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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi sun Zelong Gong Tao Zhang Jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu Wang Leyuan Ma Xuehui Li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

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自主可控平台AGV设计及视觉循线算法研究

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计算机科学与探索 2025年第1期19卷 264-276页

作者：徐诗高军孙秋君上海海事大学信息工程学院中国电信股份有限公司嘉兴分公司

设计并实现了一种基于自主可控平台的自动导引车（AGV）。AGV满足核心硬件国产化、软件开源可控的要求，并可兼容多种自主导航算法。对传统纯追踪算法在跟踪精度和安全性上进行了改进：一是载具在直线路段偏离参考轨迹较远的情况下使用D... 详细信息

设计并实现了一种基于自主可控平台的自动导引车（AGV）。AGV满足核心硬件国产化、软件开源可控的要求，并可兼容多种自主导航算法。对传统纯追踪算法在跟踪精度和安全性上进行了改进：一是载具在直线路段偏离参考轨迹较远的情况下使用Dubins路径进行快速回归；二是在大曲率参考轨迹处使用预瞄点偏移算法纠正跟踪轨迹，减小跟踪误差；三是应用动态预瞄距离和动态速度进一步减小大曲率路段的跟踪误差和安全风险。改进的算法在设计的AGV上进行了实现。在完成AGV设计和改进算法实现后，在实际环境中进行了视觉循线实验。改进的算法在0.1 m/s的速度下在曲率较小路段的平均偏差相较改进前的两种纯追踪算法变体分别减少了3.3%、7.3%，在大曲率路段减少了8.34%、23.06%；在0.5 m/s的速度下在曲率较小路段的平均偏差相较改进前的两种纯追踪算法变体分别减少了9.08%、11.33%，在大曲率路段减少了2.97%、24.67%。改进算法实验的整体结果优于使用改进前两种算法变体的结果，且设计并实现的AGV能够满足一般环境下的视觉循线导航需求，可应用于多种实际场合。

关键词：自主可控自动导引车(AGV) 跟踪控制纯追踪算法

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急性胰腺炎并发胆道系统疾病的诊治进展

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中华外科杂志 2025年第1期63卷 76-80页

作者：李启元罗岩孙备哈尔滨医科大学附属第一医院胰胆外科哈尔滨

急性胰腺炎是外科常见的急腹症, 其发展过程中往往伴随着严重的局部或全身并发症。胆道系统疾病是急性胰腺炎严重的局部并发症之一, 主要包括急性非结石性胆囊炎和胆管狭窄。急性非结石性胆囊炎常发生在急性胰腺炎的病程后期, 会加重患... 详细信息

急性胰腺炎是外科常见的急腹症, 其发展过程中往往伴随着严重的局部或全身并发症。胆道系统疾病是急性胰腺炎严重的局部并发症之一, 主要包括急性非结石性胆囊炎和胆管狭窄。急性非结石性胆囊炎常发生在急性胰腺炎的病程后期, 会加重患者全身炎症反应, 严重时可导致器官功能衰竭等, 危及生命。胆管狭窄是急性胰腺炎少见的远期严重并发症, 可诱发胆管炎、进行性肝功能损害和继发性胆汁性肝硬化等严重并发症。由于急性胰腺炎的临床症状可掩盖其他症状, 部分发病期间并发胆道系统疾病的患者未能得到及时诊治, 严重时可危及患者生命。目前, 针对急性胰腺炎继发胆道系统并发症的理想治疗策略尚不明确, 缺乏具有指导意义的指南或共识。本文结合近年来国内外相关研究进展, 对急性胰腺炎并发胆道系统疾病的发病机制、诊断及治疗策略进行阐述。

关键词：胰腺炎胆道疾病急性非结石性胆囊炎胆管狭窄

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刃宽对硬岩掘进影响的仿真及试验研究

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工程科学学报 2025年第1期47卷 13-24页

作者：尚勇孙靖东姜海峰许顺海段红磊孙朝阳北京科技大学机械工程学院北京100083 中铁工程装备集团隧道设备制造有限公司河南453000

滚刀在硬岩掘进中极易发生崩刃、偏磨等异常失效,研究硬岩掘进条件下刃型参数对滚刀破岩载荷和破岩效率的影响十分重要.本文采用滚刀破岩试验和仿真分析相结合的方法,从载荷曲线、破岩体积、破岩比能等方面分析了刃宽对滚刀破岩的影响.... 详细信息

滚刀在硬岩掘进中极易发生崩刃、偏磨等异常失效,研究硬岩掘进条件下刃型参数对滚刀破岩载荷和破岩效率的影响十分重要.本文采用滚刀破岩试验和仿真分析相结合的方法,从载荷曲线、破岩体积、破岩比能等方面分析了刃宽对滚刀破岩的影响.基于双线性本构模型及Benzeggagh–Kenane损伤断裂准则建立了岩石材料的内聚力本构模型,通过单轴抗压试验及巴西劈裂试验对内聚力本构模型的微观参数进行了校准,并进一步建立了滚刀破岩的内聚力仿真模型.结果表明:内聚力本构模型可以准确的模拟破岩过程中岩石裂纹的萌生和扩展过程.依据裂纹的萌生和扩展情况,滚刀破岩过程主要分为三个阶段:弹性阶段、裂纹萌生–扩展阶段及岩石破坏卸载阶段.滚刀破岩载荷和破岩体积随着贯入度、刀间距和刃宽的增加而增加;破岩比能随刃宽的增加呈先减小后增大的趋势.对于所选取的硬岩,采用13 mm刃宽滚刀破岩时比能最小,破岩效率最高;7 mm刃宽滚刀破岩时无法形成贯通岩片,相邻滚刀之间仍存在岩脊,破岩效率较低.

关键词：滚刀刃宽 Cohesive模型线切割试验破岩载荷破岩效率

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Single-Walled Carbon Nanotubes for Flexible Electronics and Sensors

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Journal of Materials Science & Technology 2008年第4期24卷 569-577页

作者： Xiuyun sun Yugang sun Department of Mechanical and Electronic Engineering Dezhou University Dezhou 253023 China Center for Nanoscale Materials Argonne National Laboratory 9700 South Cass Avenue Argonne Illinois 60439 USA

This article reviews the use of electronic quality single-walled carbon nanotubes grown via chemical vapor deposition （CVD） approaches at high temperatures as building blocks for fabricating flexible field-effect devices, such as thin-film transistors （TFTs） and chemical sensors. Dry transfer printing technique is developed for forming films of CVD nanotubes on low-temperature plastic substrates. Examples of TFTs with the use of nanotubes and thin dielectrics and hydrogen sensors with the use of nanotubes decorated with palladium nanoparticles are discussed in detail to demonstrate the promising potentiality of single-walled carbon nanotubes for building high performance flexible devices, which can find applications where traditional devices on rigid substrates are not suitable.

关键词： Single-walled carbon nanotubes Flexible Electronics Sensors

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Novel approach to GPS/SINS integration for IMU alignment

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Journal of Systems Engineering and Electronics 2011年第3期22卷 513-518页

作者： Wei sun Feng sun School of Geomatics Liaoning Technical UniversityFuxin 123000P.R.China College of Automation Harbin Engineering UniversityHarbin 150001P.R.China

Strapdown inertial navigation system（SINS） requires an initialization process that establishes the relationship between the body frame and the local geographic *** process,called alignment,is generally used to estimate the initial attitude *** is possible because an accurate determination of the inertial measurement unit（IMU） motion is available based on the measurement obtained from global position system（GPS）.But the update frequency of GPS is much lower than *** to the non-synchronous data streams from GPS and SINS,the initial attitude angles may not be computed accurately *** addition,the estimated initial attitude angles may have relatively large uncertainties that can affect the accuracy of other navigation *** paper presents an effective approach of matching the velocities which are provided by GPS and *** this approach,a digital high-pass filter,which implements a pre-filtering scheme of the measured signal,is used to filter the Schuler cycle of discrete velocity difference between the SINS and *** results show that this approach improves the accuracy greatly and makes the convergence time satisfy the required accuracy.

关键词： strapdown inertial navigation system(SINS) global position system(GPS) integration alignment high-pass filter.

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Inexact proximal gradient algorithm with random reshuffling for nonsmooth optimization

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Science China(Information Sciences) 2025年第1期 219-237页

作者： Xia JIANG Yanyan FANG Xianlin ZENG Jian sun Jie CHEN National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of Technology Beijing Institute of Technology Chongqing Innovation Center School of Electronic and Information Engineering Tongji University

Proximal gradient algorithms are popularly implemented to achieve convex optimization with nonsmooth regularization. Obtaining the exact solution of the proximal operator for nonsmooth regularization is challenging because errors exist in the computation of the gradient; consequently, the design and application of inexact proximal gradient algorithms have attracted considerable attention from researchers. This paper proposes computationally efficient basic and inexact proximal gradient descent algorithms with random reshuffling. The proposed stochastic algorithms take randomly reshuffled data to perform successive gradient descents and implement only one proximal operator after all data pass through. We prove the convergence results of the proposed proximal gradient algorithms under the sampling-without-replacement reshuffling *** computational errors exist in gradients and proximal operations, the proposed inexact proximal gradient algorithms can converge to an optimal solution neighborhood. Finally, we apply the proposed algorithms to compressed sensing and compare their efficiency with some popular algorithms.

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Progress of crystalline carbon nitride in synthesis,atomic structure characterization and photocatalysis

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Nano Research 2025年第1期18卷 455-476页

作者： Yueyang Tan Zhongyan Zhang Yayun Pu Zongzhao sun Limin Huang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China School of Traffic and Environment Shenzhen Institute of Information TechnologyShenzhen 518172China College of Chemistry and Chemical Engineering Linyi UniversityLinyi 276000China School of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

Crystalline carbon nitride(CCN)has emerged as a highly promising semiconductor photocatalyst with unique properties,such as enhanced charge migration rate,reduced carrier recombination probability,narrow band gap and improved light-harvesting efficiency,which are suitable for a wide range of applications in solar-to-chemical conversion,energy storage,therapeutic and environmental pollution *** the past few years,there has been an increasing number of reviews on CCN ***,most of these reviews mainly focus on synthesis methods,modification and applications,with less emphasis on the relationship between structures and properties,as well as on indepth exploration of the crystalline *** electronic instability of CCN presents challenges for conventional characterization techniques to directly and thoroughly investigate the relationship between its intrinsic atom structure and photocatalytic *** mini-review not only highlights the progress in CCN-based photocatalysts,with a focus on molten-salt synthesis(including solid-salt-induced crystallization),but also emphasizes the atomic structure characterization by specifically introducing the differential phase contrast(DPC)scanning transmission electron microscopy(STEM)technique,which is essential for enhancing our understanding of the crystal structure and photocatalytic mechanisms of ***,the review outlines the photocatalytic performance and puts forward potential challenges on CCN *** review will provide a clearer understanding of the relationship in developing precise customization strategies for CCN materials and ultimately explain the regularity and specificity of the enhanced performance in targeted photocatalytic systems.

关键词： crystalline carbon nitride synthesis characterization photocatalysis

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Electrocatalytic nitrite reduction to ammonia on isolated bismuth alloyed ruthenium

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Journal of Energy Chemistry 2025年第1期 369-376页

作者： Shiyao Shang Fuzhou Wang Zeyi sun Chaofan Qiang Ke Chu School of Materials Science and Engineering Lanzhou Jiaotong University

Electrochemical reduction of NO2-to NH3（NO2-RR） is recognized as an appealing approach for achieving renewable NH3synthesis and waste ***,we report isolated Bi alloyed Ru （Bi1Ru） as an efficient NO2-RR *** calculations and in situ electrochemical measurements reveal the creation of Bi1-Ru dual sites which can remarkably promote NO2-activation and suppress proton adsorption,while accelerating the NO2-RR protonation energetics to render a high NO2--to-NH3conversion ***,Bi1Ru assembled in a flow cell delivers an NH3yield rate of 1901.4μmol h-1cm-2and an NH3-Faradaic efficiency of 94.3%at an industrial-level current density of 324.3 mA *** study offers new perspectives for designing and constructing p-block single-atom alloys as robust and high-current-density NO2-RR catalysts toward the ammonia electrosynthesis.

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