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Image-guided conservative management of right colonic diverticulitis

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World Journal of Gastroenterology 2009年第46期15卷 5838-5842页

作者： sun Jin park sung II Choi Suk Hwan Lee Kil Yeon Lee Department of Surgery Kyung Hee University School of Medicine

AIM： To study the clinical outcomes of medical therapy in patients with right colonic diverticulitis. METHODS： The records of 189 patients with right colonic diverticulitis which was finally diagnosed by computed tomography, ultrasonography, or operative findings were retrospectively reviewed. RESULTS： Of the 189 patients hospitalized for right colonic diverticulitis, the stages of diverticulitis by a modified Hinchey classification were 26 patients （13.8%） in stage 0, 139 patients （73.5%） in stage I a, 23 patients （12.2%） in stage I b, and 1 patient （0.5%） in stage Ⅲ. Medical therapy was undertaken in 185 of 189 patients （97.9%）. One hundred and eighty three of 185 patients were successfully treated with bowel rest and antibiotics. Two patients in stage I b required a resection or surgical drainage because of an inadequate response to conservative treatment. Recurrent diverticulitis developed in 15 of 183 patients （8.2%） who responded to medical therapy. All 15 patients who suffered a second attack had uncomplicated diverticulitis, and were successfully treated with medical ***： Our results indicate that right colonic diverticulitis is essentially benign and image-guided conservative treatment is primarily required.

关键词： Ascending colon Cecum Medical therapy Colonic diverticulitis

Acute kidney injury due to intravenous detergent poisoning:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2036-2044页

作者： sungbin park Hyun-Sik Ryu Jae-Kwang Lee sung-Soo park sun-Jung Kwon Won-Min Hwang sung-Ro Yun Moon-Hyang park Yohan park Department of Internal Medicine Division of NephrologyKonyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Internal Medicine Division of Respiratory and Critical Care MedicineKonyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Pathology Konyang University HospitalCollege of MedicineDaejeon 35365South Korea

BACKGROUND Detergent poisoning mostly occurs through oral ingestion(>85%),ocular exposure(<15%),or dermal exposure(<8%).Reports of detergent poisoning through an intravenous injection are extremely *** addition,there are very few cases of renal toxicity directly caused by ***,we report a unique case of acute kidney injury caused by detergent poisoning through an accidental intravenous *** SUMMARY A 61-year-old man was intravenously injected with 20 mL of detergent by another patient in the same room of a local *** surfactant and calcium carbonate accounted for the largest proportion of the *** patient complained of vascular pain,chest discomfort,and nausea,and was transferred to our *** hospitalization,the patient’s serum creatinine level increased to 5.42 mg/dL,and his daily urine output decreased to approximately 300 *** biopsy findings noted that the glomeruli were relatively intact;however,diffuse acute tubular injury was *** edema was also noted,and the patient underwent a total of four hemodiafiltration ***,the patient’s urine output gradually increased whereas the serum creatinine level *** patient was discharged in a stable status without any *** Detergents appear to directly cause renal tubular injury by systemic *** treating a patient with detergent poisoning,physicians should be aware that the renal function may also *** addition,timely renal replacement therapy may help improve the patient’s prognosis.

关键词： Detergents Poisoning Intravenous injection Acute kidney injury Acute tubular injury Case report

Surface plasmon enhancement of photoluminescence in photo-chemically synthesized graphene quantum dot and Au nanosphere

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Nano Research 2016年第6期9卷 1866-1875页

作者： Byeongho park sun Jun Kim Ji Soo Sohn Min Sik Nam Shinill Kang Seong Chan Jun School of Mechanical Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou1120-749 Republic of Korea

Graphene quantum dots （GQDs） are promising candidates for potential applications such as novel optoelectronic devices and bio-imaging. However, insufficient light absorption to exhibit their intriguing characteristics. The strong confinement of light caused by the Au nanoparticles as an antenna can considerably boost the light absorption. With the assistance of ultraviolet irradiation, we prepared bluish-green luminescent nanospheres by the hybridiza- tion of GQD and Au nanoparticles （GQD/Au）. These nanospheres showed a photoluminescence quantum yield of up to 26.9%. The GQD/Au nanospheres were synthesized using a solution of GQDs and HAuC14 by a photochemical method with the reduction of GQDs and the formation of metallic Au. The GQDs and Au nanopartides self-assembled and aggregated into nanospheres via aurophilicity and hydrogen bonding interactions. The average size of the GQD/Au nanospheres was found to be in the range of 150-170 nm, which is much larger than that of the pristine GQDs （4-7 nm）. The GQD/Au nanospheres exhibited an absorption band at 541 nm, which indicates the presence of Au in the nanospheres. The typical absorbance features of GQDs were observed near 236 and 303 nrn. The photoluminescence characteristics were investigated using the excitation and emission spectra. The GQD/Au nanospheres exhibited two emission peaks at 468 and 529 nm in the visible range. The green fluorescent peak located at 529 nm was newly generated by the hybridization. The GQD/Au nanospheres showed an emission efficiency which was two times more than that of the intrinsic GQDs. The reason for this increase was the surface plasmon resonance from the Au particles, which improved the fluorescence property of the resulting nanospheres. These nanospheres can be perceived as outstanding candidates for applications such as displays, optoelectronic devices, and imaging of the biological samples with high emission intensity.

关键词： graphene quantum dot gold nanosphere photoluminescence UV irradiation

High-concentration dispersions of exfoliated MoS2 sheets stabilized by freeze-dried silk fibroin powder

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Nano Research 2016年第6期9卷 1709-1722页

作者： HeungBo Sim JiYong Lee Byeongho park sun Jun Kirn Shinill Kang ,WonHyoung Ryu Seong Chan Jun School of Mechanical Engineering Yonsei University Seoul 120-749 Republic of Korea

Liquid-phase exfoliation （LPE） is an attractive method for the scaling-up of exfoliated MoS2 sheets compared to chemical vapor deposition and mechanical cleavage. However, the MoS2 nanosheet yield from LPE is too small for practical applications. We report a facile method for the scaling-up of exfoliated MoS2 nanosheets using freeze-dried silk fibroin powders. Compared to MoS2 dispersion in the absence of silk fibroin powder, sonicated MoS2 dispersions with silk fibroin powder （MoSJSilk dispersion） show noticeably higher exfoliated MoS2 nanosheet yields, with suspended MoS2 concentrations in MoS2/Silk dispersions sonicated for 2 and 5 h of 1.03 and 1.39 ***-1, respectively. The MoS2 concentration in the MoS2/Silk dispersion after centrifugation above 10,000 rpm is more than four times that without the silk fibroin. The size of the dispersed silk fibroin is controlled by the change of centrifugation rate, showing the removal of silk fibroin above tens of micrometers in size after centrifugation at 2,000 rpm. Size-controlled silk fibroin biomolecules combined with MoS2 nanosheets are expected to increase the practical use of such materials in fields related to tissue engineering, biosensors and electrochemical electrodes. Atomic force microscopy and Raman spectroscopy provide the height of the MoS2 nanosheets spin-cast from MoS2/Silk dispersions, showing thicknesses of 3--6 nm. X-ray photoelectron spectroscopy and X-ray diffraction indicate that the outermost surface layer of the hydrophobic MoS2 crystals interact with oxygen-containing functional groups that exist in the hydrophobic part of silk fibroins. The amphiphilic properties of silk fibroin combined with the MoS2 nanosheets stabilize dispersions by enhancing solvent-material interactions. The large quantities of exfoliated MoS2 nanosheets suspended in the as-synthesized dispersions can be utilized for the fabrication of vapor and electrochemical devices requiring high MoS2 nanosheets contents.

关键词： MoS2 nanosheet liquid-phase exfoliation freeze-dried silk fibroin powder amount of suspended MoB2 sheet stabilized dispersion

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大运河的文化标识价值及其立法保护

湖南大学学报（社会科学版） 2024年第3期38卷 132-139页

作者：周刚志孙徐恬中南大学法学院湖南长沙410083 湖南师范大学法学院湖南长沙410081

“大运河国家文化公园”是我国的重大文化工程,也是中华民族的重要文化标识。中国大运河不仅是重要的水利文化遗产、线性文化遗产,也应当成为重要的文化景观遗产,承载“连通五大水系、促进区域交流、助力民族融合”等政治文化理念。当前... 详细信息

“大运河国家文化公园”是我国的重大文化工程,也是中华民族的重要文化标识。中国大运河不仅是重要的水利文化遗产、线性文化遗产,也应当成为重要的文化景观遗产,承载“连通五大水系、促进区域交流、助力民族融合”等政治文化理念。当前,我国大运河相关立法主要有《中华人民共和国文物保护法》等国家立法和大运河水利管理、生态环境和文化遗产保护等地方立法。为推进大运河国家文化公园建设,我国应适时制定“大运河国家文化公园法”或“大运河国家文化公园管理条例”,以弘扬大运河的“中华文化标识”价值。

关键词：国家文化公园大运河国家文化公园文化遗产立法

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Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder

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Journal of Molecular Cell Biology 2021年第5期13卷 361-373页

作者： Minsoo Kang sun Kyoung Han Suhyun Kim sungyeon park Yerin Jo Hyeryung Kang Jesang Ko Division of Life Sciences Korea UniversitySeoul 02841South Korea

Hepatic gluconeogenesis is the central pathway for glucose generation in the *** imbalance between glucose synthesis and uptake leads to metabolic diseases such as obesity,diabetes,and cardiovascular *** leucine zipper protein(sLZIP)is an isoform of LZIP and it mainly functions as a transcription *** sLZIP is known to regulate the transcription of genes involved in various cellular processes,the role of sLZIP in hepatic glucose metabolism is not *** this study,we investigated the regulatory role of sLZIP in hepatic gluconeogenesis and its involvement in metabolic *** found that sLZIP expression was elevated during glucose starvation,leading to the promotion of phosphoenolpyruvate carboxylase and glucose-6-phosphatase expression in ***,sLZIP knockdown suppressed the expression of the gluconeogenic enzymes under low glucose *** also enhanced glucose production in the human liver cells and mouse primary hepatic ***-induced cyclic adenosine monophosphate impeded sLZIP *** of glucose and pyruvate tolerance tests showed that sLZIP transgenic mice exhibited abnormal blood glucose *** findings suggest that sLZIP is a novel regulator of gluconeogenic enzyme expression and plays a role in blood glucose homeostasis during starvation.

关键词： gluconeogenic enzymes hepatic gluconeogenesis hyperglycemia transcription factor

Raman microspectrometry, FT-IR and inclusion characteristics of gem garnets from Tanzania and Madagascar

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Journal of Geoscientific Research in Northeast Asia 2004年第2期7卷 125-135页

作者： Sang-kon Kim Maeng-eon park Seung-gyun Baek Kyu-youl sung sun-ok Kim Hee-yul park Department of Environmental Geoscience Pukyong National University Busan 608-737 KoreaDepartment of Environmental Geoscience Pukyong National University Busan 608-737 KoreaDepartment of Environmental Geoscience Pukyong National University Busan 608-737 KoreaDepartment of Environmental Geoscience Pukyong National University Busan 608-737 KoreaMinerals and Materials Processing Division Korea Institute of Geoscience and Mineral Resources Daejeon 305-350 KoreaSchool of Gemology Identification & Dealer Open Cyber University Seoul 110-750 Korea

Chemical composition, Raman microspectrometry, and Fourier transform infrared(FT-IR)and SEM-CL (Cathodluminescence)analyses are carried out for Tanzania and Madagascar garnets for locality identification. Inclusion study was sustained after electron probe microanalysis(EPMA). Needle-like illmenites, apatites and zircons were the most common solid inclusions in Tanzania garnets. Madagascar garnets revealed rutile needles and apatites were also observed, but differences in size, shape and distribution patterns were noticed compared to Tanzania garnets. Tanzania garnets exhibited all types of observable fluid inclusions such as"fingerprint"pattern, called Type I-A, liquid-only(L) single phase fluid inclusion, called Type I-B and Type II-A(L+S), Type II-B(L+V)and Type III-A(L+Sylvite+S), Type III-B(L+S+V), while no more than two phase fluid inclusions found in both Madagascar and Korea garnets even if all examined garnets from three localities retained"fingerprint"features, so called, partially healed fractures, in common. Chemical composition, Raman microspectrometry and Fourier transform infrared(FT-IR)analysis taken turned out to be useful methods for the purpose of this study. Using consequences of SEM-CL and inclusion study, accordingly, the locality identification of gem-quality garnets is capable of being available in further application for other kinds of gemstones.

关键词：宝石石榴石局部鉴定 SEM-CI 拉曼分光计

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Shifts in reproductive strategies in the evolutionary trajectory of plant lineages

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Science China Life Sciences 2024年

作者： Xin-Jian Zhang Xian-Han Huang Jacob B.Landis Quan-Sheng Fu Jun-Tong Chen Peng-Rui Luo Li-Juan Li Heng-Yi Lu Hang sun Tao Deng State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of Botany Chinese Academy of Sciences Yunnan International Joint Laboratory for Biodiversity of Central Asia Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey Hortorium Cornell University BTI Computational Biology Center Boyce Thompson Institute CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden Chinese Academy of Sciences

Understanding the maintenance and shift in reproductive strategies is a fundamental question in evolutionary research. Although many efforts have been made to compare different reproductive strategies, the association between reproductive strategies and lineage divergence is largely unknown. To explore the impact of different reproductive strategies on lineage divergence, we investigated the evolution of clonality in Saxifraga sect. Irregulares+Heterisia. By integrating several lines of evidence, we found that the loss of clonality in Irregulares+Heterisia was associated with a progressive increase in diversification rate and intraspecific morphological diversity but with a reduction in species distribution range. Our findings provide insights into the ecological and evolutionary effects of different reproductive strategies,suggesting the necessity of integrating clonality into ecological and evolutional research.

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Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 619-625页

作者： Chan sun park Hee Seok Jeong Ki Bae Kim Joung-Ho Han Hee Bok Chae Sei Jin Youn Seon Mee park Department of Internal Medicine Chungbuk National University College of Medicine

BACKGROUND： Acute cholangitis in old people is a cause of mortality and prolonged hospital stay. We evaluated the effects of methods and timing of biliary drainage on the outcomes of acute cholangitis in elderly and very elderly patients. METHODS： We analyzed 331 patients who were older than 75 years and were diagnosed with acute calculous cholangitis. They were admitted to our hospital from 2009 to 2014. Patients＇ demographics, severity grading, methods and timing of biliary drainage, mortality, and hospital stay were retrospectively obtained from medical records. Clinical parameters and outcomes were compared between elderly （75-80 years, n= 156） and very elderly （≥81 years, n=175） patients. We analyzed the effects of methods [none, endoscopic retrograde cholangio- pancreatography （ERCP）, percutaneous transhepatic biliary drainage, or failure] and timing （urgent or early） of biliary drainage on mortality and hospital stay in these patients. RESULTS： Acute cholangitis in older patients manifested as atypical symptoms characterized as infrequent Charcot＇s triad （4.2%） and comorbidity in one-third of the patients. Patients were graded as mild, moderate, and severe cholangitis in 104 （31.4%）, 175 （52.9%）, and 52 （15.7%）, respectively. Urgent bili-ary drainage （≤24 hours） was performed for 80.5% （247/307） of patients. Very elderly patients tended to have more severe grades and were treated with sequential procedures of transient hiliary drainage and stone removal at different sessions. Hospital stay was related to methods and timing of biliary drainage. Mortality was very low （1.5%） and not related to patient age but rather to the success or failure of biliary drainage and severity grading of the acute cholangitis. CONCLUSIONS： The methods and timing used for biliary drainage and severity of cholangitis are the major determinants of mortality and hospital stay in elderly and very elderly patients with acute cholangitis. Urgent successful ERCP is mandatory for favorable

关键词： acute cholangitis biliary drainage prognosis elderly very elderly

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