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Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms

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World Journal of Stem Cells 2020年第9期12卷 1032-1049页

作者： Yunejin Song Jung-Yeon lim Taekyu lim Keon-Il Im Nayoun Kim Young-sun Nam Young-Woo Jeon Jong Chul Shin Hyun sun Ko In Yang Park Seok-Goo Cho Institute for Translational Research and Molecular Imaging College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Laboratory of Immune Regulation Convergent Research Consortium for Immunologic DiseaseCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Biomedicine and Health Sciences College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Precision Immunology Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Hematology Oncology Department of Internal MedicineVeterans Health Service Medical CenterSeoul 05368South Korea Department of Hematology Catholic Blood and Marrow Transplantation CenterSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Obstetrics and Gynecology CHA Bundang Medical CenterCHA UniversitySeongnam 13496South Korea Department of Obstetrics and Gynecology College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Division of Hematology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are an attractive tool to treat graft-versus-host disease because of their unique immunoregulatory *** human bone marrow-derived MSCs(BM-MSCs)were the most widely used MSCs in cell therapy until recently,MSCs derived from human umbilical cords(UC-MSCs)have gained popularity as cell therapy material for their ethical and noninvasive *** To investigate the difference in mechanisms of the immunosuppressive effects of UC-MSCs and *** To analyze soluble factors expressed by MSCs,such as indolamine 2,3-dioxygenase,cyclooxygenase-2,prostaglandin E2 and interleukin(IL)-6,inflammatory environments in vitro were reconstituted with combinations of interferon-gamma(IFN-γ),tumor necrosis factor alpha and IL-1βor with IFN-γ*** T cells were cocultured with MSCs treated with indomethacin and/or *** assess the ability of MSCs to inhibit T helper 17 cells and induce regulatory T cells,induced T helper 17 cells were cocultured with MSCs treated with indomethacin or *** graft-versus-host disease was induced in NOG mice(NOD/Shi-scid/IL-2Rγnull)and UC-MSCs or BM-MSCs were treated as cell *** Our data demonstrated that BM-MSCs and UC-MSCs shared similar phenotypic characteristics and immunomodulation ***-MSCs expressed more indolamine 2,3-dioxygenase after cytokine stimulation with different combinations of IFN-γ,tumor necrosis factor alpha-αand IL-1βor IFN-γ***-MSCs expressed more prostaglandin E2,IL-6,programmed death-ligand 1 and 2 in the in vitro inflammatory ***-2 and IL-10 were key factors in the immunomodulatory mechanisms of both *** addition,UC-MSCs inhibited more T helper 17 cells and induced more regulatory T cells than ***-MSCs and BM-MSCs exhibited similar effects on attenuating graft-versus-host *** UC-MSCs and BM-MSCs exert similar immunosuppressive effects with different mechanisms

关键词： Mesenchymal stem cells Graft-versus-host disease Umbilical cord Cell therapy Xenogeneic mouse model Immunomodulation

High-Resolution Infrared-Vacuum Ultraviolet Photoion and Pulsed Field Ionization-Photoelectron Methods for Spectroscopic Studies of Neutrals and Cations

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Chinese Journal of Chemical Physics 2008年第3期21卷 193-201页

作者： Xi Xing Beth Reed mi Kyung Bahng Peng Wang Hin Koo Woo sun Jong Baek Chee Shing Lain Cheuk Yiu Ng Department of Chemistry University of California Davis Davis California 95616 USA

我们由扫描一个单个模式的频率显示出那红外线(红外)使兴趣的分子的种类激动的光参量的振荡器( IR-OPO )激光并且修理真空的频率紫外( VUV )激光到 photoionize IR 激动的种类，多碱的 neutrals 的高分辨率的红外系列能与高敏感被获得... 详细信息

我们由扫描一个单个模式的频率显示出那红外线(红外)使兴趣的分子的种类激动的光参量的振荡器( IR-OPO )激光并且修理真空的频率紫外( VUV )激光到 photoionize IR 激动的种类，多碱的 neutrals 的高分辨率的红外系列能与高敏感被获得。这个 IR-VUV-photoion (IR-VUV-PI ) 方法基于 VUV 光电游离探查，并且这样，允许中立红外吸收器的鉴定的事实，为 isotopemers，激进分子，和簇的红外光谱学大小使它适用，它通常作为掺杂的样品存在。用单个模式 IR-OPO 激光完成的高度解决的 IR-VUV-PI 大小使 CH3X 的单个 rovibrational 状态的选择可能(X = Br 并且我) ，为搏动 VUV 的地电离光电子(VUV-PFI-PE ) 的 C2H4，和 C3H4 大小，为这些多碱的分子导致 rovibrationally 解决的光电子系列。采用高分辨率的 IR-OPO 激光获得的 IR-VUV-PI 和 IR-VUV-PFI-PE 系列的 signal-to-noise 比率比那些显著地高的这些实验表演用低分辨率的 IR-OPO 激光在以前的 IR-VUV-PI 和 IR-VUV-PFI-PE 研究观察了。在由使用 IR-VUV 激光和分子的横梁的在同一直线上的安排的 IR-VUV-PI 和 IR-VUV-PFI-PE 大小的敏感的进一步的改进被讨论。

关键词：真空紫外线红外脉冲场光电子高分辨

Organic cathode materials for rechargeable magnesium-ion batteries:Fundamentals, recent advances, and approaches to optimization

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Journal of Magnesium and Alloys 2023年第12期11卷 4359-4389页

作者： Xiaoqian He Ruiqi Cheng Xinyu sun Hao Xu Zhao Li Fengzhan sun Yang Zhan Jianxin Zou Richard M.Laine National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composites Shanghai Engineering Research Center of Mg Materials and Applications and School of Materials Science and EngineeringCenter of Hydrogen ScienceShanghai Jiao Tong UniversityShanghai 200240PR China Department of Materials Science and Engineering University of Michigan Ann ArborMI 48109-2136USA Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240PR China

Rechargeable magnesium-ion batteries(miBs) are favorable substitutes for conventional lithium-ion batteries(LIBs) because of abundant magnesium reserves, a high theoretical energy density, and great inherent safety. Organic electrode materials with excellent structural tunability,unique coordination reaction mechanisms, and environmental friendliness offer great potential to promote the electrochemical performance of miBs. However, research on organic magnesium battery cathode materials is still preliminary with many significant challenges to be resolved including low electrical conductivity and unwanted but severe dissolution in useful electrolytes. Herein, we provide a detailed overview of reported organic cathode materials for miBs. We begin with basic properties such as charge storage mechanisms(e.g., n-, p-, and bipolartype), moving to recent advances in various types of organic cathodes including carbonyl-, nitrogen-, and sulfur-based materials. To shed light on the diverse strategies targeting high-performance Mg-organic batteries, elaborate summaries of various approaches are ***, these strategies include molecular design, polymerization, mixing with carbon, nanosizing and electrolyte/separator *** review provides insights on exploring high-performance organic cathodes in rechargeable miBs.

关键词： Mg-organic batteries Organic cathode materials Energy storage Charge storage mechanism Electrochemical optimization approaches

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改进SSD算法在交通标志检测中的应用

计算机工程与应用 2023年第4期59卷 147-155页

作者：孙超温蜜景俐娜上海电力大学计算机科学与技术学院上海200090

针对交通标志检测存在误检率高、鲁棒性差等问题,提出了一种改进SSD(single shot multibox detector)的交通标志检测方法。首先从不同维度提取交通标志的位置和方向感知信息,改善目标在浅层特征图上的感受野区域。其次使用特例化的卷积... 详细信息

针对交通标志检测存在误检率高、鲁棒性差等问题,提出了一种改进SSD(single shot multibox detector)的交通标志检测方法。首先从不同维度提取交通标志的位置和方向感知信息,改善目标在浅层特征图上的感受野区域。其次使用特例化的卷积内核对深层特征图进行条件参数卷积,增强交通标志的特征表达能力。最后对通道注意力机制进行改进,在特征通道中融入目标空间信息,提升交通标志目标的显著性。实验结果表明,提出的方法相较于原始SSD在CCTSDB数据集上的检测精度提升了7.6个百分点,检测速度达到87.5 FPS;在LISA数据集上的平均准确率为94.6%,检测速率为85.0 FPS。相比于其他的检测方法,改进后的SSD算法在复杂的自然场景中对交通标志具有更好的鲁棒性。

关键词：交通标志检测 SSD 特征提取条件参数卷积注意力机制

Control Design and Implementation of a Spiral Spring Energy Storage System Connected to a Grid via PMSG

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CSEE Journal of Power and Energy Systems 2018年第3期4卷 339-351页

作者： Yang Yu Zengqiang mi Xudong Guo Xitong Niu Xiaojiang Zheng Chenjun sun State Key Laboratory of Alternate Electrical Power Systems with Renewable Energy Sources North China Electric Power UniversityBaoding 071003China State Grid Hebei Maintenance Branch Shijiazhuang 050031China Commercial Aircraft Control Information Technology(Shanghai)Co. LtdShanghai 201108China State Grid Hebei Electric Power Company Shijiazhuang 050022China

For an innovative spiral spring energy storage system,the permanent magnet synchronous generator(PMSG)is utilized as the energy conversion device due to its simple structure,low weight and high *** power generation,the output torque and moment of inertia of the spiral spring are changing continuously and simultaneously and the parameters of the PMSG show ***,the DC link voltage of the converter should be stable and the power injected into the grid needs to be ***,the change features of the external power source and the uncertainties of the generator’s internal parameters are expressed as the comprehensive disturbances,which are introduced into the dynamic model of the PMSG and also modify the dynamic ***,the high gain observers are utilized to estimate the comprehensive disturbances,and an improved robust backstepping control scheme integrating L2 gain and high gain observers is ***,the gridside inverter controller for the DC voltage loop and reactive power loop is designed based on the backstepping ***,hardware implementation is fulfilled to verify the presented *** results show that high gain observers are able to accurately estimate the external and internal interferences;the proposed control scheme can effectively suppress the external and internal interferences and guarantees output current,operating speed of the PMSG and output reactive power to correctly track respective references,and effectively stabilize the DC link voltage.

关键词： Backstepping control high gain observer L2 gain permanent magnet synchronous generator spiral spring energy storage system

基于PFC3D的粉质黏土三轴压缩破坏过程分析

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低温建筑技术 2024年第3期46卷 131-137页

作者：孙超吴多聪郭浩天吉林建筑大学测绘与勘查工程学院长春130118

为从细观角度探究粉质黏土在三轴试验加载过程中变形破坏演变过程,文中通过PFC(Particle Flow Code)3D软件模拟三轴剪切试验过程,从颗粒位移场、强接触组构变化、强接触力分布规律、配位数、黏结断裂等方面对粉质黏土变形破坏的细观演... 详细信息

为从细观角度探究粉质黏土在三轴试验加载过程中变形破坏演变过程,文中通过PFC(Particle Flow Code)3D软件模拟三轴剪切试验过程,从颗粒位移场、强接触组构变化、强接触力分布规律、配位数、黏结断裂等方面对粉质黏土变形破坏的细观演变过程进行分析研究。研究结果表明,试样剪切带随轴向应变增大而变窄,10%轴向应变时试样中部颗粒位移值最大;试验后期配位数相较于前期逐渐均匀化;黏结断裂随轴向应变的增大而呈线性增大,不完美黏结也随之增大,且试验初期没有发生黏结断裂;强接触力分布函数在试验中期显著增大而后期逐渐减小,且服从对数正态分布。研究成果以期为土体研究提供方法与参考。

关键词：粉质黏土固结不排水试验 PFC模拟黏结断裂

Improving the RF stabilities of BEPCII by a disturbance observer based controller

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Radiation Detection Technology and Methods 2021年第2期5卷 220-227页

作者： Qunyao Wang Jianping Dai Haiyin Lin Zhenghui mi Yi sun Ziwei Deng Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Background A digital low level radio frequency(DLLRF)system has been developed to replace the old analog LLRF and operated stably at BEPCII east RF station in the past two *** RF stabilities required for BEPCII are±1%in magnitude and±1 degree in *** are satisfied both by the new DLLRF and the old analog ***,the DLLRF did not improve the RF stabilities so much as expected,especially when the beam current was high in collision *** The purpose is to improve the RF stabilities further and meet the requirements by the upgraded BEPCII project(BEPC3).Method A disturbance observer based(DOB)controller to suppress the noise was developed and tested with beam at BEPCII RF *** The DOB controller works and the RF stabilities with beam may be improved from±1%to less than±0.5%in magnitude and from±1 degree to less than±0.5 degrees in phase.

关键词： RF stability Digital low-level RF(DLLRF) Disturbance-observer-based(DOB)controller

云南松幼龄林和中龄林针叶非结构性碳水化合物与碳氮磷化学计量特征分析

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西北农林科技大学学报（自然科学版） 2024年第3期52卷 30-39页

作者：刘元玺吴俊文赵志娟孙建丽肖建冬西南林业大学林学院西南地区生物多样性保育国家林业和草原局重点实验室云南昆明650224

【目的】了解亚热带地区云南松(Pinus yunnanensis)幼龄林和中龄林针叶非结构性碳水化合物(NSC)及碳(C)、氮(N)、磷(P)含量的四季动态平衡变化,以促进对不同林龄植物养分利用策略的理解。【方法】通过比较云南宜良地区云南松幼龄林(15年... 详细信息

【目的】了解亚热带地区云南松(Pinus yunnanensis)幼龄林和中龄林针叶非结构性碳水化合物(NSC)及碳(C)、氮(N)、磷(P)含量的四季动态平衡变化,以促进对不同林龄植物养分利用策略的理解。【方法】通过比较云南宜良地区云南松幼龄林(15年)和中龄林(25年)针叶NSC(可溶性糖和淀粉)含量和C、N、P含量的季节变化特征,探讨云南松幼龄林和中龄林针叶NSC含量和C、N、P化学计量特征的差异原因,以及它们之间的相关性。【结果】(1)随四季变化,云南松幼龄林和中龄林针叶可溶性糖、淀粉和NSC含量表现出不同程度的降低,可溶性糖/淀粉值先升后降,在8月最高(幼龄林为1.41,中龄林为1.85),1月最低(幼龄林为0.93,中龄林为0.88)。(2)云南松幼龄林和中龄林针叶C含量8月最低(幼龄林为389.77 g/kg,中龄林为386.10 g/kg),N含量和P含量表现为先下降后上升,且在8月份最低,1月份最高。云南松幼龄林和中龄林针叶C/N、C/P值在8月最高(幼龄林为900.25和2 624.83,中龄林为1 143.65和2 200.80),而N/P值在5月最高(幼龄林为3.38,幼龄林为2.46)。(3)云南松2个林龄林木针叶C、N、P含量与NSC含量之间呈极显著正相关;而C/N、C/P与NSC含量之间表现为极显著负相关关系,N/P与NSC含量间相关性不显著。【结论】云南松幼龄林和中龄林均通过调整其针叶NSC和C、N、P的分配应对四季气候的变化,且2个林龄间分配方式相似。在生长旺盛期(8月),云南松幼龄林和中龄林均通过增加针叶可溶性糖与淀粉之间的转化,来增强云南松针叶的生理活动;但云南松幼龄林和中龄林针叶C、N、P含量变化在生长旺盛期表现出不同的变化规律。

关键词：云南松林龄森林培育非结构性碳水化合物碳氮磷化学计量特征

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Geochemistry of rare earth elements in the mid-late Quaternary sediments of the western Philippine Sea and their paleoenvironmental significance

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Science China Earth Sciences 2014年第4期57卷 802-812页

作者： XU ZhaoKai LI TieGang WAN Shiming YIN XueBo JIANG FuQing sun HanJie JinYong CHOI DhongIl lim Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of Sciences Department of Oceanography Kunsan National University South Sea Institute Korea Institute of Ocean Science and Technology

Based on a δ18O chronology,rare earth elements(REE) and other typical elements in sediments from core MD06-3047 in the western Philippine Sea were analyzed to constrain the provenances of the sediments and investigate quantitative changes in the Asian eolian input to the study area over the last 700 *** the competing processes that might affect REE compositions,sediment provenance is the most important *** analysis suggests that the study sediments have two provenance end-members;local volcanic sources are dominant,and eolian dust from the Asian continent has a smaller *** glacial periods,eolian input to the western Philippine Sea was *** contrast,material supply from local volcanics increased during interglacial *** in eolian input to the study area were probably related to the strength of the East Asian winter monsoon(EAWM) as well as aridity in the Asian continent on an orbital time scale,and were partly influenced by local control factors on shorter time ***,we propose that the present study expands the application of the REE-based method for quantitatively estimating the eolian component from the mid-latitude northern Pacific to the low-latitude western ***,the study preliminarily confirms the influence of EAWM-transported eolian material on sedimentation in the western Philippine Sea since 700 ka.

关键词：第四纪沉积物西菲律宾海稀土元素地球化学特征古环境意义东亚冬季风亚洲大陆时间尺度