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Chinese Medical Journal 2015年第1期128卷 105-110页

作者： Chuntao Tian shixin Lu Qingxia Fan Weijie Zhang Shunchang Jiao Xiao Zhao Zhiyong Wu Liang sun Liuxing Wang Department of Oncology First Affiliated Hospital Zhengzhou University Zhengzhou Henan 450052 China Department of Etiology and Carcinogenesis Cancer Institute and Hospital Chinese Academy of Medical Sciences Beijing 100021 China Department of Oncology General Hospital of Chinese People's Liberation Army Beijing 100853 China Department of Epidemiology and Statistics College of Public Health Zhengzhou University Zhengzhou Henan 450001 China

Background：Altered immunoresponse is associated with tumorigenesis and cancer *** study assessed the levels of tumor-infiltrating CD3^＋ or CD8^＋ T lymphocytes and interleukin-2 （IL-2） protein in radically resected non-small cell lung cancer （NSCLC） tissues to predict overall survival （OS） of the patients.Methods：Paraffin-embedded tissue specimens from 129 NSCLC patients were retrospectively collected for immunostaining of CD8^＋,CD3^＋,and IL-2 *** and survival data were collected and analyzed using the Chi-squared test,Kaplan-Meier curves,and the log-rank test or the Cox regression model.Results：The data showed a significant inverse association between CD8^＋ T lymphocyte levels and IL-2 expression （r =-0.927; P =0.000） and between the levels of CD8^＋ and CD3^＋ T lymphocytes （r =-0.722; P =0.000）,but a positive association between CD3^＋ T lymphocyte levels and IL-2 expression （r =0.781; P =0.000） in NSCLC ***,the levels of CD3^＋ and CD8^＋ T lymphocytes and IL-2 expression were associated with tumor stage （P =0.023,0.006,and 0.031,respectively） and the level of CD8^＋ T lymphocytes was associated with the patient gender （P =0.024）.In addition,the levels of CD8^＋ T lymphocytes were associated with an unfavorable 5-year OS,whereas patients with high levels of CD3^＋ T lymphocytes in tumor lesions and IL-2-expressing tumors had significantly better 5-year OS rates than patients with low levels.Conclusions：The levels of CD8^＋ T cells in tumor lesions and IL-2 expression were both independent predictors of OS for these NSCLC ***,the detection of tumor-infiltrating CD3^＋ or CD8^＋ T lymphocytes and IL-2 expression could be useful to predict the prognosis of radically resected NSCLC patients.

关键词： Immunohistochemistry Immunological Parameters Non-small Cell Lung Cancer Prognostic Factors

Urban Emergency Intelligent Decision System in Rough Set on Two Universes

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A Comprehensive Framework for Decoding Salty Taste Information from EEG Signals: Distinguishing Brain Reactions to Saltiness of Comparable Intensity

第26届中国控制与决策会议

作者： Fuquan sun Xi Yu shixin Liu Fuqiang Lu College of Information Science & Engineering Northeastern University Department of Information Science Dalian Institute of Science and Technology

ISBN: (纸本)9781479937097

In recent years, much attention has been given to the urban emergency intelligent decision system. In this paper, an urban emergency intelligent decision system in rough set on two universes is proposed. We give the structure of the urban emergency intelligent decision component. The binary relation R is redefined in this paper. We also defined the emergency system and emergency decision system. A model of intelligent decision in rough set on two universes is proposed. A realization method of intelligent decision based on matrix is given, and an algorithm is proposed to build the matrix. At last an illustrative example is employed to demonstrate the concepts, and methods.

关键词： Rough Set on Two Universes Intelligent Urban Emergency Decision

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Food Science and Human Wellness 2024年

作者： Jingjing Liu Yifei Xu Xingwang Lian Tianming Liu Haohao Ning Xi Jiang shixin Yu Shikun Liu Lu Huang Xiaojun sun Jiangyong Li Dongfu Xu School of Automation Engineering， Northeast Electric Power University Department of Computer Science， the University of Georgia School of Life Science and Technology， University of Electronic Science and Technology of China

The perception of salty taste is crucial for individuals to make healthy food choices. Yet， the brain electrophysiological signals underlying salty taste perception have been poorly described. In this study， electroencephalography (EEG) was used to record brain activity induced by NaCl solution as a salty taste stimulus. A combination of a custom delivery device and stimulation paradigm was employed to preserve the salty taste signal clearly. A stimulus-response capture method was proposed that could adapt to individual differences in brain responses to salty taste and accurately segment salty taste response signals. Applying this method to the EEG processing workflow can form a complete data processing framework. The results showed that the neural response induced by salty taste reached a high activity level in the initial stage within a short period (0.2s)， and there was a sustained periodic response within 0.75s after the stimulation. Moreover， the salty taste information in the EEG signal was decoded， and discrimination of two similar concentrations of salty taste solutions was achieved far above the chance level (average identification rate: 89.66%). This study demonstrated experimental paradigms and research methods for understanding salty taste perception， which could provide references for research on other basic tastes.

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纳米SiO_2/聚甲基丙烯酸甲酯透明复合材料的制备及透光率

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复合材料学报 2017年第7期34卷 1423-1429页

作者：孙志鹏王华山韩世新天津科技大学化学工程与材料学院天津300457

首先利用γ-甲基丙烯酰氧基丙基三甲氧基硅烷(MPS)对纳米SiO_2进行表面改性(SiO_2-MPS),再通过原位聚合法在SiO_2-MPS表面接枝聚甲基丙烯酸甲酯(PMMA)。采用熔融共混法将未改性和改性SiO_2与PMMA共混制成预分散母料,再分别与PMMA熔融共... 详细信息

首先利用γ-甲基丙烯酰氧基丙基三甲氧基硅烷(MPS)对纳米SiO_2进行表面改性(SiO_2-MPS),再通过原位聚合法在SiO_2-MPS表面接枝聚甲基丙烯酸甲酯(PMMA)。采用熔融共混法将未改性和改性SiO_2与PMMA共混制成预分散母料,再分别与PMMA熔融共混制备纳米SiO_2/PMMA透明复合材料。用FTIR、TG和SEM对不同表面处理的纳米SiO_2和纳米SiO_2/PMMA复合材料的结构进行表征,并对其冲击强度、接触角和透光率进行表征。结果表明:SiO_2-MPS/PMMA复合材料中纳米SiO_2与MPS、MPS与PMMA间形成化学键,接枝率分别达到10.01%和22.95%,SiO_2-MPS-PMMA在PMMA中分散性最好,团聚现象明显减少,与纯PMMA相比,SiO_2/PMMA、SiO_2-MPS/PMMA和SiO_2-MPS-PMMA/PMMA复合材料的冲击强度、与水接触角均略有提升,透光率达到90%左右,最高可达94.2%。

关键词：母料 PMMA 纳米SiO2 透光率透明复合材料

Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island,Shanghai

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Infectious Diseases of Poverty 2022年第5期11卷 50-62页

作者： Chao Lv Jun Shang Wengang Zhang Bingqing sun Min Li Chaoyi Guo Nan Zhou Xiaokui Guo shixin Huang Yongzhang Zhu Department of Animal Health and Food Safety School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghai 200025China Shanghai Center for Animal Disease Prevention and Control Shanghai Institute for Veterinary Drugs and Feeds ControlShanghai 201103China

Background:Antimicrobial resistance(AMR)is one of the greatest threats to animal and public ***,we conducted a dynamic surveillance of Escherichia coli on Chongming Island in Shanghai during 2009-2021 to identify the characteristics and trends of Chongming’s AMR ***:Rectal(cloaca)swabs from four poultry and nine swine farms(Chongming Island,2009-2021)were collected for *** strains *** micro-broth dilution method was used to test antimicrobial susceptibility of *** isolates against 10 antimicrobial classes including 15 *** generalized linear mixed models(GLMMs)and co-occurrence analyses,we further explored the multiple-drug-resistance(MDR)combinations and dynamic patterns of *** over 10 years in two food ***:Total of 863 MDR isolates were found among 945 collected *** isolates,337 from poultry and 608 from *** isolates exhibited high resistant rates(>70%)to tetracyclines,phenicols,sulfonamides,penicillins,and aminoglycosides(only in swine).The resistant rates of swine isolates to penicillins,aminoglycosides,tetracyclines,phenicols,and polymyxins were significantly higher than those of poultry isolates,whereas resistance to fluoroquinolones was *** to polymyxins decreased similarly in swine(42.4%in 2009 to 0.0%in 2021)and poultry isolates(from 16.5%to 0.0%).However,resistance to other seven antimicrobial classes(excluding carbapenems and penicillins)declined dramatically in swine isolates,particularly fluoroquinolones(from 80.5%to 14.4%),and tendencies of resistance to the seven classes showed markedly divergent patterns in poultry *** Poisson GLMMs,the AMR carriage since 2016 was significantly lower than that of 2009(odds ratio<1),indicating a decline in the risk of MDR ***,despite the highly diverse MDR profiles,co-occurrence analysis identified two prominent MDR clusters of penicillins-phenicols-fluoroquinolones in poultry and aminoglyco

关键词： Antimicrobial resistance Escherichia coli Food animal Longitudinal trend analysis Chongming Island Shanghai

PML边界条件下孔隙介质弹性波可变网格正演模拟方法研究

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石油物探 2015年第6期54卷 652-664页

作者：孙林洁刘春成张世鑫中海油研究总院北京100028

孔隙介质弹性波正演模拟对于储层预测和油气检测具有重要的指导意义。为提高孔隙介质波场正演模拟的精度,将可变网格方法应用于基于Biot理论的双相介质弹性波高阶有限差分正演模拟方法中,有效解决了二阶混合偏导数差分近似的可变网格过... 详细信息

孔隙介质弹性波正演模拟对于储层预测和油气检测具有重要的指导意义。为提高孔隙介质波场正演模拟的精度,将可变网格方法应用于基于Biot理论的双相介质弹性波高阶有限差分正演模拟方法中,有效解决了二阶混合偏导数差分近似的可变网格过渡问题,推导了基于PML边界条件的可变网格差分格式,实现了空间与时间步长任意整数倍变化的双相介质弹性波可变网格正演模拟。对于细微地质结构或横向变化剧烈的介质区域,利用可变网格对区域精细重采样可有效提高正演的模拟精度;对于介质相对稳定的区域,采用大步长采样可保证正演计算效率。数值试验结果表明,与常规正演模拟方法相比,双相介质可变网格正演模拟方法的精度、效率有明显提高,对精细研究孔隙介质地震响应有着重要意义。

关键词： Biot理论孔隙介质 PML边界条件可变网格有限差分

预变形温度对纳米贝氏体相变动力学及组织的影响

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金属学报 2018年第8期54卷 1113-1121页

作者：徐士新余伟李舒笳王坤孙齐松首钢集团有限公司技术研究院北京100043 北京科技大学工程技术研究院北京100083 首钢集团有限公司绿色可循环钢铁流程北京市重点实验室北京100043

采用热模拟试验机在300~850℃施加20%的压缩预变形后进行300℃等温相变实验,研究了预变形温度对中碳纳米贝氏体钢等温相变动力学及组织的影响。结果表明,预变形工艺使贝氏体相变孕育期显著缩短;低温预变形工艺使贝氏体相变在整个等温区... 详细信息

采用热模拟试验机在300~850℃施加20%的压缩预变形后进行300℃等温相变实验,研究了预变形温度对中碳纳米贝氏体钢等温相变动力学及组织的影响。结果表明,预变形工艺使贝氏体相变孕育期显著缩短;低温预变形工艺使贝氏体相变在整个等温区间内均得到加速,高温预变形工艺使贝氏体相变仅在等温初期得到加速,等温后期相变速率明显减缓;随预变形温度的降低,贝氏体铁素体板条厚度逐渐增加;预变形工艺增加了贝氏体相变组织小角度晶界的频率,低温预变形试样的小角度晶界频率高于高温预变形试样。利用解析相变模型计算了贝氏体等温相变过程中的相变动力学参数n,并对贝氏体相变过程中的形核长大方式进行了判定,发现预变形工艺改变了贝氏体相变的形核位置,低温预变形试样主要以晶隅形核为主,高温预变形试样主要以晶棱、晶面形核为主。

关键词：预变形温度纳米贝氏体相变动力学显微组织解析模型

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谐振接地电网故障选线相关分析法

电力自动化设备 2008年第9期28卷 6-9,48页

作者：束洪春徐亮彭仕欣孙向飞昆明理工大学电力学院云南昆明650051 哈尔滨工业大学电气工程系黑龙江哈尔滨150001 嘉兴电力局浙江嘉兴314000 昆明供电局云南昆明650051

对于谐振接地电网,发生故障前,故障馈线与健全馈线零模电流中的不对称分量具有较强的相似性,它们之间的互相关系数会受到不对称分量的影响。对各线路故障零模电流,用故障发生之后第1个周期采样数据对应减去故障发生前1个周期采样数据,... 详细信息

对于谐振接地电网,发生故障前,故障馈线与健全馈线零模电流中的不对称分量具有较强的相似性,它们之间的互相关系数会受到不对称分量的影响。对各线路故障零模电流,用故障发生之后第1个周期采样数据对应减去故障发生前1个周期采样数据,得到零模电流的纯故障分量。提出一种基于零模电流纯故障分量的相关分析选线方法,对各馈线故障零模电流的纯故障分量在一定数据窗下进行综合相关度分析,选择最小的综合相关系数对应的馈线为故障馈线。该选线方法具有较强的抗电弧接地能力,能有效地克服系统不对称的影响。理论分析及仿真结果表明,该方法选线结果准确、可靠,进一步提高了选线保护的裕度。

关键词：谐振接地系统故障选线纯故障分量相关分析

NCE-MRA评估动脉粥样硬化型肾动脉狭窄的应用价值

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临床放射学杂志 2020年第8期39卷 1583-1587页

作者：孙闯常时新大连医科大学附属第二医院 116027 上海中医药大学附属岳阳中西医结合医院 200437

目的以血管内超声成像(IVUS)为标准,对比CT血管造影(CTA)研究结合时间-空间双重标记反转恢复序列(Time-SLIP)的非对比增强MR血管成像(NCE-MRA)在评估动脉粥样硬化型肾动脉狭窄(ARAS)的应用价值。方法搜集29例临床确诊为ARAS并同期进行了... 详细信息

目的以血管内超声成像(IVUS)为标准,对比CT血管造影(CTA)研究结合时间-空间双重标记反转恢复序列(Time-SLIP)的非对比增强MR血管成像(NCE-MRA)在评估动脉粥样硬化型肾动脉狭窄(ARAS)的应用价值。方法搜集29例临床确诊为ARAS并同期进行了CTA和IVUS检查的患者,运用结合Time-SLIP技术采用真实稳态自由进动序列(true SSFP)对狭窄侧肾动脉进行NCE-MRA检查,评估图像质量和血管狭窄程度,分析血管最狭窄处斑块形态特征,并与CTA和IVUS结果进行比较。结果29例患者共有43支肾动脉纳入研究,NCE-MRA图像优秀31支,良好8支,一般4支。以IVUS为标准,CTA和NCE-MRA对ARAS狭窄程度评估结果有明显相关性(r=0.927,P<0.01)。以IVUS为标准,CTA和NCE-MRA总体评价AS斑块的敏感度和特异度分别为92.5%和93.3%、89.2%和91.7%(P均<0.05),其中CTA和NCE-MRA在鉴别斑块纤维组织成分具有极好的一致性(k分别=0.818和0.857,P<0.05),NCE-MRA在鉴别脂质核心和近期破裂出血与IVUS具有高度一致性(k分别=0.695和0.711,P<0.05),但CTA在鉴别斑块钙化与IVUS具有极好的一致性(k=1)。结论结合Time-SLIP的肾动脉NCE-MRA可有效应用于评估导致肾动脉狭窄的AS斑块的主要构成成分并评估其稳定性,能够为临床选择治疗措施提供比CTA更有价值的参考信息。

关键词：非增强肾动脉血管成像动脉粥样硬化