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Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG sun KIM YUN sun lee SEUNG MYUNG DONG HYO JUNG KIM DA EUN lee HYEON WOONG KANG MYEONG JIN KIM JOON SEONG PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

Current progress toward eradicating Helicobacter pylori in East Asian countries: Differences in the 2013 revised guidelines between China, Japan, and South Korea

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World Journal of Gastroenterology 2014年第6期20卷 1493-1502页

作者： sun-Young lee Department of Internal Medicine Konkuk University School of Medicine

New 2013 guidelines on Helicobacter pylori(H. pylori) infection have been published in China, Japan, and South Korea. Like the previous ones, these new guidelines differ between the three countries with regard to the indications for H. pylori eradication, diagnostic methods, and treatment regimens. The most profound change among all of the guidelines is that the Japanese national health insurance system now covers the expenses for all infected subjects up to second-line treatment. This makes the Japanese indications for eradication much wider than those in China and South Korea. With regard to the diagnosis, a serum H. pylori antibody test is not recommended in China, whereas it is considered to be the most reliable method in Japan. A decrease relative to the initial antibody titer of more than 50% after 6-12 mo is considered to be the most accurate method for determining successful eradication in Japan. In contrast, only the urea breath test is recommended after eradication in China, while either noninvasive or invasive methods(except the bacterial culture) are recommended in South Korea. Due to the increased rate of antibiotics resistance, first-line treatment is omitted in China and South Korea in cases of clarithromycin resistance. Notably, the Japanese regimen consists of a lower dose of antibiotics for a shorter duration(7 d) than in the other countries. There is neither 14 d nor bismuth-based regimen in the first-line and second-line treatment in Japan. Such differences among countries might be due to differences in the approvals granted by the governments and national health insurance system in each country. Further studies are required to achieve the best results in the diagnosis and treatment of H. pylori infection based on cost-effectiveness in East Asian countries.

关键词： Helicobacter pylori Eradication Guideline Diagnosis Treatment

Effectiveness and safety of auriculotherapy for breastfeeding: a systematic review

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Journal of Traditional Chinese Medicine 2020年第5期40卷 721-737页

作者： Boram lee Chan-Young Kwon sun Haeng lee Department of Clinical Korean Medicine Graduate SchoolKyung Hee UniversitySeoul 02453Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Pediatrics of Korean Medicine Kyung Hee University Korean Medicine HospitalKyung Hee University Medical CenterSeoul 02447Republic of Korea

OBJECTIVE:To summarize and critically evaluate the evidence pertaining to the effectiveness and safety of auriculotherapy for ***:We performed a systematic search of10 databases from their inception dates to May 15,*** controlled trials evaluating the effectiveness and safety of auriculotherapy for breastfeeding were *** of bias was assessed using the Cochrane risk of bias ***:This review included 31 randomized controlled trials with 5389 *** to the obvious clinical or statistical heterogeneity,a Meta-analysis was not ***-nine studies compared auriculotherapy plus routine care with routine care *** consistent adjunctive effect of auriculotherapy was observed in increasing the volume of milk production(9 studies showed significant results in favor of auriculotherapy and 5 did not)and serum prolactin level(7 studies showed significant results in favor of auriculotherapy and 2 did not),and in facilitating the initiation of milk secretion(10 studies showed significant results in favor of auriculotherapy and 7 did not).Two studies compared auriculotherapy with no *** as a monotherapy showed significant effects in increasing serum prolactin level and facilitating the onset of milk secretion;however,it was limited and inconclusive because only two studies were included in this *** subgroup analysis of women who underwent cesarean delivery showed inconsistent results with respect to all *** serious adverse events were reported with the use of *** methodological quality of the included studies was generally ***:Although some studies showed positive results,no definite conclusion about the effectiveness and safety of auriculotherapy for breastfeeding could be drawn,owing to the low methodological quality of the included studies and the heterogeneity among ***-scale,well-designed studies are warranted on this topic.

关键词： Breastfeeding Auriculotherapy Systematic review

Imaging diagnosis of pancreatic cancer:A state-of-the-art review

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World Journal of Gastroenterology 2014年第24期20卷 7864-7877页

作者： Eun sun lee Jeong Min lee Department of Radiology Seoul National University HospitalSeoul 110-744South Korea Institute of Radiation Medicine Seoul National University College of MedicineSeoul 110-744South Korea

Pancreatic cancer(PC)remains one of the deadliest cancers worldwide,and has a poor,five-year survival rate of 5%.Although complete surgical resection is the only curative therapy for pancreatic cancer,less than20%of newly-diagnosed patients undergo surgical resection with a curative *** to the lack of early symptoms and the tendency of pancreatic adenocarcinoma to invade adjacent structures or to metastasize at an early stage,many patients with pancreatic cancer already have advanced disease at the time of their diagnosis and,therefore,there is a high mortality *** improve the patient survival rate,early detection of PC is *** diagnosis of PC relies on computed tomography(CT)and/or magnetic resonance imaging(MRI)with magnetic resonance cholangiopancreatography(MRCP),or biopsy or fine-needle aspiration using endoscopic ultrasound(EUS).Although multi-detector row computed tomography currently has a major role in the evaluation of PC,MRI with MRCP facilitates better detection of tumors at an early stage by allowing a comprehensive analysis of the morphological changes of the pancreas parenchyma and pancreatic *** diagnosis could be improved using positron emission tomography techniques in special conditions in which CT and EUS are not completely *** is essential for clinicians to understand the advantages and disadvantages of the various pancreatic imaging modalities in order to be able to make optimal treatment and management *** study investigates the current role and innovative techniques of pancreatic imaging focused on the detection of pancreatic cancer.

关键词： Pancreatic neoplasms Multi-detector computed tomography Magnetic resonance imaging Ultrasonography Endoscopic ultrasound-guided fine needle aspiration Positron-emission tomography

Laser-assisted Grinding Wheel Dressing (Ⅱ)-Experimental Researches

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Journal of Materials Science & Technology 2003年第z1期19卷 167-168页

作者： Ming CHEN Fanghong sun Youngmoon lee Seunghan YANG Jongchan lee School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200030 China School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200030 China School of Mechanical Engineering Kyungpook National University Daegu 702-701 Korea School of Mechanical Engineering Kyungpook National University Daegu 702-701 Korea School of Mechanical Engineering Kumoh National University of Technology Kumi Kyungpook 730-701 Korea

Most of the mechanical dressing technologies for resin bonded superabrasive grinding wheels are time consumingand costly. Based on the outcomes of the simulations in the previous study, this paper demonstrates the comprehensive researches on the laser-assisted dressing process control, grinding wheel topography reconfiguration by 3Dlaser scanning technology and analyses of grinding temperature. The synthesized parameter incorporates the laserdressing process parameters and can be used to the process control. In order to evaluate the laser-assisted dressingeffectiveness, the newly developed non-contact laser measuring system based on the principle of the triangulationwas used. Grain protrusion height and intergrain spacing can characterize the grinding wheel surface. A series ofgrinding tests with the laser-assisted dressed grinding wheel and mechanically dressed grinding wheel were conductedfor comparison. The results proved the feasibility of laser-assisted dressing for resin bonded superabrasive grindingwheels and revealed the importance of choosing appropriate laser dressing parameters.

关键词： Grinding wheel topography, Laser, Dressing, Grinding

ZIF-67@Cellulose nanofiber hybrid membrane with controlled porosity for use as Li-ion battery separator

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Journal of Energy Chemistry 2021年第1期30卷 170-180,I0006页

作者： Xiuxuan sun Wangwang Xu Xiuqiang Zhang Tingzhou Lei sun-Young lee Qinglin Wu School of Renewable Natural Resources Louisiana State University AgCenterBaton RougeLA 70803United States Key Biomass Energy Laboratory of Henan Province Zhengzhou 450008HenanChina Forest Products Department National Institute of Forest Science57 HoegiroDongdaemun-guSeoul 02455Republic of Korea

Zeolitic imidazolate framework-67(ZIF-67) was synthesized on the surface of cellulose nanofibers(CNFs)in methonal to address the problems of unhomogeneous pore size and pore distribution of pure CNF membrane.A combination of Energy Dispersive X-Ray Spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS) and X-ray powder diffraction(XRD) patterns were used to determine the successful synthesis of ZIF-67@*** size of the ZIF-67 particles and pore size of the ZIF-67@CNF membrane were50-200 nm and 150-350 nm, *** prepared ZIF-67@CNF membrane exhibited excellent thermal stability,lower thermal shrinkage and high surface *** discharge capacity retention of the Li-ion batteries(LIBs) made with ZIF-67@CNF,glass fiber(GF),CNF and commercial polymer membranes after 100 th cycle at 0.5 C rate were 88.41%,86.22%,83.27%,and 81.03%,*** with ZIF-67@CNF membrane exhibited a better rate capability than these with other *** damage of porous structure or peel-off of ZIF-67 was observed in the SEM images of ZIF-67@CNF membrane after100 th *** improved cycling performance,rate capability,and good electrochemical stability implied that ZIF-67@CNFs membrane can be considered as a good alternative LIB separator.

关键词： Cellulose nanofibers ZIF-67 Li-ion battery Membrane property Battery performance

An Effective Threat Detection Framework for Advanced Persistent Cyberattacks

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Computers, Materials & Continua 2023年第5期75卷 4231-4253页

作者： So-Eun Jeon sun-Jin lee Eun-Young lee Yeon-Ji lee Jung-Hwa Ryu Jung-Hyun Moon sun-Min Yi Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering Sungshin Women’s UniversitySeoul02844Korea

Recently,with the normalization of non-face-to-face online environments in response to the COVID-19 pandemic,the possibility of cyberattacks through endpoints has *** endpoint devices are managed meticulously to prevent cyberattacks and ensure timely responses to potential security *** particular,because telecommuting,telemedicine,and teleeducation are implemented in uncontrolled environments,attackers typically target vulnerable endpoints to acquire administrator rights or steal authentication information,and reports of endpoint attacks have been increasing *** persistent threats(APTs)using various novel variant malicious codes are a form of a sophisticated ***,conventional commercial antivirus and anti-malware systems that use signature-based attack detectionmethods cannot satisfactorily respond to such *** this paper,we propose a method that expands the detection coverage inAPT attack *** this model,an open-source threat detector and log collector are used synergistically to improve threat detection *** the scope of attack log collection through interworking between highly accessible open-source tools can efficiently increase the detection coverage of tactics and techniques used to deal with APT attacks,as defined by MITRE Adversarial Tactics,Techniques,and Common Knowledge(ATT&CK).We implemented an attack environment using an APT attack scenario emulator called Carbanak and analyzed the detection coverage of Google Rapid Response(GRR),an open-source threat detection tool,and Graylog,an open-source log *** proposed method expanded the detection coverage against MITRE ATT&CK by approximately 11%compared with that conventional methods.

关键词： Advanced persistent threat cybersecurity endpoint security MITRE ATT&CK open-source threat detector threat log collector

Machine Learning-Based Efficient Discovery of Software Vulnerability for Internet of Things

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Intelligent Automation & Soft Computing 2023年第8期37卷 2407-2419页

作者： So-Eun Jeon sun-Jin lee Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea

With the development of the 5th generation of mobile communi-cation(5G)networks and artificial intelligence(AI)technologies,the use of the Internet of Things(IoT)has expanded throughout *** IoT networks have improved industrial productivity and convenience,they are highly dependent on nonstandard protocol stacks and open-source-based,poorly validated software,resulting in several security ***-ever,conventional AI-based software vulnerability discovery technologies cannot be applied to IoT because they require excessive memory and com-puting *** study developed a technique for optimizing training data size to detect software vulnerabilities rapidly while maintaining learning *** results using a software vulnerability classification dataset showed that different optimal data sizes did not affect the learning performance of the learning ***,the minimal data size required to train a model without performance degradation could be determined in *** example,the random forest model saved 85.18%of memory and improved latency by 97.82%while maintaining a learning accuracy similar to that achieved when using 100%of data,despite using only 1%.

关键词： Lightweight devices machine learning deep learning software vulnerability detection common weakness enumeration

Efficient TE-Selective P-I-i-I-N GaAs/Al_( 0.35)Ga_(0.65)As Waveguide Phase Modulator at λ=1.55μm

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光学学报 2003年第S1期23卷 341-342页

作者： sun-Pil Kim Sang-sun lee Seok lee Deok-Ha Woo sun-Ho Kim Photonics Research Laboratory Division of Electrical and Computer Engineering Hanyang University 17 Hangdang-Dong Seongdong-Ku Seoul 133-791 Korea Photonics Research Center KIST P.O.Box 131 Cheongryang Seoul 130-650 Korea

We fabricated a phase modulator with significant phase shift for TE mode but negligible for TM mode. The measured phase shift efficiency was 7.9°/*** for TE mode. No modulation was observed for TM mode.

关键词： phase shift