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Simultaneous laparoscopic and arthroscopic excision of a huge juxta-articular ganglionic cyst compressing the sciatic nerve:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9028-9035页

作者： Won-Ku choi Jong-sung Oh sun-Jung Yoon Department of Obstetrics and Gynecology Medical SchoolJeonbuk National UniversityResearch Institute of Clinical Medicine of Jeonbuk National UniversityJeonju 54907South Korea Department of Orthopedic Surgery Medical SchoolJeonbuk National UniversityResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND A large ganglionic cyst extending from the hip joint to the intrapelvic cavity through the sciatic notch is a rare space-occupying lesion associated with compressive lower-extremity neuropathy.A cyst in the pelvic cavity compressing the intrapelvic-sciatic nerve is easily missed in the diagnostic process because it usually presents as atypical symptoms of an extraperitoneal-intrapelvic *** present a case of a huge ganglionic cyst that was successfully excised laparoscopically and endoscopically by a gynecologist and an orthopedic *** SUMMARY A 52-year-old woman visited our hospital complaining of pain and numbness in her left buttock while *** pain began 3 years ago and worsened,while the numbness in the left lower extremity lasted 1 *** was diagnosed and unsuccessfully treated at several tertiary referral centers many years *** resonance imaging revealed a suspected paralabral cyst(5 cm×5 cm×4.6 cm)in the left hip joint,extending to the pelvic cavity through the greater sciatic *** CA-125 and CA19-9 tumor marker levels were within normal ***,the cyst was compressing the sciatic ***,endoscopic and laparoscopic neural decompression and mass excision were performed simultaneously.A laparoscopic examination revealed a tennis-ball-sized cyst filled with gelatinous liquid,stretching deep into the hip *** excisional biopsy performed in the pelvic cavity and deep gluteal space confirmed the accumulation of ganglionic cysts from the hip joint into the extrapelvic intraperitoneal *** Intra-or extra-sciatic nerve-compressing lesion should be considered in cases of sitting pain radiating down the ipsilateral lower *** large juxta-articular ganglionic cyst was successfully treated simultaneously using laparoscopy and arthroscopy.

关键词： Paralabral cyst Ganglion cyst Intrapelvic sciatic nerve compression syndrome Deep gluteal syndrome Hip joint Laparoscopy Case report

Single-cell RNA-Seq reveals transcriptional regulatory networks directing the development of mouse maxillary prominence

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Journal of Genetics and Genomics 2023年第9期50卷 676-687页

作者： Jian sun Yijun Lin Nayoung ha Jianfei Zhang Weiqi Wang Xudong Wang Qian Bian Department of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China Shanghai Institute of Precision Medicine Shanghai 200125China Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China

During vertebrate embryonic development,neural crest-derived ectomesenchyme within the maxillary prominences undergoes precisely coordinated proliferation and differentiation to give rise to diverse craniofacial structures,such as tooth and ***,the transcriptional regulatory networks underpinning such an intricate process have not been fully ***,we perform single-cell RNA-Seq to comprehensively characterize the transcriptional dynamics during mouse maxillary development from embryonic day(E)*** single-cell transcriptome atlas of~28,000 cells uncovers mesenchymal cell populations representing distinct differentiating states and reveals their developmental trajectory,suggesting that the segregation of dental from the palatal mesenchyme occurs at ***,we identify a series of key transcription factors(TFs)associated with mesenchymal fate transitions and deduce the gene regulatory networks directed by these ***,our study provides important resources and insights for achieving a systems-level understanding of craniofacial morphogenesis and abnormality.

关键词： Craniofacial development Single-cell RNA-Seq Maxillary prominences Gene regulatory network Transcription factor

Design of 32 kbit one-time programmable memory for microcontroller units

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Journal of Central South University 2012年第12期19卷 3475-3483页

作者： JEON Hwang-gon choi In-hwa ha Pan-bong KIM Young-hee Department of Electronic Engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

A 32 kbit OTP(one-time programmable)memory for MCUs(micro-controller units)used in remote controllers was *** OTP memory is used for program and data *** is required to apply 5.5V to BL(bit-line)and 11V to WL(word-line)for a OTP cell of 0.35μm ETOX(EEPROM tunnel oxide)type by *** use 5V transistors on column data paths to reduce the area of column data paths since they require small *** addition,we secure device reliability by using HV(high-voltage)transistors in the WL ***,we change from a static logic to a dynamic logic used for the WL driver in the core ***,we optimize the WD(write data)switch ***,we can implement them with a small-area *** addition,we implement the address predecoder with a small-area logic *** area of the designed 32 kbit OTP with 5V and HV devices is 674.725μm×258.75μm(=0.1745mm2)and is 56.3% smaller than that using 3.3V devices.

关键词： one-time programmable memory micro controller unit EEPROM tunnel oxide small-area

Finger compartment syndrome due to a high-pressure washer injury:A case report

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World Journal of Clinical Cases 2023年第13期11卷 3017-3021页

作者： Jun Ho choi Seung Yeon choi Jae ha Hwang Kwang Seog Kim Sam Yong Lee Department of Plastic and Reconstructive Surgery Chonnam National University Hospital Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Although the finger compartment syndrome is not common,it compresses the neurovascular bundles in a limited space and blocks blood flow to the fingers,causing necrosis of the *** fasciotomy through unilateral or bilateral midline release of the finger can achieve decompression of the finger ***,we report a case of the compartment syndrome in a finger injury caused by a high-pressure water flow which is commonly used in car washing *** SUMMARY A 60-year-old man injured his right middle finger while using a high-pressure washer at a car washing *** patient complained of severe pain in his middle finger and a 0.2 cm punctured open wound on the volar side of the distal phalangeal joint of the middle *** fingertip was pale,numb,and characterized by severe swelling and a limited range of *** radiography showed that there was no fracture in the *** decompression was performed through finger fasciotomy by bilateral midline *** the second day after surgery,the color of the fingertip returned to pink,swelling was resolved,and the range of motion returned to *** sensation of the fingertip was completely restored,and the capillary refill test and pinprick test were *** The fingertip compartment syndrome can be caused by a high-pressure water flow damage to the fingers when using high-pressure washers at a car washing *** avoid finger necrosis,rapid diagnosis of the finger compartment syndrome and appropriate digital decompression are essential to better outcome.

关键词： Compartment syndrome Crush injuries Fasciotomy Finger injuries Case report

Injection molding of micro patterned PMMA plate

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 148-152页

作者： Yeong-Eun YOO Tae-Hoon KIM Tae-Jin JE Doo-sun choi Chang-Wan KIM sun-Kyung KIM Department of Nanomanufacturing Technology KIMM 171 Jang-dong Yusung-gu Daejeon 305-343 Korea Department of Product Design and Manufacturing Seoul National University of Technology

A plastic plate with surface micro features was injection molded to investigate the effect of pressure rise of melt on the replication of the micro structures. Prism pattern, which is used in many optical applications, was selected as a model pattern. The prism pattern is 50 μm in pitch and 108° in the vertical angle. The overall size of the plate was 335 minx213 mm and the thickness of the plate varied linearly from 2.6 mm to 0.7 ram. The prism pattern was firstly machined on the nickel plated core block using micro diamond tool and this machined pattern core was installed in a mold for injection molding of prism patterned plate. Polymethyl methacrylate （PMMA） was used as a molding material. The pressure and temperature of the melt in the cavity were measured at different positions in the cavity and the replication of the pattern was also measured at the same positions. The results show that the pressure or temperature profile through the process depends on the shape and the size of the plate. The replication is affected by the temperature and pressure profiles at the early stage of filling, which is right after the melt reaches the position to be measured.

关键词： micro prism pattern injection molding replication pressure profile temperature profile

Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy

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Microsystems & Nanoengineering 2020年第1期6卷 796-805页

作者： Jong Min Lee Ji Wook choi Christian D.Ahrberg Hyung Woo choi Jang Ho ha Seok Gyu Mun sung Joon Mo Bong Geun Chung Department of Mechanical Engineering Sogang UniversitySeoulKorea Division of Chemical Industry Yeungnam University CollegeDaeguRepublic of Korea Research Center Sogang UniversitySeoulKorea Department of Biomedical Engineering Sogang UniversitySeoulKorea

Despite their simplicity,monolayer cell cultures are not able to accurately predict drug behavior in vivo due to their inability to accurately mimic cell-cell and cell-matrix *** contrast,cell spheroids are able to reproduce these interactions and thus would be a viable tool for testing drug ***,the generation of homogenous and reproducible cell spheroids on a large scale is a labor intensive and slow process compared to monolayer cell ***,we present a droplet-based microfluidic device for the automated,large-scale generation of homogenous cell spheroids in a uniform *** the microfluidic system,the size of the spheroids can be tuned to between 100 and 130μm with generation frequencies of 70 *** demonstrated the photothermal therapy(PTT)application of brain tumor spheroids generated by the microfluidic device using a reduced graphene oxide-branched polyethyleneimine-polyethylene glycol(rGO-BPEI-PEG)nanocomposite as the PTT ***,we generated uniformly sized neural stem cell(NSC)-derived neurospheres in the droplet-based microfluidic *** also confirmed that the neurites were regulated by ***,this droplet-based microfluidic device could be a powerful tool for photothermal therapy and drug screening applications.

关键词： fluid viable simplicity

Potential risk factors for nonalcoholic steatohepatitis related to pancreatic secretions following pancreaticoduodenectomy

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World Journal of Gastroenterology 2011年第32期17卷 3716-3723页

作者： sun Choon Song Seong Ho choi Dong Wook choi Jin Seok Heo Woo Seok Kim Min Jung Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine

AIM: To identify risk factors for nonalcoholic steatohepatitis following pancreaticoduodenectomy, with a focus on factors related to pancreatic secretions. METHODS: The medical records of 228 patients who had a pancreaticoduodenectomy over a 16-mo period were reviewed retrospectively. The 193 patients who did not have fatty liver disease preoperatively were included in the final analysis. Hepatic steatosis was diagnosed using the differences between splenic and hepatic attenuation and liver-to-spleen attenuation as measured by non-enhanced computed tomography. RESULTS: Fifteen patients (7.8%) who showed postoperative hepatic fatty changes were assigned to Group A, and the remaining patients were assigned to Group B. Patient demographics, preoperative laboratory findings (including levels of C-peptide, glucagon, insulin and glucose tolerance test results), operation types, and final pathological findings did not differ significantly between the two groups; however, the frequency of pancreatic fistula (P = 0.020) and the method of pancreatic duct stenting (P = 0.005) showed significant differences between the groups. A multivari- ate analysis identified pancreatic fistula (HR = 3.332, P = 0.037) and external pancreatic duct stenting (HR = 4.530, P = 0.017) as independent risk factors for the development of postoperative steatohepatitis. CONCLUSION: Pancreatic fistula and external pancreatic duct stenting were identified as independent risk factors for the development of steatohepatitis following pancreaticoduodenectomy.

关键词： Nonalcoholic fatty liver diseases Nonalcoholic steatohepatitis Pancreatic duct stenting Pancreatic fistula Pancreatic surgery

Ascaris-mimicking common bile duct stone: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4499-4504页

作者： Seo-Youn choi ha Eun Jo Yun Nah Lee Ji Eun Lee Min Hee Lee San ghyeok Lim Boem ha Yi Radiology Soonchunhyang University HospitalBucheonBucheon 14584South Korea Digestive disease center and research institute Soonchunhyang University HospitalBucheonBucheon 14584South Korea

BACKGROUND In most cases,it is not difficult to differentiate common bile duct(CBD)stone from Ascaris infection because they are different disease entities and have different imaging *** two diseases usually demonstrate unique characteristic findings on computed tomography or magnetic resonance ***,we report a rare case from our experience in which a CBD stone mimicked and was misdiagnosed as *** SUMMARY A 72-year-old male presented with elevated serum liver *** tomography showed a hyper-attenuated,elongated lesion in the CBD lumen and associated biliary *** resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography revealed a linear filling defect in the bile ***,elongated echogenic material with a central hypoechogenic area was seen on endoscopic *** the imaging findings caused us to suspect infection with the nematode Ascaris,the lesion was revealed to be a dark-brown-colored CBD stone through endoscopic *** We report a rare case of a CBD stone that mimicked *** also review the literature for side-by-side comparisons of the imaging features of CBD stones and ascariasis.

关键词： Case report Common bile duct Gallstones Ascaris Ascariasis Multidetector computed tomography Magnetic resonance cholangiopancreatography

Decomposition behavior of yttria-stabilized zirconia and its effect on directed energy deposited Ti-based composite material

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Journal of Materials Science & Technology 2022年第17期112卷 138-150页

作者： Gwanghyo choi Won Seok choi Yoon sun Lee Dahye Kim Ji Hyun sung Seungjun An Chang-Seok Oh Amine hattal Madjid Djemai Brigitte Bacroix Guy Dirras Pyuck-Pa choi Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea 3D Additive Manufacturing Application Tech.Center Korea Institute of Industrial TechnologyDaegu 42994Republic of Korea InssTek Co. Daejeon 04763Republic of Korea Korea Institute of Materials Science 797 ChangwondaeroChangwon 51508Republic of Korea UniversitéSorbonne Paris Nord Laboratoire des Sciences des Procédés et des MatériauxLSPMCNRSUPR 3407F-93430VilletaneuseFrance Z3Dlab Parc Technologique26 Rue des SablonsMontmagny 95360France CNRS UPR3407Laboratoire des Sciences des Procédés et des MatériauxLSPMUniversitéSorbonne Paris NordF-93430VilletaneuseFrance

We report on the microstructure and the strengthening mechanisms of additively manufactured parts fabricated by directed energy deposition of Ti-6Al-4V(Ti64)powders blended with yttria-stabilized zirconia(YSZ)*** specimens showed refined microstructures as compared to bare as-deposited Ti64,where theαand columnar priorβgrain sizes decreased with increasing YSZ *** YSZ nanoparticles decomposed during the deposition process and led to the formation of yttrium oxide and some excess oxygen in the Ti64 *** decrease in the sizes of the priorβgrains could be attributed to the increasing amount of dissolved oxygen and yttrium,which promoted constitutional ***,the reduction in the size of theαgrains could be ascribed to a shift of the onset of theβ→α+βtransformation to a higher temperature and shorter time with increasing concentration of dissolved ***,the contributions of the underlying strengthening mechanisms for the as-deposited specimens were quantitatively determined.

关键词： Additive manufacturing Directed energy deposition Metal matrix composites Titanium alloys Yttrium-stabilized zirconia