检索结果-南通市图书馆

Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： sun kyung hwa.g Ik Jae Park Se Won Seo Jae Hyun Park So Jeong Park Jin Young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 637-649页

作者： Hyun-kyung So Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu gyu-Un Bae Jong-sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

galectin 3-binding protein(LgALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(TgF-β1)availability and inhibits hepatocarcinogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第10期44卷 1106-1129页

作者： Dae-hwan Kim Minjeong sung Myong-Suk Park Eun-gene sun Sumin Yoon kyung Hyun Yoo Kamalakannan Radhakrishnan sung Yun Jung Woo-Kyun Bae Sang-Hee Cho Ik-Joo Chung Department of Internal Medicine Division of Hematology and OncologyChonnam National University Medical SchoolHwasunSouth Korea Department of Internal Medicine Division of Hematology and OncologyChonnam National University Hwasun HospitalHwasunSouth Korea Combinatorial Tumor Immunotherapy MRC Center Chonnam National University Medical SchoolHwasunSouth Korea National Immunotherapy Innovation Center HwasunSouth Korea BioMedical Sciences graduate Program Chonnam National UniversityHwasunSouth Korea Department of Biological Science SookmyungWomen’s UniversitySeoulSouth Korea Clinical Vaccine R&D Center Chonnam National UniversityHwasunSouth Korea Department of Biochemistry and Molecular Pharmacology Baylor College of MedicineHoustonTexasUSA

Background:Increased galectin 3-binding protein(LgALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming growth factor-β1(TgF-β1)in the emergence of these diseases,the present study tested the hypothesis that LgALS3BP regulates the TgF-β1 signaling ***:The expression levels of LgALS3BP and TgFB1 were analyzed in patients with metabolic dysfunction-associated steatohepatitis(MASH)and *** omics techniques,such as RNA-sequencing,transposaseaccessible chromatin-sequencing assay,and liquid chromatography-tandem mass spectrometry proteomics,were used to identify the regulatory mechanisms for the LgALS3BP-TgF-β1 *** effects of altered TgF-β1 signaling by LgALS3BP were investigated in conditional LgALS3BP-knockin and LgALS3BP-knockout ***:In patients with MASH and HCC,the levels of LgALS3BP and TgFB1 exhibited positive *** of LgALS3BP by the inflammatory cytokine interferonαin HCC cells or ectopic overexpression of LgALS3BP in hepatocytes promoted the expression levels of *** fibrosis was observed in the livers of hepatocyte-specific LgALS3BP-knockin mice,with increased TgFB1 ***3BP directly bound to and assembled integrinαV,an integral mediator required for releasing active TgF-β1 from extracellular latent complex with the rearranged F-actin *** released TgF-β1 activated JunB transcription factor,which in turn promoted the TgF-β1 positive feedback ***3BP deletion in the hepatocytes downregulated TgF-β1 signaling and CCl4 induced ***,LgALS3BP depletion hindered hepatocarcinogenesis by limiting the availability of fibrogenic TgF-β***:LgALS3BP plays a crucial role in hepatic fibrosis and carcinogenesis by controlling the TgF-β1 signaling pathway,making it a promising therapeutic target in TgF-β1-related diseases.

关键词： F-actin FAK hepatic carcinogenesis IntegrinαV Interferonα JunB LgALS3BP metabolic dysfuntion-associated steatohepatitis tensile force TgF-β1

glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Mediating effect of work engagement between job characteristics and nursing performance among general hospital nurses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Nursing 2021年第3期8卷 241-248页

作者： Eun-kyung Lee sun-Hee Kim Jin-hwa Park College of Nursing Research Institute of Nursing ScienceDaegu Catholic UniversityDaegu 42472South Korea

Objective:This study aimed to determine the effects of job characteristics and work engagement on the nursing performance of nurses working in general ***:Data were collected from 169 nurses who are working in a general hospital in South Korea by using a cross-sectional descriptive survey ***:Nurses’job characteristics and work engagement showed positive effects on nursing *** effect was magnified when work engagement was used as a mediating ***:The findings elucidate the factors influencing job performance and provide managers with important information for developing programs to improve the job skills and work engagement of nurses.

关键词： general hospitals job characteristics nurse work engagement work performance

Primary malignant melanoma of uterine cervix: a suggestion of new scheme of treatment combination

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2014年第3期26卷 351-354页

作者： kyung-Jin Min Yeun-sun Kim Jin-hwa Hong Jae-Kwan Lee Dae-Sik Yang Department of Obstetrics and gynaecology Korea University Medical Centre Department of Radiation Oncology Korea University Medical Centre

Historically, the lack of melanocytes in the vaginal and cervical mucus membranes has deterred the findings of primary melanomas. Mainly due to its rarity, difficulty to diagnose, and poor prognosis, there has been no absolute agreement on comprehensive treatment so far. In this case report, we present a case of a 46-year-old woman with primary malignant melanoma of uterine cervix. She underwent neo-adjuvant chemotherapy initially followed by a radical hysterectomy. After adjuvant concurrent chemo-radiation, the patient has been followed up for 24 months. So far, she has not shown any symptoms or signs of recurrence. Further studies with more cases based on variable combinations of treatment regimen have been on the way.

关键词： Malignant melanoma uterine cervix neo-adjuvant chemotherapy chemo-radiation

Implementation of Turbulent Mixing over a Stratocumulus-Topped Boundary Layer and Its Impact in a gCM

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2009年第5期26卷 995-1004页

作者： sun-Hee SHIN kyung-Ja HA Division of Earth Environmental System Pusan National University

The effect of a vertical diffusion scheme over a stratocumulus topped boundary layer （STBL） was investigated using the YONU AgCM （Yonsei University Atmospheric general Circulation Model）. To consider the impact of clouds on the turbulence production, the turbulence mixing term, driven by radiative cooling at the cloud top, is implemented as an extended non-local diffusion scheme. In the model with this new scheme, the STBL parameterization significantly influences the lower atmosphere over the tropical and subtropical regions. Consideration of the turbulent mixing within the cloud layer leads to continuous stratocumulus formation. The cloud-top radiative cooling tends to favor more rapid entrainment and produces top-down turbulent mixing. This cooling develops a mixed layer without initiation of deep convection by surface fluxes. Variations in thermodynamical and dynamical features are produced by planetary boundary layer （PBL） cloud development. The simulated stratocumulus induces more mixing of heat and moisture due to the cloud forcing. Over STBL regions, the lower boundary layer becomes warmer and drier. It also weakens vertical motion and zonal trade winds in the eastern Pacific, which indicates that stratocumulus cloud cover plays a role in weakening the Walker circulation; that is, cloud cover damps the tropical circulation.

关键词： stratocumulus topped boundary layer non-local diffusion scheme tropical circulation general circulation model

4~6岁电声双模式助听儿童情感韵律识别能力研究

在线全文

学校读者我要写书评

暂无评论

中华耳科学杂志 2024年第3期22卷 411-414页

作者：刘晓明孙颖金星 KIM Hakyung 刘建菊北京联合大学特殊教育学院北京100075 北京教育科学研究院上海中医药大学康复医学院上海市中医药研究院康复医学研究所华东师范大学康复科学系

目的通过对4~6岁电声双模式助听儿童的高兴、中性及难过3种情感韵律进行研究,探讨不同听觉年龄电声双模式助听儿童的韵律识别能力。方法选取2022年9月至2023年12月某幼儿园就读的生理年龄4~6岁,听觉年龄1~4岁的电声双模式助听儿童32例... 详细信息

目的通过对4~6岁电声双模式助听儿童的高兴、中性及难过3种情感韵律进行研究,探讨不同听觉年龄电声双模式助听儿童的韵律识别能力。方法选取2022年9月至2023年12月某幼儿园就读的生理年龄4~6岁,听觉年龄1~4岁的电声双模式助听儿童32例,按照听觉年龄分为1.5岁组4例、2岁组6例、2.5岁组6例、3岁组6例、3.5岁组4例及4岁组6例。采用华东师范大学康复科学系自制的15个日常用句,分别用高兴、中性和难过3种不同的情感语气读出,让电声双模式助听儿童识别,共45句。分析不同听觉年龄对高兴、难过和中性3种情感韵律的识别能力。结果 1.5岁组、2岁组、2.5岁组、3岁组、3.5岁组及4岁组的情感韵律识别能力得分比较,差异无统计学意义(F=1.246,P>0.05)。6组3种不同类型情感韵律识别能力比较,差异无统计学意义(F=1.174,P>0.05),情感韵律类型和听觉年龄组之间无交互作用,差异无统计学意义(F=0.980,P>0.05)。6组不同听觉年龄情感韵律识别的正确率比较,差异有统计学意义(F=4.106,P<0.01)。结论听觉年龄1~4岁的大龄电声双模式助听儿童,情感韵律识别能力随听觉年龄的增长而升高;但不同听觉年龄对高兴、难过和中性3种情感韵律的识别不存在差异。随着听觉年龄的增长,要重视大龄电声双模式助听儿童情感韵律识别能力的训练。

关键词：听障儿童双模式助听韵律识别人工耳蜗植入儿童

K2Ti6O13 Nanoparticle-Loaded Porous rgO Crumples for Supercapacitors

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2020年第1期12卷 115-123页

作者： Chongmin Lee sun kyung Kim Hankwon Chang Hee Dong Jang Department of Nanomaterials Science and Engineering University of Science and TechnologyYuseong‑guDaejeon 34113Republic of Korea Resources Utilization Research Center Korea Institute of Geoscience and Mineral ResourcesYuseong‑guDaejeon 34132Republic of Korea

One-dimensional alkali metal titanates containing potassium,sodium,and lithium are of great concern owing to their high ion mobility and high specific surface *** those titanates are combined with conductive materials such as graphene,carbon nanotube,and carbon nanofiber,they are able to be employed as efficient electrode materials for *** hexa-titanate(K2Ti6O13,KTO),in particular,has shown superior electrochemical properties compared to other alkali metal titanates because of their large lattice parameters induced by the large radius of potassium ***,we present porous rgO crumples(PgC)decorated with KTO nanoparticles(NPs)for application to *** KTO NP/PgC composites were synthesized by aerosol spray pyrolysis and post-heat *** NPs less than 10 nm in diameter were loaded onto PgCs ranging from 3 to 5μ*** porous structure of the composites was obtained by the activation of rgO by adding an excessive amount of KOH to the *** KTO NP/PgC composite electrodes fabricated at the gO/KOH/TiO2 ratio of 1:3:0.25 showed the highest performance(275 F g−1)in capacitance with different KOH concentrations and cycling stability(83%)after 2000 cycles at a current density of 1 A g−1.

关键词： Potassium hexa-titanate Porous graphene crumples Supercapacitors

Stability of neodymium:YAg laser posterior capsulotomy in eyes with capsular tension rings

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第6期16卷 891-896页

作者： Yang kyung Cho Min sun Kim Department of Ophthalmology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

·AIM: To evaluate the stability of neodymium(Nd):YAg laser posterior capsulotomy in eyes with capsular tension rings(CTRs).·METHODS: A total of 60 eyes that underwent cataract surgery and laser posterior capsulotomy postoperatively were included in this retrospective cohort study. To evaluate the safety and stability of capsulotomy, changes in the size of posterior capsulotomy and anterior chamber depth(ACD) in three groups: the group without CTR, the group with 12 mm CTRs, and the group with 13 mm CTRs, at 1wk, 3, 12, and 15mo after capsulotomy, were compared. ·RESULTS: In the group without CTR and the group with 12 mm CTR, there was no significant change in ACD at every post-laser follow-up. In the group with 13 mm CTR, the ACD change was significant until 3mo after capsulotomy. In all groups, there was a significant increase in the area of capsulotomy between 1wk and 3mo post-laser. Between 3 and 12mo post-laser, only the group with 13 mm CTR showed a significant increase in the area of capsulotomy(Pgroups. The capsulotomy and ACD become stabilized and have not shown significant changes since 1y postlaser, even with larger CTRs. The maintenance of centrifugal capsular tension can last longer with larger CTRs, and the stability of the capsulotomy site can be reached about 12mo after capsulotomy in pseudophakic eyes with larger CTRs.

关键词： Nd:YAg laser capsulotomy capsular tension ring