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小菜蛾共生真菌棒曲霉XCE02的代谢产物及抗菌活性

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华南农业大学学报 2020年第2期41卷 76-81页

作者：丁唯嘉李明哲陈泽林蔡佳纯张梓娜李月婷孙晨昊李春远华南农业大学材料与能源学院

【目的】研究小菜蛾共生真菌棒曲霉Aspergillus clavatus XCE02代谢产物及其抗植物病原真菌的活性。【方法】柱层析技术分离纯化XCE02代谢产物,并运用波谱技术鉴定结构;滤纸片扩散法测试代谢产物对香蕉炭疽菌和小麦赤霉菌的抑菌活性。... 详细信息

【目的】研究小菜蛾共生真菌棒曲霉Aspergillus clavatus XCE02代谢产物及其抗植物病原真菌的活性。【方法】柱层析技术分离纯化XCE02代谢产物,并运用波谱技术鉴定结构;滤纸片扩散法测试代谢产物对香蕉炭疽菌和小麦赤霉菌的抑菌活性。【结果】分离鉴定出gliomasolide A、Sch725674、gliomasolide C、clavatustide A、clavatustide B、20−羟基麦角甾−4,6,8(14),22−四烯−3−酮、黄嘌呤、麦角甾醇、过氧化麦角甾醇和丁二酸10个化合物。在250μg/mL时,gliomasolide A、Sch725674和gliomasolide C对香蕉炭疽菌和小麦赤霉菌显示了高度抗菌活性,clavatustide A和clavatustide B对香蕉炭疽菌和小麦赤霉菌显示了中度抗菌活性,20−羟基麦角甾−4,6,8(14),22−四烯−3−酮对小麦赤霉菌显示了中度抗菌活性。【结论】从曲霉属分离到了gliomasolide A、gliomasolide C和20−羟基麦角甾−4,6,8(14),22−四烯−3−酮,gliomasolide A、Sch725674和gliomasolide C可作为相应抗菌农药先导化合物开展深入研究。

关键词：昆虫共生真菌棒曲霉代谢产物抗菌活性柱层析技术波谱技术滤纸片扩散法

热载流子多结太阳能电池CdSe/CdS核壳量子点和纳米片的声子瓶颈效应机理

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新能源科技 2024年第2期5卷 26-33页

作者：王睿张琛浩徐苏悦张怿河海大学新能源学院江苏南京210098

热载流子多结太阳能电池(HCMJSC)是热载流子及叠层电池概念相结合而提出的一种较有前景的第三代太阳能电池之一,其理论效率在一个标准太阳条件(即1000 W/m 2,25℃)下将高于65%,远高于32%的单节硅基电池极限效率。该型电池主要包括一个... 详细信息

热载流子多结太阳能电池(HCMJSC)是热载流子及叠层电池概念相结合而提出的一种较有前景的第三代太阳能电池之一,其理论效率在一个标准太阳条件(即1000 W/m 2,25℃)下将高于65%,远高于32%的单节硅基电池极限效率。该型电池主要包括一个宽带隙的顶结薄膜和一个适中带隙的厚底结基底,以分别高效吸收利用高能和低能光子。其广泛应用于光电器件的宽带隙CdSe/CdS低维材料体系(如量子点、纳米片等)有望成为顶结薄膜的合适候选材料。然而,该材料体系中的声子瓶颈效应(PBE)机理目前尚不明晰。文章主要研究了CdSe/CdS核壳量子点(QDs)和纳米片(NPLs)中的PBE机理;通过稳态光致发光(SSPL)和皮秒时间分辨尺度光致发光(ps-TRPL)技术,计算该材料体系的热弛豫系数(Q th),从而定量分析激发载流子的弛豫速率,同时阐述了PBE和量子点中常见的俄歇复合之间的耦合关系,最终系统研究了QDs和NPLs中载流子弛豫过程机理,提出HCMJSC的发展路径和建议。

关键词：声子瓶颈效应(PBE) 二六族半导体(Ⅱ-Ⅵsemiconductors) 量子点(QDs) 纳米片(NPLs) 热弛豫系数(Q th) 皮秒时间光致发光(ps-TRPL)

Ultrafast Modulation of the Molten Metal Surface Tension under Femtosecond Laser Irradiation

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Chinese Physics Letters 2022年第7期39卷 117-122页

作者： chenhao Li Hongtao Liang Yang Yang Zhiyong Yu Xin Zhang Xiangming Ma Wenliang Lu Zhenrong sun Ya Cheng State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China

We predict ultrafast modulation of the pure molten metal surface stress fields under the irradiation of the single femtosecond laser pulse through the two-temperature model molecular-dynamics simulations. High-resolution and precision calculations are used to resolve the ultrafast laser-induced anisotropic relaxations of the pressure components on the time-scale comparable to the intrinsic liquid density relaxation time. The magnitudes of the dynamic surface tensions are found being modulated sharply within picoseconds after the irradiation, due to the development of the nanometer scale non-hydrostatic regime behind the exterior atomic layer of the liquid *** reported novel regulation mechanism of the liquid surface stress field and the dynamic surface tension hints at levitating the manipulation of liquid surfaces, such as ultrafast steering the surface directional transport and patterning.

关键词： red profile Gibbs Ultrafast Modulation of the Molten Metal Surface Tension under Femtosecond Laser Irradiation

Flexible control strategy for HVDC transmission system adapted to intermittent new energy delivery

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Global Energy Interconnection 2021年第4期4卷 425-433页

作者： chenhao Li Kuan Li Changhui Ma Pengfei Zhang Qi Tao Yingtao sun Xin Wang State Grid Shandong Electric Power Research Institute JinanP.R.China State Grid International Development Limited BeijingP.R.China State Grid Jinan Power Supply Company JinanP.R.China Independent Power Transmission Operator S.A. 89 Dyrrachiou Str.&Kifisou 10443AthensGreece

Intermittent new energy delivery requires increasing the flexibility of ultra-high voltage direct current(DC)power *** on a converter steady-state model and a DC power model,the control angle constraints of a converter valve are relaxed for power *** this paper,a flexible DC power control method based on a fixed tap changer position is *** initial ratio of the converter transformer is *** effects of the fixed-tap changer position control on the control angle,reactive power compensation,and commutation failure are *** new control method allows a DC system to operate at a large angle and increase the additional reactive power loss while improving the commutation security ***-state and electromagnetic transient simulations in the CIGRE test system verify the validity of the method proposed in this paper and the correctness of the analysis conclusions.

关键词： Tap changer DC power Firing angle Reactive power compensation Extinction angle Commutation failure

Study of the relationship between sphenoid sinus volume and protrusions in the sphenoid sinus

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Forensic Medicine and Anatomy Research 2014年第1期2卷 2-7页

作者： Yuefeng Li Jiaqi sun Xiwen Zhu chenhao Zhao Jin Xu Ping Jiang Xinkang Tong Department of Clinical and Imaging Anatomy School of Medicine Science and Laboratory Medicine Jiangsu University Zhenjiang China Department of Medical Imaging Affiliated Hospital of Jiangsu University Zhenjiang China Department of Ophthalmology Fourth Affiliated Hospital of Jiangsu University Zhenjiang China Department of Otolaryngology Affiliated Hospital of Jiangsu University Zhenjiang China

The relationship between the volume of sphenoid sinus (SS) and the prevalence of internal carotid artery (ICA) and optic nerve (ON) protrusions in the SS was studied by using high-resolution CT imaging. The ICA and ON protrusions in SS were observed in randomly selected normal head CT scanning images from 350 adult subjects. Ac-cording to the incidence of ICA protrusion, three groups were divided into no ICA protrusion (70.75%), unilateral protrusion (8.68%) and bi-lateral protrusions (20.57%). The ON protrusion accounted for 16% in 350 subjects and accom-panied absolutely with ICA protrusion, but ICA protrusion appeared without accompanying with ON protrusion. The SS volume depended upon the protrusions in it and showed statistical dif-ferences, without ICA protrusion, the smallest size (11.16 ± 1.60) cm3;the unilateral protrusion, medium size (14.20 ± 1.80) cm3 and the bilateral protrusion, the largest size (25.03 ± 2.21) cm3. By observing 3D reconstructed models of ON and SS, we found ON was adjacent to SS (46%) and to posterior ethmoid sinuses (44%). The current study indicates that SS volume is varied with numbers of the protrusions and that ON location varies with the pneumatization of SS. Our results provide an anatomical basis to the surgeries for SS and its surrounding structures.

关键词： Sphenoid Sinus Volume Protrusion of Internal Carotid Artery CT Imaging

A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 925-938页

作者： chenhao Zhou Jialei Weng Yuan Gao Chunxiao Liu Xiaoqiang Zhu Qiang Zhou Chia-Wei Li Jialei sun Manar Atyah Yong Yi Qinghai Ye Yi Shi Qiongzhu Dong Yingbin Liu Mien-Chie Hung Ning Ren Department of Liver Surgery Liver Cancer InstituteZhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghaiChina Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Biomedical Research Center Zhongshan HospitalFudan UniversityShanghaiChina Institute of Fudan Minhang Academic Health System and Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer(SMHC)Minhang Hospital&AHSFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical UniversityTaichung

Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the incidence and mortality rates are *** the limited treatments of HCC and promising application of immunotherapy for cancer,we aimed to identify an immune-related prognostic signature that can predict overall survival(OS)rates and immunotherapy response in ***:The initial signature development was conducted using a training dataset from the Cancer Genome Atlas followed by independent internal and external validations from that resource and the Gene Expression Omnibus.A signature based nomogram was generated using multivariate Cox regression *** associations of signature score with tumor immune phenotype and response to immunotherapy were analyzed using single-sample gene set enrichment analysis and tumor immune dysfunction and exclusion algorithm.A cohort from Zhongshan Hospital was employed to verify the pre dictive robustness of the signature regarding prognostic risk and immunotherapy ***:The prognostic signature,IGS_(HCC),consisting of 22 immune-related genes,had independent prognostic ability,with training and validation ***,IGS_(HCC)stratified HCC patients with different outcomes in *** prognostic accuracy of IGS_(HCC)was better than three reported prognostic *** IGS_(HCC)-based nomogram had high accuracy and significant clinical benefits in predicting 3-and 5-year ***_(HCC)reflected distinct immunosuppressive phenotypes in low-and high-score *** with low IGS_(HCC)scores were more likely than those with high scores to benefit from ***:IGS_(HCC)predicted HCC prognosis and response to immunotherapy,and contributed to individualized clinical management.

关键词： Hepatocellular carcinoma Gene signature Immune microenvironment Prognosis Immunotherapy

Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese

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National Science Review 2022年第8期9卷 22-25页

作者： Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao chenhao Lin Zhonghan sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge Department of Cardiology Zhongshan HospitalFudan University Shanghai Institute of Cardiovascular Disease BGI Genomics BGI-Shenzhen State Key Laboratory of Genetic Engineering School of Life Sciences and Human PhenomeInstituteFudan University BGI-Shenzhen State Key Laboratory of Genetic Engineering School of Life Sciences and Human Phenome InstituteFudan University

Despite the advances made over the past decades, the known loci for coronary artery disease(CAD) still only explain<20% of the genetic variation in risk[1,2]. The known loci with the strongest effects usually confer a 20%–37% increased CAD risk and the most loci modulate risk by ≤10% [1]. While most of the current data are from European populations, the use of trans-ethnic analyses could be helpful to identify additional loci. Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD).

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基于正则化的陆基伪卫星整周模糊度解算方法

探测与控制学报 2018年第3期40卷 97-102页

作者：张晨皓孙发鱼白瑞青机电动态控制重点实验室陕西西安710065

针对特殊地理环境下陆基伪卫星系统整周模糊度解算精度不足的问题,提出了基于TIKHONOV正则化方法的陆基伪卫星定位系统整周模糊度在线解算的方法。该方法根据陆基伪卫星定位系统所处的环境,使用TIKHONOV正则化方法对观测方程的法方程进... 详细信息

针对特殊地理环境下陆基伪卫星系统整周模糊度解算精度不足的问题,提出了基于TIKHONOV正则化方法的陆基伪卫星定位系统整周模糊度在线解算的方法。该方法根据陆基伪卫星定位系统所处的环境,使用TIKHONOV正则化方法对观测方程的法方程进行处理,对法方程的病态性进行削弱。仿真验证结果表明,使用TIKHONOV正则化方法削弱法方程的病态性后,整周模糊度浮点解的解算误差缩小了数十倍,据此搜索出的整周模糊度整数解与真值相同。由此可得出结论,该方法能够提高陆基伪卫星定位系统整周模糊度的解算精度。

关键词：陆基伪卫星载波相位定位整周模糊度在线解算法方程病态 TIKHONOV正则化

Association between Insomnia and Insulin Resistance: A Cross-sectional and Mendelian Randomization Study

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Association between Insomnia and Insulin Resistance: A Cross...