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AC Conductance Through a Vibrating Molecular Dot in Kondo Regime

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Communications in Theoretical Physics 2007年第12期48卷 1107-1114页

作者： Hyun-chul Yong School of Physics Peking UniversityBeijing 100871China

In the present paper,by applying the Lang-Firsov canonical transformation and the so-called non-crossingapproximation technique,we investigate the joint effects of the electron-phonon interaction and an external alternatinggate voltage on the transport of a quantum dot system in the Kondo *** find that,while the satellite Kondoresonant peaks appear in both the averaged local density of states and the differential conductance,the main Kondopeak at the Fermi energy is greatly *** results confirm the previous ones derived by other methods,suchas the equation of motion ***,based on the picture of virtual transition between quasi-eigenstates inthe system,we also give a slightly different explanation on these phenomena.

关键词： quantum dot Kondo effect electron-phonon interaction AC conductance

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儿童药物难治性癫痫的遗传学及临床特征分析

中国全科医学 2025年第6期28卷 756-762页

作者：左然然孙素真河北省儿童医院神经内科河北省小儿癫痫与神经疾病重点实验室河北省石家庄市050000

背景目前儿童药物难治性癫痫(DRE)在儿童癫痫中的占比维持在30%左右,且常合并精神发育迟滞,影响患儿生活质量,因此DRE的诊疗仍然是神经病学的重大挑战。目的分析儿童DRE的遗传学特点及临床特征,为临床进行基因检测提供理论依据。方法回... 详细信息

背景目前儿童药物难治性癫痫(DRE)在儿童癫痫中的占比维持在30%左右,且常合并精神发育迟滞,影响患儿生活质量,因此DRE的诊疗仍然是神经病学的重大挑战。目的分析儿童DRE的遗传学特点及临床特征,为临床进行基因检测提供理论依据。方法回顾性选取2020—2022年于河北省儿童医院住院治疗且完善基因检测的95例DRE患儿为研究对象,根据基因检测结果分为基因突变阳性组(44例)和基因突变阴性组(51例)。收集患儿的一般资料(包括性别、发病年龄、用药情况、发热惊厥史、癫痫家族史等)、临床特征(发作类型、癫痫综合征、发育情况)、辅助检查[基因检测、视频脑电图(VEEG)检查、神经影像学检查],分析DRE的遗传病因及临床特征。结果95例DRE患儿中,男55例(57.9%)、女40例(42.1%),中位发病年龄为1.00(0.50,4.00)岁,用药数量为3(2,4)种;基因突变阳性组患儿发病年龄小于基因突变阴性组(Z=-5.322,P=0.001);两组患儿性别、发热惊厥史、癫痫家族史、用药数量比较,差异均无统计学意义(P>0.05)。38例(40.0%)的患儿确诊为癫痫综合征,其中76.3%(29/38)在新生儿或婴儿期发病;基因突变阳性组患儿癫痫综合征占比高于基因突变阴性组(χ^(2)=12.065,P=0.001)。临床发作类型多样,最常见的为2种及以上发作类型,占52.6%(50/95),其次为单一局灶性发作,占33.7%(32/95);两组DRE患儿发作类型比较,差异无统计学意义(χ^(2)=2.920,P=0.404)。57例患儿完善了发育筛查,其中43例(75.4%)在发病后出现不同程度的发育迟缓,33例(76.7%)表现为全面性发育迟缓;基因突变阳性组患儿发育迟缓占比高于基因突变阴性组(χ^(2)=5.728,P=0.017)。44例患儿检出变异基因,阳性检出率为46.3%,其中以离子通道类变异为主,SCN1A为最常见的单基因突变。90例(94.7%)患儿VEEG检查异常,以局灶性癫痫放电为主;基因突变阳性组患儿高峰失律占比高于基因突变阴性组(χ^(2)=7.425,P=0.006)。25例(26.3%)患儿存在结构性病因,其中基因突变阳性组12例,基因突变阴性组13例;两组DRE患儿结构性病因比较,差异无统计学意义(χ^(2)=0.039,P=0.844)。结论遗传因素为儿童DRE的重要病因,提示发病年龄小、发育迟缓与遗传性病因有关,应积极早期完善基因检测,有助于早期诊断DRE并精准治疗。

关键词：药物难治性癫痫儿童遗传学基因检测癫痫综合征临床特征全面性发育迟缓

Developing an index of sustainable development goals for local governments:the case of Gyeonggi province in korea

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Ecosystem Health and Sustainability 2021年第1期7卷 372-385页

作者： Jaekyung Koh Taewook huh Minji Ye Department of Ecology&Environment Gyeonggi Research InstituteSuwon CityKorea Department of Public Administration Gyeongsang National UniversityJinju CityKorea

This study aims to develop and evaluate the indicators of Sustainable Development Goals(hereafter SDGs)for local governments in Gyeonggi Province,South Korea from the perspective of the glocal mainstreaming of SDGs and *** surveys and focus group meetings,35 SDGs indicators that are to be implemented by both the Gyeonggi Provincial government and 31 separate local governments were selected and an overall index was calculated by standardizing 27 *** the comparative analysis of the fuzzy-set,this paper revealed the four ideal types along with the arrangement of two variables,the socio-economic SDGs index(S)and the environmental SDGs index(E),which are derived from 31 local *** short,some examples of this arrangement are the Type 1(S^(*)E:“sustainable local gov.”)including Hanam City(fuzzy score,0.729);Type 2(S^(*)e:“imbalanced local gov.(I)”)including Hwaseong City(0.862);Type 3(s^(*)E:“imbalanced local gov.(II)”)including Gapyeong County(0.922);and Type 4(s^(*)e:“unsustainable local gov.”)including Pyeongtaek City(0.650).As a result,this paper suggests policy priority should be placed on the local governments of Type 4 where all three dimensions of sustainable development pose ***,it is important for Type 2 and Type 3 to enhance policy coherence for sustainability.

关键词： Sustainable development goals localization local governments SDG index Fuzzy set analysis

Reactive Core-Shell Bottlebrush Copolymer as Highly Effective Additive for Epoxy Toughening

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Chinese Journal of Polymer Science 2021年第12期39卷 1626-1633页

作者： Junsoo Moon Yoon huh Seonghwan Kim Youngson Choe Joona Bang Department of Chemical and Biological Engineering Korea UniversitySeoul 02841Republic of Korea Department of Chemical Engineering Pusan National UniversityPusan 46241Republic of Korea

Herein,we designed a core-shell structured bottlebrush copolymer(BBP),which is composed of rubbery poly(butyl acrylate)(PBA)core and an epoxy miscible/reactive poly(glycidyl methacrylate)(PGMA)shell,as an epoxy tougheni ng age *** PGMA shell allows BBP to be uniformly dispersed within the epoxy matrix and to react with the epoxy groups,while the rubbery PBA block simultaneously induced nanocavitation effect,leading to improvement of mechanical properties of the epoxy *** mechanical properties were measured by the adhesion performance test,and the tensile and fracture test using universal testing *** BBP additives were added to the epoxy resin,a sign ifica nt improveme nt in the adhesion stren gth(2-fold increase)and fracture toughness(2-fold in crease in Kic and 5-fold in crease in Gic)compared to the neat epoxy was *** contrast,linear additives exhibited a decrease in adhesion strength and no improvement of fracture toughness over the neat *** a difference in mechanical performance was investigated by comparing the morphologies and fracture surfaces of the epoxy resins containing linear and BBP additives,confirming that the nanocavitation effect and void formation play a key role in strengthening the BBP-modified epoxy resins.

关键词： Bottlebrush polymer ROMP Additive Adhesion Epoxy toughening

Expression of apoptosis-related factors in chronic cyclosporine nephrotoxicity after cyclosporine withdrawal

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Acta Pharmacologica Sinica 2004年第4期25卷 3-13页

作者： sun-woo LIM,Bo-kyung sun,Bum-soon CHOI,Sylvia GLOWACKA,Alison J COX,Darren J KELLY,Yong-soo KIM,Jin KIM,Byung-kee BANG,chul-woo YANG Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Anatomy the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea MD PhD

AIM: To examine whether the reversibility of chronic cyclosporine A (CsA) nephrotoxicity is associated with apoptotic cell death and its regulatory factors. METHODS: Chronic CsA nephrotoxicity was induced in Sprague- Dawley rats by administering CsA (15 mg/kg, sc) for 5 weeks, and then withdrawing it for 5 or 10 weeks. The effect of CsA withdrawal on apoptotic cell death was evaluated by an in situ TdT-mediated deoxyuridine triphos- phate-biotin nick end-labeling (TUNEL) assay and the expression of pro-apoptotic [(transforming growth factor- beta1 (TGF-β1) and Fas] and anti-apoptotic [epidermal growth factors (EGF) and Bcl-2] factors. RESULTS: Discontinuation of CsA induced significant decreases in TUNEL-positive cells in a time-dependent manner and the reduction in TUNEL-positive cells was correlated with the tubulointerstitial fibrosis score (r=0.919, P<0.01). Upregulation of TGF-β1 and Fas expression in CsA-treated rat kidneys was decreased significantly after with- drawal of CsA. In contrast, downregulated EGF and Bcl-2 expression returned to normal or supernormal levels. CONCLUSION: CsA withdrawal is associated with a decrease in apoptotic cell death and with changes in the expression of pro-apoptotic and anti-apoptotic molecules involved in renal wound repair. This may constitute one of the mechanisms underlying the reversibility of chronic CsA nephrotoxicity.

关键词： cyclosporine apoptosis bcl-2 fas epidermal growth factor transforming growth factor-beta fibrosis

Epigenetic mechanisms involved in the neuroprotective effect of scorpion extract in a Parkinson's disease murine model based on multi-omics approach

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Journal of Traditional Chinese Medicine 2021年第3期41卷 390-396页

作者： Joong sun Kim Hye-sun Lim Byeong Cheol Moon Mary Jasmin Ang sung-Ho Kim Changjong Moon Boseok Seong Yunji Jang Hyung-Yong Kim chul Kim Herbal Medicine Resources Research Center Korea Institute of Oriental MedicineJeollanamdo 58245Republic of Korea College of Veterinary Medicine and BK21 Plus Project Team Chonnam National UniversityGwangju 61186Republic of Korea Future Medicine Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Research and Development Center Insilicogen Inc.Yonginsi 16954Republic of Korea

OBJECTIVE: To investigate whether scorpion extract elicits a neuroprotective effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice models, and the genes associated with the therapeutic effects using RNA sequencing(seq)***: This study investigated the changes in interaction between messenger ribonucleic acid(m RNA) expression and deoxyribonucleic acid(DNA) methylation related to the protective effects of scorpion extracts, in the substantia nigra(SN)region of a MPTP-induced Parkinson's disease(PD)***: In this model, scorpion extracts attenuated the motor impairment as demonstrated by the rotarod and open field tests. Scorpion extracts consistently attenuated the decrease of tyrosine hydroxylase(TH) positive neural cells in the SN and striatum of mice. We profiled genomewide DNA methylation using Methyl-Seq and measured the transcriptome using RNA-Seq in murine SN in the following groups: vehicle-treated MPTP-induced PD mice and scorpion extracttreated MPTP-induced PD mice. In total, 13 479 differentially expressed genes were identified in association with the anti-PD effect of the scorpion extract, mainly in the promoter and coding *** them, 47 were negatively correlated downregulated genes. Nineteen genes out of 47 downregulated genes were negatively correlated with the expression of the other 28 genes. Among these genes, SGSM1 was related to dopaminergic neurons including dopamine transporters, TH, dihydroxyphenylalanine decarboxylase, and dopamine D2 ***: This study provides insights into the anti-parkinsonian effects of scorpion extract and reveals the epigenetic targets in its therapeutic mechanism.

关键词： scorpions 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine Parkinson disease DNA methylation

Geochemistry and Origin of Layers in Single Manganese Nodule from the Philippine Sea and Manganese Nodules from Offshore Minami-Torishima, Western Pacific

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Acta Geologica Sinica(English Edition) 2014年第6期88卷 1835-1845页

作者： YAO Yungchang CHEN Juchin huh Chihan LEE Yungtan Institute of Oceanography National Taiwan University Division of Preparatory Programs for Overseas Chinese Students National Taiwan Normal University Institute of Earth Sciences Academia Sinica Department of Tourism Aletheia University

Layers from one manganese nodule dredged from the Philippine Sea（16°56＇N, 129°48＇E; water depth, 5700 m） and 45 bulk nodules from offshore Minami-Torishima Island, Japan（23°3＇N, 153°22＇E; water depth, 1200 m） were analyzed chemically and their origin is discussed based on geochemical constraints. In general, Cu, Ni, Zn and Mo tend to increase with increasing Mn content, while Co, Pb, Ba, V, Sc, Th, and the rare earth elements（REEs） show less variation with increasing Mn content. Nodule 42 H from the Philippine Sea has an average Mn/Fe ratio close to 1 and shows a positive Ce anomaly, suggesting a predominant hydrogenous origin. Profiles of 230Th230 ex and Thex/232 Th ratios in the outer ~0.3 mm of nodule 42 H indicate a steady growth rate of ~1.7 mm/Myr. Nodule E30 from offshore Minami-Torishima is characterized by lower Mn, Fe, Mn/Fe（0.53） and Mo/V（0.2） ratios but higher P and Cu/Ni（0.31） ratio relative to other nodules from that area. The Ce content of E30 is unusually low（82 ppm） when compared with other nodules from the area and it is the only nodule analyzed with a negative Ce anomaly（-0.64）. Based on the geochemical data we suggest that most nodules from offshore Minami-Torishima are primarily of hydrogenous origin except E30, which is dominated by hydrothermal input, and E45, which has about a 35% hydrothermal contribution.

关键词： manganese nodule geochemistry origin the Philippine Sea Minami-Torishima

Purification and Characterization of Cyclic AMP-Binding Protein from Ganoderma lucidum

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Chemical Research in Chinese Universities 2004年第5期20卷 588-593页

作者： WANGQi KIMJung-Sik CHUNGKi-chul CollegeofChineseMedicinalMaterials JilinAgriculturalUniversityChangchun130118P.R.China DepartmentofGeneticEngineering CollegeofAgricultureChonnamNationalUniversityKwangju500-757Korea

Cyclic AMP-binding protein was purified 30 fold from the mycelia of Ganoderma lucidum by the methods of ammonium sulfate precipitation, DEAE-cellulose, phospho-cellulose ion exchange chromatography and Sephacryl S-100 gel filtration. The molecular mass of the purified protein is 34.5 kDa and 17 kDa by Sephacryl S-100 gel filtration and SDS-ployacrylamide gel electrophoresis, respectively. From these results it is suggested that the protein has a homometric dimmer structure. The pI of the purified protein is pH 8.2 by native isoelectric focusing gel. The half-life of the protein activity in 10% glycerol at 4 ℃ is 7 d in crude extract, but its half-life is only 3 d under purifying conditions. The optimal conditions of the protein activity are at 1 ℃ and pH 7.5. Its activity is increased 6 times by 1 mmol/L Zn^(2+) and is slightly inhibited by cGMP, Cu^(2+) and Mn^(2+).

关键词： cAMP-binding protein Purification Characterization Ganoderma lucidum

Clinical significance of the leptin and leptin receptor expressions in prostate tissues

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Asian Journal of Andrology 2008年第6期10卷 923-928页

作者： Jung Hoon Kim Shin Young Lee Soon chul Myung Young sun Kim Tae-Hyoung Kim Mi Kyung Kim Departments of Urology College of Medicine Chung-Ang University Seoul 140-757 Korea Departments of Pathology College of Medicine Chung-Ang University Seoul 140-757 Korea

Aim： To evaluate the expression of leptin and leptin receptor in benign prostatic hyperplasia （BPH） and prostate cancer （PCa）, and to investigate whether they are associated with the development and progression of PCa. Methods： hnmunohistochemical staining was performed to examine the expression of leptin and leptin receptor in BPH and PCa. PCa was divided into three groups： localized PCa, locally advanced PCa and metastatic PCa. The positive staining was identified and the percentage of the positive staining was graded. We also assessed the relationship between both the Gleason score and body mass index （BMI） and PCa. Results： The percentage of the leptin expression in PCa was significantly higher than that in BPH （P 〈 0.01）. For the PCa group, the expressed levels of leptin showed a considerable correlation with localized PCa and metastatic PCa （P 〈 0.05）. Leptin receptor, however, did not reveal a definite difference between BPH and PCa. The expression of leptin indicated a significant difference between well-differentiated PCa （Gleason score ≤6） and poorly differentiated PCa （Gleason score 8-10）（P 〈 0.05）. The relation between the leptin expression level in PCa and the BMI was not remarkable （P = 0.447）. Conclusion： Our results suggest that leptin might have a promoting effect on the carcinogenesis and progression of PCa.

关键词： leptin leptin receptor prostatic neoplasms