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Role of inhibiting LIM-kinase2 in improving erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury

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Asian Journal of Andrology 2018年第4期20卷 372-378页

作者： Juhyun park sung Yong Cho Kwanjin park Ji sun Chai Hwancheol Son Soo Woong Kim Jae-Seung Paick Min Chul Cho Department of Urology Seoul National University College of Medicine SMG-SNU Boramae Medical Center Seoul 03080 Korea Department of Urology Seoul Nationa University College of Medicine Seoul National University Hospital Seoul 07061 Korea

We evaluated whether LIM-kinase 2 inhibitor （LIMK2i） could improve erectile function by suppressing corporal fibrosis through the normalization of the Rho-associated coiled-coil protein kinase 1 （ROCK1）/LIMK2/Cofilin pathway in a rat model of cavernous nerve crush injury （CNCl）. Sixty 11-week-old male Sprague-Dawley rats were divided equally into five groups： sham surgery （S）, CNCl （I）, and CNCl treated with low-dose （L）, medium-dose （M）, and high-dose （H） LIMK2i. The L, M, and H groups were treated with a daily intraperitoneal injection of LIMK2i （2.5, 5.0, and 10.0 mg kg-1 body weight, respectively） for 1 week after surgery. The erectile response was assessed using electrostimulation at 1 week, postoperatively. Penile tissues were processed for Masson＇s trichrome staining, double immunofluorescence, and Western blot assay. Erectile responses in the H group improved compared with the I group, while the M group showed only partial improvement. A significantly decreased smooth muscle/collagen ratio and an increased content of fibroblasts positive for phospho-/IMK2 were noted in the I group. The M and H groups revealed significant improvements in histological alterations and the dysregulated LIMK2/Cofilin pathway, except for LIMK2 phosphorylation in the M group. The inhibition of LIMK2 did not affect the ROCK1 protein expression. The content of fibroblasts positive for phospho-LIMK2 in the H group returned to the level found in the S group, whereas it did not in the M group. However, the L group did not exhibit such improvements. Our data suggest that the inhibition of LIMK2, particularly with administration of 10.0 mg kg^-1 body weight LIMK2i, can improve corporal fibrosis and erectile function by normalizing the LIMK2/Cofilin pathway.

关键词： erectile dysfunction fibrosis LIM kinase penis prostatectomy

Short-term interval combined chemoembolization and radiofrequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第35期20卷 12588-12594页

作者： Won Hyeok Choe Young Jun Kim Hee sun park Sang Woo park Jeong Han Kim So Young Kwon Department of Internal Medicine Konkuk University School of Medicine Department of Radiology Konkuk University School of Medicine

AIM: To investigate hepatic function after combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) with a short-term interval (0-2 d).

关键词： Child-Pugh score Liver cirrhosis Hepatocellular carcinoma Transcatheter arterial chemoembolization Radiofrequency ablation

Benign gallbladder diseases:Imaging techniques and tips for differentiating with malignant gallbladder diseases

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World Journal of Gastroenterology 2020年第22期26卷 2967-2986页

作者： Mi Hye Yu Young Jun Kim Hee sun park sung Il Jung Department of Radiology Konkuk University Medical CenterKonkuk University School of Medicine120-1 Neungdong-roGwangjin-guSeoul 05030South Korea

Benign gallbladder diseases usually present with intraluminal lesions and localized or diffuse wall *** lesions of the gallbladder include gallstones,cholesterol polyps,adenomas,or sludge and polypoid type of gallbladder cancer must subsequently be *** size,stalk width,and enhancement intensity on contrast-enhanced ultrasound and degree of diffusion restriction may help differentiate cholesterol polyps and adenomas from gallbladder *** gallbladder wall thickening is largely due to segmental or focal gallbladder adenomyomatosis,although infiltrative cancer may present *** of Rokitansky-Aschoff sinuses is pivotal in diagnosing *** layered pattern,degree of enhancement,and integrity of the wall are imaging clues that help discriminate innocuous thickening from gallbladder ***-resolution ultrasound is especially useful for analyzing the layering of gallbladder wall.A diffusely thickened wall is frequently seen in inflammatory processes of the ***,it is important to check for coexistent cancer in instances of acute *** used alone is limited in evaluating complicated cholecystitis and often requires complementary computed *** chronic cholecystitis,preservation of a two-layered wall and weak wall enhancement are diagnostic clues for excluding *** resonance imaging in conjunction with diffusion-weighted imaging helps to differentiate xathogranulomatous cholecystitis from gallbladder cancer by identifying the presence of fat and degree of diffusion *** distinctions require a familiarity with typical imaging features of various gallbladder diseases and an understanding of the roles that assorted imaging modalities play in gallbladder evaluations.

关键词： Cholesterol polyp Gallbladder adenoma Adenomyomatosis Cholecystitis Xathogranulomatous cholecystitis Gallbladder cancer Imaging techniques

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碳交易机制下园区综合能源系统优化调度

电力系统及其自动化学报 2024年第5期36卷 90-98页

作者：黄冬梅王干帅孙锦中胡安铎孙园上海电力大学电子与信息工程学院上海200090 上海电力大学数理学院上海200090

为抑制园区综合能源系统的碳排放,优化系统运行成本,提出一种以系统运行总成本最小为目标、平衡经济性和低碳性的园区综合能源系统优化调度策略。首先将阶梯式碳交易机制引入综合能源系统,然后在能源供给侧利用光热电站促进光能实现削... 详细信息

为抑制园区综合能源系统的碳排放,优化系统运行成本,提出一种以系统运行总成本最小为目标、平衡经济性和低碳性的园区综合能源系统优化调度策略。首先将阶梯式碳交易机制引入综合能源系统,然后在能源供给侧利用光热电站促进光能实现削峰填谷,在需求侧通过需求响应减少电、热能的使用成本,最后运用CPLEX进行求解,并对多个优化调度方案进行对比分析。结果表明,所提方案在有效控制系统运行成本的同时,碳排放量也得到降低,有助于园区综合能源系统实现“双碳”目标。

关键词：综合能源系统碳交易机制需求响应光热电站低碳经济

A Case of Acute Myocardial Infarction Induced by Selective Cyclooxygenase-2 Inhibitor

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Chinese Medical Journal 2017年第9期130卷 1131-1132页

作者： Kyoung-Woo Seo Jin-sun park Seung-Jea Tahk Joon-Han Shin Department of Cardiology Ajou University School of Medicine Suwon 16499 Korea

To the Editor： A 46-year-old male, having a history of coronary artery disease, and coronary artery bypass graft surgery （CABG）, was admitted to our clinic with sustained chest pain. He had a left internal mammary artery to the left anterior descending coronary artery, saphenous vein graft （SVG） to diagonal branch, and SVG to obtuse marginal artery. Up to 7 years alter CABG, patient had no complaints of chest pain. Two days before admission, medications were administered for back pain： aceclofenac （selective cyclooxygenase-2 [COX-2] inhibitor）,

关键词： COX-2抑制剂环氧合酶-2 急性心肌梗死冠状动脉诱导静脉移植 SVG 疼痛

Fermentation Patterns of Various Pectin Sources by Human Fecal Microbiota

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Food and Nutrition Sciences 2015年第12期6卷 1103-1114页

作者： Byungjick Min ok Kyung Koo Si Hong park Nathan Jarvis Steven C. Ricke Philip G. Crandall sun-ok Lee Department of Food Science University of Arkansas Fayetteville USA Center for Food Safety University of Arkansas Fayetteville USA

High Methoxy Pectin (HMP), Sugar Beet Pectin (SBP), Soy Pectin (SOY), and Fructooligosaccharide (FOS, as a positive control) were used to determine fermentation properties considering applicabil-ity as functional foods, particularly related to colon health. Certain beneficial effects of carbohy-drates in humans can be postulated as being due to microorganisms and metabolites (short-chain fatty acids (SCFAs)). Fecal samples were collected and incubated anaerobically with HMP, SBP, SOY, and FOS at 37 °C. The average degree of polymerization (DP) of HMP, SBP, and SOY was 492, 3729, and 1510, respectively. Degree of pectin methylation of each sample was 76.0% (HMP), 21.2% (SBP), and 22.8% (SOY). Total SCFAs in SOY showed the highest value compared to other samples, especially having the highest concentration of propionic acid (P < 0.05). While fermentation with FOS showed higher butyrate production, the total SCFAs with SOY, HMP, and SBP were significantly higher than FOS over 30 h (P < 0.05). From the denaturing gradient gel electrophoresis (DGGE) analysis, changes of microbiota composition were found. In conclusion, pectin samples, especially soy pectin, stimulated production of total SCFAs and composition of human fecal microbiota was modulated. Therefore, pectin samples may alter the composition of fecal microbiota and improve the colonic health.

关键词： Short-Chain Fatty Acids Soy Pectin Denaturing Gradient Gel Electrophoresis

Surgical Management of Symptomatic Adventitial Cystic Disease of the Popliteal Artery as a Cause of Deep Vein Thrombosis

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Chinese Medical Journal 2018年第17期131卷 2141-2142页

作者： Jong Seok Lee Jeong Kye Hwang sun Cheol park Sang Dong Kim Department of Surgery Division Medical Detachment Ministry of National Defense Gangwon-do 24151 Korea Department of Surgery Division of-Vascular and Transplant Surgery College of Medicine The Catholic University of Korea Seoul 06591 Korea

To the Editor： A 67-year-old female was referred for persisted swelling in right leg despite of anticoagulation during 2 months for deep vein thrombosis （DVT） of the right popliteal vein （PV）. Initial duplex ultrasonography of local clinic at 2 months ago showed the acute DVT of right PV with thrombus and dilated vein [Figure 1a].

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Development of exosome membrane materialsfused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4983-4998页

作者： Yongho Jang Jeehun park Pilsu Kim Eun-Joo park Hyungjin sun Yujin Baek Jaehun Jung Tai-kyong Song Junsang Doh Hyuncheol Kim Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea Research Institute of Advanced Materials(RIAM) Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea Department of Electronic Engineering Sogang UniversitySeoul 04107Republic of Korea Biomedical Research Institute&Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Engineering Research Bio-MAX InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Biomedical Engineering Sogang UniversitySeoul 04107Republic of Korea

Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery ***,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short half-life in the blood system,and the difficulty of surface modification of microbubbles for active *** exosome,a type of extracellular vesicle,has a preferentially targeting ability for its original *** this study,exosome-fused microbubbles(Exo-MBs)were developed by embedding the exosome membrane proteins into *** a result,the stability of Exo-MBs is improved over the conventional *** the same principle that under the exposure of ultrasound,microbubbles are cavitated and self-assembled into nano-sized particles,and Exo-MBs are self-assembled into exosome membrane proteins-embedded nanoparticles(Exo-NPs).The Exo-NPs showed favorable targeting properties to their original cells.A photosensitizer,chlorin e6,was loaded into Exo-MBs to evaluate therapeutic efficacy as a drug *** higher therapeutic efficacy of photodynamic therapy was confirmed,followed by cancer immunotherapy from immunogenic cell *** have therefore developed a novel ultrasound image-guided drug delivery platform that overcomes the shortcomings of the conventional ultrasound contrast agent and is capable of simultaneous photodynamic therapy and cancer immunotherapy.

关键词： Exosomes Microbubbles Photodynamic therapy Ultrasound Sonoporation Cancer immunotherapy Drug delivery

Mediating effect of work engagement between job characteristics and nursing performance among general hospital nurses

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Frontiers of Nursing 2021年第3期8卷 241-248页

作者： Eun-Kyung Lee sun-Hee Kim Jin-Hwa park College of Nursing Research Institute of Nursing ScienceDaegu Catholic UniversityDaegu 42472South Korea

Objective:This study aimed to determine the effects of job characteristics and work engagement on the nursing performance of nurses working in general ***:Data were collected from 169 nurses who are working in a general hospital in South Korea by using a cross-sectional descriptive survey ***:Nurses’job characteristics and work engagement showed positive effects on nursing *** effect was magnified when work engagement was used as a mediating ***:The findings elucidate the factors influencing job performance and provide managers with important information for developing programs to improve the job skills and work engagement of nurses.

关键词： general hospitals job characteristics nurse work engagement work performance