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Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice

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Biomedical and Environmental Sciences 2024年第1期37卷 19-30页

作者： MENG Li Ying TAO Wen fu LI jing ZHU Min ZHONG De Bin ZHOU jing QIN Xue WEI Rong Guo Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Clinical Laboratory The Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Jiangsu Key Laboratory of Environmental Engineering Jiangsu Academy of Environmental SciencesNanjing 210000JiangsuChina

Objective The aim of this study was to assess the impact of bisphenol A(BPA)and its substitute,bisphenol F(BPF),on the colonic fecal community structure and function of *** We exposed 6–8-week-old male C57BL/6 mice to 5 mg/(kg∙day)and 50μg/(kg∙day)of BPA or BPF for 14 *** samples from the colon were analyzed using 16S rRNA *** Gut microbiome community richness and diversity,species composition,and function were significantly altered in mice exposed to BPA or *** change was characterized by elevated levels of Ruminococcaceae UCG-010 and Oscillibacter and decreased levels of Prevotella 9 and ***,pathways related to carbohydrate and amino acid metabolism showed substantial *** Mice exposed to different BP analogs exhibited distinct gut bacterial community richness,composition,and related metabolic *** the essential role of gut bacteria in maintaining intestinal homeostasis,our study highlights the intestinal toxicity of BPs in vertebrates.

关键词： Bisphenol A(BPA) Bisphenol F(BPF) 16S rRNA Microbiota

Amide proton transfer:A new magnetic resonance imaging technology toward individualized assessment

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Chinese Medical Journal 2024年第13期137卷 1614-1616页

作者： Yiming Meng jing sun Guirong Zhang Tao Yu Department of Central Laboratory Cancer Hospital of Dalian University of TechnologyLiaoning Cancer Hospital&InstituteShenyangLiaoning 110042China Department of Biobank Cancer Hospital of Dalian University of TechnologyLiaoning Cancer Hospital&InstituteShenyangLiaoning 110042China Department of Medical Imaging Cancer Hospital of Dalian University of TechnologyLiaoning Cancer Hospital&InstituteLiaoning 110042China

To the Editor:The amide proton transfer(APT)magnetic resonance imaging(MRI)is an emerging molecular imaging method for detecting mobile proteins/peptides and the potential of hydrogen(pH)with enhanced detection sensitivity compared to direct measurement without external magnetic resonance contrast agents[Figure 1].Such changes may be potential markers for tumor aggressiveness,treatment efficacy,and overall ***,the utilization of APT can assist medical professionals in devising treatment regimens tailored to the individual needs of cancer patients,resulting in improved therapeutic outcomes.

关键词： Figure resonance transfer

Decreased eggshell strength caused by impairment of uterine calcium transport coincide with higher bone minerals and quality in aged laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1258-1277页

作者： Yu fu Jianmin Zhou Martine Schroyen Haijun Zhang Shugeng Wu Guanghai Qi jing Wang Key Laboratory of Feed Biotechnology Ministry of Agriculture and Rural AffairsInstitute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Precision Livestock and Nutrition Laboratory Gembloux Agro‑Bio TechTERRA Teaching and Research CentreUniversity of LiegeGembloux B‑5030Belgium

Background Deteriorations in eggshell and bone quality are major challenges in aged laying *** study compared the differences of eggshell quality,bone parameters and their correlations as well as uterine physiologi-cal characteristics and the bone remodeling processes of hens laying eggs of different eggshell breaking strength to explore the mechanism of eggshell and bone quality reduction and their interaction.A total of 24074-week-old Hy-line Brown laying hens were selected and allocated to a high(HBS,44.83±1.31 N)or low(LBS,24.43±0.57 N)eggshell breaking strength *** A decreased thickness,weight and weight ratio of eggshells were observed in the LBS,accompanied with ultrastructural deterioration and total Ca *** quality was negatively correlated with eggshell quality,marked with enhanced structures and increased components in the *** the LBS,the mammillary knobs and effective layer grew *** the initiation stage of eggshell calcification,a total of 130 differentially expressed genes(DEGs,122 upregulated and 8 downregulated)were identified in the uterus of hens in the LBS relative to those in the *** DEGs were relevant to apoptosis due to the cellular Ca *** values of p62 protein level,caspase-8 activity,Bax protein expression and lower values of Bcl protein expression and Bcl/Bax ratio were seen in the *** assay and hematoxylin-eosin staining showed a significant increase in TUNEL-positive cells and tissue damages in the uterus of the *** few DEGs were identified at the growth stage,similar uterine tissue damages were also observed in the *** expressions of runt-related transcription factor 2 and osteocal-cin were upregulated in humeri of the *** diameter and more structural damages of endocortical bones and decreased ash were observed in femurs of the *** The lower eggshell breaking strength may be attributed to a declined Ca transport due to uterine tissue damages,which

关键词： Bone parameter Calcium transport Eggshell quality Laying hen Tissue damage

Catalytic degradation of chlorinated volatile organic compounds(CVOCs)over Ce-Mn-Ti composite oxide catalysts

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Journal of Environmental Sciences 2024年第4期138卷 326-338页

作者： Zhiwei Zhou Qianqian Li Guijin Su Jiaxin Pang Bohua sun jing Meng Bin Shi Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Environmental Nanotechnology and Health Effects State Key Laboratory of Environmental Chemistry and EcotoxicologyResearch Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Developing industrially moldable catalysts with harmonized redox performance and acidity is of great significance for the efficient disposal of chlorinated volatile organic compounds(CVOCs)in actual exhaust ***,commercial TiO_(2),typically used for molding catalysts,was chosen as the carrier to fabricate a series of Ce_(0.02)Mn_(0-0.24)TiO_(x) materials with different Mn doping ratios and employed for chlorobenzene(CB)*** introduction of Mn remarkedly facilitated the synergistic effect of each element via the electron transfer processes:Ce^(3+)+Mn^(4+/3+)■Ce^(4+)+Mn^(3+/2+)and Mn^(4+/3+)+Ti^(4+)■Mn^(3+/2+)+Ti^(3+).These synergistic interactions in Ce_(0.02)Mn_(0.04-0.24)TiO_(x),especially Ce_(0.02)Mn_(0.16)TiO_(x),significantly elevated the active oxygen species,oxygen vacancies and redox properties,endowing the superior catalytic oxidation of *** the Mn doping amount increased to 0.24,a separate Mn_(3)O_(4) phase appeared,which in turn might weaken the synergistic ***,the acidity of Ce_(0.02)Mn_(0.04-0.24)TiO_(x) was decreased with the Mn doping,regulating the balance of redox property and ***,Ce_(0.02)Mn_(0.16)TiO_(x) featured relatively abundant B-acid *** coordinating redox ability and moderate acidity promoted the deep oxidation of CB and RCOOH-intermediates,as well as the rapid desorption of Cl species,thus obtaining sustainable *** comparison,CeTiO_(x) owned the strongest acidity,however,its poor redox property was not sufficient for the timely oxidative decomposition of the easier adsorbed CB,resulting in its rapid *** finding provides a promising strategy for the construction of efficient commercial molding catalysts to decompose the industrial-scale CVOCs.

关键词： Chlorobenzene Ce_(0.02)Mn_(0-0.2)4tiox materials Redox ability Acidity Synergistic interaction

Health risk assessment of trace metal(loid)s in agricultural soils based on Monte Carlo simulation coupled with positive matrix factorization model in Chongqing, southwest China

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Journal of Mountain Science 2024年第1期21卷 100-112页

作者： MA Jie CHU Lijuan sun jing WANG Shenglan GE Miao DENG Li Chongqing Ecological and Environmental Monitoring Center Chongqing 401147China Key Laboratory of Organic Pollutants in Environmental Chemical Behavior and Ecological Toxicology of Chongqing Chongqing 401147China Department of Pediatrics Chongqing Health Center for Women and ChildrenChongqing 401147China Department of Pediatrics Women and Children’s Hospital of Chongqing Medical UniversityChongqing 401147China

This study aimed to investigate the pollution characteristics, source apportionment, and health risks associated with trace metal(loid)s(TMs) in the major agricultural producing areas in Chongqing, China. We analyzed the source apportionment and assessed the health risk of TMs in agricultural soils by using positive matrix factorization(PMF) model and health risk assessment(HRA) model based on Monte Carlo simulation. Meanwhile, we combined PMF and HRA models to explore the health risks of TMs in agricultural soils by different pollution sources to determine the priority control factors. Results showed that the average contents of cadmium(Cd), arsenic (As), lead(Pb), chromium(Cr), copper(Cu), nickel(Ni), and zinc(Zn) in the soil were found to be 0.26, 5.93, 27.14, 61.32, 23.81, 32.45, and 78.65 mg/kg, respectively. Spatial analysis and source apportionment analysis revealed that urban and industrial sources, agricultural sources, and natural sources accounted for 33.0%, 27.7%, and 39.3% of TM accumulation in the soil, respectively. In the HRA model based on Monte Carlo simulation, noncarcinogenic risks were deemed negligible(hazard index <1), the carcinogenic risks were at acceptable level(10^(-6)

关键词： Monte Carlo simulation Health risk assessment Trace metal(loid)s Positive matrix factorization Agricultural soils

Character of Convective Systems Producing Short-Term Heavy Precipitation in Central China Revealed by Kilometer and Minute Interval Observations

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Journal of Meteorological Research 2024年第3期38卷 530-541页

作者： Zitong CHEN Yunying LI Zhiwei ZHANG jing sun Chengzhi YE Anyuan XIONG College of Meteorology and Oceanography National University of Defense TechnologyChangsha410073China High Impact Weather Key Laboratory of China Meteorological Administration Changsha410073China Unit No.92192 of Chinese People’s Liberation Army Ningbo315000China Hubei Key Research Laboratory for Heavy Rain Monitoring and Warning Institute of Heavy RainChina Meteorological AdministrationWuhan430223China Institute of Meteorological Sciences of Hunan Province Hunan Meteorological BureauChangsha410118China National Meteorological Information Centre China Meteorological AdministrationBeijing100081China

Accurate forecasting of heavy precipitation in central China is still a challenge,within which a key issue is our still incomplete understanding of the convective systems(CSs)responsible for such *** this study,through use of an iterative rain-cell tracking algorithm,the macroscale characteristics(scale,intensity,duration,etc.)of the CSs that produced 595 short-term heavy precipitation events in Hunan Province,central China,are quantitatively analyzed,based on radar reflectivity,echo top,and rainfall observations at 1-km and 6-min intervals in April-September of *** results show that CSs present significant seasonal and diurnal *** CSs usually cover a larger echo area with stronger convective cores and thus generate more precipitation than summer CSs,though summer CSs develop more vigorously and *** initiated at 1400-1600 local time are characterized by the strongest convection and a smaller spatiotemporal scale,causing violent and transient showers with typical areal precipitation of 0.5-1 mm km^(−2),but less total *** analyses of the relationships among the scale,intensity,duration,and total precipitation of CSs reveal that the convective intensity is linearly correlated to the spatiotemporal scale of CSs,with the duration increasing on average by 0.0372 h dBZ^(−1);the echo area is significantly correlated to the total precipitation,and the duration and rainfall amount are connected with the area expansion rate(AER)of CSs:when the AER exceeds 50%,CSs expand rapidly with increasing total precipitation,but the duration is *** findings provide a helpful reference for the forecasting of short-term heavy precipitation induced by CSs in central China.

关键词： convective system radar reflectivity factor total precipitation iterative rain-cell tracking

High-Precision Doppler Frequency Estimation Based Positioning Using OTFS Modulations by Red and Blue Frequency Shift Discriminator

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China Communications 2024年第2期21卷 17-31页

作者： Shaojing Wang Xiaomei Tang jing Lei Chunjiang Ma Chao Wen Guangfu sun School of Electronic Science National University of Defense TechnologyChangsha 410073China

Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Doppler frequency for positioning is a promising research direction on communication and navigation integration. To tackle the high Doppler frequency and low signal-to-noise ratio(SNR) in satellite communication, this paper proposes a Red and Blue Frequency Shift Discriminator(RBFSD) based on the pseudo-noise(PN) *** paper derives that the cross-correlation function on the Doppler domain exhibits the characteristic of a Sinc function. Therefore, it applies modulation onto the Delay-Doppler domain using PN sequence and adjusts Doppler frequency estimation by red-shifting or blue-shifting. Simulation results show that the performance of Doppler frequency estimation is close to the Cramér-Rao Lower Bound when the SNR is greater than -15dB. The proposed algorithm is about 1/D times less complex than the existing PN pilot sequence algorithm, where D is the resolution of the fractional Doppler.

关键词： channel estimation communication and navigation integration Orthogonal Time Frequency and Space pseudo-noise sequence red-blue frequency shift discriminator

Combined Effect of Temperature and Cadmium on Molecular Responses of Hsp70 and P-gp Genes in Crassostrea gigas

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Journal of Ocean University of China 2024年第4期23卷 1115-1120页

作者： HU Fanguang sun Ming LIU Guangbin jing Yuanyuan CHEN Qun ZHANG Tianwen Marine Science Research Institute of Shandong Province Qingdao 266104China

To evaluate the combined effect of temperature and cadmium on the molecular responses of heat shock protein 70(hsp70)and P-glycoprotein(P-gp)in mantle,digestive gland and gills of Crassostrea gigas,oysters were exposed to combinations of five temperature levels(10,15,20,25,and 30℃)and 10μg L^(-1)cadmium for 21 *** were sampled for mRNA quantification by qPCR,and the results showed that the P-gp gene expression changed significantly after treatment at different temperatures and different treatment *** P-gp gene expression was the highest in the digestive *** with the control group,the P-gp gene expression in cadmium treatment groups at all the different temperatures were significantly higher than the control *** control oysters(kept at 10℃during the whole experiment without cadmium)expressed low levels of hsp70,but the groups treated with cadmium displayed somewhat higher *** present study demonstrated hsp70 and P-gp played an important role in the detoxification of Cd in ***,and confirmed temperature should be considered for the assessment of Cd-induced toxicity in oysters.

关键词： temperature cadmium P-gp hsp70 Crassostrea gigas

Triphenylphosphine-Assisted Exsolution Engineering on Ruddlesden-Popper Perovskites for Promoting Oxygen Evolution

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Energy & Environmental Materials 2024年第4期7卷 433-441页

作者： Juan Bai jing Shang Jun Mei Dongchen Qi Ting Liao Ziqi sun School of Chemistry and Physics Queensland University of Technology Centre for Materials Science Queensland University of Technology School of Materials Science and Engineering Shaanxi University of Science and Technology School of Mechanical Medical and Process Engineering Queensland University of Technology

Metal exsolution engineering has been regarded as a promising strategy for activating intrinsically inert perovskite oxide catalysts toward efficient oxygen evolution *** metal exsolution processes on perovskites are often achieved by using the reducing hydrogen gas; however,this is not effective for the relatively stable phase,such as Ruddlesden-Popper perovskite oxides.

关键词： exsolution oxygen evolution perovskite reconstruction Ruddlesden–Popper