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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

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Frontiers of Medicine 2022年第5期16卷 701-713页

作者： Shi-yong sun Department of Hematology and Medical Oncology Emory University School of Medicine and Winship Cancer Institute of Emory UniversityAtlantaGA 30322USA

A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generation epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(EGFR-TKIs),such as osimertinib,which have shown remarkable success in the treatment of advanced NSCLC with EGFR activating mutations,in order to achieve maximal response duration or treatment *** is a major type of programmed cell death tightly associated with cancer development and *** of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance is accordingly a key mechanism of drug acquired resistance in cancer *** has been clearly shown that effective induction of apoptosis is a key mechanism for third generation EGFR-TKIs,particularly osimertinib,to exert their therapeutic efficacies and the development of resistance to apoptosis is tightly associated with the emergence of acquired ***,restoration of cell sensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquired resistance to third generation EGFR-TKIs.

关键词： acquired resistance EGFR inhibitor apoptosis lung cancer

Existence and multiplicity of positive solutions for an elastic beam equation

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Applied Mathematics(A Journal of Chinese Universities) 2011年第3期26卷 253-264页

作者： sun yong-ping College of Electron and Information Zhejiang University of Media and Communications Hangzhou310018 China.

This paper investigates the boundary value problem for elastic beam equation of the formu″″（t） q（t）f（t, u（t）,u′（t）,u″（t）,u′″（t））, 0〈t〈1,with the boundary conditionsu=（0）=u′（1）=u″（0）=u′″（1）=0.The boundary conditions describe the deformation of an elastic beam simply supported at left and clamped at right by sliding clamps. By using Leray-Schauder nonlinear alternate, Leray-Schauder fixed point theorem and a fixed point theorem due to Avery and Peterson, we establish some results on the existence and multiplicity of positive solutions to the boundary value problem. Our results extend and improve some recent work in the literature.

关键词： Positive solution existence and multiplicity elastic beam equation fixed point theorem nonlinear alternate.

Monotone positive solution for three-point boundary value problem

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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 279-285页

作者： sun yong-ping College of Electronics and Information Zhejiang University of Media and Communications Hangzhou310018 China

In this paper, the existence of monotone positive solution for the following secondorder three-point boundary value problem is studied：x″（t）＋f（t,x（t））=0,0〈t〈1,x′（0）=0,x（1）＋δx′（η）=0,where η ∈ （0, 1）, δ∈ [0, ∞）, f ∈ C（[0, 1] × [0, ∞）, [0, ∞））. Under certain growth conditions on the nonlinear term f and by using a fixed point theorem of cone expansion and compression of functional type due to Avery, Anderson and Krueger, sufficient conditions for the existence of monotone positive solution are obtained and the bounds of solution are given. At last, an example is given to illustrate the result of the paper.

关键词： three-point boundary value problem fixed point theorem monotone positive solution

Existence and iteration of monotone positive solutions for a third-order two-point boundary value problem

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Applied Mathematics(A Journal of Chinese Universities) 2008年第4期23卷 413-419页

作者： sun yong-ping School of Electronics and Information Zhejiang University of Media and Communications Hangzhou 310018 China

The existence of nondecreasing positive solutions for the nonlinear third-order twopoint boundary value problem u′″（t）＋ q（t）f（t,u（t）,u′（t）） = 0, 0 〈 t 〈 1, u（0） = u″（0） = u′（1） = 0 is studied.... 详细信息

关键词： third-order two-point boundary value problem monotone iterative method positive solution,existence iterative scheme

Uniform Boundedness of Torsion Subgroups of Linear Groups

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Acta Mathematica Sinica,English Series 2008年第2期24卷 305-310页

作者： Bin yong sun Institute of Mathematics Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China

The torsion conjecture says： for any abelian variety A defined over a number field k, the order of the torsion subgroup of A（k） is bounded by a constant C（k,d） which depends only on the number field k and the dimension d of the abelian variety. The torsion conjecture remains open in general. However, in this paper, a short argument shows that the conjecture is true for more general fields if we consider linear groups instead of abelian varieties. If G is a connected linear algebraic group defined over a field k which is finitely generated over Q,Г is a torsion subgroup of G（k）. Then the order of Г is bounded by a constant C＇（k, d） which depends only on k and the dimension d of G.

关键词： linear algebraic group finite subgroup torsion conjecture torsion subgroup

Shear Stress Distribution in the Vicinity of Tilting Disk Heart Valve Model

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Chinese Physics Letters 1997年第1期14卷 28-31页

作者： sun yong-da Department of Applied Physics Tianjin UniversityTianjin 300072

The visualizations of pulsatile flows through tilting disk heart valve models were completed by means of the technique of the dynamic flow *** distribution of the fluid shear stresses in the near vicinity of heart val... 详细信息

关键词： Shear flows flow

Genome editing opens a new era for physiological study and directional breeding of fishes

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Science Bulletin 2017年第3期62卷 157-158页

作者： sun, yong-Hua State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan China 430072

In recent years, the whole life science community has witnessed the advance and breakthrough in the genome editing technologies, including zinc-finger nucleases （ZFNs）, transcription activator-like effector （TALE） nucleases （TALENs） and clustered, regularly interspaced, short palindromic repeats （CRISPR）-CRISPR-associated （Cas） systems （CRISPR/Cas9） [1-3]. With these tools, scientists are able to introduce site-specific modifications in the genome of a wide range of organisms from invertebrates to vertebrates.

关键词：编辑技术基因组定向育种生理学无脊椎动物鱼类位点特异性生命科学

Thermodynamics properties and thermal conductivity of Mg_2Pb at high pressure

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Science China(Physics,Mechanics & Astronomy) 2013年第10期56卷 1854-1860页

作者： DUAN yongHua sun yong Faculty of Material Science and Technology Kunming University of Science and Technology Key Lab of Advanced Materials of Yunnan Province Kunming University of Science and Technology

The thermodynamics properties and thermal conductivity of Mg2Pb at high pressures have been calculated by *** enthalpy of formation and heat capacity obtained at 0 GPa are in good agreement with the experiments and other theoretical *** thermal conductivity and coefficient of thermal expansion of Mg2 Pb at high pressure were *** thermal conductivity presents a second-order polynomial with *** calculated thermal conductivity of Mg2Pb indicates that it is suitable to be used as thermal conductor at 0 K.

关键词： thermodynamics properties thermal conductivity first-principles Mg2Pb

First-principles calculations of optical properties of Mg_2Pb

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Science China(Physics,Mechanics & Astronomy) 2014年第2期57卷 233-238页

作者： DUAN yongHua sun yong School of Material Science and Technology Kunming University of Science and Technology Key Lab of Advanced Materials of Yunnan Province Kunming University of Science and Technology

Based on the density functional theory （DFT）, the electronic structures and optical properties of Mg2Pb are calculated by using the local density approximation （LDA） and plane wave pseudo-potential method. The calculation results show that the indirect band gap width of Mg2Pb is 0.02796 eV. The optical properties of MgzPb have isotropic characteristics, the static dielectric function of Mg2Pb is ε1（0） = 10.33 and the refractive index is n0 = 3.5075. The maximum absorption coefficient is 4.8060×10^5 cm-1. The absorption in the photon energy range of 25-40 eV approaches to zero, shows the optical colorless and transparent behaviors.

关键词： first-principles Mg2Pb electronic structure optical properties