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Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 244-251页

作者： Gil Chun Park sung Gyu Lee Young In yoon Kyu Bo sung Gi Young Ko Dong Il Gwon Dong Hwan jung Yong Kyu jung Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(PVE)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with PVE *** present study aimed to clarify whether preoperative sequential TACE and PVE before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall ***:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November *** were divided into four groups according to the procedure performed before the surgery:sequential TACE and PVE(TACE-PVE),PVE-only,TACE-only,or na?ve control *** baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were ***:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and PVE were well *** TACE-PVE group had a higher mean increase in percentage FLR volume compared with that of the PVE-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-PVE group had significantly better overall and disease-free survival rates compared with the other groups(both P<0.001).Conclusions:Sequential TACE and PVE prior to surgery can be an effective therapeutic strategy for patients with HCC scheduled for major hepatic *** active application of preoperative sequential TACE and PVE for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression.

关键词： Sequential selective transcatheter Arterial chemoembolization Portal vein embolization Hepatocellular carcinoma Future liver remnant

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Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks

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Journal of Pharmaceutical Analysis 2022年第5期12卷 743-754页

作者： Nguyen Hoang Anh Young Cheol yoon Young Jin Min Nguyen Phuoc Long Cheol Woon jung sun Jo Kim Suk Won Kim Eun Goo Lee Daijie Wang Xiao Wang sung Won Kwon College of Pharmacy Seoul National UniversitySeoul08826Republic of Korea School of Pharmaceutical Sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Biological Engineering Technology Innovation Center of Shandong Province Heze Branch of Qilu University of Technology(Shandong Academy of Sciences)HezeShandong274000China

Lipidomics coverage improvement is essential for functional lipid and pathway construction.A powerful approach to discovering organism lipidome is to combine various data acquisitions,such as full scan mass spectrometry(full MS),data-dependent acquisition(DDA),and data-independent acquisition(DIA).Caenorhabditis elegans(***)is a useful model for discovering toxic-induced metabolism,highthroughput drug screening,and a variety of human disease *** determine the lipidome of *** and investigate lipid disruption from the molecular level to the system biology level,we used integrative data *** methyl-tert-butyl ether method was used to extract L4 stage *** after exposure to triclosan(TCS),perfluorooctanoic acid,and nanopolystyrene(nPS).Full MS,DDA,and DIA integrations were performed to comprehensively profile the *** lipidome by Q-Exactive Plus *** annotated lipids were then analyzed using lipid ontology and pathway *** annotated up to 940 lipids from 20 lipid classes involved in various functions and *** biological investigations revealed that when *** were exposed to nPS,lipid droplets were disrupted,whereas plasma membrane-functionalized lipids were likely to be changed in the TCS treatment *** nPS treatment caused a significant disruption in lipid ***,glycerophospholipid,and ether class lipids were those primarily hindered by ***,toxicant exposure frequently involved numerous lipid-related pathways,including the phosphoinositide 3-kinase/protein kinase B *** conclusion,an integrative data acquisition strategy was used to characterize the *** lipidome,providing valuable biological insights into hypothesis generation and validation.

关键词： Caenorhabditis elegans Lipidomics Data-dependent acquisition Data-independent acquisition

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Gouty tenosynovitis with compartment syndrome in the hand: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7492-7496页

作者： Dong Yun Lee SuRak Eo SooA Lim jung Soo yoon Department of Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Gout is a common type of inflammatory arthritis caused by the deposition of monosodium urate crystals in the joints and surrounding *** typically appears with abrupt and intense pain,redness,and swelling in the affected *** frequently targets the lower extremities,such as the big ***,rarely,gout can manifest in atypical locations,including the hands,leading to an uncommon presentation known as gouty ***,it can result in significant morbidity owing to the potential for severe complications,such as myonecrosis and compartment *** SUMMARY An 82-year-old male patient with a history of hypertension,cerebral infarction,Parkinson's disease,and recurrent gout attacks sought medical attention because of progressive pain and swelling in the right *** findings revealed forearm swelling,raising concerns of possible tenosynovitis,bursitis,septic arthritis,and compartment syndrome.A fasciotomy was performed to decompress the patient’s hands and *** procedure revealed diffuse tenosynovitis,tophi with a pus-like discharge surrounding the carpal tunnel,and involvement of the flexor and extensor tendon ***,microbiological investigations,including Gram staining,acid-fast bacilli,tuberculosis,and nontuberculous mycobacteria,yielded negative *** patient was ultimately diagnosed with a severe gouty attack with compartment syndrome and *** arthritis and infectious flexor tenosynovitis were ruled *** debridement and inflammation control were initiated,followed by staged closure with a skin *** Septic-like complications can occur in the absence of infection in severe gout attacks with pus-like discharges due to compartment syndrome and *** can be used to differentiate between gouty attacks,septic arthritis,and infectious *** of the flexor and extensor muscles,as in this case,is *** study contributes to the literature

关键词： Compartment syndrome Extensor compartment Gout Tenosynovitis Case report

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Refractive errors in high myopic eyes after phacovitrectomy for macular hole

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 369-373页

作者： Donghyun Jee Yi-Ryeung Park Kyoung In jung Eunchul Kim Tae yoon La Department of Ophthalmology and Visual Science College of Medicine Catholic University of Korea St. Vincent Hospital Department of Ophthalmology and Visual Science College of Medicine Catholic University of Korea Seoul St. Mary's Hospital Department of Ophthalmology and Visual Science College of Medicine Catholic University of Korea Bucheon St.Mary's Hospital

AIM: To examine the refractive prediction error in high myopic eyes after ***: This retrospective comparative case series included 91 eyes(18 high myopic eyes and 73 non-high myopic eyes) of 91 patients who underwent successful phacovitrectomy(phacoemulsification, intraocular lens implantation, and pars plana vitrectomy). The high myopic eyes were defined as the eye with more than 26.0mm of axial length. The postoperative prediction error of mean error and mean absolute error were evaluated at4 mo postoperatively. Axial length and keratometry measurement were performed preoperatively and 4mo postoperatively using the IOL ***: The refractive outcome after phacovitrectomy showed significantly greater myopic shift in the high myopic eyes [-1.08 ±0.87 diopters(D)] than that in the non-high myopic eyes(-0.43 ±0.63 D, P =0.004). Axial length and keratometric value in the high myopic eyes were significantly increased(P =0.043, 0.037 respectively),whereas those in the non-high myopic group were not significantly increased(P =0.135, 0.347 respectively). The change of the axial length in the myopic eye(0.46±0.28 mm)was greater than that in the non- high myopic eye(0.11 ± 0.34 mm; P <0.001).CONCLUSION: High myopic eyes showed more myopic shift than non-high myopic eyes after *** cause of myopic shift in high myopic eyes seems tobe attributed to actual elongation of the axial length in high myopia.

关键词： axial length high myopic eyes keratometry phacovitrectomy refractive errors

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Superficial foveal avascular zone area changes before and after idiopathic epiretinal membrane surgery

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1711-1715页

作者： Yo Sep yoon Je Moon Woo Jong Eun Woo jung Kee Min Department of Ophthalmology Ulsan University Hospital College of Medicine University of Ulsan

To investigate the foveal morphological changes and foveal avascular zone（FAZ）area before and after epiretinal membrane（ERM）***-two eyes with treatmentnaive ERM were included in this retrospective *** central foveal thickness（CFT）and FAZ area were measured via swept-source optical coherence tomography（SS-OCT）and OCT angiography pre-and *** unaffected fellow eyes were used as *** preoperative superficial FAZ area was significantly smaller in patients（0.08±0.04 mm^2）than in controls（0.33±0.09 mm^2;P〈0.001）.The postoperative superficial FAZ（0.12±0.06 mm^2）area was significantly greater than the preoperative area（P〈0.001）.The preoperative superficial FAZ area was strongly negatively correlated with CFT（P〈0.001,rho=-0.763）.ERM induced significant foveal morphological changes and reduction of the superficial FAZ *** thickness was restored and FAZ area increased ***,the process is rather slow and the recovery is incomplete.

关键词： central foveal thickness epiretinal membrane foveal avascular zone optical coherence tomography angiography

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Successful reconstruction of an ankle defect with free tissue transfer in a hemophilia A patient with repetitive hemoarthrosis:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4079-4083页

作者： Dong Yun Lee SooA Lim SuRak Eo jung Soo yoon Department of Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Hemophilia, an uncommon yet consequential hereditary bleeding disorder, manifests as two clinically indistinguishable forms that hinder the normal functioning of the coagulation cascade. This impairment renders individuals more susceptible to excessive bleeding during significant surgical interventions. Moreover, individuals with severe hemophilia frequently encounter recurring hemarthrosis, resulting in progressive joint destruction and, subsequently, the need for hip and knee replacement *** SUMMARY The patient was a 53-year-old man with hemophilia A as the underlying disease and had self-injected factor Ⅷ twice weekly for several decades. He had undergone ankle fusion surgery for recurrent hemarthrosis at the Department of Orthopedic Surgery 1 mo prior and was referred to our department because of skin necrosis after a hematoma at the surgical site. An anterolateral thigh perforator free flap was created after three cycles of factor Ⅷ administration in addition to the concomitant administration of tranexamic acid(TXA)(Transamin 250 mg cap, 1 cap tid, q8h). After the operation, from postoperative days(PODs) 1-5, the factor Ⅷ dose and interval were maintained, and q12h administration was tapered to q24h administration after POD 6. Because the patient’s flap was stable 12 d after the operation, factor Ⅷ administration was tapered to twice a week. At 6 mo follow-up, the patient recovered well without any *** To the best of our knowledge, there are very few reports of successful free flaps in patients with hemophilia, and none have been reported in patients with hemophilia A. Moreover, there are several reports on the efficacy of TXA in free flaps in general patients;however, there are no case reports of combining factor Ⅷ and TXA in patients with hemophilia. Therefore, we report this case to contribute to future academic research.

关键词： Free tissue transfer Anterolateral thigh free flap Hemophilia A Hemoarthrosis Factor VIII Tranexamic acid Case report

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Liver abscess and sepsis with Bacillus pantothenticus in an immunocompetent patient:A first case report

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World Journal of Gastroenterology 2009年第42期15卷 5360-5363页

作者： jung Sik Na Tae Hyung Kim Heung Su Kim Sang Hyun Park Ho Sup Song Sang Woo Cha Hee jung yoon Department of Internal Medicine Eulji University College of MedicineDaejeon 302-799South Korea

Bacillus species are aerobic,gram-positive,spore forming rods that are usually found in the soil,dust,streams,and other environmental *** for ***(***) ,most species display low virulence,and only rarely cause infections in hosts with weak or damaged immune *** are two case reports of *** as a potentially serious bacterial pathogen causing a liver abscess in an immunologically competent *** herein report a case of liver abscess and sepsis caused by *** in an immunocompetent *** now,no case of liver abscess due to *** has been reported.

关键词： Bacillus pantothenticus, Bacillus species Immunocompetence Liver abscess and sepsis

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Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial

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World Journal of Gastroenterology 2019年第46期25卷 6790-6798页

作者： So Jeong Kim Jun-Won Chung Hyun sun Woo Su Young Kim jung Ho Kim yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park College of Medicine Gachon University Graduate School of MedicineIncheon 21936South Korea Division of Gastroenterology Department of Internal MedicineGachon University Gil Medical CenterIncheon 21565South Korea Division of Gastroenterology Department of Internal MedicineYonsei University Wonju College of MedicineWonju 26426South Korea

BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(***)eradication rates afforded by the standard triple ***,2-wk firstline four-drug regimens must be *** To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and *** Patients infected with *** were prospectively randomized to receive mBCQT or CT for 2 *** featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice *** included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice *** 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm *** either the histological or rapid urease test was positive,*** infection was *** The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ *** intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The *** eradication rates of the 2-wk mBCQT and CT regimens are *** patients show good compliance,and more CT than mBCQT patients experience adverse events.

关键词： Helicobacter pylori Therapy Bismuth-containing quadruple therapy Concomitant therapy

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Endoscopic management of occluded metal biliary stents:Metal versus 10F plastic stents

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World Journal of Gastroenterology 2010年第42期16卷 5347-5352页

作者： Won Jae yoon Ji Kon Ryu jung Won Lee Dong-Won Ahn Yong-Tae Kim Yong Bum yoon Sang Myung Woo Woo Jin Lee Division of Gastroenterology Department of Internal MedicineSeoul National University College of Medicine101 Daehang-roJongno-guSeoul110-744South Korea Center for Liver Cancer National Cancer Center323 Ilsan-roIlsandong-guGoyang-siGyeonggi-do410-769South Korea

AIM:To compare the efficacy of self-expandable metal stents(SEMSs) with 10F plastic stents(PSs) in the endoscopic management of occluded ***:We retrospectively reviewed the medical records of 56 patients who underwent SEMS insertion for palliation of unresectable malignant biliary obstruction between 2000 and 2007 and subsequent endoscopic retrograde biliary drainage(ERBD) with SEMS or PS for initial SEMS occlusion between 2000 and ***:Subsequent ERBD with SEMS was performed in 29 patients and with PS in *** median time to stent occlusion after subsequent ERBD was 186 d in the SEMS group and 101 d in the PS group(P= 0.118).Overall median stent patency was 79 d for the SEMS group and 66 d for the PS group(P = 0.379).The mean number of additional biliary drainage procedures after subsequent ERBD in patients that died(n = 50) during the study period was 2.54 ± 4.12 for the SEMS group and 1.85 ± 1.95 for the PS group(P = 0.457).The mean total cost of additional biliary drainage procedures after the occlusion of subsequent SEMS or PS was $410.04 ± 692.60 for the SEMS group and $630.16 ± 671.63 for the PS group(P = 0.260).Tumor ingrowth as the cause of initial SEMS occlusion was the only factor associated with a shorter time to subsequent stent occlusion(101 d for patients with tumor ingrowth vs 268 d for patients without tumor ingrowth,P = 0.008).CONCLUSION:Subsequent ERBD with PSs offered similar patency and number of additional biliary drainage procedures compared to SEMSs in the management of occluded SEMS.

关键词： Stents Biliary tract neoplasms Obstructive jaundice Endoscopy Endoscopic retrograde cholangiopancreatography

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Fabrication of curved micro structures on photoresist layer

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 100-103页

作者： Jae sung yoon Tae-Jin JE Doo-sun CHOI sung Hwan CHANG Kyung-Hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery and Materials (KIMM) Daejeon 305-343 Korea

A novel fabrication process for micro patterns with curvature was introduced. The curved structures were made by compensating rectangular micro structures with liquid photoresist layer. Because of the surface tension of the liquid in micro scale, various shapes of meniscus can he made on the micro channels. The micro channels were made on the silicon suhstrate in advance, and then the liquid layer was coated on the micro channels. From the nature of liquid behavior, the curved patterns with smooth surface are obtained, which cannot be made easily with the conventional mechanical machining, as well as with the microfabrication processes, such as wet and dry etching. With this principle, it is expected that the smooth and curved surfaces can be made by simple processes and the results can be applied widely, such as optical patterns.

关键词： micro pattern liquid layer MEMS micro channel silicon substrate

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