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Fundamental Research 2024年第3期4卷 660-670页

作者： Xinlu sun Zhifu mi Lu Cheng D'Maris Coffman Yu Liu The Bartlett School of Sustainable Construction University College LondonLondon WC1E 7HBUnited Kingdom College of Urban and Environmental Sciences Peking UniversityBeijing 100871China

The European Commission has proposed a Carbon Border Adjustment Mechanism(CBAM)to reduce carbon leakage and create a level playing field for its domestic products and imported ***,the effectiveness of the proposal remains unclear,especially when it triggers threats of retaliation from trading partners of the European *** apply a Computable General Equilibrium model-Global Trade Analysis Project-to assess the economic and environmental impacts of different CBAM *** we show that the effectiveness of the CBAM to address carbon leakage risks is rather limited,and the CBAM raises concerns over global welfare costs,Correct to Gross Domestic Product(GDP)losses,and violation of equality *** retaliation leads to multiplied welfare losses,which would mostly be borne by poor *** results question the carbon leakage reduction effect of a unilateral trade policy and suggest that climate change mitigation still needs to be performed within the framework of international cooperation.

关键词： Carbon border adjustment mechanism Carbon leakage Climate change mitigation Floorcarbon price Trade retaliation

Filiform polyposis in the sigmoid colon: A case series

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World Journal of Gastroenterology 2010年第19期16卷 2443-2447页

作者： Chang Geun Lee Yun Jeong Lim Jong sun choi Jin Ho Lee Department of Internal Medicine Dongguk University-Seoul Graduate School of Medicine Goyang 411-773 South Korea

Filiform polyposis is a rare condition of uncertain patho-genesis that is usually found in association with Crohn’s disease, ulcerative colitis, intestinal tuberculosis or histiocytosis X. We report seven interesting cases of polyposis with various pathologic components, mainly located in the left side of the colon with no associated inflammatory bowel disease, intestinal tuberculosis or histiocytosis X. Multiple finger-like polypoid lesions with the appearance of stalactites were noted on the left side of the colon, especially in the sigmoid area, at the time of colonoscopy. The polyps had a variety of sizes and shapes and were shown to have various histopathologic components among the different patients. Although filiform polyposis localized in the sigmoid colon appears not to have high oncogenic potential, periodic follow-up seems to be needed.

关键词： Filiform polyposis Sigmoid colon Inflammatory bowel disease

Image-guided conservative management of right colonic diverticulitis

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World Journal of Gastroenterology 2009年第46期15卷 5838-5842页

作者： sun Jin Park sung II choi Suk Hwan Lee Kil Yeon Lee Department of Surgery Kyung Hee University School of Medicine

AIM： To study the clinical outcomes of medical therapy in patients with right colonic diverticulitis. METHODS： The records of 189 patients with right colonic diverticulitis which was finally diagnosed by computed tomography, ultrasonography, or operative findings were retrospectively reviewed. RESULTS： Of the 189 patients hospitalized for right colonic diverticulitis, the stages of diverticulitis by a modified Hinchey classification were 26 patients （13.8%） in stage 0, 139 patients （73.5%） in stage I a, 23 patients （12.2%） in stage I b, and 1 patient （0.5%） in stage Ⅲ. Medical therapy was undertaken in 185 of 189 patients （97.9%）. One hundred and eighty three of 185 patients were successfully treated with bowel rest and antibiotics. Two patients in stage I b required a resection or surgical drainage because of an inadequate response to conservative treatment. Recurrent diverticulitis developed in 15 of 183 patients （8.2%） who responded to medical therapy. All 15 patients who suffered a second attack had uncomplicated diverticulitis, and were successfully treated with medical ***： Our results indicate that right colonic diverticulitis is essentially benign and image-guided conservative treatment is primarily required.

关键词： Ascending colon Cecum Medical therapy Colonic diverticulitis

α-Lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats

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World Journal of Gastroenterology 2005年第31期11卷 4883-4885页

作者： sung-Joo Park Sang-Wan Seo Ok-sun choi Cheung-Seog Park Department of Pharmacology 1 Hoegi-dong

AIM: α-Lipoic acid (ALA) has been used as an *** aim of this study was to investigate the effect of α-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in ***: ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 μg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase,amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced ***: ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However,the secretion of IL-1β, IL-6, and TNF-α were comparable in CCK octapeptide-induced acute ***: ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.

关键词： α-Upoic add AoJte pancreatitis Proinflammatory cytokines Cholecystokinin

Single port laparoscopic right hemicolectomy with D3 dissection for advanced colon cancer

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World Journal of Gastroenterology 2010年第2期16卷 275-278页

作者： sung Il choi Kil Yeon Lee sun Jin Park Suk-Hwan Lee Department of Surgery School of MedicineKyung Hee University#1 Hoegi-dong Dongdaemun-guSeoul 130-702 South Korea

We report the first case of single port laparoscopic right hemicolectomy for advanced colon *** abdominal 3 cm length incision was made via the umbilicus.A small wound retractor and a surgical glove were used as a single *** soft tissue anterior to the superior mesenteric vein was completely removed and D3 lymph node dissection was *** total operative time was 180 min with minimal blood loss (<50 mL).The size of the tumor was 5 cm×3 cm and its tumor stage was ***-nine lymph nodes were harvested and none were *** believe that single port surgery for colon cancer is a feasible and safe procedure with surgical results comparable to conventional laparoscopic procedures.

关键词： Single port laparoscopic surgery Colon cancer D3 lymph node dissection

Laparoscopic resection of an adrenal pseudocyst mimicking a retroperitoneal mucinous cystic neoplasm

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World Journal of Gastroenterology 2009年第23期15卷 2923-2926页

作者： Bum-Soo Kim sun-Hyung Joo sung-Il choi Jeong-Yoon Song Division of Hepatobiliary Surgery Department of Surgery Kyung Hee University College of Medicine and East-West Neo Medical Center 149 Sangil-dong Gangdong-gu Seoul 134-727 South Korea

Adrenal pseudocysts are rare cystic masses that arise within the adrenal gland and are usually non-functional and asymptomatic. Adrenal pseudocysts consist of a fibrous wall without a cellular lining. We report a patient with a 9 cm, left-sided suprarenal cystic mass who presented with abdominal discomfort of 2 years＇ duration. A 38-year-old woman was referred to our service for evaluation of abdominal discomfort and gastrointestinal symptoms. Routine laboratory tests were within normal limits. An abdominal computed tomography scan showed a 9 cm × 8 cm × 8 cm well-defined cystic lesion displacing the left kidney. Magnetic resonance imaging showed a cystic lesion with low signal intensity on the Tl-weighted image and high signal intensity on the T2-weighted image. A laparoscopic left adrenalectomy was performed to diagnose the lesion. The final pathology showed an adrenal pseudocyst without a cellular lining. The patient had no postoperative complications and she was discharged four days after surgery.

关键词： Adrenal gland Pseudocyst Laparoscopy Adrenalectomy

COVID-19 Stay-At-Home Orders and Older Adults’ Cognitive Health — United States, June 2018–February 2022

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China CDC weekly 2022年第45期4卷 1002-1006,I0003页

作者： Nam sun choi Tianzi Li Jingxiang Pan Selena Yue Jing Li Department of Population Health Sciences Weill Cornell Medical CollegeCornell UniversityNew YorkNYU.S. The Comparative Health Outcomes Policy and Economics(CHOICE)InstituteSchool of PharmacyUniversity of WashingtonSeattleWAU.S.

What is already known about this topic?Lack of social activities is known to negatively impact cognitive functioning and increase risk of cognitive impairment,including dementia,among older *** is added by this report?Coronavirus disease 2019(COVID-19)stay-at-home orders implemented in the *** during the pandemic were not found to negatively affect cognitive functioning of older *** are the implications for public health practice?There may have been no severe,unintended consequences of the COVID-19 stay-at-home orders in terms of their impact on cognitive functioning and risk of dementia among older adults,lending further support to use of such orders.

关键词： impairment consequences COV

Effect of SMAD7 gene overexpression on TGF-β1-induced profibrotic responses in fibroblasts derived from Peyronie＇s plaque

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Asian Journal of Andrology 2015年第3期17卷 487-492页

作者： min Ji choi Kang-Moon Song Jin-mi Park mi-Hye Kwon Ki-Dong Kwon Soo-Hwan Park Dong-Soo Ryu Ji-Kan Ryu Jun-Kyu Suh Department of Urology National Research Center for Sexual Medicine Inha University School of Medicine Incheon 400-711 Korea Department of Urology Changwon Samsung Medical Center Changwon 630-522 Korea Inha Research Institute for Medical Sciences Inha University School of Medicine Incheon 400-711 Korea

Transforming growth factor-β1 （TGF-β1） has been identified as one of the most important fibrogenic cytokines associated with Peyronie＇s disease （PD）. The mothers against decapentaplegic homolog 7 （SMAD7） is an inhibitory Smad protein that blocks TGF-J3 signaling pathway. The aim of this study was to examine the anti-fibrotic effect of the SMAD7 gene in primary fibroblasts derived from human PD plaques. PD fibroblasts were pretreated with the SMAD7 gene and then stimulated with TGF-β1. Treated fibroblasts were used for Western blotting, fluorescent immunocytochemistry, hydroxyproline determination, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assays. Overexpression of the SMAD7 gene inhibited TGF-β1-induced phosphorylation and nuclear translocation of SMAD2 and SMAD3, transdifferentiation of fibroblasts into myofibroblasts, and quashed TGF-β1-induced production of extracellular matrix protein and hydroxyproline. Overexpression of the SMAD7 gene decreased the expression of cyclin D1 （a positive cell cycle regulator） and induced the expression of poly （ADP-ribose） polymerase 1, which is known to terminate Smad-mediated transcription, in PD fibroblasts. These findings suggest that the blocking of the TGF-β pathway by use of SMAD7 may be a promising therapeutic strategy for the treatment of PD.

关键词： cell culture decapentaplegic homolog 7 fibrosis Peyronie's disease transforming growth factor-beta

Bio-Manufacturing Research Center at Tsinghua University

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Bio-Design and Manufacturing 2019年第2期2卷 137-143页

作者： Ting Zhang Feng Lin Tao Xu Lei Zhang Rui Yao Yuan Pang Shengli mi Shaohua Ma Wei sun Biomanufacturing Center Department of Mechanical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China Biomanufacturing and Medical Devices Frontier Innovation Center Department of Mechanical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing 100084People’s Republic of China “Biomanufacturing and Engineering Living Systems”Innovation International Talents Base(111 Base) Beijing 100084People’s Republic of China Biomanufacturing Engineering Laboratory of Shenzhen Graduate School at ShenzhenTsinghua UniversityShenzhen 518055People’s Republic of China Tsinghua.Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055People’s Republic of China

Overview and research infrastructure As one of the leading laboratories in the interdisciplinary field of additive manufacturing and bio-3D printing,the Bio-Manufacturing Center at Tsinghua University is highly dedicated to conducting cutting-edge research in the emerging field of *** latter is comprised of research involving biomaterials,living cells,proteins,and/or other biological compounds as basic building blocks to fabricate biomimetic structures,in vitro functional biological models and/or cellular systems with application to tissue engineering,regenerative medicine,disease pathogenesis,drug screening,and tissue/organ-on-a-chip.

关键词： Tsinghua University living cell Pathogenesis of disease

Optimization of Solid-Phase Extraction Conditions for Perfluorooctanoic Acid in Leachate

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Wuhan University Journal of Natural Sciences 2022年第4期27卷 341-348页

作者： WANG Ying ZENG Xiaolan YU Zhipeng JIN Jiyuan mi Ruidong sun Yuan Power China Chengdu Engineering Corporation Limited Chengdu 610072SichuanChina College of Environment and Ecology Chongqing UniversityChongqing 400045China

In order to optimize the solid phase extraction(SPE)conditions of perfluorooctanoic acid(PFOA)in the raw leachate and treated leachate,the effects of activator properties,SPE cartridge,p H value,ionic strength,and eluent properties were studied through single factor *** optimal results of each single factor were *** that the concentration of PFOA in the treated leachate is lower than that of the raw leachate,the SPE conditions of the treated leachate have been further *** on the above single-factor experiment,the main influencing factors were screened out as the volume of activator,ionic strength,and volume of eluent,and the three-factor threelevel response surface methodology(RSM)was *** optimum SPE conditions of PFOA from treated landfill leachate were as follows:Activation of weak anion exchange(WAX)cartridge with 10 mL methanol,dosage of 600 mg KCl,6 m L 1%ammonia methanol eluted PFOA,the theory recovery rate is over95.67%.It has been verified that the error between the predicted value and the actual extraction recovery is small and has good repeatability.

关键词： response surface methodology(RSM) box-behnken design perfluorooctanoic acid solid phase extraction detection method