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Parallel ADR Detection Based on Spark and BCPNN

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Tsinghua Science and Technology 2019年第2期24卷 195-206页

作者： Li sun shan sun Tianlei Wang Jiyun Li Jingsheng Lin School of Computer Science and Technology Donghua University Ruijin Hospital Affiliated to shanghai Jiao Tong University

Adverse Drug Reaction(ADR) is one of the major challenges to the evaluation of drug safety in the medical field. The Bayesian Confidence Propagation Neural Network(BCPNN) algorithm is the main algorithm used by the World Health Organization to monitor ADRs. Currently, ADR reports are collected through the spontaneous reporting system. However, with the continuous increase in ADR reports and possible use scenarios, the efficiency of the stand-alone ADR detection algorithm will encounter considerable challenges. Meanwhile, the BCPNN algorithm requires a certain number of disk I/O, which leads to considerable time consumption. In this study,we propose a Spark-based parallel BCPNN algorithm, which speeds up data processing and reduces the number of disk I/O in BCPNN, and two optimization strategies. Then, the ADR data collected from the FDA Adverse Event Reporting System are used to verify the performance of the proposed algorithm and its optimization *** show that the parallel BCPNN can significantly accelerate data processing and the optimized algorithm has a high acceleration rate and can effectively prevent memory overflow. Finally, we apply the proposed algorithm to a dataset provided by a real medical consortium. Experiments further prove the performance and practical value of the proposed algorithm.

关键词： Adverse Drug Reaction (ADR) Bayesian Confidence Propagation Neural Network (BCPNN) parallel Spark

New formula for predicting the plastic buckling pressure of steel torispherical heads under internal pressure

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 618-630页

作者： Sheng YE Keming LI Jinyang ZHENG shan sun Institute of Process Equipment Zhejiang UniversityHangzhou 310027China Engineering Research Center for High Pressure Process Equipment and Safety of Ministry of Education Hangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems Hangzhou 310058China

Thin-walled torispherical heads under internal pressure can fail by plastic buckling because of compressive circumferential stresses in the head ***,existing formulas still have limitations,such as complicated expressions and low accuracy,in determining buckling *** this paper,we propose a new formula for calculating the buckling pressure of torispherical heads based on elastic-plastic analysis and experimental ***,a finite element(FE)method based on the arc-length method is established to calculate the plastic buckling pressure of torispherical heads,considering the effects of material strain hardening and geometrical *** buckling pressure results calculated by the FE method in this paper have good consistency with those of BOSOR5,which is a program for calculating the elastic-plastic bifurcation buckling pressure based on the finite difference energy ***,the effects of geometric parameters,material parameters,and restraint form of head edge on buckling pressure are ***,a new formula for calculating plastic buckling pressure is developed by fitting the curve of FE results and introducing a reduction factor determined from experimental ***,based on the experimental results,we compare the predictions of the new formula with those of existing *** is shown that the new formula has a higher accuracy than the existing ones.

关键词： Torispherical head Plastic buckling Elastic-plastic analysis Prediction formula Finite element method

The Thermal Decomposition of Calcium Carbonate

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Chinese Chemical Letters 2001年第8期12卷 745-746页

作者： Yu Ting ZHAO Tong shan sun Bing sun Department of Chemistry Shandong UniversityJinan 250100

The thermogravimetry(TG) and derivative thermogravimetry(DTG) curves of the thermal decomposition reaction of calcium carbonate have been measured at five different heating rates. The kinetic parameters and the reaction mechanism of the reaction were evaluated from analysis of the TG and DTG curves by using the Ozawa method, the combined integral and differential methods and the reduced equations derived by us.

关键词： Calcium carbonate kinetic parameters non-isothermal kinetics TG-DTG

An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota

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Chinese Journal of Natural Medicines 2019年第1期17卷 3-14页

作者： sun shan-shan WANG Kai MA Ke BAO Li LIU Hong-Wei School of Life Sciences University of Science and Technology of China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences University of Chinese Academy of Sciences

Metabolic syndrome characterized by obesity, hyperglycemia and liver steatosis is becoming prevalent all over the world. Herein, a water insoluble polysaccharide(WIP) was isolated and identified from the sclerotium of Poria cocos, a widely used Traditional Chinese Medicine. WIP was confirmed to be a(1-3)-β-D-glucan with an average Mw of 4.486 × 10~6 Da by NMR and SEC-RI-MALLS analyses. Furthermore, oral treatment with WIP from P. cocos significantly improved glucose and lipid metabolism and alleviated hepatic steatosis in ob/ob mice. 16 S DNA sequencing analysis of cecum content from WIP-treated mice indicated the increase of butyrate-producing bacteria Lachnospiracea, Clostridium. It was also observed that WIP treatment elevated the level of butyrate in gut, improved the gut mucosal integrity and activated the intestinal PPAR-γ pathway. Fecal transplantation experiments definitely confirmed the causative role of gut microbiota in mediating the benefits of WIP. It is the first report that the water insoluble polysaccharide from the sclerotium of P. cocos modulates gut microbiota to improve hyperglycemia and hyperlipidemia. Thereby, WIP from P. cocos, as a prebiotic, has the potential for the prevention or cure of metabolic diseases and may elucidate new mechanism for the efficacies of this traditional herbal medicine on the regulation of lipid and glucose metabolism.

关键词： Poria cocos Water insoluble polysaccharide Metabolic syndrome Prebiotics Gut microbiota

Wave-induced stress and estimation of its driven effect on currents

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Science China Earth Sciences 2004年第12期47卷 1147-1154页

作者： sun Fu GAO shan WANG Wei QIAN Chengchun Physical Oceanography Laboratory Ocean University of China Qingdao 266003 China Physical Oceanography Laboratory Ocean University of China Qingdao 266003 China Physical Oceanography Laboratory Ocean University of China Qingdao 266003 China Physical Oceanography Laboratory Ocean University of China Qingdao 266003 China

A genuine geostrophic small amplitude wave solution is deduced for the first time from the general form of linear fluid dynamic equations with the f-plane approximation, where the horizontal component of angular velocity of the earth rotation is taken into account. The Coriolis- induced stress obtained from this solution consists of lateral and reverse component, while its first order approximation is reduced to the result of Hasselmann or Xu Zhigang. Accordingly, combining the Coriolis-induced wave stress with the virtual wave stress proposed by Longuet-Higgins, the ratio of total wave-induced stress to wind stress on the sea surface is es- timated, through which the importance of the wave-induced stress is emphasized in the study of the currents in the seas around China, especially in the Bohai Sea and the Yellow Sea.

关键词： waves, geostrophy, stress, currents.

Recent advances of multidimensional sensing: from design to applications

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Science China Chemistry 2019年第12期62卷 1601-1618页

作者： Sihua Qian shan sun Yuhui Wang Zhongjun Li Hengwei Lin Ningbo Institute of Materials Technology&Engineering(NIMTE) Chinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Recently,multidimensional(or multi-channel)sensing methodology has attracted broad attention in the field of analytical chemistry due to its fascinating merits.A variety of multidimensional sensors based on sensor arrays,lab-on-a-molecule/nanoparticle and smart chip strategies have been designed to differentiate chemical structure and property similar analytes and complex *** recognition algorithms are usually used and allow these sensors to fulfill such *** this review,the recent advances of multidimensional sensor devices were firstly summarized,and particularly focused on their design strategies and applications in monitoring of biological active molecules,biomarkers,microbes,foods and beverages,***,some limitations and possible solutions of multidimensional sensors were *** finally,potential applications of this technique in the future were *** review would help the readers who are interested in multidimensional sensing methodology to understand the research progresses and trends.

关键词： multidimensional sensor multi-channel sensor sensor arrays smart chip lab-on-a-molecule/nanoparticle

Cryptic diversity and rampant hybridization in annual gentians on the Qinghai-Tibet Plateau revealed by population genomic analysis

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Plant Diversity 2024年第2期46卷 194-205页

作者： Peng-Cheng Fu Qiao-Qiao Guo Di Chang Qing-Bo Gao shan-shan sun School of Life Science Luoyang Normal UniversityLuoyang 471934PR China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001PR China

Understanding the evolutionary and ecological processes involved in population differentiation and speciation provides critical insights into biodiversity formation. In this study, we employed 29,865 single nucleotide polymorphisms(SNPs) and complete plastomes to examine genomic divergence and hybridization in Gentiana aristata, which is endemic to the Qinghai-Tibet Plateau(QTP) region. Genetic clustering revealed that G. aristata is characterized by geographic genetic structures with five clusters(West, East, Central, South and North). The West cluster has a specific morphological character(i.e., blue corolla) and higher values of FSTcompared to the remaining clusters, likely the result of the geological barrier formed by the Yangtze River. The West cluster diverged from the other clusters in the Early Pliocene;these remaining clusters diverged from one another in the Early Quaternary. Phylogenetic reconstructions based on SNPs and plastid data revealed substantial cyto-nuclear conflicts. Genetic clustering and D-statistics demonstrated rampant hybridization between the Central and North clusters,along the Bayankala Mountains, which form the geological barrier between the Central and North clusters. Species distribution modeling demonstrated the range of G. aristata expanded since the Last Interglacial period. Our findings provide genetic and morphological evidence of cryptic diversity in G. aristata, and identified rampant hybridization between genetic clusters along a geological *** findings suggest that geological barriers and climatic fluctuations have an important role in triggering diversification as well as hybridization, indicating that cryptic diversity and hybridization are essential factors in biodiversity formation within the QTP region.

关键词： Gentiana aristata Hybrid zone Qinghai-Tibet Plateau Plastome Nuclear SNPs

Isolation and Characterization of Nine Microsatellite Markers for Red-backed Ratsnake,Elaphe rufodorsata

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Asian Herpetological Research 2016年第3期7卷 227-228页

作者： Tianlong FU shan sun Chaonan ZHU Yanfu QU Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal University

The red-backed ratsnake（Elaphe rufodorsata） is widely distributed in East Asia, especially China. This species is a common snake in plain river network region. In the past several decades, E. rufodorsata has dramatically declined due to the effect of human activities and over hunting for traditional Chinese medicine. We developed nine species-specific microsatellite loci in 190 individuals collected from Huzhou, Zhejiang province in China. These markers revealed a high degree of genetic diversity（13–41 alleles per locus） and heterozygosity（H O ranged from 0.266 to 0.941, and H E ranged from 0.851 to 0.937）. No locus exhibited significant deviations from Hardy–Weinberg equilibrium. There was no evidence of linkage disequilibrium among pairs of loci. These microsatellite markers were described in our study will be valuable tools for the long term management and population-level studies（e.g. the population structure, genetic diversity and variation, individual paternity and evolutionary history） of the species.

关键词： microsatellite alleles backed heterozygosity linkage locus ranged snake declined evolutionary

Design of motion control system of pipeline detection AUV

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Journal of Central South University 2017年第3期24卷 637-646页

作者： JIANG Chun-meng WAN Lei sun Yu-shan Science and Technology on Underwater Vehicle Laboratory Harbin Engineering University Harbin 150001 China

A great number of pipelines in China are in unsatisfactory condition and faced with problems of corrosion and cracking,but there are very few approaches for underwater pipeline *** detection autonomous underwater vehicle(PDAUV) is hereby designed to solve these problems when working with advanced optical,acoustical and electrical sensors for underwater pipeline *** is a test bed that not only examines the logical rationality of the program,effectiveness of the hardware architecture,accuracy of the software interface protocol as well as the reliability and stability of the control system but also verifies the effectiveness of the control system in tank experiments and sea *** motion control system of PDAUV,including both the hardware and software architectures,is introduced in this *** software module and information flow of the motion control system of PDAUV and a novel neural network-based control(NNC) are also ***,a real-time identification method based on neural network is used to realize system *** tank experiments and sea trials are carried out to verify the feasibility and capability of PDAUV control system to complete underwater pipeline detection task.

关键词： pipeline detection autonomous underwater vehicle (PDAUV) novel neural network-based control motion controlsystem embedded system architecture system identification