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Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3

Bone Research 2024年第2期12卷 438-452页

作者： Bowen fu Jianlin Shen Xuenong Zou Nian sun Ze Zhang Zengping Liu Canjun Zeng Huan Liu Wenhua Huang Guangdong Medical Innovation Platform for Translation of 3D Printing Application The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangdong Provincial Key Laboratory of Digital Medicine and BiomechanicsNational Key Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510145 GuangdongChina Department of Foot and Ankle Surgery Center for Orthopedic SurgeryThe Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina Department of Orthopedics Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Central Laboratory Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080 GuangdongChina Nanfang Hospital Southern Medical UniversityGuangzhou 510515 GuangdongChina Guangzhou Blood Center Guangzhou 510095 GuangdongChina Department of Orthopedics The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000 SichuanChina

Extracellular matrix(ECM)stiffening is a typical characteristic of cartilage aging,which is a quintessential feature of knee osteoarthritis(KOA).However,little is known about how ECM stiffening affects chondrocytes and other molecules *** study mimicked the physiological and pathological stiffness of human cartilage using polydimethylsiloxane(PDMS)*** demonstrated that epigenetic Parkin regulation by histone deacetylase 3(HDAC3)represents a new mechanosensitive mechanism by which the stiffness matrix affected chondrocyte *** found that ECM stiffening accelerated cultured chondrocyte senescence in vitro,while the stiffness ECM downregulated HDAC3,prompting Parkin acetylation to activate excessive mitophagy and accelerating chondrocyte senescence and osteoarthritis(OA)in ***,intra-articular injection with an HDAC3-expressing adeno-associated virus restored the young phenotype of the aged chondrocytes stimulated by ECM stiffening and alleviated OA in *** findings indicated that changes in the mechanical ECM properties initiated pathogenic mechanotransduction signals,promoted the Parkin acetylation and hyperactivated mitophagy,and damaged chondrocyte *** results may provide new insights into chondrocyte regulation by the mechanical properties of ECM,suggesting that the modification of the physical ECM properties may be a potential OA treatment strategy.

关键词： chondrocyte osteoarthritis stiffness

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Thermal comfort in a building with Trombe wall integrated with phase change materials in hot summer and cold winter region without air conditioning

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Energy and Built Environment 2024年第1期5卷 58-69页

作者： Jie Li Yuan Zhang Ziyang Zhu Jiangtian Zhu jing Luo Fen Peng Xiaoqin sun School of Energy and Power Engineering Changsha University of Science and TechnologyChangshaHunan 410114PR China

Trombe wall and phase change materials(PCMs)are two effective ways to regulate indoor thermal ***,Trombe wall surfers from overheating in summer and PCMs suffer from low heat transfer rate caused by the limited thermal *** compensate the shortcomings of the two methods,this paper proposed a Trombe wall system integrated with *** on a light-weight building envelope in Changsha,China,the thermal comfort of 10 kinds of Trombe wall systems with PCMs with a melting temperature of 18-28℃ were *** the integrated indoor discomfort duration(I_(D)),integrated indoor discomfort degree-hour(I_(DH)),indoor air temperature(T_(in)),PCM liquid fraction(γ)and heat flux across wall(q)as evaluation indexes,the indoor thermal comfort was assessed in hot summer and cold winter *** show that the Trombe wall helped PCMs complete the phase change process *** wall with PCM25 next to the wall inner surface possessed the lowest annual I_(D) and I_(DH),as 2877 h and 12,974℃·h,*** with the values in a traditional building,the I_(D) and I_(DH) were reduced by 7.01% and 14.14%.In order to give full play to the heat storage and heat release of the Trombe wall with PCMs,PCMs with phase change temperature 7℃ lower than the peak ambient temperature in summer or 8℃ higher than the winter night temperature was recommended according to regional climate conditions.

关键词： Trombe wall Phase change materials Integrated indoor discomfort duration Integrated discomfort degree-hour Liquid fraction

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Correlation between abdominal computed tomography signs and postoperative prognosis for patients with colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2145-2156页

作者： Shao-Min Yang Jie-Mei Liu Rui-Ping Wen Yu-Dong Qian jing-Bo He jing-Song sun Department of Radiology Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical UniversityFoshan 528315Guangdong ProvinceChina Department of Rehabilitation Medicine Shunde HospitalSouthern Medical UniversityFoshan 528399Guangdong ProvinceChina Department of Radiology Lecong Hospital of ShundeFoshan 528315Guangdong ProvinceChina Department of Ultrasound Lecong Hospital of ShundeFoshan 528315Guangdong ProvinceChina

BACKGROUND Patients with different stages of colorectal cancer(CRC)exhibit different abdominal computed tomography(CT)***,the influence of CT signs on CRC prognosis must be *** To observe abdominal CT signs in patients with CRC and analyze the correlation between the CT signs and postoperative *** The clinical history and CT imaging results of 88 patients with CRC who underwent radical surgery at Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical University were retrospectively *** and multivariate Cox regression analyses were used to explore the independent risk factors for postoperative death in patients with *** three-year survival rate was analyzed using the Kaplan-Meier curve,and the correlation between postoperative survival time and abdominal CT signs in patients with CRC was analyzed using Spearman correlation *** For patients with CRC,the three-year survival rate was 73.86%.The death group exhibited more severe characteristics than the survival group.A multivariate Cox regression model analysis showed that body mass index(BMI),degree of periintestinal infiltration,tumor size,and lymph node CT value were independent factors influencing postoperative death(P<0.05 for all).Patients with characteristics typical to the death group had a low three-year survival rate(log-rankχ2=66.487,11.346,12.500,and 27.672,respectively,P<0.05 for all).The survival time of CRC patients was negatively correlated with BMI,degree of periintestinal infiltration,tumor size,lymph node CT value,mean tumor long-axis diameter,and mean tumor short-axis diameter(r=-0.559,0.679,-0.430,-0.585,-0.425,and-0.385,respectively,P<0.05 for all).BMI was positively correlated with the degree of periintestinal invasion,lymph node CT value,and mean tumor short-axis diameter(r=0.303,0.431,and 0.437,respectively,P<0.05 for all).CONCLUSION The degree of periintestinal infiltration,tumor size,and lymph node CT value are c

关键词： Colorectal cancer Abdominal Computed tomography signs Radical surgery Prognosis Correlation

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EjGASA6 promotes flowering and root elongation by enhancing gibberellin biosynthesis

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Journal of Integrative Agriculture 2024年第5期23卷 1568-1579页

作者： Qian Chen Shunyuan Yong Fan Xu Hao fu Jiangbo Dang Qiao He Danlong jing Di Wu Guolu Liang Qigao Guo Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education)/College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China State Cultivation Base of Crop Stress Biology for Southern Mountainous Land of Southwest University/Academy of Agricultural Sciences of Southwest University Chongqing 400715China College of Agronomy and Biotechnology Southwest UniversityChongqing 400715China

The Gibberellic Acid-stimulated Arabidopsis(GASA)gene family is involved in the regulation of gene expression and plant growth,development,and stress *** investigate the function of loquat GASA genes in the growth and developmental regulation of plants,a loquat EjGASA6 gene homologous to Arabidopsis AtGASA6 was ***6 expression was induced by gibberellin,and ectopic transgenic plants containing this gene exhibited earlier bloom and longer primary roots since these phenotypic characteristics are related to higher gibberellin *** analysis and qRT-PCR results showed that the expression levels of GA3ox1 and GA20ox1,which encode key enzymes in gibberellin biosynthesis,were significantly ***,we confirmed that EjGASA6 could promote the expression of GA20ox1 via the luciferase reporter ***,our results suggest that EjGASA6 promotes blooming and main-root elongation by positively regulating gibberellin *** findings broaden our understanding of the role of GASAs in plant development and growth,and lay the groundwork for future research into the functions of EjGASA6 in regulating loquat growth and development.

关键词： loquat EjGASA6 gibberellin synthesis biological function

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Molecular solid solution of lanthanide-titanium-oxo clusters with enhanced photocatalytic hydrogen evolution

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Science China Chemistry 2024年第2期67卷 529-535页

作者： Rong Chen Chao-Long Chen Hui Zhang Zi-Han Wang fu-Li sun Ming-Hao Du Gui-Lin Zhuang Cheng Wang La-Sheng Long Lan-sun Zheng Xiang-Jian Kong Collaborative Innovation Centre of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China College of Chemical Engineering Zhejiang University of TechnologyHangzhou310032China

Molecular solid solutions of metal clusters containing different metal centers with well-defined structures can accurately regulate the HOMO-LUMO gap,but are rarely ***,a series of colorless lanthanide-titanium-oxo clusters Ln_(2)Ti_4(μ_(2)-O)_(2)(μ_(3)-O)_4(Piv)_(10)(THF)_(2)(Ln_(2)Ti_4,Ln = Eu,Gd,Tb,and Ce,HPiv = pivalic acid) were synthesized by the reaction of pivalic acid with Ln(Ac)_(3) and titanium *** light yellow crystal of cluster solid solutions Eu_(2)Ti_(4-x)Cd_(x),containing a mixture of Eu_(2)Ti_4 and Eu_(2)Ti_(3)Cd,was obtained by in situ doping Cd^(2+) and S^(2–).Eu_(2)Ti_(3.92)Cd_(0.08) displays efficient photocatalytic hydrogen evolution activity without a co-catalyst,which is up to 2.6 times that of Eu_(2)Ti_*** time-resolved transient absorption spectroscopy and spin-polarized density functional calculations showed that the enhanced photocatalytic performance of Eu_(2)Ti_(4-x)Cd_(x) can be attributed to the narrower HOMO-LUMO gap and lower LUMO position than that of Eu_(2)Ti_*** studyprovides an in situ doping method to realize the simple preparation of cluster solid solution.

关键词： molecular solid solution lanthanide-titanium-oxo clusters photocatalytic hydrogen evolution

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基于第一性原理的β-C_(3)N_(2)笼中原子嵌入引起的超硬磁性新材料设计

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Science China Materials 2024年第6期67卷 2032-2038页

作者：孙丽萍付波涛常景 College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610068China College of Physics and Electronic Engineering Center for Computational SciencesSichuan Normal UniversityChengdu 610068China

基于第一性原理计算,我们通过将客体原子嵌入β-C_(3)N_(2)笼状结构的内在空腔中,预测了机械超硬和可控磁性的共存.以氢掺杂(H@β-C_(3)N_(2))和氟掺杂(F@β-C_(3)N_(2))为例,我们的研究表明两种掺杂构型是稳定的,并发现它们分别属于反... 详细信息

基于第一性原理计算,我们通过将客体原子嵌入β-C_(3)N_(2)笼状结构的内在空腔中,预测了机械超硬和可控磁性的共存.以氢掺杂(H@β-C_(3)N_(2))和氟掺杂(F@β-C_(3)N_(2))为例,我们的研究表明两种掺杂构型是稳定的,并发现它们分别属于反铁磁半导体和铁磁半金属.这些有趣的磁相变源于它们在费米能级周围独特的能带结构,并可通过具有半填充占据的3D Hubbard模型和Stoner模型很好地解释.此外,H@β-C_(3)N_(2)和F@β-C_(3)N_(2)的高维氏硬度(49.0和48.2 GPa)表明它们具有笼状超硬材料特征.因此,氢和氟在β-C_(3)N_(2)笼中的掺杂分别产生了一种新型的超硬反铁磁半导体和超硬铁磁半金属,这些材料在极端条件下具有潜在的应用前景.我们的工作为设计具有优异机械性能和磁性的新型高性能多功能材料提供了一种有效的策略,这可能会为超硬材料未来在自旋电子学的应用提供理论依据.

关键词： first-principles calculations clathrateβ-C_(3)N_(2) super-hard materials ferromagnetic semi-metal

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Ribosome-inspired electrocatalysts inducing preferential nucleation and growth of three-dimensional lithium sulfide for high-performance lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第7期94卷 517-526页

作者： Zhen Wu Wenfeng He Jiahui Yang Yunuo Gu Ruiqi Yang Yiran sun Jiajia Yuan Xin Wang Junwu Zhu Yongsheng fu Key Laboratory for Soft Chemistry and functional Materials of Ministry of Education Nanjing University of Science and TechnologyNanjing 210094JiangsuChina School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina FEB Res Inst Far East BatteryWuxi 214200JiangsuChina

Nucleation of lithium sulfide(Li_(2)S)induced by electrocatalysts plays a crucial role in mitigating the shut-tle ***,short-chain polysulfides on electrocatalysts surfaces tend to re-dissolve into elec-trolytes,delaying Li_(2)S supersaturation and its *** this study,we draw inspiration from the ribosome-driven protein synthesis process in cells to prepare ultrasmall nitrogen-doped MoS_(2) nanocrys-tals anchored on porous nitrogen-doped carbon networks(N-MoS_(2)-NC)***,the ex-situ SEM demonstrates that ribosome-inspired N-MoS_(2)-NC electrocatalysts induce early nucleation and rapid growth of three-dimensional Li_(2)s during *** calculations reveal that the Li-s bond length in N-MoS_(2)-Li_(2)S(100)is shorter,and the corresponding interfacial formation energy is lower than in MoS_(2)-Li_(2)S(100).This accelerated conversion of lithium polysulfides to Li_(2)S can enhance the utilization of active substances and inhibit the shuttle *** study highlights the potential of ribosome-inspired N-MoS_(2)-NC in improving the electrochemical stability of Li-S batteries,providing valuable insights for future electrocatalyst design.

关键词： Lithium-sulfur batteries Electrocatalysts Nanocrystals Ribosome-inspired Nucleation and growth

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Proliferating cell nuclear antigen of Ulva prolifera is involved in the response to temperature stress

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Journal of Oceanology and Limnology 2024年第4期42卷 1227-1241页

作者： Hongyan HE Juanjuan YANG Yuan HE Xiuwen YANG Caiwei fu Dongren ZHANG jingwei DONG Aurang ZEB jing QU Songdong SHEN School of Biology&Basic Medical Sciences Soochow UniversitySuzhou 215101China Department of Pathology Affiliated Hospital and Medical School of Nantong UniversityNantong 226001China

Ulva prolifera is the most common specie causative to green tide,and its growth is sensitive to temperature ***,the mechanisms of *** response to temperature stress remain *** this study,high temperature(36℃)stimulus promoted the death of unformed cell wall protoplasts and delayed the division of formed cell wall protoplasts,while low-temperature(4℃)stimulus did not,suggesting that the mechanisms of the response of *** to high and low temperature stresses are *** results show that proliferation-related genes were differentially expressed under high and low-temperature stresses,especially the proliferating cell nuclear antigen(PCNA)and cyclins(CYCs).Subsequently,the interaction between PCNA and Cyclin A was confirmed by Co-immunoprecipitation,yeast two-hybrid,and so ***,high-and low temperature stresses induced the expression of PCNA and Cyclin A in varying of degrees,and activated extracellular signal-regulated kinase(ERK)signal *** results suggest,PCNA,Cyclin A,and ERK signal pathway played important roles in the resistance of *** to temperature ***,high-temperature stress induced an increase of miR-2916 in abundance,and exhibiting reverse expression of PCNA;and PCNA was target gene of miR-2916,suggesting that miR-2916 protected *** from high-temperature stress via post-transcriptionally regulation of *** study laid a foundation for understanding the function of PCNA and Cyclin A,moreover,it has a guiding significance to explore the mechanisms of the response to temperature stress from proliferation-related genes regulatory networks in ***.

关键词： UIva prolifera proliferating cell nuclear antigen Cyclin A extracellular signal-regulated kinase microRNA temperature stress

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Electroacupuncture ameliorates blood-brain barrier disruption after ischemic stroke through histone acetylation regulation at the matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 2 genes

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Journal of Traditional Chinese Medicine 2024年第4期44卷 734-744页

作者： CHEN Yonglin OUYANG Ling MENG Lingling WU Bufan PENG Rou LIU Sitong HOU Dan WANG Yaling jing Xinyue LU Shengfeng fu Shuping Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese Medicine

OBJECTIVE: To explore whether the regulation of matrix metalloproteinase 9(MMP-9)/tissue inhibitors of MMPs(TIMPs) gene expression through histone acetylation is a possible mechanism by which electroacupuncture(EA)protects blood-brain barrier(BBB) integrity in a middle cerebral artery occlusion(MCAO) rat ***: Male Sprague-Dawley rats were divided into four groups: the sham group, the MCAO group, the MCAO + EA(MEA) group, and the MCAO + EA + HAT inhibitor(HATi) group. The MCAO model was generated by blocking the middle cerebral artery. EA was applied to Baihui(GV20). Samples were collected 1 or 3 d after reperfusion. Neurological function scores and Evans blue extravasation were employed to evaluate the poststroke injury. The effect of EA on MMP-9/TIMPs gene expression was assessed by real-time fluorescence quantitative polymerase chain reaction(RT-qPCR) and chromatin immunoprecipitation(ChIP). RESULTS: Our results showed that EA treatment prominently improved neurological function and ameliorated BBB disruption. The RT-qPCR assay showed that EA reduced the expression of MMP-9 and promoted TIMP-2 mRNA expression, but HATi reversed these effects of EA. In addition, ChIP results revealed that EA decreased the enrichment of H3K9ace/H3K27ace at MMP-9 promoters and notably stimulated the recruitment of H3K9ace/H3K27ace at TIMP-2 promoter. CONCLUSION: EA treatment at Baihui(GV20) regulates the transcription of MMP-9 and TIMP-2 through histone acetylation modification in the acute stage of stroke, which preserves the structural integrity of the BBB in MCAO rats. These findings suggested that the histone acetylation-mediated transcriptional activity of target genes may be a crucial mechanism of EA treatment in stroke.

关键词： blood-brain barrier electroacupuncture histone acetylation matrix metalloproteinase 9 tissue inhibitor of metalloproteinases

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Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma

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World Journal of Clinical Cases 2024年第2期12卷 285-292页

作者： Sha-Sha sun Xiao-Di Guo Wen-Dong Li jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TACE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse *** Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DCR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma Combination therapy Tumor response

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