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Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial

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World Journal of Gastroenterology 2019年第46期25卷 6790-6798页

作者： So Jeong Kim Jun-Won chung Hyun sun Woo Su Young Kim Jung Ho Kim Yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park College of Medicine Gachon University Graduate School of MedicineIncheon 21936South Korea Division of Gastroenterology Department of Internal MedicineGachon University Gil Medical CenterIncheon 21565South Korea Division of Gastroenterology Department of Internal MedicineYonsei University Wonju College of MedicineWonju 26426South Korea

BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(***)eradication rates afforded by the standard triple ***,2-wk firstline four-drug regimens must be *** To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and *** Patients infected with *** were prospectively randomized to receive mBCQT or CT for 2 *** featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice *** included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice *** 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm *** either the histological or rapid urease test was positive,*** infection was *** The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ *** intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The *** eradication rates of the 2-wk mBCQT and CT regimens are *** patients show good compliance,and more CT than mBCQT patients experience adverse events.

关键词： Helicobacter pylori Therapy Bismuth-containing quadruple therapy Concomitant therapy

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Convergent adaptive evolution——how common, or how rare?

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National Science Review 2020年第6期7卷 945-946页

作者： chung-I Wu Guo-Dong Wang Shuhua Xu School of Life Sciences Sun Yat-Sen University Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences CAS-MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

This Special Topic contains one perspective and three original articles that address the topic of convergent evolution. How common, and how important, is convergent adaptation in evolution? These are the questions the... 详细信息

关键词： CANCER SELECTION

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Is Osteosarcoma between the Two Peak Ages Different?

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Journal of Cancer Therapy 2018年第1期9卷 64-78页

作者： Taehun Kim Hak sun chung Wan-Hyeong Cho Dae-Geun Jeon So Hak chung Department of Orthopaedic Surgery Kosin University Gospel Hospital Busan Republic of Korea Department of Orthopaedic Surgery Korea Cancer Center Hospital Seoul Republic of Korea

Background: Unlike two known peak age groups (10 - 14 and older than 65 years of age), there was relatively scant attention in osteosarcoma patients between them, and previous reports had analyzed other than Asians. Therefore we conducted this study with Korean patients and focused on 20 - 40 years of age, then investigated age-specific or race-specific meaningful outcomes. Materials and Methods: 379 patients who were newly diagnosed as osteosarcoma in two Korean major cancer hospitals from September 1986 to July 2015 with more than 2-year follow-up were retrospectively studied. There were 290 patients with 20 - 40 years of age, 60 patients aged 19 or younger, and 29 patients aged 41 or older. Age at diagnosis, gender, location of primary lesion, metastasis at diagnosis, histologic subtypes, histologic response were analyzed as prognostic factors by overall survival (OS) and event-free survival (EFS) rates. Results: Primary pelvic lesion and poor histologic response were significantly unfavorable prognostic factors, but not age-specific. However, proportion of metastasis at diagnosis was significantly highest in 20 - 40 years of age group. For the age at diagnosis, older patients presented poorer 5-year OS and EFS rates, but for 10-year, 20 - 40 years of age group showed unusually better prognosis than younger age’s, with statistic significance in OS rates but not in EFS rates. Conclusion: Osteosarcoma patients with 20 - 40 years of age in Korea presented relatively better prognosis after longer-term 10-year despite their late diagnosis causing more metastasis at diagnosis, which emphasized expedite diagnosis and appropriate treatment to expect much better prognosis than peak age groups.

关键词： Osteosarcoma Age Young Adult Outcome Prognosis

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Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： Kim-Hung Lam Sarah Sze-Wah Ho Pik-Ling Lam Johnny Cheuk-On Tang Zhao-Xiang Bian Albert sun-Chi Chan Hua Li Wai-Yeung Wong chung-Hin Chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

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On the low reproducibility of cancer studies

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National Science Review 2018年第5期5卷 619-624页

作者： Haijun Wen Hurng-Yi Wang Xionglei He chung-I Wu State Key Laboratory of Biocontrol College of Ecology and EvolutionSun Yat-Sen University Graduate Institute of Clinical Medicine and Hepatitis Research Center Taiwan University and Hospital Department of Ecology and Evolution University of Chicago

INTRODUCTION Previous reports have suggested that close to 90%of cancer biology publications are irreproducible. The low number has recently been corroborated by five detailed replication studies in e Life, which have been commented on in Nature (Replication studies offer much more than technical *** 2017;541:259–60). While the irreproducibility is often attributed to human factors, which are remediable, the

关键词： On the low reproducibility of cancer studies

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Ab　initio　Studies　on　Boron　Clusters　and　Their　Corresponding　Boranes　with　T_d,O_h　and　I_h　Symmetries

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Chemical Research in Chinese Universities 1997年第1期13卷 46-50页

作者： YU Wei zhou, ZHANG Ming yu and sun Chia chung (Institute of Theoretical Chemistry, Jilin University, Changchun, 130023)

The thermal stability and bonding characteristics of the larger boron clusters B n and their corresponding boranes with T d , O h or I h symmetries were studied by means of ab initio... 详细信息

The thermal stability and bonding characteristics of the larger boron clusters B n and their corresponding boranes with T d , O h or I h symmetries were studied by means of ab initio method. The results obtained from the calculation show that the clusters and boranes are all thermally stable to a different extent. The number of the skeletal bonding orbitals of B n H 2- n satisfies the Wades rule, but this kind of clusters need not be a complete triangular face polyhedron. The results also indicate that the larger neutral boranes B n H n may exist.

关键词： Boron cluster Thermal stability Electron deficient property

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Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain:A retrospective case series of single center experience

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World Journal of Clinical Cases 2023年第32期11卷 7785-7794页

作者： sungwon Kim sun Woong Kim Byung Chan Lee Du Hwan Kim Duk Hyun sung Department of Physical and Rehabilitation Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Physical and Rehabilitation Medicine Jungdap HospitalSuwon 16480South Korea Physical Medicine and Rehabilitation Chung-Ang University HospitalSeoul 06973South Korea Physical Medicine and Rehabilitation Chung-Ang UniversitySeoul 06973South Korea Department of Physical and Rehabilitation Medicine Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Osteomalacia(OM)is frequently confused with various musculoskeletal or other rheumatic diseases,especially in patients with adult-onset widespread musculoskeletal pain because of its low prevalence and non-specific *** To facilitate the early diagnosis and etiology-specific treatment of adult-onset hypophosphatemic *** A retrospective review of medical records was performed to screen adult patients who visited a physiatry locomotive medicine clinic(spine and musculoskeletal pain clinic)primarily presenting with widespread musculoskeletal pain at a single tertiary hospital between January 2011 and December *** enrolled patients with hypophosphatemia,high serum bone-specific alkaline phosphatase levels,and at least one imaging finding suggestive of *** Eight patients with adult-onset hypophosphatemic OM were *** back was the most common site of *** dominant symmetric muscle weakness was observed in more than half of the *** scintigraphy was the most useful imaging modality for diagnosing OM because radiotracer uptake in OM showed characteristic *** patients were diagnosed with adefovir(ADV)-induced Fanconi syndrome,and the other two patients were diagnosed with tumor-induced OM and light-chain nephropathy,*** phosphorus and vitamin D supplementation and treatment for the underlying etiologies,improvements in pain,muscle strength,and gait were observed in all *** Mechanical pain characteristics,hypophosphatemia,and distinctive bone scintigraphy patterns are the initial diagnostic indicators of adult-onset hypophosphatemic ***-induced Fanconi syndrome is the most common etiology of hypophosphatemic OM in hepatitis B virus-endemic countries.

关键词： Hypophosphatemia Osteomalacia Widespread musculoskeletal pain Bone scintigraphy Hepatitis B virus Phosphaturic mesenchymal tumor

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Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 329-335页

作者： Jin Kwon chung Shin Ae Park Hee sun Hwang Kwang sung Kim Yang Je Cho Yong sung You Young Sik Kim Ju Woong Jang sung Jin Lee Department of Ophthalmology Soonchunhyang University College of Medicine Soonchunhyang University Seoul Hospital Seou104401 Korea Eyegene Inc. Seou107528 Korea Nune Eye Hospital Seou106198 Korea Cellumed. Co. Ltd. Seoul 08501 Korea

AIM：To evaluate the effect of exogenous recombinant human bone morphogenic protein-7（rhBMP-7）on transforming growth factor-β（TGF-β）-induced epithelial mesenchymal cell transition（EMT）and assessed its antifibrotic effect via topical ***：The cytotoxic effect of rhBMP-7 was evaluated and the EMT of human corneal epithelial cells（HECEs）was induced by TGF-β. HECEs were then cultured in the presence of rhBMP-7 and/or hyaluronic acid（HA）. EMT markers,fibronectin,E-cadherin,α-smooth muscle actin（α-SMA）,and matrix metaloproteinase-9（MMP-9）,were evaluated. The level of corneal fibrosis and the reepithelization rate were evaluated using a rabbit keratectomy model. Expression of α-SMA in keratocytes were quantified following treatment with different concentrations of ***：Treatment with rhBMP-7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion（31.6%; P〈0.05）,the α-SMA protein level（72.2%; P〈0.01）,and MMP-9 expression（23.6%,P〈0.05）in HECEs compared with cells grown in the presence of TGF-β alone. E-cadherin expression was significantly enhanced（289.7%; P〈0.01）in the presence of rhBMP-7. Topical application of rhBMP-7 combined with 0.1% HA significantly reduced the amount of α-SMA~＋ cells by 43.18%（P〈0.05）at a concentration of 2.5 μg/mL and by 47.73%（P〈0.05）at 25 μg/mL,compared with the control group,without disturbing corneal ***：rhBMP-7 attenuates TGF-β-induced EMT in vitro,and topical application of rhBMP-7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reepithelization. Topical rhBMP-7 application as biological eye drops seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reepithelization disorders.

关键词： bone morphogenic protein-7 corneal fibrosis epithelial mesenchymal transition myodifferentiation transforming growth factor-β

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What went wrong in science publishing?

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National Science Review 2017年第4期4卷 518-519页

作者： chung-I Wu Mu-Ming Poo School of Life Science Sun Yat-Sen University Department of Ecology and Evolution University of Chicago

Science publishing has changed dramatically in the last few *** scientific reports are prepared by the authors,processed by the journals and evaluated by the academia all have serious problems at *** scientific fields,particularly biological sciences,have become dominated by major publishing enterprises and their‘high-profile’journals.

关键词： What went wrong in science publishing

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Replies to the commentaries on the question of ‘Is it time to abandon the biological species concept?’

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National Science Review 2020年第8期7卷 1407-1409页

作者： chung-I Wu Xinfeng Wang Ziwen He Suhua Shi State Key Laboratory of Biocontrol Guangdong Key Lab of Plant ResourcesSchool of Life Sciences Sun Yat-Sen University

In reassessing the biological species concept(BSC), the central disagreement is whether the concept of species should be linked to the process of species formation. Here, we argue that species should be, and can only be, defined in the context of the process of speciation. By evaluating BSC this way, we find the large body of genomic evidence on ‘speciation with gene flow’ does not constitute sufficient evidence to reject BSC. Whether and how BSC should be continually re-examined in light of the genomic evidence will be the crux of the debate on species and their origin.

关键词： HELIANTHUS-ANNUUS ANNUAL sunFLOWERS GENE EXCHANGE HYBRIDIZATION

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