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Screening of Brown Planthopper Resistant miRNAs in Rice and Their Roles in Regulation of Brown Planthopper Fecundity

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Rice science 2022年第6期29卷 559-568,I0031-I0033页

作者： LÜJun LIU Jinhui CHEN Lin sun jiawei SU Qin LI Shihui YANG Jianhua ZHANG Wenqing State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

MicroRNAs(miRNAs)can participate in plant-insect interactions,which regulate plant defense *** this study,we analyzed the miRNA expression profiles of six rice varieties before and after brown planthopper(BPH)-*** identified 45 differentially expressed miRNAs between BPH-susceptible and BPH-resistant rice varieties and 144 miRNAs that responded to ***,miRNAs may be involved in multiple pathways regulating rice defense response against *** addition,we found that the genetic history of rice varieties determined the regulation mode of the miRNA and affected the amounts,types,changing trends and response periods of miRNAs in response to *** conclude,we scanned seven potential cross-kingdom miRNAs,of which miR5795 may target the vitellogenin gene in BPH,causing a 16.07%reduction in BPH *** results provide new miRNA information of rice-BPH interactions and BPH-resistant rice variety breeding.

关键词： Nilaparvata lugens insect-resistant rice miR5795 fecundity

宁夏某精细化工园区废水可生化性与生物抑制性研究

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环境科学学报 2024年第6期44卷 123-131页

作者：孙佳薇田林锋金建华蒙昌鸿姜文娟胡桂荣董海波赵宏宇席劲瑛清华大学环境学院北京100084 同济大学环境科学与工程学院上海200092 石嘴山市生态环境监测站石嘴山753099 宁夏工业设计院有限责任公司银川750000

针对宁夏某精细化工园区废水可生化性与生物抑制性进行了研究.结果发现,该园区内废水以化工、制药类废水为主,各排水单位BOD5/CODCr(B/C)值大多小于0.20,说明废水可生化性较差,生化处理能力相对较弱.部分废水对活性污泥中的微生物存在... 详细信息

针对宁夏某精细化工园区废水可生化性与生物抑制性进行了研究.结果发现,该园区内废水以化工、制药类废水为主,各排水单位BOD5/CODCr(B/C)值大多小于0.20,说明废水可生化性较差,生化处理能力相对较弱.部分废水对活性污泥中的微生物存在明显抑制作用,抑制率>90%,主要与该类废水毒性高、难降解有关;经现有臭氧催化氧化和生物滤池单元处理后,废水抑制率分别减少17%、10%,说明两种处理方法能够一定程度上去除工业废水中部分有毒物质,降低废水对污泥中微生物的抑制性.该园区内工业废水对市政污水处理厂活性污泥的抑制率为46%~96%,均存在抑制作用,经处理后仍含有有毒难降解物质.由于工业污泥与生活污泥菌群结构不同,从而导致了耗氧速率(OUR)的显著性差异.按照官能团分类,化工园区内经预处理后废水中主要毒性物质为卤代烃、苯系物、酚类和有机硫化合物等,这些物质分子量较大且在水环境中很难被生物降解,均对终端处理单位活性污泥中的微生物有抑制作用,进而影响整体工艺的处理效果.同时发现,废水的B/C与OUR呈正相关关系,相关系数为0.614(p<0.05),说明生物的抑制性冲击作用是制约处理出水水质改善的重要因素.本研究揭示了宁夏某精细化工园区废水处理系统中污水可生化性与生物抑制性,并提出了废水处理改进措施,为该类废水处理效能提升提供了科学支撑.

关键词：化工园区废水可生化性生物抑制性

基于超声深度学习影像组学的乳腺癌新辅助化疗疗效预测

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中国医疗设备 2024年第4期39卷 122-129页

作者：张恒赵彤张赛孙佳伟李晓琴倪昕晔南京医科大学附属常州第二人民医院放疗科江苏常州213003 江苏省医学物理工程研究中心江苏常州213003 南京医科大学医学物理研究中心江苏常州213003 江苏省常州市医学物理重点实验室江苏常州213003 南京医科大学附属常州第二人民医院超声科江苏常州213003

目的开发一种结合超声影像组学、深度学习和临床特征的综合模型,以预测乳腺癌新辅助化疗(Neoadjuvant Chemotherapy,NAC)后的病理完全缓解(Pathological Complete Response,pCR)。方法共纳入117例乳腺癌患者,按照7∶3的比例随机划分为... 详细信息

目的开发一种结合超声影像组学、深度学习和临床特征的综合模型,以预测乳腺癌新辅助化疗(Neoadjuvant Chemotherapy,NAC)后的病理完全缓解(Pathological Complete Response,pCR)。方法共纳入117例乳腺癌患者,按照7∶3的比例随机划分为训练集和验证集。采用Mann-Whitney U检验、随机森林递归消除算法和最小绝对收缩和选择算子进行特征筛选及影像组学/深度学习标签构建。对患者的临床参数进行单/多因素分析,以选择有效特征构建临床模型。然后利用逻辑回归算法将临床特征与影像组学、深度学习标签相结合,构建临床-影像组学-深度学习综合模型。从预测效果、校准能力和临床实用性方面评估模型性能。结果临床-影像组学-深度学习综合模型相比于单独的临床、影像组学和深度学习模型在训练集和验证集中均显示出最高的曲线下面积(训练集:0.949 vs.0.788 vs.0.815 vs.0.928;验证集:0.931 vs.0.643 vs.0.778 vs.0.901)。校准曲线和决策曲线证实综合模型具有良好的预测性能。结论与单一模型比较,综合模型对术前预测乳腺癌患者NAC后的pCR状态具有更高价值。

关键词：超声影像组学深度学习乳腺癌新辅助化疗病理完全缓解

Compressive holographic sensing simplifies quantitative phase imaging

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Light(Science & Applications) 2023年第6期12卷 946-948页

作者： jiawei sun Juergen W.Czarske Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenDresdenGermany Laboratory of Measurement and Sensor System Technique(MST) TU DresdenHelmholtzstrasse 1801069 DresdenGermany Cluster of Excellence Physics of Life TU DresdenDresdenGermany Institute of Applied Physics TU DresdenDresdenGermany

Quantitative phase imaging (QPI) has emerged as method for investigating biological specimen and technical objects. However, conventional methods often suffer from shortcomings in image quality, such as the twin image artifact. A novel computational framework for QPI is presented with high quality inline holographic imaging from a single intensity image. This paradigm shift is promising for advanced QPI of cells and tissues.

关键词： holographic phase shortcomings

Downregulated cytotoxic CD8^(+)T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids

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Cellular & Molecular Immunology 2022年第4期19卷 527-539页

作者： Heng Xu Zhu Zhu Jian Hu jiawei sun Yan Wo Xianshu Wang Hongzhi Zou Bin Li Yixin Zhang Department of Plastic and Reconstructive Surgery Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Biostatistics Epidemiology and InformaticsUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Genekinder Medicaltech(Shanghai)Co. LtdShanghaiChina Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghaiChina Creative Biosciences(Guangzhou)Co. Ltd.GuangzhouGuangdongChina Department of Colorectal Surgery Guangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-Sen UniversityGuangdongChina Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of MedicineShanghaiChina

Keloids are an abnormal fibroproliferative wound-healing disease with a poorly understood pathogenesis,making it difficult to predict and prevent this disease in clinical *** disease-specific signatures at the molecular and cellular levels in both the blood circulation and primary lesions is urgently needed to develop novel biomarkers for risk assessment and therapeutic targets for recurrence-free *** is mounting evidence of immune cell dysregulation in keloid *** this study,we aimed to profile keloid scar tissues and blood cells and found that downregulation of cytotoxic CD8^(+)T cells is a keloid signature in the peripheral blood and keloid ***-cell RNA sequencing revealed that the NKG2A/CD94 complex was specifically upregulated,which might contribute to the significant reduction in CTLs within the scar tissue *** addition,the NKG2A/CD94 complex was associated with high serum levels of soluble human leukocyte antigen-E(sHLA-E).We subsequently measured sHLA-E in our hospital-based study cohort,consisting of 104 keloid patients,512 healthy donors,and 100 patients with an interfering *** sensitivity and specificity of sHLA-E were 83.69%(87/104)and 92.16%(564/612),respectively,and hypertrophic scars and other unrelated diseases exhibited minimal interference with the test ***,intralesional therapy with triamcinolone combined with 5-fluorouracil drastically decreased the sHLA-E levels in keloid patients with better prognostic outcomes,while an incomplete reduction in the sHLA-E levels in patient serum was associated with higher ***-E may effectively serve as a diagnostic marker for assessing the risk of keloid formation and a prognostic marker for the clinical outcomes of intralesional treatment.

关键词： Keloid Biomarker T cell immunology

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一种高压发生器XPSI板故障诊断方法

电工技术 2024年第16期 163-167页

作者：周忠卫孙家伟蔡树向杨文广董轩豪天津市93534部队天津301700 烟台大学机电汽车工程学院山东烟台264005 烟台大学文学与新闻传播学院山东烟台264005

提出了一种高压发生器XPSI板的故障诊断方法,通过诊断XPSI板上的五种核心芯片,定位出XPSI板的故障原因。系统以STM32F103RE芯片为控制芯片,采集各芯片检测电路的测试点电压值,通过RS-232串口将采集的电压值传输到上位机,并在串口调试助... 详细信息

提出了一种高压发生器XPSI板的故障诊断方法,通过诊断XPSI板上的五种核心芯片,定位出XPSI板的故障原因。系统以STM32F103RE芯片为控制芯片,采集各芯片检测电路的测试点电压值,通过RS-232串口将采集的电压值传输到上位机,并在串口调试助手中显示。通过对比各电路采集的实际电压值与理论值,判断芯片是否损坏,从而实现故障诊断。

关键词：高压发生器XPSI板故障诊断芯片检测

The Construction of Urban Cultural Space of Physical Bookstores in Shanghai,China

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校园英语 2020年第6期 248-250页

作者： sun jiawei College of Film-Television & Communication Shanghai Normal University

Based on the analysis of the development status of physical bookstores in Shanghai,this paper discusses their characteristics of openness,difference,commerciality and intellectual-cultural orientation as urban space,and puts forward that physical bookstores should be oriented by the overall demand of citizens,supported by scene construction,driven by technology convergence,andenhancedthevalue by cultural appreciation to develop into a mature and stable third space format of the city.

关键词： Physical bookstores Urban space Cultural space

基于NMDAR1/cGMP通路探究“三法三穴”对轻度慢性压迫性神经损伤大鼠脊髓背角的镇痛启动机制

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北京中医药大学学报 2024年第7期47卷 1017-1024页

作者：杨震杰萨出拉于天源陈金平张润龙张英琦张汉钰孙佳伟刘家玥北京中医药大学针灸推拿学院北京102488

目的探究“三法三穴”推拿手法对轻度慢性压迫性神经损伤(minor CCI)模型大鼠的镇痛启动机制。方法 35只SD大鼠按照随机数字表法分为5组,即正常组、假手术组、模型组、推拿组、推拿+MK-801组。模型组、推拿组和推拿+MK-801组结扎右侧... 详细信息

目的探究“三法三穴”推拿手法对轻度慢性压迫性神经损伤(minor CCI)模型大鼠的镇痛启动机制。方法 35只SD大鼠按照随机数字表法分为5组,即正常组、假手术组、模型组、推拿组、推拿+MK-801组。模型组、推拿组和推拿+MK-801组结扎右侧坐骨神经干建立minor CCI大鼠模型;假手术组仅暴露右侧坐骨神经,不予结扎;正常组不予任何操作。正常组不予任何干预措施;模型组、假手术组造模后第7天予抓握束缚9 min;推拿组造模后第7天进行1次三法(点法、拨法、揉法)三穴(右侧“殷门”“承山”“阳陵泉”)干预,每法每穴干预1 min,共9 min;推拿+MK-801组造模后第5~7天鞘内注射MK-801,每次6μg(10μL),每日1次,最后一次鞘内注射30 min后再进行推拿干预,推拿具体操作同推拿组。造模前、造模后、干预后检测各组大鼠冷敏阈值(CST)和机械缩足反射阈值(MWT);干预后,免疫组织化学法检测腰4~6节段脊髓背角中环磷酸鸟苷(cGMP)蛋白阳性表达,蛋白质印迹法检测腰4~6节段脊髓背角中N-甲基-D-天冬氨酸受体1(NMDAR1)、神经源型一氧化氮合酶(nNOS)、可溶性鸟苷酸环化酶β(sGCβ)、蛋白激酶G1(PKG1)蛋白表达,实时荧光PCR法检测腰4~6节段脊髓背角中NMDAR1、nNOS、sGCβ、cGMP、PKG1 mRNA表达。结果与正常组、假手术组比较,造模后模型组、推拿组和推拿+MK-801组CST升高,MWT降低(均P<0.05);干预后模型组腰4~6节段脊髓背角中cGMP蛋白阳性表达增多,NMDAR1、nNOS、sGCβ、PKG1蛋白表达增多,NMDAR1、nNOS、sGCβ、cGMP、PKG1 mRNA表达增多(均P<0.05)。与模型组比较,干预后推拿组和推拿+MK-801组CST降低,MWT升高(均P<0.05);推拿组、推拿+MK-801组腰4~6节段脊髓背角中cGMP蛋白阳性表达减少,NMDAR1、nNOS、sGCβ、PKG1蛋白表达减少,NMDAR1、nNOS、sGCβ、cGMP、PKG1 mRNA表达减少(均P<0.05)。结论推拿干预1次后即可有效改善周围神经病理性疼痛引起的温度觉、机械痛觉过敏症状,可能是通过NMDAR1/cGMP/蛋白激酶G信号通路启动镇痛,从而发挥即刻镇痛作用。

关键词：推拿神经病理性疼痛 N-甲基-D-天冬氨酸受体1 脊髓背角镇痛大鼠

Stress Concentration Effect in Interface Between Conductor and Epoxy Resin in Coaxial Components of Power Equipment

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 412-420页

作者： Chuang Wang Kang Lei Qing sun Hui Li jiawei Zhang Lang Zhao Zongren Peng School of Electrical Engineering Xi’an University of TechnologyXi’an 710054China Xi’an Power Supply Company State Grid Shaanxi Electric Power CompanyXi’an 710032China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

The spacer used in gas insulated switchgear(GIS)plays a vital role in its safe *** mismatch of mechanical properties between conductor and insulating material in spacers results in stress concentration at the interface between *** a hydrostatic test,mechanical damages are often initiated from the *** this paper,the stress between aluminum conductors and epoxy resin is studied by using a simplified coaxial structure *** measurement system and finite element simulation are used to explore the generation of stress and strain during curing and *** real-time measurement of strain at the interface shows that the residual strain in the entire process is primarily generated during the cooling ***,the temperature and stress/strain distribution at the interface during the cooling stage are further studied,and combined with experiments and *** consistency between the finite element simulation and the experimental measurement results verifies the validity of the simulation method *** results show that the maximum of the first principal stress generated during the cooling stage of the production process is concentrated on the upper and lower edges of the interface which is critical to the impact of the production quality of the spacer.

关键词： Epoxy resin GIS interface stress/strain distribution