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Applications of dynamical complexity theory in traditional Chinese medicine

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Frontiers of Medicine 2014年第3期8卷 279-284页

作者： Yan Mal Shuchen sun Chung-kang Peng Division of Interdisciplinary Medicine and Biotechnology Beth Israel Deaconess Medical Centel Harvard Medical School Boston MA 02215USA Sleep CenteR Eye Hospital China Academy of Chinese Medical Sciences Beijing 100040 China Department of Otolaryngology Guang 'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Center for Dynamical Biomarkers and Translational Medicine National Central University Chung-Li Taiwan China

Traditional Chinese medicine （TCM） has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach arc not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy （MSE） analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.

关键词： traditional Chinese medicine Multiscale Entropy dynamical complexity system level applications

Numerical simulation for thermal response test performance in closed-loop vertical ground heat exchanger

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Science China(Technological Sciences) 2011年第7期54卷 1668-1673页

作者： CHOI Jong Min LEE Chulho PARK Moonseo kang Shin-hyung CHOI Hangseok Department of Mechanical Engineering Hanbat National University School of Civil Environmental and Architectural Engineering Korea University Department of Mechanical Engineering Konyang University

In this study, a series of numerical analyses was performed in order to evaluate the performance of full-scale closed-loop vertical ground heat exchangers constructed in Wonju, South Korea. The circulating HDPE pipe, borehole and surrounding ground formation were modeled using FLUENT, a finite-volume method (FVM) program, for analyzing the heat transfer process of the ground heat exchanger system. Two user-defined functions (UDFs) accounting for the difference in the temperature of the circulating inflow and outflow fluid and the variation of ground temperature with depth were adopted in the FLUENT modeling. The thermal conductivities of grouts (cement vs. bentonite) measured in laboratory were used as input values in the numerical analyses to compare the thermal efficiency of the cement and bentonite grouts used for installing the closed-loop vertical ground heat exchanger. A series of numerical analyses was carried out to simulate in-situ thermal response tests performed in the construction site. From the comparison between the in-situ thermal response test results and numerical simulations, the average thermal conductivity of the ground formation in the construction site is back-calculated as approximately 4 W/mK. This value can be used in evaluating the long-term performance of the closed-loop vertical ground heat ex changer.

关键词： closed-loop vertical ground heat exchanger cement grout bentonite grout in-situ thermal response test finite-volumemethod thermal conductivity

Curvature Dependence of Interfacial Properties for Associating Lennard-Jones Fluids:A Density Functional Study

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Chinese Physics Letters 2011年第2期28卷 168-171页

作者： sun Zong-Li kang Yan-Shuang Science and Technology College North China Electric Power UniversityBaoding 071051 College of Science Agriculture University of HebeiBaoding 071001

Classical density functional theory is used to study the associating Lennard Jones fluids in contact with spherical hard wall of different curvature *** interfacial properties including contact density and fluid-solid intcrfacial tension are *** influences of associating energy,curvature of hard wall and the hulk density of fluids on these properties are analyzed in *** results may provide helpful clues to understand the interfacial properties of other complex fluids.

关键词： curvature interfacial spherical

Finite Element Analysis of the Steel Reinforced Plastic Pipe

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Journal of Materials Science & Technology 2003年第Z1期19卷 43-45页

作者： Hongyi sun Wenqi MA Dachang kang Keding ZHAO Harbin University of Science and Technology Harbin 150080 China Daqing Oilfields Postdoctoral Workstation Daqing 163453 China Harbin Institute of Technology Harbin 150001 China Daqing Oilfields Postdoctoral Workstation Daqing 163453 China Harbin Institute of Technology Harbin 150001 China Harbin Institute of Technology Harbin 150001 China

The steel reinforced plastic pipe is a kind of green environmental protection pipelines with double-sides corrosionresisting and better withstanding to medium working pressure. The structure and technical process of this pipe are described briefly in this paper, and the finite element analysis has been done for the sake of understanding the distributions of stress and displacement inside this pipe under hydrostatic pressure. The analysis results are very important for safety application of the steel reinforced plastic pipe.

关键词： Steel reinforced plastic pipe, Finite element analysis

Impulsive synchronization of a nonlinear coupled complex network with a delay node

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Chinese Physics B 2012年第1期21卷 133-139页

作者： sun Wen Chen Zhong kang Yu-Hong School of Information and Mathematics Yangtze UniversityJingzhou 434023China School of Foreign Studies Yangtze UniversityJingzhou 434023China

We investigate the impulsive synchronization of a nonlinear coupled complex network with a delay node. Both delay coupling and non-delay coupling, as well as the symmetrical coupling matrix and the asymmetrical coupling matrix are considered. Based on the comparison theorem of an impulsive differential system, some novel synchronization criteria are derived. Finally, numerical simulations demonstrate the effectiveness of the proposed synchronization criteria.

关键词： complex network impulsive control synchronization nonlinear coupled

The role of extracellular vesicles in animal reproduction and diseases

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1634-1656页

作者： Sangiliyandi Gurunathan Min-Hee kang Hyuk Song Nam hyung Kim Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology Konkuk UniversitySeoul 05029Korea Guangdong Provincial Key Laboratory of Large Animal models for Biomedicine Wuyi UniversityJiangmen 529020China

Extracellular vesicles(EVs)are nanosized membrane-enclosed compartments that serve as messengers in cell-to-cell communication,both in normal physiology and in pathological *** can transfer functional proteins and genetic information to alter the phenotype and function of recipient cells,which undergo different changes that positively affect their structural and functional *** fluids are enriched with several subpopulations of EVs,including exosomes,microvesicles(MVs),and apoptotic bodies carrying several cargoes,such as lipids,proteins,and nucleic *** associated with the reproductive system are actively involved in the regulation of different physiological events,including gamete maturation,fertilization,and embryo and fetal *** can influence follicle development,oocyte maturation,embryo production,and endometrial-conceptus *** loaded with cargoes are used to diagnose various diseases,including pregnancy disorders;however,these are dependent on the type of cell of origin and pathological ***-derived microRNAs(miRNAs)and proteins in the placenta regulate inflammatory responses and trophoblast invasion through intercellular delivery in the placental *** review presents evidence regarding the types of extracellular vesicles,and general aspects of isolation,purification,and characterization of EVs,particularly from various types of ***,we discuss EVs as mediators and messengers in reproductive biology,the effects of EVs on placentation and pregnancy disorders,the role of EVs in animal reproduction,in the male reproductive system,and mother and embryo *** addition,we emphasize the role of microRNAs in embryo implantation and the role of EVs in reproductive and therapeutic ***,we discuss the future perspectives of EVs in reproductive biology.

关键词： Embryos Extracellular vesicles Implantation MicroRNA Pregnancy disorders

Autophagy and inflammation in ischemic stroke

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Neural Regeneration Research 2020年第8期15卷 1388-1396页

作者： Yun Mo Yin-Yi sun kang-Yong Liu Department of Neurology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Department of Neurology Shanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai university of medicine&health Sciences Affiliated Zhoupu hospitalShanghaiChina

Appropriate autophagy has protective effects on ischemic nerve tissue,while excessive autophagy may cause cell *** inflammatory response plays an important role in the survival of nerve cells and the recovery of neural tissue after *** studies have found an interaction between autophagy and inflammation in the pathogenesis of ischemic *** study outlines recent advances regarding the role of autophagy in the post-stroke inflammatory response as follows.(1)Autophagy inhibits inflammatory responses caused by ischemic stimulation through mTOR,the AMPK pathway,and inhibition of inflammasome activation.(2)Activation of inflammation triggers the formation of autophagosomes,and the upregulation of autophagy levels is marked by a significant increase in the autophagy-forming markers LC3-II and *** stimulates microglia and inhibits ULK1 activity by direct phosphorylation of p38 MAPK,reducing the flux and autophagy level,thereby inducing inflammatory activity.(3)By blocking the activation of autophagy,the activation of inflammasomes can alleviate cerebral ischemic *** can also regulate the phenotypic alternation of microglia through the nuclear factor-κB pathway,which is beneficial to the recovery of neural tissue after *** have shown that some drugs such as resveratrol can exert neuroprotective effects by regulating the autophagy-inflammatory *** studies suggest that the autophagy-inflammatory pathway may provide a new direction for the treatment of ischemic stroke.

关键词： autophagy cerebral ischemia function inflammasome inflammation ischemia/refusion ischemic stroke macroautophagy neuroinflammation oxygen glucose deprivation

Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation

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International Journal of Oral Science 2022年第2期14卷 164-173页

作者： So Mi Jeon Je sun Lim Su Hwan Park hyung Joon Kim hyung-Ryong Kim Jong-Ho Lee Department of Health Sciences The Graduate School of Dong-A UniversityBusanRepublic of Korea Department of Oral Physiology Periodontal Diseases Signaling Network Research CenterDental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanRepublic of Korea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuRepublic of Korea Department of Biomedical Sciences Dong-A UniversityBusanRepublic of Korea

The programmed cell death ligand 1(PD-L1)and its receptor programmed cell death 1(PD-1)deliver inhibitory signals to regulate immunological tolerance during immune-mediated ***,the role of PD-1 signaling and its blockade effect on human dental pulp stem cells(h DPSCs)differentiation into the osteo-/odontogenic lineage remain *** show here that PD-L1 expression,but not PD-1,is downregulated during osteo-/odontogenic differentiation of h ***,PD-L1/PD-1 signaling has been shown to negatively regulate the osteo-/odontogenic differentiation of h ***,depletion of either PD-L1 or PD-1 expression increased ERK and AKT phosphorylation levels through the upregulation of Ras enzyme activity,which plays a pivotal role during h DPSCs osteo-/odontogenic *** with nivolumab(a human anti-PD-1 monoclonal antibody),which targets PD-1 to prevent PD-L1 binding,successfully enhanced osteo-/odontogenic differentiation of h DPSCs through enhanced Ras activity-mediated phosphorylation of ERK and *** findings underscore that downregulation of PD-L1 expression accompanies during osteo-/odontogenic differentiation,and h DPSCs-intrinsic PD-1 signaling inhibits osteo-/odontogenic *** findings provide a significant basis that PD-1 blockade could be effective immunotherapeutic strategies in h DPSCs-mediated dental pulp regeneration.

关键词： death finding monoclonal

Natural marmatite photocatalyst for treatment of mineral processing wastewater to help zero wastewater discharge

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Journal of Environmental Sciences 2024年第8期142卷 83-91页

作者： Meirong Wu Wei sun Xiangsong Meng Jianhua kang Yue Yang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

Mineral processing wastewater(MPW)with large discharge and high toxicity affects environmental safety,and the realizing zero discharge of MPW is of great significance for reducing environmental pollution,saving water resources,and promoting the sustainable development of the mining *** this study,we reported natural marmatite(NM)as a low-cost and efficient photocatalyst for the treatment of MPW to help zero wastewater *** photocatalytic activity of NM was evaluated by the removal of total organic carbon(TOC)from MPW under visible-light illumination,and the optimal degradation conditions were *** showed that superoxide free radicals(^(·)O_(2)^(-))were the dominant active species responsible for organic pollutants degradation,and 74.25%TOC removal was obtained after 120 min reaction under the optimum treatment ***,the wastewater treated by NM photocatalysis can be reused in the flotation system without adverse impact on the product *** on these findings,a model of zero wastewater discharge for flotation with the help of photocatalytic treatment was established,it indicated that the water of the whole system can be balanced without affecting the ore dressing index,which showed that visible light-driven photocatalyst has a promising application prospect in the treatment and recycling of industrial wastewater.

关键词： Natural mineral Photocatalysis Industrial wastewater Wastewater recycling Water balance