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Real-time-guided bone regeneration around standardized critical size calvarial defects using bone marrow-derived mesenchymal stem cells and collagen membrane with and without using tricalcium phosphate: an in vivo microcomputed tomographic and histologic e

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International Journal of Oral Science 2016年第1期8卷 7-15页

作者： Khalid Al-Hezaimi sundar ramalingam Mansour Al-Askar Aws S ArRejaie Nasser Nooh Fawad Jawad Abdullah Aldahmash Muhammad Atteya Cun-Yu Wang Engineer A.B.Growth Factors and Bone Regeneration Research Chair and 3D Imaging Center College of DentistryKing Saud UniversityRiyadhSaudi Arabia Department of Periodontics and Community Dentistry College of DentistryKing Saud UniversityRiyadhSaudi Arabia Department of Oral and Maxillofacial Surgery College of DentistryKing Saud UniversityRiyadhSaudi Arabia Department of Substitutive Dental Sciences College of DentistryUniversity of DammamDammamSaudi Arabia Stem Cell Unit Department of AnatomyCollege of MedicineKing Saud UniversityRiyadh Division of Oral Biology and Medicine School of DentistryUniversity of California at Los AngelesLos AngelesUSA

The aim of the present real time in vivo micro-computed tomography （pCT） and histologic experiment was to assess the efficacy of guided bone regeneration （GBR） around standardized calvarial critical size defects （CSD） using bone marrow-derived mesenchymal stem cells （BMSCs）, and collagen membrane （CM） with and without tricalcium phosphate （TCP） graft material. In the calvaria of nine female Sprague-Dawley rats, full-thickness CSD （diameter 4.6 mm） were created under general anesthesia. Treatment-wise, rats were divided into three groups. In group 1, CSD was covered with a resorbable CM; in group 2, BMSCs were filled in CSD and covered with CM; and in group 3, TCP soaked in BMSCs was placed in CSD and covered with CM. All defects were closed using resorbable sutures. Bone volume and bone mineral density of newly formed bone （NFB） and remaining TCP particles and rate of new bone formation was determined at baseline, 2, 4, 6, and 10 weeks using in vivo pCT. At the lOth week, the rats were killed and calvarial segments were assessed histologically. The results showed that the hardness of NFB was similar to that of the native bone in groups I and 2 as compared to the NFB in group 3. Likewise, values for the modulus of elasticity were also significantly higher in group 3 compared to groups 1 and 2. This suggests that TCP when used in combination with BMSCs and without CM was unable to form bone of significant strength that could possibly provide mechanical ＂lock＂ between the natural bone and NFB. The use of BMSCs as adjuncts to conventional GBR initiated new bone formation as early as 2 weeks of treatment compared to when GBR is attempted without adiunct BMSC therapy.

关键词： bone marrow-derived mesenchymal stem collagen membrane critical size defect guided bone regeneration tricalciumphosphate

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.Li Nagendran ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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Novel technique(ramalingam technique)of port site retrograde intra renal surgery through exteriorized ureter during laparoscopy

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Asian Journal of Urology 2023年第3期10卷 372-375页

作者： Manickam ramalingam Kallappan Senthil Sivasankaran Nachimuthu Urology Department Hindusthan HospitalCoimbatoreIndia

Occurrence of significant sized renal calculi along with ureteric pathology is not *** presented two patients:one with significant sized renal calculi along with lower ureteric stricture,and second case with significant sized renal calculi with primary obstructive mega ureter needing surgery for both the renal calculi and ureteric *** both patients laparoscopy was done,and the ureter was mobilised and divided just above the level of the pathology and exteriorised through the nearest sited port,and retrograde intra-renal surgery(RIRS)was done using flexible ureteroscope and *** laparoscopy was resumed,and ureteric reimplantation directly into the bladder or with a Boari flap was *** entire procedure was completed in a single *** novel technique of exteriorizing the ureter through the laparoscopic port site for flexible ureteroscopy in a case of lower ureteric pathology with renal stone is an advantageous option to manage both pathologies in a single *** has a better stone clearance than shock wave lithotripsy and less morbidity than percutaneous nephrolithotomy(PCNL).

关键词： ureter surgery bladder

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Performance studies on recycled aggregate concrete with treated recycled aggregates

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Waste Disposal and Sustainable Energy 2023年第4期5卷 451-459页

作者： Malathy ramalingam Jagan Sivamani Karuppasamy Narayanan Faculty Department of Civil EngineeringSona College of TechnologySalemTamil NaduIndia

Excessive construction activities generate huge quantities of waste that are disposed of in nearby sites,leading to environmental *** the concrete fractions of construction wastes for their utilization as aggregates has been predominant among industrialists and researchers in recent ***,the smearance of cement mortar on the recycled aggregates affects the concrete *** treatments were developed to remove the weak cement mortar or seal the micro-pores on the adhered cement mortar of recycled *** paper investigates the comparative efficiency of acid and carbonation treatment on recycled coarse aggregate(RCA)properties and its behaviour on recycled aggregate concrete(RAC).The RCA was treated with HCl acid at 0.1 mol/L,0.5 mol/L,and 0.8 mol/L and CO_(2) at 0.1 bar,0.2 bar,and 0.4 bar and tested for their physical properties,and the concrete mixtures with treated recycled aggregates were tested for fresh and hardened *** could be observed that the properties of RAC were affected owing to the smearance of weak mortar,whereas for the concrete with carbonated(RACc)and chemically treated aggregates(RACa),the concrete properties tended to *** strength of RAC was 28.59%less than that of normal aggregate concrete(NAC),whereas the strength of RACc and RACa was enhanced by 16.44%and 9.7%compared to that of RAC at 28 *** water absorption of RAC was 47.51%more than that of NAC,whereas the water absorption of RACa and RACc was 28.67%and 33.75%lesser than ***-soaking the RCA with acids removes the adhered mortar due to its acidic *** contrast,in carbonation,the CO_(2) reacts with the Ca(OH)_(2) on the cement mortar to form CaCO_(3),filling the micro-cracks in the cement mortar on the RCA.

关键词： Recycled aggregates Chemical Carbonation Adhered mortar Recycled aggregate concrete Strength Water absorption

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Emerging mosquito-borne arboviral infection Zika-An epidemiological review

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Asian Pacific Journal of Tropical Biomedicine 2020年第5期10卷 193-200页

作者： Ashwini Malla Balamurugan Shanmugaraj Sathishkumar ramalingam Plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar UniversityCoimbatoreTamil NaduIndia

The unprecedented resurgence and geographical expansion of arboviral infections such as dengue, chikungunya, yellow fever, and Zika have a significant impact on human health and pose a serious threat to public health globally in recent years. Zika virus is a Flavivirus and is transmitted to humans through an infected mosquito bite. The Zika virus has been identified in many countries in Africa, Asia, and Pacific islands and sporadic human cases have been reported since 1947. The non-specific clinical symptoms of Zika fever are often misdiagnosed with other arboviral infections, especially dengue and chikungunya. Till now, there is no vaccine or specific antiviral treatment for Zika infection. The recent emergence of Zika is alarming and highlights the need for arboviral research to develop an effective treatment. Here in this review, we discussed the epidemiology of Zika, which has re-emerged in the recent decade and caused international concern.

关键词： Arboviruses Epidemiology Mosquito Zika

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Dye-tolerant marine Acinetobacter baumannii-mediated biodegradation of reactive red

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Water Science and Engineering 2018年第4期11卷 265-275页

作者： Sneha Unnikrishnan Mohd Hashim Khan Karthikeyan ramalingam School of Life Sciences B.S.Abdur Rahman Crescent Institute of Science and Technology

The objective of this study was to isolate a potent dye-degrading microbe that can be used to reduce the pollution caused by industrial *** red 198 is an extensively used textile dye and is a major environmental pollutant in water bodies. In this study, a bacterial strain was isolated from sea sediments and identified as Acinetobacter baumannii with 16S rRNA sequencing. The isolated bacteria were immobilized in calcium alginate and decolorization studies were carried out to determine the optimum pH, temperature, dye concentration, inoculum volume,and static/agitated condition using the one factor at a time(OFAT) approach. The Box-Behnken design, a type of response surface methodology,was adopted to improve the degradation efficiency. At 37℃ using an inoculum volume of six beads, 96.20% decolorization was observed in 500 mg/L of reactive red 198 after 72 h. Dye degradation was confirmed with UV-visible spectroscopy and Fourier-transform infrared(FTIR)spectroscopy studies of the dye and degraded metabolites. Microbial toxicity studies using Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and phytotoxicity studies using Vigna radiata proved that the toxicity of the dye was significantly reduced after degradation. We can conclude that the isolated A. baumannii strain is an efficient dye-degrading microbe that can be used to reduce the pollution caused by industrial dyes.

关键词： Immobilization Box-Behnken design Response surface methodology Microbial toxicity Dye degradation

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Chikungunya infection:A potential re-emerging global threat

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 910-915页

作者： Shanmugaraj Bala Murugan ramalingam Sathishkumar Plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar University

Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently, re-emergence of Chikungunya viral infection harmed many in Asian and African countries. Chikungunya was considered as a major threat in developing and underdeveloped countries; the recent epidemiological outbreak of Chikungunya in La Reunion urges the global researchers to develop effective vaccine against this viral disease. In this review, Chikungunya, pathogenesis and epidemiology were briefly described.

关键词： Aedes mosquitoes Alphavirus Arthropod-borne disease Chikungunya Non-Structural Proteins Structural Proteins

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Epidemiology, clinical features and transmission of re-emerging arboviral infection chikungunya

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Asian Pacific Journal of Tropical Biomedicine 2019年第4期9卷 135-139页

作者： Balamurugan Shanmugaraj Ashwini Malla Sathishkumar ramalingam Plant Genetic Engineering Laboratory Department of Biotechnology Bharathiar University Bharat Biotech International Limited Genome Valley

A number of re-emerging and emerging infectious diseases including chikungunya, West Nile, yellow fever, Zika, dengue, Japanese encephalitis, and others have increased in recent years, which threaten the public health across the globe. Chikungunya is a neglected re-emerging arboviral infection caused by chikungunya virus. Arboviral infections such as chikungunya, Zika and dengue have similar epidemiology, transmission cycles and clinical symptoms, which makes it difficult to diagnose these three infections. Moreover, there is no commercial vaccine or licensed therapy available for chikungunya infection, thus causing severe burden worldwide. Vector control may reduce the disease risk; however, this remains a challenge due to many factors including, but not limited to, evolution of insecticide resistance in mosquitoes, gaps in vector control tools, urbanization, environmental and demographic changes. Effective integrated vector control strategies and surveillance measures along with affordable vaccine development or anti-viral therapy are essential to control the infection. In this review, we discuss the epidemiology of mosquito-borne infection chikungunya which has re-emerged as an international concern in recent decades.

关键词： Arboviruses Chikungunya Epidemiology Mosquito

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Uniform assembly of gold nanoparticles on S-doped g-C3N4 nanocomposite for effective conversion of 4-nitrophenol by catalytic reduction

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Journal of Materials Science & Technology 2020年第5期40卷 176-184页

作者： Vellaichamy Balakumar Hyungjoo Kim Ji Won Ryu ramalingam Manivannan Young-A Son Department of Advanced Organic Materials Engineering Chungnam National University220 Gung-dongYuseong-guDaejeon305-764South Korea

In this work,a simple synthesis of sulfur doped graphitic carbon nitride(S-g-C3N4)act as a support cum stabilizers for gold nanoparticles(Au)and its was characterized by UV–vis and XRD to measure the absorbance and crystallinity,*** functional group and morphology of the samples were identified using FT-IR and ***,the Au@S-g-C3N4 nanocatalyst exhibits good catalytic performance and stability in the reduction of hazardous 4-nitrophenol(NP)compared to S-g-C3N4 using Na ***,the Au@S-g-C3N4 nanocomposite holds a good catalytic efficiency(near 100%)achieved by within 5 *** highest catalytic reduction of NP is due to the synergistic effect of Au nanoparticles decorated on *** fast electron transfer reduction mechanism was elucidated and *** reusability and stability of the developed nanocomposites were also observed in consecutive reduction *** filtering and catalyzing device was used for the direct conversion of NP polluted *** method can open a new avenue for the metal nanoparticles based carbon materials heterogeneous catalyst and its reduction of toxic contaminants.

关键词： Gold nanoparticles S-doped g-C3N4 Catalytic reduction 4-nitrophenol

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Comparative studies on numerical sensitivity of different scenarios of enhanced oil recovery by water-alternating-gas(CO_(2))injection

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Petroleum Research 2023年第4期8卷 505-513页

作者： Saddam Mohammed Mohammed Nasser Achinta Bera Vivek ramalingam School of Energy Technology Pandit Deendayal Energy UniversityGandhinagarGujarat382007India

Enhanced oil recovery by CO_(2) injection technology(CO_(2)-EOR)plays a crucial role in enhancing oil production and the permanent sequestration of anthropogenic CO_(2) in depleted oil ***,the availability of CO_(2) in oil field locations and its mobility in contrast with reservoir fluids are prime challenges in CO_(2)-*** cost of CO_(2) and its availability at the oil fields has prompted investigations on efficient injection of CO_(2) at the fields to achieve the best sweep efficiency *** strategies such as water-alternating-gas(WAG),simultaneous vertical and horizontal WAG,simultaneous water injection into the aquifer and vertical WAG,water and gas injection simultaneously but separately(SS-WAG),and water and gas injection simultaneously but not separately(SNS-WAG)play a significant role,as well as the purity of CO_(2).In this work,the significance of the above criteria was investigated indi-vidually and in *** coupled sequence of injection rate,soaking time,WAG ratio,and purity of injected CO_(2) for enhancement of oil production were delineated.A realistic reservoir simulation model conceptualizing the CO_(2)-EOR system with five spot injection patterns was developed by the company *** history-matched model that was developed was used to investigate the sensitivity of the coupled effects to the criteria listed above on oil *** investigations quantitatively emphasized that purity and soaking time of CO_(2) have an inverse effect in the oil production rate and that SNS-WAG resulted in a better oil production rate than SS-WAG.

关键词： Water-alternating-gas Enhanced oil recovery Sensitivityanalysis Modelingand simulation Simultaneouslybut not separately water-alternating-gas(SS-WAG) Simultaneously pressure maintenance and WAG

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