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Improved Programming Efficiency through Additional Boron Implantation at the Active Area Edge in 90 nm Localized Charge-Trapping Non-volatile Memory

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Chinese Physics Letters 2010年第6期27卷 164-166页

作者： XU Yue YAN Feng CHEN Dun-Jun SHI Yi WANG Yong-gang LI Zhi-Guo YANG Fan WANG Jos-Hua LIN Peter CHANG jian-Guang Department of Physics Nanjing University Nanjing 210093 Semiconductor Manufacturing International (Shanghai) Corporation Shanghai 201203 College of Electronic Science and Engineering Nanjing University of Posts and Telecommunications Nanjing 210003

As the scaling-down of non-volatile memory （NVM） cells continues, the impact of shallow trench isolation （STI） on NVM cells becomes more severe. It has been observed in the 90nm localized charge-trapping non-volatile memory （NROMTM） that the programming efficiency of edge cells adjacent to STI is remarkably lower than that of other cells when channel hot electron injection is applied. Boron segregation is found to be mainly responsible for the low programming efficiency of edge cells. Meanwhile, an additional boron implantation of 10°tilt at the active area edge as a new solution to solve this problem is developed.

关键词： Mental ability Cells Lymphocytes Volatility Volatilization Efficiency Boron Piggeries

偏置电压和温度对22 nm FDSOI器件单粒子瞬态的影响研究

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集成电路与嵌入式系统 2024年第7期24卷 30-36页

作者：黄潇枫李臣明王海滨孙永姝王亮郭刚汪学明河海大学人工智能与自动化学院常州213200 河海大学信息科学与工程学院常州213200 北京微电子技术研究所北京100076 中国原子能科学研究院国防科技工业抗辐照应用技术创新中心北京102413 中煤科工集团常州研究院有限公司常州213015

针对22 nm FDSOI工艺在辐射环境下的单粒子瞬态问题,基于Sentaurus TCAD仿真工具对22 nm FDSOI NMOS进行建模,仿真研究了22 nm FDSOI NMOS的单粒子瞬态敏感区域,以及不同偏置电压和工作温度对单粒子瞬态的影响机理。仿真结果表明,22 nm ... 详细信息

针对22 nm FDSOI工艺在辐射环境下的单粒子瞬态问题,基于Sentaurus TCAD仿真工具对22 nm FDSOI NMOS进行建模,仿真研究了22 nm FDSOI NMOS的单粒子瞬态敏感区域,以及不同偏置电压和工作温度对单粒子瞬态的影响机理。仿真结果表明,22 nm FDSOI NMOS的敏感区域为体区和靠近体区的LDD区域;随着偏置电压的升高,漏端总收集电荷逐渐增大,漏端瞬态脉冲电流的脉冲宽度逐渐减小;相较于偏置电压对单粒子瞬态的影响,工作温度对22 nm FDSOI NMOS单粒子瞬态的影响并不明显。

关键词： 22 nm FDSOI 单粒子瞬态亚阈值 TCAD

Quantitative evaluation of colorectal tumour vasculature using contrast-enhanced ultrasound:Correlation with angiogenesis and prognostic significance

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世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 2052-2062页

作者： Ming-Hui Li Wei-Wei Li Ling He jian-Fang Li sun-Yan Zhang Department of Ultrasound Tumor Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionsChina Department of Medical Imaging Baoding Maternal and Child Health HospitalBaoding 071023Hebei ProvinceChina Department of Ultrasonography Nantong Haimen District People’s HospitalNantong 226100Jiangsu ProvinceChina

BACKGROUND Ultrasound is a vital tool for the diagnosis and management of colorectal cancer(CRC).Contrast-enhanced ultrasound(CEUS)is a non-invasive,safe,and cost-effective method for evaluating tumour blood vessels,that play a crucial role in tumour growth and *** To explore CEUS’s role in the quantitative evaluation of CRC blood vessels and their correlation with angiogenesis markers and *** This study prospectively enrolled 100 patients with CRC confirmed by *** patients received preoperative CEUS *** parameters,such as peak intensity(PI),time to peak(TTP),and area under the curve(AUC),were derived from time-intensity curve(TIC)*** tissue samples were obtained during surgery and examined immunohistochem-ically to assess the expression of angiogenesis markers,including vascular endo-thelial growth factor(VEGF)and microvessel density(MVD).The correlation between CEUS parameters,angiogenesis markers,and clinicopathological features was evaluated using appropriate statistical *** Quantitative CEUS parameters(PI,TTP,and AUC)showed significant correlations with VEGF expression(P<0.001)and MVD(P<0.001),indicating a strong link between tumour blood vessels and *** PI,reduced TTP,and expanded AUC values were significantly related to higher tumour stage(P<0.001),lymph node metastasis(P<0.001),and distant metastasis(P<0.001).Furthermore,these parameters were recognized as independent predictors of overall survival and disease-free survival in multivariate analysis(P<0.001).CONCLUSION CEUS has a high potential in guiding treatment planning and predicting patient ***,more com-prehensive,multicentre studies are required to validate the clinical utility of CEUS in CRC management.

关键词： Contrast-enhanced ultrasound Colorectal cancer Tumour angiogenesis Prognosis Microvessel density Vascular endothelial growth factor Tumour

Comparative analysis and phylogenetic and evolutionary implications of mitogenomes of Chinese Sinocyclocheilus cavefish(Cypriniformes:Cyprinidae)

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Zoological Research 2023年第4期44卷 779-781页

作者： Wan-Sheng jiang Jie Li Hong-Mei Xiang Chao sun jian-Bo Chang Jun-Xing Yang Hunan Engineering Laboratory for Chinese Giant Salamander’s Resource Protection and Comprehensive Utilization and Key Laboratory of Hunan Forest Products and Chemical Industry EngineeringJishou UniversityZhangjiajieHunan 427000China College of Biology and Environmental Sciences Jishou UniversityJishouHunan 416000China Hubei Fisheries Science Research Institute WuhanHubei 430071China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Water Resources Engineering and Management School of Water Resources and Hydropower EngineeringWuhan UniversityWuhanHubei 430072China

DEAR EDITOR,Cavefish are of considerable interest due to the remarkable morphological changes that occurred during their adaptation to cave or subterranean river *** changes are thought to involve trade-offs in metabolic requirements and energy *** play a vital role in oxygen use and energy metabolism;thus,mitochondrial genes are likely to have experienced specific selective pressures during cavefish *** this study,we assembled and annotated the mitogenome of Sinocyclocheilus sanxiaensis,a typical cavefish species in *** this sequence and other available mitogenomes from the NCBI database,we reconstructed an updated phylogeny of Sinocyclocheilus based on 29 *** species groups were revealed,with the recently erected *** species group *** determine whether divergent selective pressures have acted on the protein-coding genes(PCGs)of the 29 Sinocyclocheilus species exhibiting different morphological features(including eye shape and body color),the fish were classified into three groups according to their cave-related *** branch model test revealed higher nonsynonymous/synonymous substitution ratios(ω)in the cave-dwelling groups,potentially resulting from a balance between adaptive selection and relaxed functional *** analysis using site and branch-site models identified 24 highly credible positive selection sites located on nine PCGs,with most sites also showing radical changes in amino acid *** study sheds light on the phylogeny and mitogenomic evolution of Sinocyclocheilus cavefish,highlighting their successful adaptation and survival in subterranean environments.

关键词： fish phylogeny habitat

PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats

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Genes & Diseases 2022年第1期9卷 252-267页

作者： Hong Chen Chao Zhou jianfeng Zheng Zhaosi Zhang Yongbing Deng Chongjie Cheng Zongduo Guo gang Huo Cheng Yin Xiaochuan sun Department of Neurosurgery of the First Affiliated Hospital of Chongqing Medical University Chongqing 400016PR China Department of Neurosurgery of the Chongqing Emergency Medical Center Chongqing 400014PR China Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072PR China

In early brain injury(EBI)after subarachnoid hemorrhage(SAH),white matter(WM)axonal injury plays a key role in the prognosis of the *** purpose of this study was to investigate the effects of phosphatase and tensin homolog deleted on chromosome ten(PTEN)on axonal injury and neuronal apoptosis post-SAH in rats and to find its underlying ***-associated virus was injected into the lateral ventricle to suppress or promote *** function post-SAH in animals was determined by the modified Garcia score,beam balance,and Rotarod test,and the blood–brain barrier disruption was assessed by the brain water *** injury post-SAH was observed by TEM and determined by IF,and neuron apoptosis was measured by TUNEL *** mechanism was analyzed by Western blot to detect p-PTEN/PTEN,p-AKT/AKT,p-GSK-3β/GSK-3β,p-CRMP-2/CRMP-2,axonal injury markerβ-APP and pro-and anti-apoptosis proteins,including Bax and Bcl-2,*** found *** knocking down PTEN,neuronal apoptosis and axonal injury were alleviated,and nerve function and blood–brain barrier were protected;accordingly,after overexpression of PTEN,neuronal apoptosis and axon damage were aggravated,and nerve function damage and blood–brain barrier damage were *** and AKT/GSK-3β/CRMP-2 pathway were jointly involved in regulating neuronal apoptosis and WM axon injury after *** to our research,PTEN was a negative factor of EBI,and together with the AKT/GSK-3β/CRMP-2 signaling pathway aggravates neuronal apoptosis and WM axon damage after *** of PTEN expression may become a new target for SAH treatment.

关键词： AKT/GSK-3β/CRMP-2 pathway Axonal injury Early brain injury Neuronal apoptosis PTEN Subarachnoid hemorrhage

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

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Cellular & Molecular Immunology 2020年第5期17卷 533-535页

作者： Yuanhong Xuand Zhigang Tian Meijuan Zheng Yong Gao gang Wang Guobin Song Siyu Liu Dandan sun Yuanhong Xu Zhigang Tian Department of Clinical Laboratory First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Clinical Laboratory Fuyang Second People’s HospitalFuyang Infectious Disease Clinical CollegeAnhui Medical UniversityFuyangAnhuiChina Division of Molecular Medicine Hefei National Laboratory for Physical Sciences at Microscalethe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life SciencesUniversity of Science and Technology of ChinaHefeiAnhuiChina Institute of Immunology University of Science and Technology of ChinaHefeiAnhuiChina

In December 2019,a novel coronavirus was first reported in Wuhan,China.1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and is responsible for coronavirus disease 2019(COVID-19).Up to 28 February 2020,79,394 cases have been confirmed according to China’s National Health *** China,the virus has spread rapidly to over 36 countries and territories.

关键词： lymphocytes acute respiratory

Father＇s Character Analysis in Dangal

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Journal of Literature and Art Studies 2018年第2期8卷 282-287页

作者： XU jian-gang ZHENG Xiao-yu China Three Gorgeous University Yichang China

A work＇s theme, significance, thought and influence are embodied by the characters＇ personality and behavior. Thus, the protagonists appear to be particularly important. They represent the main ideas of the work and the author＇s intention. Dangal （English： Wrestling competition） is a 2016 Indian Hindi-language biographical sports drama film directed by Nitesh Tiwari. Produced by Walt Disney Pictures, Aamir Khan Productions and UTV Motion Pictures, it stars Aamir Khan as Mahavir Singh Phogat, an amateur wrestler, who trains his daughters Geeta Phogat and Babita Kumari to be world-class wrestlers, both of who go on to win medals at the 2010 Commonwealth Games. The paper will enhance people＇s comprehension to the Indian film--Dangal and the paternal love under the patriarchal domination through the analysis of the father Mahavir Singh Phogat.

关键词： Dangal paternity paternal love

Determination and Difference Analysis of DNA Methylation Content Both in Blood and Muscle Tissue of Pigs

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Agricultural Sciences in China 2008年第8期7卷 1010-1015页

作者： LIANG Qiu-ju LIU Li-na PENG jian sun Zhi-da jianG Si-wen Key Open Laboratory of Swine Genetics and Breeding Ministry of Agriculture Huazhong Agricultural University Wuhan 430070 P.R. China Zhongnan Branch Wuhan University of Science and Technology Wuhan 430223 P.R.China College of Food Science and Technology Huazhong Agricultural University Wuhan 430070 P.R.China

In this experiment, DNA samples from parental lines Large White, Landrace, and Meishan pigs, and their hybrids Large White × Landrace, Landrace × Large White, Large White × Meishan, and Meishan × Large White pigs were used for the determination of DNA methylation content in both blood and muscle tissue. The differences about DNA methylation content between parental lines and their hybrids were analyzed. These will offer theoretical support from molecular level for heterosis. High performance liquid chromatography （HPLC） was firstly used to detect DNA methylation content. The average DNA methylation content in 163 DNA samples of muscle tissue was 16.92%, whereas, the average DNA methylation content in 182 samples of blood was 6.49%, the difference between which was especially prominent （P 〈 0.01）. In blood, the methylation content was lower than 10%, with the highest level of 9.93% in Landrace x Large White and the lowest of 2.97% in Landrace. The difference between Large White and Landrace was highly significant （P 〈 0.01）, but not significant between Large White and Meishan; and the differences between reciprocal cross hybrids in both hybrid systems were significant （P 〈 0.05）. In muscle tissue, the differences in methylation content among three parents were not significant （P 〉0.05）; and the differences between reciprocal cross hybrids in both hybrid systems were not significant （P 〉 0.05）, but between different hybrid systems, the hybrids had a significant difference （P 〈0.05）. The average methylation content in muscle samples was higher than that in blood samples, and the methylation in different tissues was different.

关键词： HPLC DNA methylation pig

Alterations in gut microbiota are related to metabolite profiles in spinal cord injury

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Neural Regeneration Research 2023年第5期18卷 1076-1083页

作者： jian-Ning Kang Zheng-Fang sun Xin-Yu Li Xiao-Di Zhang Zheng-Xin Jin Ce Zhang Ying Zhang Hui-Yun Wang Na-Na Huang jian-Hao jiang Bin Ning Central Hospital Affiliated to Shandong First Medical University Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong ProvinceChina Department of Spinal Surgery Jinan Central HospitalCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina School of Clinical Medicine Weifang Medical UniversityWeifangShandong ProvinceChina Department of Traumatic Orthopedics Binzhou Medical University HospitalBinzhou Medical UniversityBinzhouShandong ProvinceChina

Studies have shown that gut microbiota metabolites can enter the central nervous system via the blood-spinal cord barrier and cause neuroinflammation, thus constituting secondary injury after spinal cord injury. To investigate the correlation between gut microbiota and metabolites and the possible mechanism underlying the effects of gut microbiota on secondary injury after spinal cord injury, in this study, we established mouse models of T8–T10 traumatic spinal cord injury. We used 16 S rRNA gene amplicon sequencing and metabolomics to reveal the changes in gut microbiota and metabolites in fecal samples from the mouse model. Results showed a severe gut microbiota disturbance after spinal cord injury, which included marked increases in pro-inflammatory bacteria, such as Shigella, Bacteroides, Rikenella, Staphylococcus, and Mucispirillum and decreases in anti-inflammatory bacteria, such as Lactobacillus, Allobaculum, and Sutterella. Meanwhile, we identified 27 metabolites that decreased and 320 metabolites that increased in the injured spinal cord. Combined with pathway enrichment analysis, five markedly differential amino acids(L-leucine, L-methionine, L-phenylalanine, L-isoleucine and L-valine) were screened out, which play a pivotal role in activating oxidative stress and inflammatory responses following spinal cord injury. Integrated correlation analysis indicated that the alteration of gut microbiota was related to the differences in amino acids, which suggests that disturbances in gut microbiota might participate in the secondary injury through the accumulation of partial metabolites that activate oxidative stress and inflammatory responses. Findings from this study provide a new theoretical basis for improving the secondary injury after spinal cord injury through fecal microbial transplantation.

关键词： 16S rRNA gene amplicon sequencing amino acid metabolism dysbacteriosis gut microbiota inflammation metabolic disturbance metabolites metabolomics secondary injury spinal cord injury