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Metabolites and micronutrition in modulating amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第6期19卷 1183-1184页

作者： Katerina Claud Jun sun Department of Medicine University of Illinois ChicagoChicagoILUSA Jesse Brown VA Medical Center Chicago ChicagoILUSA

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative *** majority of ALS cases are sporadic with only about 20%of familial *** in families with genetic predisposition,there is significant phenotypic va... 详细信息

关键词： sclerosis amyotrophic cases

An Encode-and CRT-Based Scalability Scheme for Optimizing Transmission in Blockchain

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1733-1754页

作者： Qianqi sun Fenhua Bai Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China

Blockchain technology has witnessed a burgeoning integration into diverse realms of economic and societal ***,scalability challenges,characterized by diminished broadcast efficiency,heightened communication overhead,and escalated storage costs,have significantly constrained the broad-scale application of *** paper introduces a novel Encode-and CRT-based Scalability Scheme(ECSS),meticulously refined to enhance both block broadcasting and ***,ECSS categorizes nodes into distinct domains,thereby reducing the network diameter and augmenting transmission ***,ECSS streamlines block transmission through a compact block protocol and robust RS coding,which not only reduces the size of broadcasted blocks but also ensures transmission ***,ECSS utilizes the Chinese remainder theorem,designating the block body as the compression target and mapping it to multiple modules to achieve efficient storage,thereby alleviating the storage burdens on *** evaluate ECSS’s performance,we established an experimental platformand conducted comprehensive *** results demonstrate that ECSS attains superior network scalability and stability,reducing communication overhead by an impressive 72% and total storage costs by a substantial 63.6%.

关键词： Blockchain network coding block compression transmission optimization

Strong Subgame Consistency of the Core in Stochastic Network Formation Games

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Journal of the Operations Research Society of China 2024年第1期12卷 189-213页

作者： Ping sun Elena Parilina Faculty of Applied Mathematics and Control Processes Saint Petersburg State UniversitySaint Petersburg199034Russia

We consider a model of network formation as a stochastic game with random duration proposed initially in sun and Parilina(Autom Remote Control 82(6):1065–1082,2021).In the model,the leader first suggests a joint project to other players,i.e.,the network connecting ***,the players are allowed to form fresh links with each other updating the initially proposed *** stage payoff of any player is defined depending on the network *** are two types of randomness in the network formation process:(i)links may fail to be formed with different probabilities although players intend to establish them,(ii)the game process may terminate at any stage or transit to the next stage with a certain probability ***,a network is formed as a result of players’decisions and realization of random *** cooperative version of the stochastic game is *** particular,we examine the properties of subgame consistency as well as strong subgame consistency of the *** provide a payment mechanism or regularization of the core elements to sustain its subgame consistency and avoid the player’s deviations from the cooperative *** addition,the distribution procedure of the core elements is regularized in case there are negative payments to achieve only nonnegative payments to the players at any *** sufficient condition of a strongly subgame consistent core is also *** illustrate our theoretical results with a numerical example.

关键词： Stochastic game Network formation Core Strong subgame consistency

Co-doped Ni_(3)S_(2) nanosheet array: A high-efficiency electrocatalyst for alkaline seawater oxidation

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Nano Research 2024年第3期17卷 1050-1055页

作者： Meng Yue Xun He Shengjun sun Yuntong sun Mohamed S.Hamdy Mhamed Benaissa Alsamani A.M.Salih Jun Liu Xuping sun College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Chemical Engineering College of EngineeringUniversity of Ha’ilP.O.Box 2440Ha’il 81441Saudi Arabia Department of Otolaryngology-Head&Neck Surgery West China HospitalSichuan UniversityChengdu 610041China

Developing efficient and durable oxygen evolution reaction(OER)catalysts holds great promise for green hydrogen production via seawater electrolysis,but remains a ***,we report a Co-doped Ni_(3)S_(2) nanosheet array on Ni foam(Co-Ni_(3)S_(2)/NF)as a high-efficiency OER electrocatalyst for *** alkaline conditions,Co-Ni_(3)S_(2)/NF requires an overpotential of only 368 mV to drive 100 mA·cm^(–2),superior to Ni_(3)S_(2)/NF(385 mV).Besides,it exhibits at least 50-h continuous electrolysis.

关键词： Co doping Ni_(3)S_(2)nanosheet array oxygen evolution reaction seawater electrolysis electrocatalyst

Defects and morphology engineering for constructing V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S nanotube heterojunction arrays toward efficient bifunctional electrocatalyst for overall water splitting

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Journal of Energy Chemistry 2024年第7期94卷 29-40页

作者： Wenyuan sun Alan Meng Lei Wang Guicun Li Jinfeng Cui Yongkai sun Zhenjiang Li College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Key Laboratory of Optic-electric Sensing and Analytical Chemistryfor Life Science MOE College of Chemistry and Molecular EngineeringQingdao Universityof Science and TechnologyQingdao 266042ShandongChina College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Qingdao Huanghai University Qingdao 266000ShandongChina College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061ShandongChina

The development of highly active,stable and inexpensive electrocatalysts for hydrogen production by defects and morphology engineering remains a great ***,S vacancies-rich Ni_(3)S_(2)@Cu_(2)S nan-otube heterojunction arrays were in-situ grown on copper foam(V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF)for efficient electrocatalytic overall water *** the merits of nanotube arrays and efficient electronic mod-ulation drived by the OD vacancy defect and 2D heterojunction defect,the resultant V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF electrocatalyst exhibits excellent electrocatalytic activity with a low overpotential of 47 mV for the hydrogen evolution reaction(HER)at 10 mA cm^(-2) current density,and 263 mV for the oxygen evolution reaction(OER)at 50 mA cm^(-2) current density,as well as a cell voltage of 1.48 V at 10 mA cm^(-2).Moreover,the nanotube heterojunction arrays endows V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF with outstanding stability in long-term catalytic processes,as confirmed by the continuous chronopotentiom-etry tests at current densities of 10 mA cm^(-2) for 100 h.

关键词： Nanotubearrays Heterojunction Vacancy Bifunctional electrocatalyst Overall water splitting

NADPH oxidase 4(NOX4)as a biomarker and therapeutic target in neurodegenerative diseases

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Neural Regeneration Research 2024年第9期19卷 1961-1966页

作者： Napissara Boonpraman sun Shin Yi BK21 four Program Department of Medical SciencesSoonchunhyang UniversityAsanSouth Korea Department of Biomedical Laboratory Science Soonchunhyang UniversityAsanSouth Korea iConnectome Co.Ltd.CheonanSouth Korea

Diseases like Alzheimer’s and Parkinson’s diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NADPH oxidase 4, is viewed as a potential therapeutic touchstone and indicative marker for these ailments. This in-depth review brings to light distinct features of NADPH oxidase 4, responsible for generating superoxide and hydrogen peroxide, emphasizing its pivotal role in activating glial cells, inciting inflammation, and disturbing neuronal functions. Significantly, malfunctioning astrocytes, forming the majority in the central nervous system, play a part in advancing neurodegenerative diseases, due to their reactive oxygen species and inflammatory factor secretion. Our study reveals that aiming at NADPH oxidase 4 within astrocytes could be a viable treatment pathway to reduce oxidative damage and halt neurodegenerative processes. Adjusting NADPH oxidase 4 activity might influence the neuroinflammatory cytokine levels, including myeloperoxidase and osteopontin, offering better prospects for conditions like Alzheimer’s disease and Parkinson’s disease. This review sheds light on the role of NADPH oxidase 4 in neural degeneration, emphasizing its drug target potential, and paving the path for novel treatment approaches to combat these severe conditions.

关键词： Alzheimer’s disease astrocytes mitochondrial dysfunction myeloperoxidase NADPH oxidase 4 NADPH oxidase 4 inhibitors neurodegenerative diseases osteopontin Parkinson’s disease reactive oxygen species

Insight into the development of electrolytes for aqueous zinc metal batteries from alkaline to neutral

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Chinese Chemical Letters 2024年第2期35卷 232-241页

作者： An Duan Sha Luo Wei sun School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China

Aqueous zinc metal batteries are considered as promising candidates for next-generation electrochemical energy storage devices,especially for large-scale energy storage,due to the advantages of high-safety,high energy density and low *** the bridge connecting cathode and anode,electrolyte provides a realistic operating *** alkaline and neutral aqueous zinc metal batteries,issues associated with electrolyte and anode are still *** this review,we reveal the development and evolution of electrolytes for aqueous zinc metal batteries from alkaline to neutral via the description of fundamentals and challenges in terms of comparison and *** also elaborate the strategies in electrolytes regulation and highlight the basic roles and progresses in additives engineering.

关键词： Aqueous electrolytes Zinc metal batteries pH-dependent chemistry Electrolyte regulation Additives engineering

Experimental and simulation research on hollow AZ31 magnesium alloy three-channel joint by hot extrusion forming with sand mandrel

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Journal of Magnesium and Alloys 2024年第1期12卷 98-109页

作者： Shi Shengnan Wang Hongyu Teng Fei Jiang Lei sun Juncai sun Jie Zhang Shunhu Transportation Engineering College Dalian Maritime UniversityDalianLiaoning 106026China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangLiaoning 110819China Shagang School of Iron and Steel Soochow UniversitySuzhouJiangsu 215021China

Magnesium alloy is one of the lightest metal structural *** weight is further reduced through the hollow ***,the hollow structure is easily damaged during *** order to maintain the hollow structure and to transfer the stresses during the high temperature deformation,the sand mandrel is *** this paper,the hollow AZ31 magnesium alloy three-channel joint is studied by hot extrusion *** as one of solid granule medium is used to fill the hollow magnesium *** extrusion temperatures are 230℃ and 300℃,*** process parameters(die angle,temperature,bottom thickness,sidewall thickness,edge-to-middle ratio in bottom,bottom shape)of the hollow magnesium alloy are analyzed based on the results of experiments and the finite element *** results are shown that the formability of the hollow magnesium alloy will be much better when the ratio of sidewall thickness to the bottom thickness is 1:*** when edge-to-middle ratio in bottom is about 1:1.5,a better forming product can be *** best bottom shape in these experiments will be convex based on the forming *** grain will be refined obviously after the *** the microstructures will be shown as *** these lines will be well agreement with the mold in the corner.

关键词： AZ31 magnesium alloy Three-channel joint Sand Experiments and the finite element Die angle

Towards Data-Driving Multi-View Evaluation Framework for Scratch

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Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： Xiaolin Chai Yan sun Yan Gao Department of Computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:Computational Thinking(CT)ability,visual presentation aesthetics,and code *** them,the assessment of CT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch Computational Thinking(CT) visual aesthetic static analysis integration policy machine learning