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Effect of nourishing Yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： sun Yanyan XUE Yuanyuan sun Wen WANG Yonghong YU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJECTIVE:To elucidate the mechanism of the nourishing Yin and purging fire Chinese herbal mixture(NYPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were randomly assigned to normal group(N),long light exposure group(L),NYPF and normal saline group(NS).Rats in the L,NYPF and NS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the N group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the NYPF group or NS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-E1),and on the day when the second estrous interphase occurred in rats of L group(L-E2),***:On day 34,all rats in the L group,80%of rats in the NS group,40%of rats in the N group,and 20%of rats in the NYPF group showed complete opening of the *** P28,m RNA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the N group(P<0.05).The rats in the L and NS groups had significantly lower hypothalamic argininephenylalanine-amide(RFamide)-related peptide 3(RFRP-3)m RNA levels than those in the N group(P<0.05),whereas RFRP-3 m RNA level was significantly higher in the NYPF group than that in the L group(P<0.05).At L-VO,the ovarian index of the L and NS groups was significantly higher than that of the N group(P<0.05)and estradiol(E2)level of the NYPF group was significantly lower than that of the N and NS groups(P<0.05);hypothalamic Kiss-1 m RNA level in the L and NS groups was significantly higher than that in the N and NYPF groups(P<0.05),whereas hypothalamic RFRP-3 m RNA level in the L,NYPF,and NS groups was significantly lower than that in the N group(P<0.05).At L-E1,E2 level of the L and NS groups was significantly higher than that of the N group(P<0.01),wher

关键词： light puberty precocious kisspeptins RFRP-3 melatonin Nourishing Yin and Purging Fire

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非均质地基中盾构隧道的纵向变形分析

铁道科学与工程学报 2023年第6期20卷 2222-2234页

作者：王祖贤施成华曹成勇彭铸孙影杰中南大学土木工程学院湖南长沙410075 深圳大学土木与交通工程学院广东深圳518060

盾构隧道沿纵向将不可避免地穿越多种地层,地基的非均质性和非连续性是广泛存在的。针对非均质地基中盾构隧道的纵向变形问题,将盾构隧道视为非均质Winkler地基中的Euler-Bernoulli梁,建立非均匀地基中盾构隧道纵向力学性能分析的非均质... 详细信息

盾构隧道沿纵向将不可避免地穿越多种地层,地基的非均质性和非连续性是广泛存在的。针对非均质地基中盾构隧道的纵向变形问题,将盾构隧道视为非均质Winkler地基中的Euler-Bernoulli梁,建立非均匀地基中盾构隧道纵向力学性能分析的非均质Winkler地基-EB梁模型,基于中心差分原理,推导得到解析模型控制方程的显式有限差分解。通过与既有研究成果的对比,验证解析模型的可靠性。而后,基于所建立的解析模型系统分析2类典型非均质地基条件下地基变异性对盾构隧道纵向变形和内力的影响,进一步讨论软硬地层渐变时隧道的纵向力学特性。研究结果表明:不同地基条件下所推导的有限差分解与既有有限元结果较为吻合,证明所建立的解析模型及其解答是准确可靠的;相邻地基刚度的差异会显著影响盾构隧道的纵向变形和内力,软硬地层交界面处隧道变形和内力会产生明显变化,且隧道剪力在此达到最大值,易产生环间错台等病害;对于软硬突变地层,隧道最大差异沉降随软弱地基刚度的减小线性增大,而最大弯矩和剪力的变化呈现出一定的非线性;对于含软弱层的软硬交替地层,软弱层相对刚度和相对长度均会显著影响隧道的纵向变形和内力,隧道最大差异沉降和最大弯矩及剪力随软弱层相对刚度和相对长度的变化具有明显的非线性特性;相比于软硬地层的突变,地层的渐变使得隧道剪力显著减小,有利于改善盾构隧道的纵向力学性能。

关键词：非均质地基盾构隧道纵向变形解析模型有限差分解

早期应用阿托伐他汀对急性冠脉综合征患者血浆IL-6和hs-CRP的影响

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社区医学杂志 2007年第3S期5卷 8-9页

作者：孙英杰青岛大学医学院研究生山东青岛266000

目的探讨早期应用阿托伐他汀对急性冠脉综合征患者血浆白介素-6、高敏C-反应蛋白(hs-CRP)的影响。方法 44例急性冠脉综合征患者随机分为阿托伐汀治疗组10 mg/d和常规治疗组(对照组)各22例。急性冠脉综合征患者在治疗1周前后分别测定... 详细信息

目的探讨早期应用阿托伐他汀对急性冠脉综合征患者血浆白介素-6、高敏C-反应蛋白(hs-CRP)的影响。方法 44例急性冠脉综合征患者随机分为阿托伐汀治疗组10 mg/d和常规治疗组(对照组)各22例。急性冠脉综合征患者在治疗1周前后分别测定血清白介素-6、高敏C-反应蛋白和血脂水平。结果阿托伐他汀组治疗1周后血清白介素-6及高敏C-反应蛋白均有明显下降(P<0.05)。结论早期应用阿托伐他汀治疗可降低急性冠脉综合征患者的血清白介素-6和高敏C-反应蛋白水平;阿托伐他汀的抗炎作用独立于降脂作用以外,急性冠脉综合征患者早期应用他汀类治疗可能获益较大。

关键词：急性冠脉综合征阿托伐他汀白介素-6 高敏C反应蛋白

Natural polysaccharide-based smart CXCR4-targeted nano-system for magnified liver fibrosis therapy

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Chinese Chemical Letters 2024年第2期35卷 341-346页

作者： Liqiong sun Xinping Luo Chenxi Zhou Zhanwei Zhou Minjie sun College of Horticulture Nanjing Agricultural UniversityNanjing 210095China NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients State Key Laboratory of Natural MedicinesDepartment of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China

Activated hepatic stellate cells(aHSCs),the main source of extracellular matrix deposition,are key targets in liver ***,no effective drug specific to aHSCs has been clinically applied due to poor drug delivery ***,we designed a CXC chemokine receptor 4(CXCR4)-targeted reactive oxygen species(ROS)-responsive platform AMD-Dex-ROS-responsive-sorafenib(ARS)based on natural polysaccharide and thioctic acid frame,which can deliver anti-fibrosis drug represented by sorafenib specifically to aHSCs on account of CXCR4 over-expression on aHSCs,and smartly disassemble via ROS-responsive thioketal rupture relying on high intracellular ROS in HSCs,realized on-demand drug release and effective liver fibrosis ***,in this platform,the CXCR4 antagonist AMD3100 not only enhanced aHSCs targeting efficiency of sorafenib but also effectively magnified the aHSCs elimination of sorafenib by blocking stroma cell derived factor-1(SDF-1)/CXCR4-induced aHSCs protection,resulting in synergistic anti-fibrosis *** platform provided a new approach for drug delivery system design and liver fibrosis treatment.

关键词： Nanoparticle CXCR4 antagonism ROS-responsive Hepatic stellate cells Liver fibrosis

Rate-limiting factors in hydrate decomposition through depressurization across various scales:A mini-review

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Chinese Journal of Chemical Engineering 2024年第3期67卷 206-219页

作者： Xian sun Peng Xiao Qinfeng Shi Lingban Wang Zhenbin Xu Yuhao Bu Xiaohui Wang Yifei sun Changyu sun Guangjin Chen State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China Jining University Jining 273115China

Natural gas hydrate is an energy resource for methane that has a carbon quantity twice more than all traditional fossil fuels ***,their practical application in the field has been limited due to the challenges of long-term preparation,high costs and associated *** studies,on the other hand,offer a safe and cost-effective means of exploring the mechanisms of hydrate dissociation and optimizing exploitation *** hydrate decomposition is a complicated process along with intrinsic kinetics,mass transfer and heat transfer,which are the influencing factors for hydrate decomposition *** identification of the rate-limiting factor for hydrate dissociation during depressurization varies with the scale of the reservoir,making it challenging to extrapolate findings from laboratory experiments to the actual *** review aims to summarize current knowledge of investigations on hydrate decomposition on the subject of the research scale(core scale,middle scale,large scale and field tests)and to analyze determining factors for decomposition rate,considering the various research scales and their associated influencing factors.

关键词： Gas hydrate Rate-limiting factors Research scale Depressurization Decomposition

妊娠期糖代谢异常早期干预对巨大儿发生率效果分析

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中国医药导报 2010年第35期7卷 42-43页

作者：孙英杰辽宁省鞍山市铁西区妇幼保健所辽宁鞍山114013

目的:对妊娠期糖代谢异常的早期规范治疗巨大儿的发生率效果进行分析。方法:将2008年1月～2010年1月在我所进行定期检查糖代谢异常的孕妇142例随机分为两组,同意规范治疗设为干预组(80例),不同意规范治疗设为对照组(62例)。结果:两组围... 详细信息

目的:对妊娠期糖代谢异常的早期规范治疗巨大儿的发生率效果进行分析。方法:将2008年1月～2010年1月在我所进行定期检查糖代谢异常的孕妇142例随机分为两组,同意规范治疗设为干预组(80例),不同意规范治疗设为对照组(62例)。结果:两组围生儿结局的比较,差异有统计学意义(P<0.05、P<0.01)。巨大儿组孕妇空腹血糖、餐后2 h血糖较正常体重儿组孕妇更高,差异有统计学意义(P<0.05)。结论:早期规范治疗妊娠期糖代谢异常,有效降低巨大儿的发生率,有助于减少母儿并发症。

关键词：妊娠期糖代谢异常早期规范治疗巨大儿

黑龙江省初中教学改革现状调研报告——以齐齐哈尔市、大庆市实地调研为例

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当代教研论丛 2018年第8期5卷 7-8,15页

作者：孙英杰黑龙江省教育学院黑龙江哈尔滨150080

2017年,黑龙江省教育学院组织开展了初中教学改革现状的调研活动。笔者参与了齐齐哈尔、大庆两市的初中教学改革现状的实地调研活动,既看到了一些优秀的教育教学经验,也通过与一线教师座谈,发现了各学科教学存在的典型问题,这里笔者亦... 详细信息

2017年,黑龙江省教育学院组织开展了初中教学改革现状的调研活动。笔者参与了齐齐哈尔、大庆两市的初中教学改革现状的实地调研活动,既看到了一些优秀的教育教学经验,也通过与一线教师座谈,发现了各学科教学存在的典型问题,这里笔者亦参考国内同行的先进经验,提出了解决问题的方法。

关键词：初中教学改革调研报告

Online control for pressure regulation of oxygen mask based on neural network

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Control Theory and Technology 2024年第3期22卷 487-501页

作者： Ligan Zhao Qinglin sun Hao sun Jin Tao Zengqiang Chen College of Artificial Intelligence Nankai UniversityTianjin 300350China Silo Al Helsinki 00100Finland

The aviation oxygen mask,which has a small volume of less than 1L and strong air tightness,imposes extremely high requirements on control performance of the oxygen *** on analyses of the operation principle of oxygen supply system,the dynamic model is established through the combination of mechanism analysis and experimental *** that the traditional fixed-parameter controllers are difficult to meet the control requirements with changes in pulmonary ventilation,this paper presents an online feedback controller based on neural network compensation(NNC),with connection weights that can be updated without *** mathematical simulations at different respiratory parameters,such as respiratory rate,are performed to verify the superior lower inspiratory resistance of controller with *** terms of hardware,an embedded AI control platform is to complete the experimental ***,the work may have downward compatibility to achieve stable oxygen supply in civil fields,such as medical ventilators,high-altitude expeditions.

关键词： Neural network Online control Pressure regulation AI platform

维普期刊数据库评论

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基于CIS理论的绿色大学评价指标体系研究

中国环境管理干部学院学报 2013年第5期23卷 75-78页

作者：孙英杰中国环境管理干部学院河北秦皇岛066004

通过研究绿色大学建设过程中出现的不足,提出构建绿色大学评价指标体系是建设绿色大学的前提。以CIS(企业识别系统)理论为依据,从理念层、行为层和物质层三个层面进行研究,构建了一个由3个一级指标12个二级指标和45个三级指标构成的绿... 详细信息

通过研究绿色大学建设过程中出现的不足,提出构建绿色大学评价指标体系是建设绿色大学的前提。以CIS(企业识别系统)理论为依据,从理念层、行为层和物质层三个层面进行研究,构建了一个由3个一级指标12个二级指标和45个三级指标构成的绿色大学评级指标体系。最后对绿色大学的评价方法进行了简单陈述。

关键词： CIS 绿色大学评价指标体系