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Prostate calculi in cancer and BPH in a cohort of Korean men：presence of calculi did not correlate with cancer risk

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Asian Journal of Andrology 2010年第2期12卷 215-220页

作者： Eu-Chang Hwang Hyang-Sik Choi Chang-Min Im Seung-II Jung sun-Ouck Kim Tack-Won Kang Dong-Deuk kwon Kwang-sung Park Soo-Bang Ryu Department of Urology Chonnam National University Medical School Gwangju 501-75 7 Korea

Prostatic calculi are common and are associated with inflammation of the prostate. Recently,it has been suggested that this inflammation may be associated with prostate carcinogenesis. The aim of this study was to investigate the relationship between prostatic calculi and prostate cancer （PCa） in prostate biopsy specimens. We retrospectively analyzed 417 consecutive patients who underwent transrectal ultrasonography （TRUS） and prostate biopsies between January 2005 and January 2008. Based on the biopsy findings,patients were divided into benign prostatic hyperplasia and PCa groups. TRUS was used to detect prostatic calculi and to measure prostate *** correlations between PCa risk and age,serum total PSA levels,prostate volume,and prostatic calculi were analyzed. Patient age and PSA,as well as the frequency of prostatic calculi in the biopsy specimens,differed significantly between both the groups （P〈0.05）. In the PCa group,the Gleason scores （GSs） were higher in patients with prostatic calculi than in patients without prostatic calculi （P = 0.023）. Using multivariate logistic regression analysis,we found that patient age,serum total PSA and prostate volume were risk factors for PCa （P = 0.001）,but that the presence of prostatic calculi was not associated with an increased risk of PCa （P = 0.13）. In conclusion,although the presence of prostatic calculi was not shown to be a risk factor for PCa,prostatic calculi were more common in patients with PCa and were associated with a higher GS among these men.

关键词： calculi prostate prostatic neoplasms risk factors

Heavy metal chemistry in soils received long-term application of organic wastes

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Journal of Agricultural Chemistry and Environment 2012年第1期1卷 1-9页

作者： Soon-Ik kwon Yeon-Ah Jang Kye-Hoon Kim Goo-Bok Jung Min-Kyeong Kim Hae Hwang Mi-Jin Chae Seung-Chang Hong Kyu-Ho So sun-Gang Yun kwon-Rae Kim Gyeongnam National University of Science and Technology Jinju South Korea National Academy of Agricultural Science (NAAS) RDA Suwon South Korea The University of Seoul Seoul South Korea

This study was carried out to understand the long-term effect of organic waste treatment on the fate of heavy metals originated from the organic wastes, together with examination of changes in soil properties. For this, the soils received three different organic wastes (municipal sewage sludge, alcohol fermentation processing sludge, pig manure compost) in three different rates (12.5, 25, 50 ton/ha/yr) for 7 years (1994 - 2000) were used. To see the long-term effect, plant growth study and soil examination were conducted twice in 2000 and 2010, respectively. There was no additional treatment of organic wastes for post ten years after ceasing organic waste treatment for seven years. Soil examination conducted in 2010 showed decreases in soil pH, EC, total nitrogen, organic matter, available phosphorus, exchangeable cations and heavy metal contents in all soils received organic wastes compared to the results obtained in 2000. Speciation of heavy metals in soil through sequential extraction showed that organically bound Cu was the dominant species in all treatment and exchangeable Cu was increased in the plots treated with municipal sewage sludge and alcohol fermentation processing sludge. organically bound Ni increased from 25% - 30% to 32% - 45% in 2010 inall treatment while Pb showed increase in carbonate form in all treatments. Zn existed mainly as sulfide and residual forms, showing increases in organically bound form in all treatment during post ten years.

关键词： Heavy Metal Long-Term Application Organic Wastes Sequential Extraction

Bioprocessed Black Rice Bran Potentiates the Growth Inhibitory Activity of an Immune Checkpoint Inhibitor against Murine Colon Carcinoma

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Food and Nutrition Sciences 2023年第12期14卷 1149-1171页

作者： Kyung Hee Lee Ki sun kwon Woon Sang Hwang Wha Young Lee Jeanman Kim Sang Jong Lee sung Phil Kim Mendel Friedman STR Biotech Co. Ltd. Chuncheon Republic of Korea U.S. Department of Agriculture Western Regional Research Center Agricultural Research Service Albany CA USA

This study determined the effect of orally fed polysaccharide-rich bioprocessed (fermented) black rice bran produced by culturing with shiitake (Lentinus edodes) mushroom mycelium on CT-26 colon cancer cells in vivo in an intracutaneously transplanted mouse tumor alone and in combination with intraperitoneally administered anti-PD-1 immune checkpoint inhibitor. Analysis of the isolated tumor weights at the end of the study shows that the average tumor size in control mice is 3.78 grams, and the average tumor size in mice treated with anti-PD-1 antibody is 2.16 grams. The average tumor size in mice treated with BRB-F alone is 2.25 grams, and the average tumor size in mice treated with anti-PD-1 antibody BRB-F combination is 1.38 grams. Thus, BRB-F or anti-PD-1 antibody alone each reduce tumor size by 40.5% or 42.9%, whereas the combination of BRB-F and anti-PD-1 antibody reduces tumor size by 63.5%, with their cooperative effect being statistically significant. The observed anti-tumor effects were accompanied by a series of biomarkers associated with cancer formation and inhibition. These results indicate that the reported potentiation of cancer therapy using drug-based medical chemotherapies with added checkpoint inhibitors in human patients are mechanistically similar with the functional food evaluated in the present study. These beneficial effects in mice challenge clinicians to investigate if the black rice bran food product can also protect against human cancer.

关键词： Black Rice Bran Mushroom Mycelia Bioprocessing Immune Checkpoint Inhibitor Mice Tumor Regression Cancer Prevention Biomarkers Mechanism Research Needs

Ton EBP transcription factor promotes diabetic nephropathy via hyperglycemia-induced macrophage activation

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Flexible and transparent thin-film light-scattering photovoltaics about fabrication and optimization for bifacial operation

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： sun Woo Lim Soo Youn Choi Eun Jin Yoo Whaseon Lee-kwon Hwan Hee Lee Jun Ho Lee Satoru Sanada Afshin Parsa Hyug Moo kwon Transplantation Research Center Catholic University of Korea Department of Biological Sciences UNISTKorea Department of Medicine University of Maryland BaltimoreUSA

＜正＞Diabetic nephropathy（DN）is the leading cause of end-stage renal disease accounting for more than 50%of the *** is characterized by histological changes such as glomerular sclerosis and interstitial fibrosis,and functional changes such as proteinuria and renal *** develops slowly over＞10years in 30–40%of patients with *** therapy for DN as well as risk assessment of DN at early stages of diabetes is lacking.

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npj Flexible Electronics 2023年第1期7卷 388-397页

作者： Soo-Won Choi Jae-Ho Park Ji-Woo Seo Chaewon Mun Yonghun Kim Pungkeun Song Myunghun Shin Jung-Dae kwon Surface&Nano Materials Division Korea Institute of Materials ScienceChangwonGyeongnam 51508Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Cell R&D Team Hanhwa QCells202 Sansusandan 2-roLwol-myeonJincheon-gunChungcheongbuk-do 27816Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyangGyeonggi 10540Republic of Korea Department of Advance Materials Engineering University of Science and Technology(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

Flexible and transparent thin-film silicon solar cells were fabricated and optimized for building-integrated photovoltaics and bifacial operation.A laser lift-off method was developed to avoid thermal damage during the transfer of light-scattering structures onto colorless polyimide substrates and thus enhance front-incidence photocurrent,while a dual n-type rear window layer was introduced to reduce optical losses,facilitate electron transport for rear incidence,and thus enhance performance during bifacial *** introduction of the window layer increased the rear-to-front power conversion efficiency ratio to~86%.The optimized bifacial power conversion efficiency for front and rear irradiances of 1 and 0.3 sun,respectively,equaled 6.15%,and the average transmittance within 500–800 nm equaled 36.9%.Additionally,the flexible and transparent solar cells fabricated using laser lift-off exhibited good mechanical reliability(i.e.,sustained 500 cycles at a bending radius of 6 mm)and were therefore suitable for building-integrated photovoltaics.

关键词： transparent scattering film

Hemorrhagic hemangioma in the liver:A case report

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World Journal of Gastroenterology 2015年第23期21卷 7326-7330页

作者： Jeong Min Kim Woo Jin Chung Byoung Kuk Jang Jae Seok Hwang Yong Hoon Kim Jung Hyeok kwon Mi sun Choi Department of Internal Medicine Keimyung University School of Medicine Department of Hepatobiliary Surgery Keimyung University School of Medicine Department of Radiology Keimyung University School of Medicine Department of Pathology Keimyung University School of Medicine

Hemangioma is the most common type of benign tumor that arises in the liver. Although rupture and hemorrhage of hepatic hemangioma are rare complications, they can be the cause of mortality. The authors report a case of hemorrhagic hepatic hemangioma: in a 54-yearold woman who was admitted with epigastric *** had taken oral contraceptives several weeks *** results of a blood examination were normal. An abdominal computed tomography scan revealed a tumor in hepatic segment 4, and a hemorrhage inside the cystic mass was suspected. The mass was removed laparoscopically to confirm the tumor properties and control the hemorrhage. The pathologic findings of the resected mass were consistent with hepatic hemangioma with intratumoral hemorrhage. The patient was discharged 8 d after the surgery, without further complications or complaints, and the patient's condition was found to have improved during follow-up.

关键词： Hemangioma Liver Hemorrhage Tumor Complication

Protection of Allergic Asthma in Mice by Black Rice Bran Bioprocessed with Shiitake Mushroom Mycelia

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Food and Nutrition Sciences 2023年第4期14卷 341-368页

作者： Ki sun kwon Woon Sang Hwang Kyung Hee Lee Kyung Jin Kim Wha Young Lee Jeanman Kim Sang Jong Lee sung Phil Kim Mendel Friedman STR Biotech Co. Ltd. Chuncheon Republic of Korea U.S. Department of Agriculture Western Regional Research Center Agricultural Research Services Albany CA USA

We evaluated the potential of orally fed new food formulations to inhibit biomarkers reported to be involved in the causes of allergic asthma in mice. Asthma, a serious non-communicable disease, affects both adults and children and can be undertreated. New functional foods could provide therapeutic approaches. Here, the anti-asthma mechanism of a new functional food and three isolated fractions produced by bioprocessing black rice bran with shiitake mushroom mycelia was evaluated in mast cells, B cells, and orally fed mice and compared with non-bioprocessed black rice bran. In vitro, the treatments inhibited RBL-2H3 cell degranulation and immunoglobulin E (IgE) production. The in vitro anti-asthma effects were confirmed in orally fed mice following asthma induction by alumina and chicken egg ovalbumin (OVA). The suppression of asthma resulted from the inhibition of inflammation- and immune-related substances, including OVA-specific IgE, thymic stromal lymphopoietin, eotaxin, leukotriene C4, prostaglandin D2, and vascular cell adhesion molecule-1 in bronchoalveolar lavage fluid and serum. The treatment also reversed the thickening of the lung airway wall. The inflammation and asthma inhibition seems to be regulated by the balance of the T-helper cells’ Th1/Th2 immune response and the inhibition of multiple biomarkers associated with the cause of asthma. Future human clinical studies with adults and children should determine the potential therapeutic value of the anti-asthma effects of the new functional foods.

关键词： Black Rice Bran Shiitake Mushrooms Bioprocessed Functional Food Mast Cells Mice Feeding Studies Bioassays Cytokines Immunoglobulins Bronchial Lavage Fluid Histology Anti-Inflammatory Effect Asthma Prevention Research Needs

Enantioselective production of（S）-ketoprofen in dispersed aqueous reaction system induced by chiral cyclodextrin

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Enantioselective production of（S）-ketoprofen in dispersed ...

Chemical characterization of rainwater over Suwon region during farming and non-farming periods

The Eighth China-Japan-Korea Joint Symposium on Enzyme Engineering

作者： Kwang-Woo Lee Tae-kwon Kim Hyun-Ae Bae Gab-Sang Shin sun-Hwa Kim Yong-Hyun Lee Department of Genetic Engineering College of Natural Sciences Kyungpook National University

＜正＞Introduction Ketoprofen,one of well known profen belongs to the family of 2-arylpropionic acid,is produced currently in a large quantity as the racemic mixture of（R）-and（S）-ketoprofen,and only a（S）-ketoprofen exhibits the therapeutic *** resolution of racemic 2-arylpropionic acids using lipases or esterases has been

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Journal of Agricultural Chemistry and Environment 2013年第1期2卷 1-7页

作者： Min-Kyeong Kim Jong-Sik Lee Goo-Bok Jung Byong-Gu Ko Soon-Ik kwon Min-Young Kim Kyu-Ho So sun-Gang Yun Department of Agricultural Environment National Academy of Agricultural Science Rural Development Administration (RDA) Suwon Republic of Korea Dresearch Planning Division Rural Development Administration Suwon Republic of Korea

Recently, special attention has been givento acid rain and its problem to environment such as acid precipitation and air pollution in East *** the present study, rainwater samples werecollected from Apr to Oct (farming period) and from Nov to Mar (non-farming period) in 2009 ~ 2011. The samples were chemically characterized for the assessment of emission sources. Suwon region, a typical agricultural area in Gyeonggi province (South Korea) was chosen as a study site. The content of ionic species and theirtemporal variation were used forfactor analysis, which was used to presume the natural and anthropogenic sources depending upon the farming and non-farming periods. The cationsobserved during farming and non-farming periods were?> Na+> Ca2+> K+> H+> Mg2+and Na+> N?>Ca2+> H+= Mg2+> K+, respectively. The anions during farming and non-farming periods were?>?> Cl- and?>?> Cl-, respectively. While the amounts of sulfate, one of the major dissolved components of rainwater were 113.5 and 177.0 ueq.L-1, the ones of NSS-?(Non-Sea Salt sulfate) were 93.7 and 87.1% during farming and non-farming periods, respectively. The comparison of observed pH values (pHobs) with the theoretical pH values (pHthe) showed that the neutralization of rainwater considerably went along during farming and non-farming periods. The highest amountof rainfall throughout the year was310.5 mmin August and its corre sponding nitrogen loading was5.03 kg·ha-1. The major ion contents for crop growth, , Ca2+, K+, Mg2+, were 49.4, 5.5, 18.1,1.4 kg·ha-1from April to October. The major contributions to the existing chemical ions in rainwaters during farming and non-farming periods were from the natural sources (sea and soil) and the anthropogenic sources (human and animal waste, vehicular emission + fossil fuels combustion), respectively.

关键词： Acidity Discharge Nutrient Rainwater