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Prognostic role of plasma level of angiopoietin-1,angiopoietin-2,and vascular endothelial growth factor in hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第27期27卷 4453-4467页

作者： Gwang Hyeon Choi Eun sun Jang Jin-Wook Kim Sook-hyang Jeong Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

BACKGROUND Most hepatocellular carcinomas(HCCs)are hypervascular,with characteristic features of hepatic arterial supply to the *** factors involved in tumor angiogenesis include angiopoietin-1(Ang-1),angiopoietin-2(Ang-2),and vascular endothelial growth factor(VEGF).AIM To investigate the profiles of plasma levels of angiogenesis markers in patients with HCC and evaluate their roles in predicting overall survival(OS)and progression-free survival(PFS).METHODS Plasma samples from 240 prospectively enrolled HCC patients in the very early to advanced stages were used to measure the levels of Ang-1,Ang-2,and *** associations with clinical characteristics,OS,and PFS were *** The median plasma levels of Ang-1,Ang-2,and VEGF were 3216 pg/mL,1684 pg/mL,and 26.5 pg/mL,*** plasma level of Ang-2 showed a significant increase from early stage[Barcelona clinic liver cancer(BCLC)A]to intermediate(BCLC B)and advanced stage HCC(BCLC C/D),whereas Ang-1,VEGF,and alpha-fetoprotein(AFP)levels in the plasma did not show any such *** analysis,propensity score-matched analysis,and timedependent receiver operating curve analysis revealed that Ang-2 levels had the highest predictive power for OS and *** Ang-1 nor VEGF was significantly associated with OS or *** neutrophil-to-lymphocyte ratio was an independent factor for OS and *** The plasma levels of Ang-2 correlated with liver function,tumor stage,and tumor invasiveness,showing better performance in predicting OS and PFS than AFP,Ang-1,or VEGF.

关键词： Hepatocellular carcinoma Angiogenesis Biomarker Prognosis Survival

Acute kidney injury due to intravenous detergent poisoning:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2036-2044页

作者： sungbin Park Hyun-Sik Ryu Jae-Kwang lee sung-Soo Park sun-Jung Kwon Won-Min Hwang sung-Ro Yun Moon-hyang Park Yohan Park Department of Internal Medicine Division of NephrologyKonyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Internal Medicine Division of Respiratory and Critical Care MedicineKonyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Pathology Konyang University HospitalCollege of MedicineDaejeon 35365South Korea

BACKGROUND Detergent poisoning mostly occurs through oral ingestion(>85%),ocular exposure(<15%),or dermal exposure(<8%).Reports of detergent poisoning through an intravenous injection are extremely *** addition,there are very few cases of renal toxicity directly caused by ***,we report a unique case of acute kidney injury caused by detergent poisoning through an accidental intravenous *** SUMMARY A 61-year-old man was intravenously injected with 20 mL of detergent by another patient in the same room of a local *** surfactant and calcium carbonate accounted for the largest proportion of the *** patient complained of vascular pain,chest discomfort,and nausea,and was transferred to our *** hospitalization,the patient’s serum creatinine level increased to 5.42 mg/dL,and his daily urine output decreased to approximately 300 *** biopsy findings noted that the glomeruli were relatively intact;however,diffuse acute tubular injury was *** edema was also noted,and the patient underwent a total of four hemodiafiltration ***,the patient’s urine output gradually increased whereas the serum creatinine level *** patient was discharged in a stable status without any *** Detergents appear to directly cause renal tubular injury by systemic *** treating a patient with detergent poisoning,physicians should be aware that the renal function may also *** addition,timely renal replacement therapy may help improve the patient’s prognosis.

关键词： Detergents Poisoning Intravenous injection Acute kidney injury Acute tubular injury Case report

Hepatocellular carcinoma,decompensation,and mortality based on hepatitis C treatment:A prospective cohort study

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World Journal of Gastroenterology 2022年第30期28卷 4182-4200页

作者： Gwang Hyeon Choi Eun sun Jang Young Seok Kim Youn Jae lee In Hee Kim sung Bum Cho Han Chu lee Jeong Won Jang Moran Ki Hwa Young Choi Dahye Baik Sook-hyang Jeong Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907JeonbukSouth Korea Department of Internal Medicine Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine The Catholic University of KoreaSeoul 06591South Korea Cancer Control and Population Health Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408South Korea

BACKGROUND Prospective studies of the long-term outcomes of patients with hepatitis C virus(HCV)infection after treatment with interferon-based therapy(IBT)or directacting antivirals(DAA)are limited in many Asian *** To elucidate the incidences of hepatocellular carcinoma(HCC)and death/transplantation based on treatment with IBT or DAA,to compare the outcomes of the sustained virologic response(SVR)to IBT and DAA,and to investigate outcome-determining factors after *** This cohort included 2054 viremic patients(mean age,57 years;46.5%male;27.4%with cirrhosis)prospectively enrolled at seven hospitals between 2007 and *** were classified as the untreated group(n=619),IBT group(n=578),and DAA group(n=857).Outcomes included the incidences of HCC and death/*** incidences of the outcomes for each group according to treatment were calculated using an exact method based on the Poisson distribution.A multivariate Cox regression analysis was performed to determine the factors associated with HCC or death/transplantation,followed by propensity score matching to confirm the *** During a median of 4.1 years of follow-up,HCC and death/transplantation occurred in 113 and 206 patients,respectively,in the entire *** with the untreated group,the incidences of HCC and death/transplantation were significantly lower in the IBT group[adjusted hazard ratio(aHR)0.47,95%CI:0.28-0.80 and aHR 0.28,95%CI:0.18-0.43,respectively]and the DAA group(aHR 0.58,95%CI:0.35-0.96,and aHR 0.19,95%CI:0.20-0.68,respectively).Among 1268 patients who attained SVR with IBT(n=451)or DAA(n=816),the multivariable-adjusted analysis showed no differences in the risks of HCC(HR 2.03;95%CI:0.76-5.43)and death/transplantation(HR 1.38;95%CI:0.55-3.49)between the two *** was confirmed by a propensity score-matching *** factors for HCC after SVR were age,genotype 1,and the presence of *** Treatment and achieving SVR

关键词： Hepatitis C virus Direct-acting antiviral Sustained virologic response Hepatocellular carcinoma Mortality

Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

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World Journal of Gastroenterology 2016年第42期22卷 9427-9436页

作者： Junhyeon Cho Sang Soo lee Yun Suk Choi Yejoo Jeon Jung Wha Chung Joo Yeong Baeg Won Keun Si Eun sun Jang Jin-Wook Kim Sook-hyang Jeong Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine Gyeongsang National University Changwon Hospital Gyeongsang National University College of Medicine

AIM To clarify the prevalence of occult hepatitis B virus(HBV) infection(OBI) and the association between OBI and liver disease progression, defined as development of liver cirrhosis or hepatocellular carcinoma(HCC), worsening of Child-Pugh class, or mortality in cases of chronic hepatitis C virus(HCV) infection. METHODS This prospective cohort study enrolled 174 patients with chronic HCV infection(chronic hepatitis, n = 83; cirrhosis, n = 47; HCC, n = 44), and evaluated disease progression during a mean follow-up of 38.7 mo. OBI was defined as HBV DNA positivity in 2 or moredifferent viral genomic regions by nested polymerase chain reaction using 4 sets of primers in the S, C, P and X open reading frame of the HBV genome. RESULTS The overall OBI prevalence in chronic HCV patients at enrollment was 18.4%, with 16.9%, 25.5% and 13.6% in the chronic hepatitis C, liver cirrhosis and HCC groups, respectively(P = 0.845). During follow-up, 52 patients showed disease progression, which was independently associated with aspartate aminotransferase > 40 IU/L, Child-Pugh score and sustained virologic response(SVR), but not with OBI positivity. In 136 patients who were not in the SVR state during the study period, OBI positivity was associated with neither disease progression, nor HCC development. CONCLUSION The prevalence of OBI in chronic HCV patients was 18.4%, and OBI was not associated with disease progression in South Koreans.

关键词： Hepatitis B virus Hepatitis C virus Disease control Oncogenesis

Gender Differences in Rapid Eye Movement-Related Sleep Disordered Breathing

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Health 2015年第1期7卷 106-111页

作者： Minjung Youn Joo Young Kwon Kyu sun lee Jung Hyun Park hyang Woon lee Department of Neurology Ewha Womans University School of Medicine and Ewha Medical Research Institute Seoul Korea Department of Neurology Ajou University School of Medicine Suwon Korea

Sleep disordered breathing (SDB) is an independent risk factor for cardiovascular disease. It is known to be associated more frequently with men than women, particularly in the premenopausal age range. The goal of this study is to evaluate gender differences among Korean patients diagnosed with SBD. This study included 309 patients who visited our Sleep Clinic due to sleep-related symptoms and were diagnosed with SDB by overnight polysomnography (PSG). We analyzed age, gender, body mass index, various PSG indices including sleep stages, apnea-hypopnea index (AHI) and AHI ratio in rapid eye movement (REM) versus non-REM (NREM) sleep stages (R:N ratio). Of those 309 patients diagnosed with obstructive sleep apnea, 217 (70.2%) were men (mean age 51.05 ± 12.64 years) and 92 (29.8%) were women (mean age 64.53 ± 10.43 years). The mean AHI during total sleep time was 30.34 ± 21.17 in men and 21.47 ± 17.14 in women (P P P = 0.402). REM SDB with R:N ratio higher than 2.0 was more frequently observed in women than in men, 34.8% (32/92) of women, compared with 11.9% (26/217) in men (P 60 years old. These findings suggest the possibility of different pathophysiologic mechanisms of SDB between genders and also between NREM versus REM sleep, which can be partly explained by the influence of female sex hormones.

关键词： Women Sleep Disordered Breathing Obstructive Sleep Apnea Rapid Eye Movement Sleep Apnea-Hypopnea Index

Modified rendezvous intrahepatic bile duct cannulation technique to pass a PTBD catheter in ERCP

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World Journal of Gastroenterology 2010年第42期16卷 5388-5390页

作者： Tae Hoon lee Sang-Heum Park Sae Hwan lee Chang-Kyun lee Suck-Ho lee Il-Kwun Chung Hong Soo Kim sun-Joo Kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University College of MedicineCheonan Hospital23-20 Bongmyung-dongCheonan-siChungcheongnam-do330-721South Korea

The rendezvous procedure combines an endoscopic technique with percutaneous transhepatic biliary drainage(PTBD).When a selective common bile duct cannulation fails,PTBD allows successful drainage and retrograde access for subsequent rendezvous ***,rendezvous procedures such as the PTBDassisted over-the-wire cannulation method,or the parallel cannulation technique,may be available when a bile duct cannot be selectively *** selective intrahepatic bile duct(IHD) cannulation fails,this modified rendezvous technique may be a feasible *** report the case of a modified rendezvous technique,in which the guidewire was retrogradely passed into the IHD through the C2 catheter after end-to-end contact between the tips of the sphincterotome and the C2 catheter at the ampulla's orifice,in a 39-year-old man who had been diagnosed with gallbladder carcinoma with a metastatic right IHD *** this procedure may be a feasible and timesaving technique.

关键词： Endoscopic retrograde cholangiopancreatography Intrahepatic bile duct Rendezvous technique

Primary endoscopic approximation suture under cap-assisted endoscopy of an ERCP-induced duodenal perforation

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World Journal of Gastroenterology 2010年第18期16卷 2305-2310页

作者： Tae Hoon lee Byoung Wook Bang Jee In Jeong Hyung Gil Kim Seok Jeong Seon Mee Park Don Haeng lee Sang-Heum Park sun-Joo Kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University College of MedicineCheonan Hospital Division of Gastroenterology Department of Internal MedicineInha University School of Medicine Division of Gastroenterology Department of Internal MedicineChungbuk National University College of Medicine

Duodenal perforation during endoscopic retrograde cholangiopancreatography(ERCP) is a rare complication,but it has a relatively high mortality *** diagnosis and prompt management are key factors for the successful treatment of ERCP-related *** management of perforation can initially be conservative in cases resulting from sphincterotomy or guide wire ***,the current standard treatment for duodenal free wall perforation is surgical ***,several case reports of endoscopic closure techniques using endoclips,endoloops,or fully covered metal stents have been *** describe four cases of iatrogenic duodenal bulb or lateral wall perforation caused by the scope tip that occurred during ERCP in tertiary referral *** the cases were simply managed by endoclips under transparent capassisted *** on the available evidence and our experience,endoscopic closure was a safe and feasible method even for duodenoscope-induced *** results suggest that endoscopists may be more willing to use this treatment.

关键词： Duodenal perforation Endoscopic retrograde cholangiopancreatography Endoscopic therapy Endoclip

A case of a duodenal duplication cyst presenting as melena

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World Journal of Gastroenterology 2013年第38期19卷 6490-6493页

作者： Seung Yeon Ko sun Hye Ko sungeun Ha Mi sung Kim hyang Mi Shin Myong Ki Baeg Department of General Surgery College of MedicineThe Catholic University of Korea Department of Internal Medicine College of MedicineThe Catholic University of Korea Department of Pathology College of MedicineThe Catholic University of Korea

Duodenal duplication cysts are benign rare congenital anomalies reported mainly in the pediatric population,but seldom in *** depend on the type and location and can present as abdominal pain,distension,dysphagia or *** have been reported to be responsible for duodenal obstruction,pancreatitis and,in rare cases,gastrointestinal *** present a case of a duodenal duplication cyst in a 43-year-old man presenting as *** gastroduodenoscopy and colonoscopy did not reveal any bleeding ***,the patient began passing melena after 3 d,with an acute decrease in hemoglobin *** studies revealed a duplication cyst in the second portion of the duodenum which was surgically *** revealed a duodenal duplication cyst consisting of intestinal *** was no further bleeding and the patient recovered *** rare cases,duodenal duplication cysts might cause gastrointestinal bleeding and should be included in the differential diagnosis.

关键词： Gastrointestinal hemorrhage Duodenum Duplication

Prostate calculi in cancer and BPH in a cohort of Korean men：presence of calculi did not correlate with cancer risk

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Asian Journal of Andrology 2010年第2期12卷 215-220页

作者： Eu-Chang Hwang hyang-Sik Choi Chang-Min Im Seung-II Jung sun-Ouck Kim Tack-Won Kang Dong-Deuk Kwon Kwang-sung Park Soo-Bang Ryu Department of Urology Chonnam National University Medical School Gwangju 501-75 7 Korea

Prostatic calculi are common and are associated with inflammation of the prostate. Recently,it has been suggested that this inflammation may be associated with prostate carcinogenesis. The aim of this study was to investigate the relationship between prostatic calculi and prostate cancer （PCa） in prostate biopsy specimens. We retrospectively analyzed 417 consecutive patients who underwent transrectal ultrasonography （TRUS） and prostate biopsies between January 2005 and January 2008. Based on the biopsy findings,patients were divided into benign prostatic hyperplasia and PCa groups. TRUS was used to detect prostatic calculi and to measure prostate *** correlations between PCa risk and age,serum total PSA levels,prostate volume,and prostatic calculi were analyzed. Patient age and PSA,as well as the frequency of prostatic calculi in the biopsy specimens,differed significantly between both the groups （P〈0.05）. In the PCa group,the Gleason scores （GSs） were higher in patients with prostatic calculi than in patients without prostatic calculi （P = 0.023）. Using multivariate logistic regression analysis,we found that patient age,serum total PSA and prostate volume were risk factors for PCa （P = 0.001）,but that the presence of prostatic calculi was not associated with an increased risk of PCa （P = 0.13）. In conclusion,although the presence of prostatic calculi was not shown to be a risk factor for PCa,prostatic calculi were more common in patients with PCa and were associated with a higher GS among these men.

关键词： calculi prostate prostatic neoplasms risk factors