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Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

Protein & Cell 2016年第3期7卷 210-221页

作者： Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China FSU-CAS Innovation Institute Foshan University Foshan 528000 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Universidad Cato1ica San Antonio de Murcia (UCAIVI) Campus de los Jer6nimos N° 135 Guadalupe 30107 Murcia Spain Beijing Hospital of the Ministry of Health Beijing 100730 China Department of Gynecology and Obstetrics Peking University Third Hospital Beijing 100191 China Department of Neurology Peking University First Hospital Beijing 100034 China Beijing Institute for Brain Disorders Capital Medical University Beijing 100069 China University of Chinese Academy of Sciences Beijing 100049 China

Xeroderma pigmentosum （XP） is a group of genetic disorders caused by mutations of XP-associated genes, resulting in impairment of DNA repair. XP patients frequently exhibit neurological degeneration, but the underlying mechanism is unknown, in part due to lack of proper disease models. Here, we generated patientspecific induced pluripotent stem cells （iPSCs） harboring mutations in five different XP genes including XPA, XPB, XPC, XPG, and XPV. These iPSCs were further differentiated to neural cells, and their susceptibility to DNA damage stress was investigated. Mutation of XPA in either neural stem cells （NSCs） or neurons resulted in severe DNA damage repair defects, and these neural cells with mutant XPA were hyper-sensitive to DNA damage-induced apoptosis. Thus, XP-mutant neural cells represent valuable tools to clari the molecular mechanisms of neurological abnormalities in the XP patients.

关键词： xeroderma pigmentosum iPSC disease model neural stem cell. neuron

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Water-responsive gel extends drug retention and facilitates skin penetration for curcumin topical delivery against psoriasis

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Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 61-75页

作者： Qing Yao Yuanyuan Zhai Zhimin He Qian Wang Lining sun Tuyue sun Leyao Lv Yingtao Li Jiyong Yang Donghui Lv Ruijie Chen Hailin Zhang Xiang Luo Longfa Kou Wenzhou Municipal Key Laboratory of Pediatric Pharmacy Department of PharmacyThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhou 325035China Key Laboratory of Structural Malformations in Children of Zhejiang Province Wenzhou 325027China Wenzhou key Laboratory of basic science and translational research of radiation oncology Wenzhou 325027China Beijing Baoyi Technology Co. LtdBeijing 101115China Institute of Pharmaceutics Shaoxing UniversityShaoxing 312000China

Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin *** drug application is recommended as the first-line *** formulation strategies have been developed and explored for enhanced topical psoriasis ***,these preparations usually have low viscosity and limited retention on the skin surface,resulting in low drug delivery efficiency and poor patient *** this study,we developed the first water-responsive gel(WRG),which has a distinct water-triggered liquid-to-gel phase transition ***,WRG was kept in a solution state in the absence of water,and the addition of water induced an immediate phase transition and resulted in a high viscosity *** was used as a model drug to investigate the potential of WRG in topical drug delivery against *** vitro and in vivo data showed that WRG formulation could not only extend skin retention but also facilitate the drug permeating across the *** a mouse model of psoriasis,curcumin loaded WRG(CUR-WRG)effectively ameliorated the symptoms of psoriasis and exerted a potent anti-psoriasis effect by extending drug retention and facilitating drug *** mechanism study demonstrated that the anti-hyperplasia,anti-inflammation,anti-angiogenesis,anti-oxidation,and immunomodulation properties of curcumin were amplified by enhanced topical drug delivery ***,neglectable local or systemic toxicity was observed for CUR-WRG *** study suggests that WRG is a promising formulation for topically psoriasis treatment.

关键词： Psoriasis Sol-gel transition Water-responsive Curcumin Topical drug delivery

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New loci for refractive errors and ocular biometric parameters in young Chinese Han adults

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Science China(Life Sciences) 2022年第10期65卷 2050-2061页

作者： Yunyun sun Zi-Bing Jin Shifei Wei Hongyan Jia Kai Cao Jianping Hu Caixia Lin Wenzai An Jiyuan Guo He LiJing Fu Shi-Ming Li Ningli Wang the Anyang University Students Eye Study Group the Anyang University Students Eye Study Group Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBejing 100730China Beijing Institute of Ophthalmology Bejing 100730China Anyang Eye Hospital Anyang 455000China 不详

Myopia has become a major public health issue with an increasing *** are still individuals who experience similar environmental risk factors and,yet,remain ***,there might be genetic factors protecting people from *** the opposite ocular characteristics of primary angle closure glaucoma(PACG)to myopia and possible common pathway between them,we propose that certain risk genes for PACG might act as a protective factor for *** this study,2,678 young adults were genotyped for 37 targeted single nucleotide *** with emmetropia,rs1401999(allele C:OR=0.795,P=0.03;genotype in dominant model:OR=0.759,P=0.02)and rs1258267(allele A:OR=0.824,P=0.03;genotype in dominant model:OR=0.603,P=0.01)were associated with low to moderate myopia and high myopia,*** under recessive model of rs11024102 was correlated with myopia(OR=1.456,P=0.01),low to moderate myopia(OR=1.443,P=0.02)and high myopia(OR=1.453,P=0.02).However,these associations did not survive Bonferroni ***,rs1401999,rs1258267,and rs11024102 showed associations with certain ocular biometric parameters in different *** study suggests that ABCC5,CHAT and PLEKHA7 might be associated with refractive errors by contributing to the regulation of ocular biometry,in terms of uncorrected results and their biological functions.

关键词： candidate gene myopia high myopia ocular biometry primary angle-closure glaucoma

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公民逝世后器官捐献供肾损伤相关分子标志物的研究进展

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器官移植 2020年第4期11卷 526-532页

作者：韩飞孙启全中山大学附属第三医院肾移植科广州510630

供肾短缺是肾移植面临的一大难题,对供肾功能的准确评估可以降低器官的弃用率,以挽救更多的尿毒症患者。与病理学检查相比,循环中的分子标志物检测在临床应用中较为方便。本文就目前已发现的肾损伤标志物血清肌酐和血清胱抑素C(Cys-C)... 详细信息

供肾短缺是肾移植面临的一大难题,对供肾功能的准确评估可以降低器官的弃用率,以挽救更多的尿毒症患者。与病理学检查相比,循环中的分子标志物检测在临床应用中较为方便。本文就目前已发现的肾损伤标志物血清肌酐和血清胱抑素C(Cys-C)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肝型脂肪酸结合蛋白(L-FABP)、线粒体DNA(mtDNA)、肾损伤分子-1(kim-1)和白细胞介素-18(IL-18)等方面的研究进展进行简要介绍。

关键词：肾移植分子标志物扩大标准供者线粒体DNA 血清胱抑素C(Cys-C) 中性粒细胞明胶酶相关脂质运载蛋白(NGAL) 肝型脂肪酸结合蛋白(L-FABP) 肾损伤分子-1(kim-1)

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软性话语抗争:青少年公共参与中的网络语言使用研究

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湖南大学学报（社会科学版） 2021年第3期35卷 140-147页

作者：郑欣孙天梦南京大学新闻传播学院江苏南京210093

在中国互联网的舆论环境中,青少年在公共参与时经常使用流行的网络语言来表达自己的态度和立场。本研究选取“95后”“00后”的青少年作为研究对象,对其在公共参与中,通过网络语言的使用、传播与扩散,进行话语抗争的过程进行了分析。研... 详细信息

在中国互联网的舆论环境中,青少年在公共参与时经常使用流行的网络语言来表达自己的态度和立场。本研究选取“95后”“00后”的青少年作为研究对象,对其在公共参与中,通过网络语言的使用、传播与扩散,进行话语抗争的过程进行了分析。研究发现,青少年在公共参与中使用网络语言进行的话语抗争,是一种软性话语抗争。它是在青少年个体的表演、群体的围观、整体的惯性中逐渐形成、扩散和被“包装”的,具有底层性、弱者武器性质的一种日常软性话语抗争。它开始于话语,也往往止步于话语,而不是像“传统”的社会运动和集体行动中,话语作为抗争的可调用工具或文化要素,或者作为一种延伸。青少年的这种软性话语抗争,从语言角度投射了中国青少年在公共参与语境中的复杂处境。

关键词：话语抗争公共参与网络语言青少年

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Oxygenation alleviates waterlogging‑caused damages to cherry rootstocks

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Molecular Horticulture 2023年第1期3卷 283-305页

作者： Yuxuan Wang Yan Xu Jieming Xu Wanxia sun Zhengxin Lv Muhammad Aamir Manzoor Xunju Liu Zhiyu Shen Jiyuan Wang Ruie Liu Matthew DWhiting Songtao Jiu Caixi Zhang Department of Plant Science School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Department of Horticulture Washington State UniversityProsserWA 99350USA

Waterlogging has occurred more frequently in recent years due to climate change,so it is a huge threat to crop yield and *** cherry,a fruit tree with a high economic value,is sensitive to waterlogging *** of the most effective methods for enhancing the waterlogging tolerance of sweet cherries is to select waterlogging-tolerant ***,the waterlogging tolerance of different cherry rootstocks,and the underlying mechanism remains ***,we first evaluated the waterlogging resistance of five sweet cherry rootstocks planted in *** data showed that‘Gisela 12’and‘Colt’were the most waterlogging-sensitive and-tolerant among the five tested varieties,*** effectively alleviated the adverse impacts of waterlogging stress on cherry ***,we found that the waterlogging group had lower relative water content,Fv/Fm value,net photosynthetic rate,and higher antioxidant enzyme activities,whereas the oxygenated group performed better in all these ***-Seq analysis revealed that numerous DEGs were involved in energy production,antioxidant metabolism,hormone metabolism pathways,and stress-related transcription *** findings will help provide management strategies to enhance the waterlogging tolerance of cherry rootstocks and thereby achieve higher yield and better quality of cherries.

关键词： Cherry Waterlogging Hypoxia Oxygenation Transcriptome analysis

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Formation of copper boride on Cu(111)

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Fundamental Research 2021年第4期1卷 482-487页

作者： Chengguang Yue Xiao-Ji Weng Guoying Gao Artem ROganov Xiao Dong Xi Shao Xiaomeng Wang Jian sun Bo Xu Hui-Tian Wang Xiang-Feng Zhou Yongjun Tian Center for High Pressure Science State Key Laboratory of Metastable Materials Science and TechnologySchool of ScienceYanshan UniversityQinhuangdao 066004China Key Laboratory of Weak-Light Nonlinear Photonics School of PhysicsNankai UniversityTianjin 300071China Skolkovo Institute of Science and Technology Skolkovo Innovation Center3 Nobel StreetMoscow 121025Russia National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Boron forms compounds with nearly all metals,with notable exception of copper and other group IB and IIB ***,we report an unexpected discovery of ordered copper boride grown epitaxially on Cu(111)under ultrahigh *** tunneling microscopy experiments combined with ab initio evolutionary structure prediction reveal a remarkably complex structure of 2D-Cu_(8)B_(14).Strong intra-layer p–d hybridization and a large amount of charge transfer between Cu and B atoms are the key factors for the emergence of copper *** makes the discovered material unique and opens up the possibility of synthesizing ordered low-dimensional structures in similar immiscible systems.

关键词： Molecular beam epitaxy Scanning tunneling microscopy Cu(111) Boron Copper boride

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Separate支架在治疗胃十二指肠恶性梗阻中的应用

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介入放射学杂志 2003年第6期12卷 431-435页

作者：何旭顾建平楼文胜陈亮苏浩波 Ji-Hoon Shin Jin-Oh Lim Tae-Hyuang kim Ho-young Song 南京医科大学附属南京第一医院介入科 210006 Deaprtment of Radiology Asan Medical CenterUniveristy of Ulsan College of MedicineSeoulKorea

目的　探讨Separate支架置入术在姑息性治疗不能手术的胃肠道恶性梗阻的可行性和有效性。方法　 34例患者采用经口置入Separate支架治疗不能手术的恶性胃十二指肠梗阻。梗阻的原因分别是胃癌 1 1例、胰腺癌 1 2例、转移性肿瘤 3例、胆... 详细信息

目的　探讨Separate支架置入术在姑息性治疗不能手术的胃肠道恶性梗阻的可行性和有效性。方法　 34例患者采用经口置入Separate支架治疗不能手术的恶性胃十二指肠梗阻。梗阻的原因分别是胃癌 1 1例、胰腺癌 1 2例、转移性肿瘤 3例、胆道肿瘤 6例和十二指肠癌 2例。透视下分别将Separate支架的外层带膜支架和内层裸支架同轴重叠释放在狭窄病变处。结果　技术成功率为 97% ,未发生严重并发症。 33例患者胃肠道梗阻症状缓解或消失 ,在Separate支架置入后 ,患者进食能力评分平均从 3.8提高到 1 .2。随访期间未发现支架移位和肿瘤内生性生长等并发症 ,1例患者由于肿瘤浸润致支架近端梗阻复发 ,置入第 2枚支架。

关键词： Separate支架胃十二指肠恶性梗阻支架置入术钡餐检查介入治疗

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Effects of adding different types of carbon on the structure and magnetic properties of SmCo_(6.9)Hf_(0.1) alloy

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Journal of Rare Earths 2013年第12期31卷 1168-1174页

作者：孙继兵步绍静杨薇王洪水崔春翔何辰辉 Key Laboratory for New Type of Functional Materials in Hebei Province School of Materials Science and EngineeringHebei University of Technology

In this paper,SmCo6.9 Hf0.1 as-cast alloys and ribbons with the addition of either graphite（C） or carbon nanotubes（CNTs） were prepared by arc melting and melt-spinning,*** effects of adding carbon on the structure and magnetic properties SmCo6.9 Hf0.1 were investigated by means of X-ray diffraction（XRD）,scanning electron microscopy（SEM）,transmission electron microscopy（TEM）,magnetic force microscopy（MFM） and vibrating sample magnetometer（VSM）.It was found that the microstructure and magnetic structure of SmCo6.9 Hf0.1 ribbons were changed obviously due to the introduction of C or CNTs,although their crystal structure was characterized as the same Sm（Co,Hf）7 single phase,no matter carbon was added or *** a result,the magnetic properties of carbon-contained ribbons were enhanced in a certain *** was considered to be related to the refined equiaxed grains,small domain size and the pinning effect of C or CNTs-rich *** magnetic properties of SmCo6.9 Hf0.1（CNTs）0.05 ribbons reached Hc =12.5 kOe,Mr =57.0 emu/g and Mr/M2 T =0.788.

关键词： magnetically ordered materials rapid-solidification crystal structure magnetic measurements rare earths

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TDJ-GST202型高速锁闭止轮顶在齐齐哈尔站的应用

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减速顶与调速技术 2005年第3期 8-11页

作者：牛永涛孙一丁哈尔滨铁路局减速顶调速系统研究所黑龙江哈尔滨150006

本文详细介绍了TDJ-GST202型高速锁闭止轮顶在齐齐哈尔客站的实际应用情况,结果证明该设备能满足使用单位提出的各项技术要求,提高了客运站旅客列车的止轮、防溜效果,是一种比较有效的防溜制式,为解决客车线,到发线及编组站货物列车的... 详细信息

本文详细介绍了TDJ-GST202型高速锁闭止轮顶在齐齐哈尔客站的实际应用情况,结果证明该设备能满足使用单位提出的各项技术要求,提高了客运站旅客列车的止轮、防溜效果,是一种比较有效的防溜制式,为解决客车线,到发线及编组站货物列车的止轮、防溜问题提供了一个较为成熟的方案。

关键词：编组场到发线止轮顶停车防溜

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