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Biological membrane derived nanomedicines for cancer therapy

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Science China Chemistry 2021年第5期64卷 719-733页

作者： lele sun Zijian Xiong Fengyun Shen Zhanhui Wang Zhuang Liu Institute of Functional Nano&Soft Materials Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Luoyang Key Lab of Basic and Clinical Application of Biomaterials Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyang 471000China

The development of nanomedicine systems for applications in cancer therapies has been widely explored in the last *** inherent biocompatibility,nanomedicine devices derived from biological membranes have shown many unique advantages compared with traditional artificial nanomaterials for biomedical ***,we present a comprehensive review of the recent development of cell membrane derived nanomedicines in cancer *** firstly outline the advantages of biological membranes in nanomedicine design derived from their intrinsic characteristics,and then discuss the applications of biological membrane derived *** the first major category of membrane-derived nanomedicine,synthetic nanoparticles are usually camouflaged with cell membranes to acquire additional *** other type of membrane-based nanomedicine is directly using the engineered cell membrane-derived vesicles or nanovesicles secreted by cells for tumor *** last,we discuss the challenges of membrane-derived nanomedicines towards future clinical applications,following with perspectives on possible solutions to the current problems.

关键词： biological membrane nanomedicines cancer therapy

Spontaneous caving and gob-side entry retaining of thin seam with large inclined angle

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International Journal of Mining Science and Technology 2014年第4期24卷 441-445页

作者： Zhang Yongqin Tang Jianxin Xiao Daqiang sun lele Zhang Weizhong State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing University Sichuan Dazhu Coal-Electricity Group Corporation Zhangji Coal Mine Co. Ltd. Huainan Mining Group Co. Ltd. School of Environment and Civil Engineering Wuhan Institute of Technology

Based on the research method of combining simulation analysis with field testing by distinct element process UDEC, we have analyzed the roof deformation and failure laws and roadway support technology of gob-side entry retaining in a thin seam with a large inclined angle. The results show that during exploitation in seams with large inclined angle, rotational subsidence of the main roof under the gob area is small and can maintain balance, so there is no need to provide artificial permanent support resistance for the main roof near the upper side to control rotational subsidence. Obstructed by the dense scrap rail,waste rock from the immediate roof caving slides from the upper gob area to the lower area and fills it,which strikes a balance between the immediate roof under the goaf after it fractures into large pieces and filling waste rocks.

关键词： Large inclined angle Gob-side entry retaining Spontaneous caving Thin seam Field test

Nanoscale Precise Editing of Multiple Immune Stimulating Ligands on DNA Origami for T Cell Activation and Cell-Based Cancer Immunotherapy

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CCS Chemistry 2024年第3期6卷 719-732页

作者： lele sun Fengyun Shen Zijian Xiong Yu Chao Chunhai Fan Zhuang Liu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Lab Carbon Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu School of Life Sciences Shanghai UniversityShanghai 200444 School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 201240

The spatial arrangement of activating ligands is known to have great influence on T cell ***,independently studying each ligand’s spatial organization parameter that affects T cell activation remains a great ***,with DNA origami,we precisely organized the CD3ɛantibodies simulating T cell receptor(TCR)ligands and CD28 antibodies simulating co-stimulatory ligands to interrogate the independent role of TCR-ligand spacing and local copy numbers as well as the spacing between TCR ligands and co-stimulatory ligands on T cell *** found that T cell activation benefited fromlocally concentrated TCR ligands with a shorter spacing and was maximized by an∼38 nm spacing between TCR ligands and co-stimulatory *** T cell expander constructed based on our findings could efficiently expand CD8+T cells for tumor ***,the DNA nanostructurebased ligands’precise arrangement can be a unique tool in studying immune cell activations and cellbased immunotherapies.

关键词： DNA origami T cell activation T cell receptor immune cancer immunotherapy

Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy

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Nano Research 2021年第1期14卷 212-221页

作者： Wenjun Zhu Qian Chen Qiutong Jin Yu Chao lele sun Xiao Han Jun Xu Longlong Tian Jinglei Zhang Teng Liu Zhuang Liu Institute of Functional Nano&Soft Materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologyJiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordination nanosheets composed of Zn^(2+)and Tetrakis(4-carboxyphenyl)porphyrin(TCPP)are *** exhibiting greatly enhanced ultrasoundtriggered ROS generation useful for noninvasive SDT,such Zn-TCPP 2D nanosheets show high loading capacity of oligodeoxynudeotides such as cytosine—phosphorothioate-guanine(CpG),which is a potent toll like receptor 9(TLR9)agonist useful in activating immune *** effective SD T of primary tumors could release tumor-associated antigens,which working together with Zn-TCPP/CpG adjuvant nanosheets could function like whole-tumor-cell vaccines and trigger tumor-specific immune ***,ultrasound itself could strengthen anti-tumor immune responses by improving the tumor-infiltration of T cells and limiting regulatory T cells in the tumor ***,SDT using Zn-TCPP/CpG nanosheets after destruction of primary tumors could induce potent antitumor immune responses to inhibit distant abscopal tumors without direct SD T ***,SDT with Zn-TCPP/CpG could trigger strong immunological memory effects to inhibit cancer recurrence after elimination of primary ***,the 2D coordination nanosheet may be a promising platform to deliver potent SDT-triggered immunotherapy for highly effective cancer treatment.

关键词： two-dimensional nanosheets biodegradable sonodynamic therapy regulate immunosuppressive TME immunotherapy

COVID-19 exacerbates psoriasis progression through inducing IFN-αexpression

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 379-380,I0002页

作者： Mingjia Hu lele sun Qing Zhao Yanyan Li Zhenzhen Wang Hong Liu Furen Zhang Hospital for Skin Diseases Shandong First Medical UniversityJinanShandongChina Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical SciencesJinanShandongChina

As a global public health issue that can cause systemic diseases,COVID-19 inflicts various harms on patients and impacts those with *** is primarily driven by a subset of T helper cells and the cytokines[1],and microbial infection is a predisposing factor in up to 45%of patients[2].Infection with SARS-CoV-2 may trigger the aggravation of ***,we conducted a survey to explore the proportion of psoriasis patients who experienced exacerbation and relapse after SARS-CoV-2 infection and also performed a preliminary investigation into the mechanisms *** hundred and twenty-four psoriasis patients(79 males and 45 females)who contracted COVID-19 were followed up and provided detailed information.

关键词： psoriasis infection diseases

Coating tetrahedral DNA framework with endosomolytic peptides for improved stability and cytosolic delivery

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Advanced Sensor and Energy Materials

Advanced Sensor and Energy Materials 2024年第2期3卷 1-5页

作者： Jinjun He Xiang Ji Zihui Xu Wei He Yan Zhao lele sun Lan Ma Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China Institute of Materiobiology Department of ChemistryCollege of ScienceShanghai UniversityShanghai 200444China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen518055 China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Division of Physical Biology Department CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China State Key Laboratory of Chemical Oncogenomics Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

DNA nanostructures have emerged as promising carriers for drug ***,challenges such as low stability,poor cellular uptake efficiency,and vulnerability to lysosomal degradation still hinder their therapeutic *** this study,we demonstrate the coating of tetrahedral DNA frameworks(TDF)with the endosomolytic peptide L17E through electrostatic interactions to address these *** findings highlight that L17E coating substantially enhances the stability of TDFs and improves their uptake efficiency into RAW264.7 cells through endocytosis and ***,L17E coating enables efficient endosomal release of ***,we employed L17E-coated TDF to deliver osteogenic growth peptide and demonstrated its potential applications in inhibiting periodontitis both in vitro and in *** straightforward and cost-effective strategy holds promise for advancing the biomedical applications of DNA nanostructures.

关键词： Tetrahedral DNA framework Endosomolytic peptides Stability Endosomal escape Efficient delivery

Dapsone hypersensitivity syndrome

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Chinese Medical Journal 2023年第13期136卷 1560-1562页

作者： Qing Zhao lele sun Yonghu sun Dean Naisbitt Hong Liu Furen Zhang Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Department of Molecular and Clinical Pharmacology MRC Centre for Drug Safety ScienceUniversity of LiverpoolLiverpoolUK

Dapsone hypersensitivity syndrome(DHS)was first reported by Lowe and Smith[1]in 1949 in Nigeria and was termed“dapsone syndrome”by Allday and Barnes[2]in *** is a drug-induced hypersensitivity syndrome(DIHS)caused by dapsone 404’-diaminodiphenylsulfone(DDS).DHS is characterized by fever,rash,lymphadenopathy,and hepatitis,which usually develop after patients receive DDS for 5 to 6 *** studies have estimated DHS prevalence and fatality rates of 1.4%and 9.9%,respectively.[3]Until recently,the“wait and see”approach was used for patients with suspected ***,we review recent developments in DHS research,focusing on its etiology,pathogenesis,diagnosis,and prevention,to make DDS a safer medication for most of the population through the prospective exclusion of susceptible patients before DDS administration.

关键词： DHS prevention diagnosis

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侧向轧制变胞机构的动力学仿真与优化设计

华中科技大学学报（自然科学版） 2024年第6期52卷 56-62页

作者：孙乐乐张海鸥华中科技大学机械科学与工程学院湖北武汉430074

为了解决电弧增材制造存在变形及微观组织形态和力学性能较差的问题,采用轧制使材料的力学性能得到极大改善.为了合理设计轧制机构,针对一种侧向轧制变胞机构进行动力学分析和优化设计,分别分析了杆件尺寸、主动件速度、弹簧刚度在变胞... 详细信息

为了解决电弧增材制造存在变形及微观组织形态和力学性能较差的问题,采用轧制使材料的力学性能得到极大改善.为了合理设计轧制机构,针对一种侧向轧制变胞机构进行动力学分析和优化设计,分别分析了杆件尺寸、主动件速度、弹簧刚度在变胞机构运动过程中对变胞机构的影响.首先,分析了侧向轧制变胞机构的原理,得到了机构的基本结构;然后,选取合适的设计变量初始值与边界值,确定目标函数及约束条件;最后,在机械系统动力学自动分析(ADAMS)软件中建立机构的虚拟样机模型,在一定的侧向轧制力下,以主动件的驱动力最小为优化目标进行仿真求解,得到驱动力的最优解和相应设计变量的最优值.结果表明:最小驱动力较优化前减小了15.48%,主动件速度、杆件尺寸、弹簧刚度对变胞机构的影响程度是依次减弱的.

关键词：变胞机构电弧增材制造优化设计动态仿真机械系统动力学自动分析(ADAMS)

基于改进YOLO v4网络的马铃薯自动育苗叶芽检测方法

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农业机械学报 2022年第6期53卷 265-273页

作者：修春波孙乐乐天津工业大学控制科学与工程学院天津300387 天津工业大学天津市电气装备智能控制重点实验室天津300387

为提高马铃薯幼苗叶芽检测识别的准确率,提高自动育苗生产系统的工作效率,提出了基于YOLO v4网络的改进识别网络。将YOLO v4特征提取部分CSPDarknet53中的残差块(Residual Block)替换为Res2Net,并采用深度可分离卷积操作减小计算量。由... 详细信息

为提高马铃薯幼苗叶芽检测识别的准确率,提高自动育苗生产系统的工作效率,提出了基于YOLO v4网络的改进识别网络。将YOLO v4特征提取部分CSPDarknet53中的残差块(Residual Block)替换为Res2Net,并采用深度可分离卷积操作减小计算量。由此,在增大卷积神经网络感受野的同时,能够获得叶芽更加细小的特征信息,减少马铃薯叶芽的漏检率。设计了基于扩张卷积的空间特征金字塔(DSPP模块),并嵌入和替换到特征提取部分的3个特征层输出中,用于提高马铃薯叶芽目标识别定位的准确性。采用消融实验对改进策略的有效性进行了验证分析。实验结果表明,改进的识别网络对马铃薯叶芽检测的精确率为95.72%,召回率为94.91%,综合评价指标F1值为95%,平均精确率为96.03%。与Faster RCNN、YOLO v3、YOLO v4网络相比,改进的识别网络具有更好的识别性能,从而可有效提高马铃薯自动育苗生产系统的工作效率。

关键词：深度学习马铃薯叶芽检测扩张卷积感受野 YOLO v4