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The Wnt-dependent and Wnt-independent functions of BCL9 in development,tumorigenesis,and immunity:Implications in therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 701-710页

作者： Minjie Wu Heng Dong Chao Xu Mengqing sun Haojin Gao Fangtian Bu jianxiang Chen College of Pharmacy and Department of Hepatology Institute of Hepatology and Metabolic DiseasesThe Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer CentreSingapore 169610Singapore Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China

B-cell CLL/lymphoma 9(BCL9)is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types,mainly through potentiating the Wnt/β-catenin ***,increasing evidences indicate that BCL9 also plays multiple Wnt-independent ***,we summarized the updates of the canonical and non-canonical functions of BCL9 in cellular,physiological,or pathological ***,we also concluded that the targeted inhibitors disrupt the interaction ofβ-catenin with BCL9 reported recently.

关键词： BCL9 Development Immunity Multifaceted functions Therapeutic target Tumorigenesis

IEC 62499:2021《轨道交通受流系统受电弓滑板试验方法》标准要点解析

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铁道车辆 2024年第4期62卷 61-63,113页

作者：杨才智潘利科袁远陈立明孙健翔朱晓晗中国铁道科学研究院集团有限公司标准计量研究所北京100081

受电弓滑板是轨道交通受流系统中的关键部件,其质量影响机车车辆的传输电力运行状况。为保障滑板质量,国内外先后制修订了滑板的相关标准。随着国内外滑板试验技术和方法标准的日益完善,对IEC 62499:2008《轨道交通受流系统受电弓碳滑... 详细信息

受电弓滑板是轨道交通受流系统中的关键部件,其质量影响机车车辆的传输电力运行状况。为保障滑板质量,国内外先后制修订了滑板的相关标准。随着国内外滑板试验技术和方法标准的日益完善,对IEC 62499:2008《轨道交通受流系统受电弓碳滑板试验方法》标准进行了修订,新版IEC62499:2021《轨道交通受流系统受电弓滑板试验方法》标准已发布。文章对更改的适用范围、电流负载下的温度特性试验、自动降弓动作性能试验、机械抗疲劳强度试验的方法和更改的验收标准,以及增加的试验方法进行了解析,为标准使用者实施提供了参考。

关键词：受电弓滑板试验方法标准解析

MOF-derived Se doped MnS/Ti_(3)C_(2)T_(x) as cathode and Zn-Ti_(3)C_(2)T_(x) membrane as anode for rocking-chair zinc-ion battery

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Nano Research 2024年第4期17卷 2781-2789页

作者： Kaisheng sun Zemao Xiao Yunfei Shen Heng Lv Jianpeng Zhu jianxiang Pang Yang Zheng Wenwen Kong Long Chen School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi UniversityShihezi 832003China CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and DevicesCenter of Materials Science and Optoelectronics EngineeringXinjiang Technical Institute of Physics and Chemistry of CASUrumqi 830011China

Mn-based zinc ion battery has the advantages of low cost and high performance,which makes it the promising energy storage ***,the poor conductivity and the agglomeration in the synthesis process of manganese-based materials restrict the performance of ***,the Se-doped MnS/Ti_(3)C_(2)T_(x)(Se-MnS/Ti_(3)C_(2)T_(x))composite material derived from Mn-based metal-organic framework is *** tests show that Se-doped could generate S defects and enhance the electrochemical activity of *** the same time,the introduction of Ti_(3)C_(2)T_(x) substrate is conducive to exposing more sulfur defects and improving the utilization rate of *** the mechanism study,it is found that Se-MnS/Ti_(3)C_(2)T_(x) is transformed into S/Se co-doped Mn3O_(4) at the first charge,which innovatively elucidated the behavior of S/Se during *** the electrochemical performance test,the specific capacity can reach 74.7 mAh·g^(-1) at 5.0 A·g^(-1).In addition,the Zn-Ti_(3)C_(2)T_(x) membrane electrode is prepared by vacuum filtration as the zinc-poor anode,which is assembled into the rocking chair full battery to avoid dendrite growth and exhibit excellent rate *** addition of Zn2+weakens the electrostatic repulsion between the interlayers of MXene,and the formation of the folded morphology aids the penetration of the *** 1.0 A·g^(-1),the capacity can reach 50.6 mAh·g^(-1).This work is helpful to promote the research and development of the reaction mechanism of manganese based rocking chair batteries.

关键词： rocking-chair zinc-ion battery MnS Zn-Ti_(3)C_(2)T_(x) membrane Se doped Ti_(3)C_(2)T_(x) composite

Influence of nano-mechanical evolution of Ti_(3)AlC_(2) ceramic on the arc erosion resistance of Ag-based composite electrical contact material

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Journal of Advanced Ceramics 2024年第2期13卷 176-188页

作者： Xuelian Wu Chengzhe Wu Xinpeng Wei Wanjie sun Chengjian Ma Yundeng Zhang Gege Li Liming Chen Dandan Wang Peigen Zhang Zhengming sun jianxiang Ding School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243032China Analytical and Testing Center Yancheng Institute of TechnologyYancheng 224051China School of Materials Science and Engineering Changzhou UniversityChangzhou 213164China Jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China

Al-containing MAX phase ceramic has demonstrated great potential in the field of high-performance low-voltage electrical contact *** the anti-arc erosion mechanism of the MAX phase is crucial for further improving performance,but it is not *** this study,Ag/Ti_(3)AlC_(2) electrical contact material was synthesized by powder metallurgy and examined by nanoindentation techniques such as constant loading rate indentation,creep testing,and continuous stiffness *** results indicated a gradual degradation in the nano-mechanical properties of the Ti_(3)AlC_(2) reinforcing phase with increasing arc erosion times,although the rate of this degradation appeared to decelerate over arc erosion ***,continuous stiffness measurements highlighted the uneven mechanical properties within Ti_(3)AlC_(2),attributing this heterogeneity to the phase’s *** the early(1-100 times)and intermediate(100-1000 times)stages of arc erosion,the decline in the nano-mechanical properties of Ti_(3)AlC_(2) was primarily ascribed to the decomposition of Ti_(3)AlC_(2) and limited surface *** the later stage of arc erosion(1000-6200 times),the inner region of Ti_(3)AlC_(2) also sustained arc damage,but a thick oxide layer formed on its surface,enhancing the mechanical properties and overall arc erosion resistance of the Ag/Ti_(3)AlC_(2).

关键词： MAX phase nano-mechanical properties decomposition surface oxidation anti-arc erosion mechanism

Zincophilic Ti_(3)C_(2)Cl_(2)MXene and anti-corrosive Cu NPs for synergistically regulated deposition of dendrite-free Zn metal anode

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Journal of Materials Science & Technology 2024年第2期169卷 137-147页

作者： Yunfei Shen Yi Liu Kaisheng sun Tiantian Gu Gang Wang Yue Yang jianxiang Pang Yang Zheng Xiaodong Yang Long Chen Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China Institute for Chemistry Chemnitz University of TechnologyChemnitz 09107Germany CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and DevicesCenter of Materials Science and Optoelectronics EngineeringXinjiang Technical Institute of Physics and Chemistry of CASUrumqi 830011China Key Laboratory of Ecophysics and Department of Physics College of ScienceShihezi UniversityShihezi 832003China

Dendrites growth,chemical corrosion,and hydrogen evolution reaction(HER)on zinc anodes are the main barriers for the development of aqueous zinc-ion batteries(AZIBs).Constructing interfacial protec-tive layer is an effective way to alleviate the side reactions on the ***,Cu/Ti_(3)C_(2)Cl_(2)MXene(CMX)with high zincophilic and hydrophobic property is prepared by the lewis molten salts etching method,and the CMX interface protection layer is constructed by a simple spin *** CMX coat-ing layer can provide abundant nucleation sites and uniformize the charge distribution through the zin-cophilic Ti_(3)C_(2)Cl_(2)MXene matrix,leading to homogenous Zn *** addition,the hydrophobic coat-ing contained anti-corrosive Cu nanoparticles can prevent the Zn anode from the electrolyte,beneficial for suppressing the chemical corrosion and ***,the stable and reversible Zn plating/stripping is achieved for the Zn anode coated by the CMX,which exhibits the lifespan of over 1400 h at 0.5 mA cm^(−2),and even can steadily run for 700 h with 65 mV at 10 mA cm^(−2).Furthermore,CMX@Zn shows a high coulombic efficiency of over 100%for 3800 cycles,which indicates that the CMX@Zn electrode has excellent stability and reversibility of Zn stripping/*** full batteries assembled with ZnCoMnO/C(ZCM)cathodes also exhibits higher capacity(450.6 mAh g^(−1)at 0.1 A g^(−1))and cycle stability(capacity retention of 70%after 1500 cycles).This work enhanced the lifespan of AZIBs and broaden the research of multifunctional coating layer to other secondary batteries based on metal anodes.

关键词： Zinc anode Spin coating Zincophilic MXene Anti-corrosive Cu NPs Multifunctional coating

欧洲18世纪均势隐喻的演变与“牛顿—笛卡尔式”国际关系本体论的形成

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国际政治研究 2023年第3期44卷 81-107,7页

作者：孙健翔南京大学国际关系研究院 210063

权力的平衡是一种公认的隐喻表达,经典力学理论通过“隐喻”的方式影响了人们对国际关系的认识。18世纪的均势隐喻发生了巨大变化,均势隐喻的嬗变既取决于控制相对权力兴衰的军事经济动态,也取决于基于宇宙学之下规则和论述的建构,新的... 详细信息

权力的平衡是一种公认的隐喻表达,经典力学理论通过“隐喻”的方式影响了人们对国际关系的认识。18世纪的均势隐喻发生了巨大变化,均势隐喻的嬗变既取决于控制相对权力兴衰的军事经济动态,也取决于基于宇宙学之下规则和论述的建构,新的宇宙学建构使得权力政治和均势政策合法化和自然化。这一时期有关国际关系智识的增长和进步有赖于自然科学的发展。政治经济及自然科学的发展促使“牛顿—笛卡尔式”国际关系本体论伴随新的国际秩序诞生,这一本体论至今仍然深刻影响着主流国际关系理论。均势的隐喻不仅代表了彼时国际政治的特征,更代表了启蒙运动对科学的信仰,以及在唯物主义自然哲学下人类对自己控制世界和未来的信念。

关键词：国际政治理论均势隐喻牛顿—笛卡尔式国际关系本体论

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运载火箭软件系统安全性分析

Aerospace China 2023年第3期24卷 3-9页

作者： sun jianxiang XU Chuanming An Zhanxin Wang Xiaoling Beijing Aerospace Automatic Control Institute Beijing 100854

At present,the number,scale and complexity of launch vehicle software systems have increased *** is no longer a simple stack of independent configuration items,but a tightly integrated complex distributed software *** to improve the safety of complex launch vehicle software systems has become a new topic under launch vehicle *** paper introduces in detail the contents and processes of software system safety analysis based on use case of the Long March 5B launch vehicle with innovations including analysis methods for key sequences,key events,failure modes and countermeasures.

关键词： launch vehicle software system safety analysis

基于国产PVA纤维的ECC混凝土制备及性能研究

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建筑结构 2023年第S1期53卷 1569-1573页

作者：袁宇辉李安孙健翔中交四航工程研究院有限公司广州510230 河海大学力学与材料学院南京211100

采用具有显著成本优势的国产聚乙烯醇(PVA)纤维制备了高延性水泥基复合材料(PVA-ECC),通过控制单因素变量的方法研究了PVA纤维掺量、粉煤灰掺量、水胶比、石英砂粒径对PVA-ECC的力学性能的影响,并在最优设计参数条件下对比分析了国产与... 详细信息

采用具有显著成本优势的国产聚乙烯醇(PVA)纤维制备了高延性水泥基复合材料(PVA-ECC),通过控制单因素变量的方法研究了PVA纤维掺量、粉煤灰掺量、水胶比、石英砂粒径对PVA-ECC的力学性能的影响,并在最优设计参数条件下对比分析了国产与日本PVA-ECC的性能差异,最终提出一种基于国产PVA纤维的ECC制备工艺。研究结果表明:采用国产PVA纤维,水泥∶粉煤灰∶砂∶纤维∶水∶减水剂=1∶2.2∶1.16∶0.066∶0.866∶0.0063,制备一种28 d抗压强度为42.7 MPa,抗折强度为15.1 MPa,极限拉应变为2.43%的国产PVA-ECC。与日本PVA纤维相比,采用国产PVA纤维制备ECC抗压和抗折强度分别为日本PVA纤维制备的ECC的98.4%和92.1%,国产PVA制备的ECC极限拉应变为日本的91.6%,两种ECC均能达到2.0%以上,且国产的在成本方面更具有优势。国产PVA纤维在ECC拉伸过程中更多是拔断而不是滑移拔出,而日本纤维多为滑移拔出。

关键词： PVA-ECC PVA纤维工作性能力学性能配合比设计

Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies

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Journal of Traditional Chinese Medicine 2020年第4期40卷 690-702页

作者： Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi sun jianxiang Li Yusi Luo Hui Li Lingru Center for Studies in Constitution Research and Reproductive Sciences of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Institute for Tibetan Medicine China Tibetology Research CenterBeijing 100101China

OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease ***:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and *** types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort *** statistical methods were employed for data ***:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different *** 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and *** found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constit

关键词： Body constitution Medicine,Chinese traditional Clinical study Review