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Development and validation of a nutrition-related genetic-clinical-radiological nomogram associated with behavioral and psychological symptoms in Alzheimer’s disease

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中华医学杂志(英文版) 2024年第18期137卷 2023 Nov 29页

作者： Jiang Jiwei Liu Yaou Wang Anxin Zhuo Zhizheng Shi Hanping Zhang Xiaoli Li Wenyi sun mengfan Jiang Shirui Wang Yanli Zou Xinying Zhang Yuan Jia Ziyan Xu Jun Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China National Clinical Research Center for Neurological Diseases Beijing China Department of Radiology Beijing Tiantan Hospital Capital Medical University Beijing China Department of Gastrointestinal Surgery Beijing Shijitan Hospital Capital Medical University Beijing China Department of Clinical Nutrition Beijing Shijitan Hospital Capital Medical University Beijing China Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China

Background: Few evidence is available in the early prediction models of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD). This study aimed to develop and validate a novel genetic-clinical-radiological nomogram for evaluating BPSD in patients with AD and explore its underlying nutritional ***: This retrospective study included 165 patients with AD from the Chinese Imaging, Biomarkers, and Lifestyle (CIBL) cohort between June 1, 2021, and March 31, 2022. Data on demographics, neuropsychological assessments, single-nucleotide polymorphisms of AD risk genes, and regional brain volumes were collected. A multivariate logistic regression model identified BPSD-associated factors, for subsequently constructing a diagnostic nomogram. This nomogram was internally validated through 1000-bootstrap resampling and externally validated using a time-series split based on the CIBL cohort data between June 1, 2022, and February 1, 2023. Area under receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) were used to assess the discrimination, calibration, and clinical applicability of the ***: Factors independently associated with BPSD were:CETP rs1800775 (odds ratio [OR] = 4.137, 95% confidence interval [CI]: 1.276-13.415,P = 0.018), decreased Mini Nutritional Assessment score (OR = 0.187, 95% CI: 0.086-0.405,P <0.001), increased caregiver burden inventory score (OR = 8.993, 95% CI: 3.830-21.119,P <0.001), and decreased brain stem volume (OR = 0.006, 95% CI: 0.001-0.191,P = 0.004). These variables were incorporated into the nomogram. The area under the ROC curve was 0.925 (95% CI: 0.884-0.967,P <0.001) in the internal validation and 0.791 (95% CI: 0.686-0.895,P <0.001) in the external validation. The calibration plots showed favorable consistency between the prediction of nomogram and actual observations, and the DCA showed that the model was clinically useful in both validatio

关键词： Alzheimer’s disease Behavioral and psychological symptoms Nutrition Brain stem Cholesterol ester transfer proteins Nomogram

猪急性腹泻综合征冠状病毒分子检测方法研究进展

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现代畜牧兽医 2024年第7期 70-74页

作者：申秋平黄子惠孙丽孙梦凡蔡恒庄林林江苏农林职业技术学院江苏镇江212400

猪急性腹泻综合征冠状病毒(swine acute diarrhea syndrome coronavirus,SADS-CoV)是一种新型猪α冠状病毒,可引起5日龄以下仔猪出现剧烈呕吐、腹泻和脱水,并导致高死亡率。早期、精准诊断对科学防控SADS-CoV感染具有重要的现实意义。... 详细信息

猪急性腹泻综合征冠状病毒(swine acute diarrhea syndrome coronavirus,SADS-CoV)是一种新型猪α冠状病毒,可引起5日龄以下仔猪出现剧烈呕吐、腹泻和脱水,并导致高死亡率。早期、精准诊断对科学防控SADS-CoV感染具有重要的现实意义。文章介绍了SADS-CoV分子检测方法研究进展,包括酶联免疫吸附试验(ELISA)、逆转录聚合酶链式反应(RT-PCR)及其衍生技术(多重RT-PCR、荧光定量RT-PCR、多重荧光定量RT-PCR、微滴数字PCR)、核酸等温扩增技术[环介导等温扩增(LAMP)、重组酶聚合酶扩增(RPA)],对上述检测方法的优缺点进行了总结和讨论,并对SADS-CoV分子检测方法的未来发展方向进行了展望,以期为科学防控SADS-CoV提供参考。

关键词： SADS-CoV ELISA RT-PCR LAMP RPA

Nutrition in Alzheimer's disease:a review of an underappreciated pathophysiological mechanism

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Science China(Life Sciences) 2023年第10期66卷 2257-2279页

作者： Jiwei Jiang Hanping Shi Shirui Jiang Anxin Wang Xinying Zou Yanli Wang Wenyi Li Yuan Zhang mengfan sun Qiwei Ren Jun Xu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for Neurological Diseases Beijing 100070China Department of Gastrointestinal Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing 100038China

Alzheimer's disease(AD)is the leading cause of dementia in older individuals and is an escalating challenge to global public *** therapy of AD is one of the well-funded areas;however,little progress has been made due to the complex *** evidence has demonstrated that modifying risk factors and lifestyle may prevent or delay the incidence of AD by 40%,which suggests that the management should pivot from single pharmacotherapy toward a multipronged approach because AD is a complex and multifaceted ***,the gut-microbiota-brain axis has gained tremendous traction in the pathogenesis of AD through bidirectional communication with multiple neural,immune,and metabolic pathways,providing new insights into novel therapeutic *** nutrition is an important and profound environmental factor that influences the composition and function of the *** Nutrition for Dementia Prevention Working Group recently found that dietary nutrition can affect cognition in AD-related dementia directly or indirectly through complex interactions of behavioral,genetic,systemic,and brain ***,considering the multiple etiologies of AD,nutrition represents a multidimensional factor that has a profound effect on AD onset and ***,mechanistically,the effect of nutrition on AD is uncertain;therefore,optimal strategies or the timing of nutritional intervention to prevent or treat AD has not been ***,this review summarizes the current state of knowledge concerning nutritional disorders,AD patient and caregiver burden,and the roles of nutrition in the pathophysiology of *** aim to emphasize knowledge gaps to provide direction for future research and to establish optimal nutrition-based intervention strategies for AD.

关键词： Alzheimer's disease nutrition diet pathogenesis metabolism brain-gut axis

Genomic selection of eight fruit traits in pear

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Horticultural Plant Journal 2024年第2期10卷 318-326页

作者： Manyi sun Mingyue Zhang Satish Kumar mengfan Qin Yueyuan Liu Runze Wang Kaijie Qi Shaoling Zhang Wenjing Chang Jiaming Li Jun Wu College of Horticulture State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjingJiangsu 210095China State Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTai'anShandong 271018China The New Zealand Institute for Plant and Food Research Limited Private Bag 1401Havelock North 4157New Zealand Zhongshan Biological Breeding Laboratory NanjingJiangsu 210014China

Genomic selection (GS) has the potential to improve selection efficiency and shorten the breeding cycle in fruit tree breeding. In this study,we evaluated the effect of prediction methods, marker density and the training population (TP) size on pear GS for improving its performance and reducing cost. We evaluated GS under two scenarios:(1) five-fold cross-validation in an interspecific pear family;(2) independent validation. Based on the cross-validation scheme, the prediction accuracy (PA) of eight fruit traits varied between 0.33 (fruit core vertical diameter)and 0.65 (stone cell content). Except for single fruit weight, a slightly better prediction accuracy (PA) was observed for the five parametrical methods compared with the two non-parametrical methods. In our TP of 310 individuals, 2 000 single nucleotide polymorphism (SNP) markers were sufficient to make reasonably accurate predictions. PAs for different traits increased by 18.21%-46.98%when the TP size increased from 50to 100, but the increment was smaller (-4.13%-33.91%) when the TP size increased from 200 to 250. For independent validation, the PAs ranged from 0.11 to 0.45 using rrBLUP method. In summary, our results showed that the TP size and SNP numbers had a greater impact on the PA than prediction methods. Furthermore, relatedness among the training and validation sets, and the complexity of traits should be considered when designing a TP to predict the test panel.

关键词： Pear Pyrus Prediction method TP size SNP marker number

本体感觉神经促进技术联合核心稳定性训练对功能性踝关节不稳患者下肢功能康复的影响

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中华物理医学与康复杂志 2017年第11期39卷 834-838页

作者：孙孟凡扈盛武汉体育学院运动康复研究中心武汉430079

目的观察本体感觉神经促进技术（PNF）联合核心稳定性训练对功能性踝关节不稳（FAI）患者下肢功能康复的影响。方法选取FAI患者20例，按随机数字表法分为实验组和对照组，每组患者10例。2组患者均采用常规康复训练，对照组在此基础上增... 详细信息

目的观察本体感觉神经促进技术（PNF）联合核心稳定性训练对功能性踝关节不稳（FAI）患者下肢功能康复的影响。方法选取FAI患者20例，按随机数字表法分为实验组和对照组，每组患者10例。2组患者均采用常规康复训练，对照组在此基础上增加躁关节肌力训练和本体感觉训练；实验组则在常规康复训练的基础上增加PNF联合核心稳定性训练。2组患者均于治疗前和治疗12次后（治疗后）采用Cumberland踝关节不稳定评价问卷（CAIT）、踝关节等速向心肌力测试、踝关节本体感觉测试、星形偏移平衡测试（SEBT）进行评定。结果治疗后，2组患者的CAIT评分与组内治疗前比较差异均有统计学意义（P〈0．01），且实验组治疗后的CAIT评分与对照组比较，差异亦有统计学意义（P〈O．05）。治疗后，2组患者的踝关节等速肌力测试、本体感觉测试与组内治疗前比较，差异均有统计学意义（P〈O．05）。治疗后，实验组SEBT测试各项数值与组内治疗前比较，差异均有统计学意义（P〈0．05），且实验组治疗后的外后（PLAT）、后（POST）、内后（PMED）、内（MediM，MED）、内前（AMED）5个方向上SEBT测试数值与对照组治疗后比较，差异均有统计学意义P〈0．05）。结论PNF联合核心稳定性训练可改善FAI患者踝关节的功能（肌力和本体感觉）和下肢动态平衡能力。

关键词：功能性踝关节不稳康复训练本体感觉神经促进技术核心训练

Divergent responses of runoff to climate change in the upper basins of the Third Pole dominated by westerlies and monsoon

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Science China Earth Sciences 2024年第8期67卷 2592-2614页

作者： Qikai sun Fengge SU He sun State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China

The diverse climates,distribution of snow and glaciers,and geographic locations directly affect the runoff response to climate change in the upper basins of the Third *** present,a comprehensive analysis of runoff variations and their distinct responses to climate change in the westerlies-and monsoon-dominated upper basins is still *** study comprehensively analyzed annual runoff variations in westerlies-dominated basins(the upper basins of the Aksu(UAKS),Syr Darya(USRD),Yarkant(UYK),Hotan(UHT),Amu Darya(UAMD),and Indus(UI))and monsoon-dominated basins(the upper basins of the Yangtze(UYA),Yellow(UYE),Lancang(ULC),Nujiang(UNJ),and Yarlung Zangbo(UYZ))of the Third Pole from 1961 *** multi-source meteorological data and large-scale circulation factors,this study investigated the divergent responses of runoff in the upper basins to climate change,and explored the large-scale circulation mechanisms underlying runoff variations in these upper *** results showed that:(1)The annual runoff in the majority of upper basins(except for the UYE and UYZ)exhibited an increasing trend,and the annual runoff in the UAKS,UYK,and UI showed a significant increasing trend from1961 to *** annual runoff in the upper basins of the Third Pole changed abruptly from decreasing to increasing between the 1980s and 2000s,with the exception of the UYE.(2)The runoff in the monsoon-dominated upper basins has been controlled primarily by changes in precipitation over the past 55 *** contrast,the runoff in the westerlies-dominated upper basins exhibited three distinct long-term responses to climate change:temperature-dominated(UYK and UHT),precipitation-dominated(USRD and UAMD),and the combined influence of precipitation and temperature(UAKS and UI).Since the 1960s,the sensitivity of runoff to warm season temperature changes in the most westerlies-dominated upper basins has decreased,while the response of runoff to precipitation changes has intensified.(3)The stud

关键词： Upper basins of the Third Pole Climate change Westerlies and monsoon Runoff variations Large-scale circulation factors

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New perspectives on deep carbon cycling

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Science China Earth Sciences 2024年第8期67卷 2411-2422页

作者： Weidong sun Center of Deep Sea Research Key Laboratory of Ocean Observation and ForecastingInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The proto-atmosphere serves as a crucial starting point for the carbon *** based on atmospheric data from Mars and Venus suggest that Earth's proto-atmosphere contained>110 bar of CO_(2)and>2.6 bar of *** protoatmosphere had over 1000 bar of water vapor during the magma ocean stage,assuming the proto-ocean had a volume of two oceans of *** this stage both water and carbon dioxide were in a supercritical state at the magma-atmosphere *** serpentinization reactions occurred due to rock-water interaction,producing abundant ***,nitrogen is reduced to ammonia,and carbon dioxide to methane,forming carbonate *** proto-atmosphere dominated by methane,ammonia,and hydrogen formed a significant amount of amino acids through *** process is essential not only to the origin of life,but also to the early carbon-nitrogen cycle on *** the Hadean eon,a large amount of CO_(2)was sequestered as carbonate and organic ***,it mainly entered the deep mantle through mantle overturn or *** the mantle transition zone,carbonate undergoes“Redox freezing”,where carbonate is reduced to diamond through oxidation of ferrous iron in the *** the lower mantle,Fe^(2+)undergoes disproportionation reactions,forming Fe^(3+)and metallic *** these,Fe^(3+)mainly resides in bridgmanite,thereby increasing the oxygen fugacity of the lower mantle,while metallic iron falls to the Earth's *** distribution of carbon in the mantle is crucial for deep carbon *** density curves of diamond and mantle peridotite melt intersect at the bottom of the mantle transition zone(about 660 km).This density crossover leads to the accumulation of diamond during the magma ocean *** materials such as subducting slabs enter the lower mantle,compensatory upwelling of lower mantle material *** enters the upper mantle,decomposes,releasing Fe^(3+)ions and oxidizes diamond

关键词： Carbon cycling Proto-atmosphere Amino acids Subduction initiation Passive margin subduction Atmospheric carbon dioxide

Fossil Equidae in the Linxia Basin with Biostratigraphic and Paleozoogeographic Significance

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 1-9页

作者： sun Boyang Key Laboratory of Vertebrate Evolution and Human Origins of the Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

The Linxia Basin is characterized by an abundance of Cenozoic sediments,that contain exceptionally rich fossil *** are abundant in the Linxia Basin,the fossil record of equids in this region including 16 species that represent 10 *** comparison to other classic late Cenozoic areas in China,the Linxia Basin stands out,because the fauna and chronological data accompanying Linxia equids render them remarkably useful for *** anchitheriines in the region,such as Anchitherium and Sinohippus,represent early equids that appeared in the late stages of the middle and late Miocene,*** the equines,most species of Chinese hipparions have been identified in the Linxia Basin and some species of the genera Hipparion and Hippotherium have FAD records for ***,Equus eisenmannae is one of the earliest known species of Equus in the Old World and is well-represented at the Longdan *** species with precise geohistorical distributions can serve as standards for high-resolution chronological units within this *** at the eastern margin of the Tibetan Plateau and subject to considerable uplift,the Linxia Basin has served as a biogeographic transition area for equids throughout the late Cenozoic.

关键词： Equidae Cenozoic biostratigraphy paleozoogeography Linxia Basin

Achieving simultaneously high conversion and high selectivity for light olefins directly producing from syngas

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Science China Chemistry 2024年第3期67卷 753-754页

作者： Yuhan sun Shanxi Research Institute Huairou Research LaboratoryTaiyuan 030032China Institute of Carbon Neutrality ShanghaiTech UniversityShanghai 201210China

The activity and selectivity are two primary indexes of a successful catalyst for chemical reactions. However,achieving a high activity and a high selectivity simultaneously is a long-standing challenge in catalysis, the socalled activity-selectivity trade-off. In the article recently published in Science, a research team led by Prof.

关键词： selectivity simultaneous catalysis