potential. The present proteome-based study of the hamster epididymal spermatozoa of caput and cauda led to the identification of 113 proteins spots using Matrix- assisted laser desorption/ionization tandem mass spectrometry （MALDI-MS/MS） analysis. Comparison of these 113 protein spots indicated that 30 protein spots （corresponding to 20 proteins） were significantly changed in intensity. Five proteins were increased and eleven were decreased in intensity in the cauda epididymal spermatozoa. In addition, two proteins, glucose-regulated protein precursor （GRP78） and tumor rejection antigen （GP96）, were unique to the caput epididymal spermatozoa, while one protein, fibrinogen-like protein 1, was unique to cauda epididymal spermatozoa. A few of the five proteins, which increased in intensity, were related to sperm metabolism and ATP production during epididymal maturation. The changes in intensity of a few proteins such as ERp57, GRP78, GP96, Hsp60, Hsp70, and dihydrolipoamide S-acetyltransferase were validated by immunoblotting. The present study provides a global picture of the changes in protein composition occurring during hamster sperm epididymal maturation, besides being the first ever report on the proteome of hamster spermatozoa.

关键词： epididymis hamster motility proteome spermatozoa

采用地质统计方法确定地下水抽水影响范围的实例研究

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陕西水利 1992年第6期 33-35页

作者： S.Majumder n.S.sundaram 李雷中国矿业大学

一、引言在世界许多地方的露天矿中都碰到了地下水问题。当开采延伸到含水层的原始测压水面以下时,常要借助于对含水层的强排疏干措施,以降低测压水面和防止矿区涌水。抽水影响范围通常超出采区边界并达到离矿区很远的地方。对影响范围... 详细信息

一、引言在世界许多地方的露天矿中都碰到了地下水问题。当开采延伸到含水层的原始测压水面以下时,常要借助于对含水层的强排疏干措施,以降低测压水面和防止矿区涌水。抽水影响范围通常超出采区边界并达到离矿区很远的地方。对影响范围的确定,有助于提前知道因测压水面降低可能受影响的区域。由抽水形成的新测压水面在矿坑附近会形成凹坑,从理论上来说,它要延伸到无限远处,才能与原始测压区相交。因此,用这种方法不能得到抽水的影响范围。在这样的情况下,应用地质统计方法可以解决抽水的影响范围问题。二。

关键词：地下水地质统计法抽水影响