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Infections in Alcoholic Hepatitis

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 718-725页

作者： Bhupinder Kaur Russell Rosenblatt Vinay sundaram Internal Medicine Department Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNYUSA Department of Gastroenterology and Hepatology and Comprehen-sive Transplant Center Cedars-Sinai Medical CenterLos AngelesCAUSA

Severe alcoholic hepatitis (sAH) is defined by a modified discriminant function ≥32 or model for end-stage liver disease (MELD) >20. Patients with sAH are in an immu-nocompromised state attributed to cirrhosis-related immu-noparesis and corticosteroid use. Individuals with sAH often develop severe infections that adversely impact short-term prognosis. Currently, the corticosteroid prednisolone is the only treatment with proven efficacy in sAH;however, the combination of corticosteroid treatment and altered host defense in sAH has been thought to increase the risk of acquiring of bacterial, opportunistic fungal, and viral infec-tions. newer studies have shown that corticosteroids do not increase occurrence of infections in those with sAH;unfor-tunately, the lack of response to corticosteroids may instead predispose to infection development. Prompt and appropri-ate antibiotic treatment is therefore essential to improving patient outcomes. This review highlights common infections and risk factors in patients with sAH. Additionally, current diagnostic, therapeutic, and prophylactic strategies in these patients are discussed.

关键词： Alcoholic hepatitis Infections Corticosteroids STOPAH Antibiotic treatment Aspergillosis Immunodeficiency Alcoholic liver disease

Design of Precise Multiplier Using Inexact Compressor for Digital Signal Processing

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Computer Systems Science & Engineering 2022年第8期42卷 619-638页

作者： nagarajan Shanmugam Vijeyakumar Krishnasamy natarajan Kalaiselvi sundaram Saravanakumar natarajan Electronics and Communication Engineering Dr.Mahalingam College of Engineering and TechnologyPollachi642003Tamil NaduIndia

In the recent years,error recovery circuits in optimized data path units are adopted with approximate computing *** this paper the novel multipliers have effective utilization in the newly proposed two different 4:2 approximate compressors that generate Error free Sum(ES)and Error free Carry(EC).Proposed ES and Proposed EC in 4:2 compressors are used for performing Partial Product(PP)*** structural arrangement utilizes Dadda structure based *** to the regularity of PP arrangement Dadda multiplier is chosen for compressor implementation that favors easy standard cell ASIC *** this,the proposed compression idealogy are more effective in the smallest n columns,and the accurate compressor in the remaining most significant *** limits the error in the multiplier output to be not more than 2n for an n X n *** choice among the proposed compressors is decided based on the significance of the sum and carry signals on the multiplier *** an enhancement to the proposed multiplier,we introduce two Area Efficient(AE)variants viz.,Proposed-AE(P-AE),and P-AE with Error Recovery(P-AEER).The proposed basic P-AE,and P-AEER designs exhibit 46.7%,52.9%,and 52.7%PDP reduction respectively when compared to an approximate multiplier of minimal error type and are designed with 90nm ASIC *** proposed design and their performance validation are done by using Cadence *** performance evaluations are carried out using cadence encounter with 90nm ASIC *** proposed-basic P-AEA and P-AEER designs demonstrate 46.7%,52.9%and 52.7%PDP reduction compared to the minimal error approximate *** proposed multiplier is implemented in digital image processing which revealed 0.9810 Structural SIMilarity Index(SSIM),to the least,and less than 3%deviation in ECG signal processing application.

关键词： Approximate computing precise multiplier PP compression area-efficient error-recovery approach

Metaheuristics with Optimal Deep Transfer Learning Based Copy-Move Forgery Detection Technique

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Intelligent Automation & Soft Computing 2023年第1期35卷 881-899页

作者： C.D.Prem Kumar S.Saravana sundaram Department of Information Technology Hindusthan College of Engineering and TechnologyCoimbatore641032TamilnaduIndia Department of Electrical and Electronics Engineering Hindusthan College of Engineering and TechnologyCoimbatore641032TamilnaduIndia

The extensive availability of advanced digital image technologies and image editing tools has simplified the way of manipulating the image *** effective technique for tampering the identification is the copy-move *** image processing techniques generally search for the patterns linked to the fake content and restrict the usage in massive data ***-ingly,deep learning(DL)models have demonstrated significant performance over the other statistical *** this motivation,this paper presents an Optimal Deep Transfer Learning based Copy Move Forgery Detection(ODTL-CMFD)*** presented ODTL-CMFD technique aims to derive a DL model for the classification of target images into the original and the forged/tampered,and then localize the copy moved *** perform the feature extraction process,the political optimizer(PO)with Mobile networks(Mobilenet)model has been derived for generating a set of useful ***,an enhanced bird swarm algorithm(EBSA)with least square support vector machine(LS-SVM)model has been employed for classifying the digital images into the original or the forged *** utilization of the EBSA algorithm helps to properly modify the parameters contained in the Multiclass Support Vector Machine(MSVM)technique and thereby enhance the classification *** ensuring the enhanced performance of the ODTL-CMFD technique,a series of simulations have been performed against the benchmark MICC-F220,MICC-F2000,and MICC-F600 *** experimental results have demonstrated the improvised performance of the ODTL-CMFD approach over the other techniques in terms of several evaluation measures.

关键词： Copy move detection image forgery deep learning machine learning parameter tuning forensics

Role of omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes on intestinal barrier integrity and immunity in animals

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1240-1261页

作者： Tamil Selvi sundaram Carlotta Giromini Raffaella Rebucci Juraj Pistl Mangesh Bhide Antonella Baldi Department of Veterinary Science for Health Animal Production and Food SafetyUniversity of MilanVia Trentacoste 220134 MilanItaly University of Veterinary Medicine and Pharmacy in Kosice Komenskeho 68/7304181 KosiceSlovakia

The gastrointestinal tract of livestock and poultry is prone to challenge by feedborne antigens,pathogens,and other stress factors in the farm *** physiological inflammation and oxidative stress that arises firstly disrupts the intestinal epithelial barrier followed by other components of the gastrointestinal *** the present review,the interrelationship between intestinal barrier inflammation and oxidative stress that contributes to the pathogenesis of inflammatory bowel disease was ***,the role of naturally existing immunomodulatory nutrients such as the omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes in preventing intestinal barrier inflammation was *** on the existing evidence,the possible molecular mechanism of these bioactive nutrients in the intestinal barrier was outlined for application in animal diets.

关键词： Citrus pectin Immunomodulatory nutrients Inflammation Intestinal epithelial barrier Milk-derived exosomes Omega-3 polyunsaturated fatty acids Oxidative stress

Mutual Self‑Regulation of d‑Electrons of Single Atoms and Adjacent nanoparticles for Bifunctional Oxygen Electrocatalysis and Rechargeable Zinc‑Air Batteries

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nano-Micro Letters 2023年第4期15卷 40-57页

作者： sundaram Chandrasekaran Rong Hu Lei Yao Lijun Sui Yongping Liu Amor Abdelkader Yongliang Li Xiangzhong Ren Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China College of Chemistry and Bioengineering Guilin University of TechnologyGuilin 541004People’s Republic of China Shenzhen Key Laboratory of Special Functional Materials Shenzhen Engineering Laboratory for Advanced Technology of CeramicsCollege of Materials Science and EngineeringGuangdong Research Center for Interfacial Engineering of Functional MaterialsShenzhen UniversityShenzhen 518060People’s Republic of China Shanghai Key Laboratory for R&D and Application of Metallic Functional Materials Institute of New Energy for VehiclesSchool of Materials Science and EngineeringTongji UniversityShanghai 201804People’s Republic of China Department of Design and Engineering Faculty of Science&TechnologyBournemouth UniversityPoole BH125BBDorsetUK

Rechargeable zinc-air batteries(ZABs)are a promising energy conversion device,which rely critically on electrocatalysts to accelerate their rate-determining reactions such as oxygen reduction(ORR)and oxygen evolution reactions(OER).Herein,we fabricate a range of bifunctional M-n-C(metal-nitrogen-carbon)catalysts containing M-nx coordination sites and M/MxC nanoparticles(M=Co,Fe,and Cu)using a new class ofγ-cyclodextrin(CD)based metal-organic framework as the *** the two types of active sites interacting with each other in the catalysts,the obtained Fe@C-FenC and Co@C-ConC display superior alkaline ORR activity in terms of low half-wave(E1/2)potential(~0.917 and 0.906 V,respectively),which are higher than Cu@C-CunC(~0.829 V)and the commercial Pt/C(~0.861 V).As a bifunctional electrocatalyst,the Co@C-ConC exhibits the best performance,showing a bifunctional ORR/OER overpotential(ΔE)of~0.732 V,which is much lower than that of Fe@C-FenC(~0.831 V)and Cu@C-CunC(~1.411 V),as well as most of the robust bifunctional electrocatalysts reported to *** X-ray absorption spectroscopy and density functional theory simulations reveal that the strong electronic correlation between metallic Co nanoparticles and the atomic Co-n4 sites in the Co@C-ConC catalyst can increase the d-electron density near the Fermi level and thus effectively optimize the adsorption/desorption of intermediates in ORR/OER,resulting in an enhanced bifunctional electrocatalytic *** Co@C-ConC-based rechargeable ZAB exhibited a maximum power density of 162.80 mW cm^(−2) at 270.30 mA cm^(−2),higher than the combination of commercial Pt/C+RuO2(~158.90 mW cm^(−2) at 265.80 mA cm^(−2))*** the galvanostatic discharge at 10 mA cm^(−2),the ZAB delivered an almost stable discharge voltage of 1.2 V for~140 h,signifying the virtue of excellent bifunctional ORR/OER electrocatalytic activity.

关键词： Cyclodextrin CD-MOF Single-atom catalyst ORR/OER Zinc-air battery

在镰状细胞疾病患儿中胎盘生长因子促进肺动脉高压的发生

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中华高血压杂志 2010年第9期18卷 864-864页

作者：叶鹏 sundaram n Tailor A Mendelsohn L Wansapura J Wang X Higashimoto T Pauciulo MW Gottliebson W Kalra VK nichols WC Kato GJ Malik P

在镰状细胞病（sickle cell disease，SCD）患者中，肺动脉高压通常被认为是造成一氧化氮生成减少和早期病死的原因之一。之前，该研究小组已发现胎盘生长因子（placenta growth factor，PLGF），一种由红细胞产生的血管生成因子，诱导... 详细信息

在镰状细胞病（sickle cell disease，SCD）患者中，肺动脉高压通常被认为是造成一氧化氮生成减少和早期病死的原因之一。之前，该研究小组已发现胎盘生长因子（placenta growth factor，PLGF），一种由红细胞产生的血管生成因子，诱导不受低氧控制的肺内皮细胞中肺血管收缩内皮素1（pulmonary vasoconstrictor endothelin-1）的表达。研究人员应用慢病毒载体，

关键词：胎盘生长因子肺动脉高压镰状细胞疾病患儿一氧化氮生成血管生成因子镰状细胞病肺血管收缩

Increased plasma malondialdehyde and fructosamine in anemic H pylori infected patients:Effect of treatment

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World Journal of Gastroenterology 2007年第5期13卷 796-800页

作者： G Vijayan RC sundaram Zachariah Bobby Abdoul Hamide n Selvaraj n Rattina Dasse Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry 605006 India Department of Medicine Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry 605006 India

AIM: To unravel the possible association of malon-dialdehyde (MDA) and fructosamine in anemic H pylori infected patients and to observe the alteration in MDA and fructosamine levels in these patients after treatment for one ***: Fructosamine, MDA and glucose were estimated in 22 anemic H pylori infected patients and 16 healthy controls. Hematological parameters were also evaluated in both the groups using Sysmex-K-100 automated cell counter. The H pylori infected patients were randomly divided into two groups. H pylori infected patients in GroupⅠreceived both iron supplementation and anti-H pylori therapy, while patients in Group Ⅱ received only iron supplementation. All the biochemical and hematological parameters were estimated after one month of treatment. RESULTS: In anemic H pylori infected patients, while MDA (5.41 ± 2.16 vs 2.26 ± 0.50; P nd fructosamine (2.64 ± 0.93 vs 1.60 ± 0.35; P nificantly increased, iron (32.72 ± 14.93 vs 110.25 ± 26.58; P n (6.9 ± 2.6 vs 12.66 ± 0.74; P nd ferritin (28.82 ± 16.27 vs 140.43 ± 30.72; P nificantly decreased compared with the controls. With partial correlation analysis, fructosamine was found to have a significant positive correlation with MDA. In GroupⅠ, while MDA level decreased significantly (3.11 ± 1.73 vs 5.50 ± 2.46; P nificant increase in iron (84.09 ± 29.51 vs 36.09 ± 17.81; P n (10.40 ± 1.11 vs 7.42 ± 1.90; P nd ferritin (116.91 ± 63.34 vs 30.46 ± 17.81; P ne month. There was no significant change in the levels of fructosamine in groupⅠafter treatment. Similarly, no significant alterations were noted in the levels of MDA, fructosamine, hemoglobin or ferritin in Group Ⅱ patients after one month of ***: An increased level of fructosamine and MDA was found in anemic H pylori infected patients. Present data supports the premise that lipid peroxi

关键词：幽门螺杆菌感染贫血果糖胺丙二醛血浆含量

The clinical outcomes of laser with suction device in mini-percutaneous nephrolithotomy

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Asian Journal of Urology 2022年第1期9卷 63-68页

作者： Abhishek Gajendra Singh sundaram Palaniappan Shrikant Jai Gopal Tak Arvind Ganpule Ravindra Sabnis Mahesh Desai Department of Urology Muljibhai Patel Urological HospitalVirendradesai MargNadiadGujaratIndia

Objective:To evaluate the safety,efficacy and feasibility of laser with suction device in mini-percutaneous nephrolithotomy(mini-PCnL).Methods:A retrospective study was conducted including 200 patients who underwent mini-PCnL for renal *** patients underwent PCnL using Electro-Medical Systems *** addition to the laser in 100 patients,a suction device was used(laser with suction[LWS]).In the other 100,suction device was not used(laser with no additional suction[LOS]).Mini-PCnL was performed using standard technique and Karl Storz minimally invasive PCnL-medium system was *** end point was stone ***:Both the groups were comparable in terms of demographic *** stone size was 15.24±5.90 mm and 16.16±5.53 mm in LWS and LOS,*** Hounsfield unit of stone was 1285.64 and 1206.79 in LWS and LOS,*** time was less in LWS group(56.89±19.65 min)as compared to LOS(62.01±28.81 min).At one-month follow-up,radiological complete clearance was 96%in LWS and 92%in *** subgroup analysis of stones larger than 18 mm,the clearance rate was in favour of LWS(85.7%vs.100%)and also the need for nephrostomy placement was less in LWS ***:LWS device is safe and efficacious when used with *** stones greater than 18 mm,it has a better stone free rate as compared to using no suction.

关键词： Mini-percutaneous nephrolithotomy Laser with suction Stone clearance

Theoretical prediction and validation of global horizontal solar irradiance for a tropical climate in India

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Frontiers in Energy 2015年第3期9卷 311-321页

作者： Sivasankari sundaram Jakka SARAT CHAnDRA BABU Department of Chemical Engineering National Institute of Technology Tiruchirappalli 620015 India

This paper aims to propose monthly models responsible for the theoretical evaluation of the global horizontal irradiance of a tropical region in India which is Sivagangai situated in Tamilnadu. The actual measured global horizontal irradiance hails from a 5 MW solar power plant station located at Sivagangai in Tamilnadu. The data were monitored from May 2011 to April 2013. The theoretical assessment was conducted differently by employing a programming platform called Microsoft Visual Basic 2010 Express. A graphical user interface was created using Visual Basic 2010 Express, which provided the evaluation of empirical parameters for model formulation such as daily sunshine duration （5）, maximum possible sunshine hour duration （S0）, extra terrestrial horizontal global irradiance （H0） and extra terrestrial direct normal irradiance （G0）. The proposed regression models were validated by the significance of statistical indicators such as mean bias error, root mean square error and mean percentage error from the predicted and the actual values for the region considered. Comparison was made between the proposed monthly models and the existing normalized models for global horizontal irradiance evaluation.

关键词： global horizontal irradiance (GHI) mean biaserror root mean square error mean percentage error,coefficient of regression Visual Basic 2010 Express