检索结果-南通市图书馆

Enhanced Electrochemical Performance of Poly(ethylene oxide)Composite Polymer Electrolyte via Incorporating Lithiated Covalent Organic Framework

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Transactions of Tianjin University 2022年第1期28卷 67-72页

作者： Yuan yao Yu Cao Gang Li Cheng Liu Zhongyi Jiang fusheng Pan Jie sun Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Sinopec Research Institute of Petroleum Processing Beijing 100728China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515031China

The lithiated covalent organic framework(named TpPa-SO_(3) Li),which was prepared by a mild chemical lithiation strategy,was introduced in poly(ethylene oxide)(PEO)to produce the composite polymer electrolytes(CPEs).Li-ion can transfer along the PEO chain or across the layer of TpPa-SO_(3) Li within the nanochannels,resulting in a high Li-ion conductivity of3.01×10^(-4)S/cm at 60℃.When the CPE with 0.75 wt.%TpPa-SO_(3) Li was used in the LiFePO_(4)‖Li solid-state battery,the cell delivered a stable capacity of 125 mA·h/g after 250 cycles at 0.5 C,60℃.In comparison,the cell using the CPE without TpPa-SO_(3) Li exhibited a capacity of only 118 mA·h/g.

关键词： Lithiated covalent organic framework Composite polymer electrolytes Poly(ethylene oxide) Solid-state lithium-ion batteries

S100A8 promotes epithelial-mesenchymal transition and metastasis under TGF-β/USF2 axis in colorectal cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2021年第2期41卷 154-170页

作者： Si Li Jun Zhang Senmi Qian Xuesong Wu Liang sun tianyi Ling yao Jin Wenxiao Li Lichao sun Maode Lai Fangying Xu Department of Pathology and Pathophysiology and Department of General Surgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058P.R.China Department of Pathology and Pathophysiology Zhejiang University School of MedicineHangzhouZhejiang 310058P.R.China Key Laboratory of Disease Proteomics of Zhejiang Province Zhejiang University School of MedicineHangzhouZhejiang 310058P.R.China State Key Laboratory of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China

Background:The transforming growth factor-β(TGF-β)pathway plays a pivotal role in inducing epithelial-mesenchymal transition(EMT),which is a key step in cancer invasion and ***,the regulatory mechanism of TGF-βin inducing EMT in colorectal cancer(CRC)has not been fully *** previous studies,it was found that S100A8 may regulate *** study aimed to clarify the role of S100A8 in TGF-β-induced EMT and explore the underlying mechanism in ***:S100A8 and upstream transcription factor 2(USF2)expression was detected by immunohistochemistry in 412 CRC ***-Meier survival analysis was *** vitro,Western blot,and migration and invasion assays were performed to investigate the effects of S100A8 and USF2 on TGF-β-induced *** metastasis models were used to determine in vivo metastasis *** reporter and chromatin immunoprecipitation assay were used to explore the role of USF2 on S100A8 ***:During TGF-β-induced EMT in CRC cells,S100A8 and the transcription factor USF2 were upregulated.S100A8 promoted cell migration and invasion and ***2 transcriptionally regulated S100A8 expression by directly binding to its promoter ***,TGF-βenhanced the USF2/S100A8 signaling axis of CRC cells whereas extracellular S100A8 inhibited the USF2/S100A8 axis of CRC cells.S100A8 expression in tumor cells was associated with poor overall survival in ***2 expression was positively related to S100A8 expression in tumor cells but negatively related to S100A8-positive stromal ***:TGF-βwas found to promote EMT and metastasis through the USF2/S100A8 axis in CRC while extracellular S100A8 suppressed the USF2/S100A8 ***2 was identified as an important switch on the intracellular and extracellular S100A8 feedback loop.

关键词： colorectal cancer epithelial-mesenchymal transition metastasis prognosis transforming growth factor-β upstream transcription factor 2 S100 calcium-binding protein A8

MXene:An efficient hemoperfusion sorbent for the removal of uremic toxins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materiomics 2023年第6期9卷 1129-1140页

作者： tianyi Wang Wei Gu Lu Yu Xin Guo Jian Yang Xiaoyu sun Jun Guan Lin Zhou Chengyin Wang Hang yao Xiuyun Zhang Guoxiu Wang College of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225000Jiangsu ProvinceChina Centre for Clean Energy Technology School of Mathematics and PhysicsFaculty of ScienceUniversity of Technology SydneyBroadwaySydneyNSW2007Australia Clinical Medical College Su Bei People's HospitalYangzhou UniversityYangzhou225000Jiangsu ProvinceChina College of Physical Science and Technology Yangzhou UniversityYangzhou225000Jiangsu ProvinceChina

MXene,a family of two-dimensional(2D)transition metal carbides and nitrides have attracted extensive interests for many biochemical applications,including tumour elimination,biosensors,and magnetic resonance imaging(MRI).In this article,we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease(ESRD)*** scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption,electrostatic interaction surface of 2D MXene,and transformation of protein secondary structure.2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease.

关键词： 2D materials MXene Hemoperfusion Middle molecular weight toxin Protein bound toxin Adsorption

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

锂硫电池中的催化作用

化学进展 2021年第3期33卷 442-461页

作者：潘福生姚远孙洁天津大学化工学院绿色化学化工教育部重点实验室天津300072

锂硫电池理论能量密度高达2600 Wh·kg^(-1),单质硫的理论容量可达1675 mAh·g^(-1),远高于商业化的锂离子电池正极材料,但多硫化锂的“穿梭效应”等问题对其性能影响严重。目前研究主要采用基于“阻挡”的物理限制和化学吸附策略将多... 详细信息

锂硫电池理论能量密度高达2600 Wh·kg^(-1),单质硫的理论容量可达1675 mAh·g^(-1),远高于商业化的锂离子电池正极材料,但多硫化锂的“穿梭效应”等问题对其性能影响严重。目前研究主要采用基于“阻挡”的物理限制和化学吸附策略将多硫化锂限制在正极侧。而基于“疏导”的催化转化策略则通过加快氧化还原反应动力学,在抑制“穿梭效应”的同时实现降低过电位、诱导Li2S均匀沉积等功能。本文综述了锂硫电池中的催化作用,基于是否产生氧化还原中间体将其分为吸附-转化机制和氧化还原介导机制两类;并介绍了相关的材料及常用的表征技术和研究方法。

关键词：锂硫电池多硫化物催化作用机制

Crocus genome reveals the evolutionary origin of crocin biosynthesis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第4期14卷 1878-1891页

作者： Zhichao Xu Shanshan Chen Yalin Wang Ya Tian Xiaotong Wang tianyi Xin Zishan Li Xin Hua Shengnan Tan Wei sun Xiangdong Pu Hui yao Ranran Gao Jingyuan Song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs Engineering Research Center of Chinese Medicine ResourceMinistry of EducationBeijing 100193China College of Life Science Northeast Forestry UniversityHarbin 150040China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine China Academy of Chinese Medical SciencesInstitute of Chinese Materia MedicaBeijing 100700China Analysis and Testing Center of Northeast Forestry University Harbin 150040China School of Pharmacy Anhui Medical UniversityInflammation and Immune Mediated Diseases Laboratory of Anhui ProvinceHefei 230032China

Crocus sativus (saffron) is a globally autumn-flowering plant, and its stigmas are the most expensive spice and valuable herb medicine. Crocus specialized metabolites, crocins, are biosynthesized in distant species, Gardenia (eudicot) and Crocus (monocot), and the evolution of crocin biosynthesis remains poorly understood. With the chromosome-level Crocus genome assembly, we revealed that two rounds of lineage-specific whole genome triplication occurred, contributing important roles in the production of carotenoids and apocarotenoids. According to the kingdom-wide identification, phylogenetic analysis, and functional assays of carotenoid cleavage dioxygenases (CCDs), we deduced that the duplication, site positive selection, and neofunctionalization of Crocus-specific CCD2 from CCD1 members are responsible for the crocin biosynthesis. In addition, site mutation of CsCCD2 revealed the key amino acids, including I143, L146, R161, E181, T259, and S292 related to the catalytic activity of zeaxanthin cleavage. Our study provides important insights into the origin and evolution of plant specialized metabolites, which are derived by duplication events of biosynthetic genes.

关键词： Crocus sativus WGT Crocin biosynthesis Carotenoids Apocarotenoids CCDs

Ultrafine red phosphorus confined in reasonably designed pitch-based carbon matrix built of well-interconnected carbon nanosheets for high-performance lithium and potassium storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Resources Chemicals and Materials 2024年第1期3卷 54-61页

作者： Chang Liu Junjun yao Ying sun Yaming Zhu Hongmei Li Daming Feng Hui Li Yunlei Yang Quanxing Mao tianyi Ma Institute of Clean Energy Chemistry Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials of Liaoning ProvinceCollege of ChemistryLiaoning UniversityShenyang 110036China School of Science RMIT UniversityMelbourneVIC 3000Australia Institute of Chemical Engineering University of Science and TechnologyLiaoningAnshan 114051China College of Materials Science and Engineering Shenyang Aerospace UniversityShenyang 110136China

Red phosphorus has been well-recognized as promising anode materials for lithium-ion batteries(LIBs)and potassium-ion batteries(PIBs)due to its extremely high theoretical capacity and low ***,the huge volume change and poor electric conductivity severely limit its further practical ***,the nanoscale ultrafine red phosphorus has been successfully confined in a three-dimensional pitch-based porous carbon skeleton composed of well-interconnected carbon nanosheets through the vaporization-condensation *** for the traditional requirement of high electric conductivity and stable mechanical stability,the micropores and small mesopores in the porous carbon matrix centered at 1 to 3 nm and the abundant amount of oxygen-containing functional groups are also beneficial for the high loading and dispersion of red *** anode for LIBs,the composite exhibits high reversible discharge capacities of 968 mAh g^(-1),excellent rate capabilities of 593 mAh g^(-1)at 2 A g^(-1),and long cycle performance of 557 mAh g^(-1)at 2 A g^(-1).More impressively,as the anode for PIBs,the composite presents a high reversible capacity of 661 mAh g^(-1)and a stable capacity of 312 mAh g^(-1)at 0.5 A g^(-1)for 500 cycles with a capacity retention up to 84.3%.This work not only sheds light on the structure design of carbon hosts with specific pore structure but also open an avenue for high value-added utilization of coal tar pitch.

关键词： Carbon anodes Coal tar pitch Lithium-ion batteries Potassium-ion batteries Red phosphorus

Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第3期6卷 888-896页

作者： Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi yao tianyi Liu Jinwen Song Liangliang sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen yao Wei-Fen Xie Fu-Sheng Wang Department of Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina Wuhan Huoshenshan Hospital WuhanChina Department of Respiratory Changzheng HospitalSecond Military Medical UniversityShanghaiChina Optical Valley Branch of Maternal and Child Hospital of Hubei Province WuhanChina Department of Hematology Second Medical Center of Chinese PLA General HospitalBeijingChina Peking University Clinical Research Institute Peking University First HospitalBeijingChina Department of Infectious Disease General Hospital of Central Theater CommandWuhanChina VCANBIO Cell&Gene Engineering Corp. LtdTianjinChina National Industrial Base for Stem Cell Engineering Products TianjinChina Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Key Laboratory of Cancer Center Fifth Medical Center of Chinese PLA General HospitalBeijingChina Department of Endocrinology and Metabolism Changzheng HospitalSecond Military Medical UniversityShanghaiChina Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Nursing Department Fifth Medical Center of Chinese PLA General HospitalBeijingChina immunotherapy Programme Champalimaud Centre for the UnknownLisbonPortugal Med Clinic University of MainzMainzGermany Center for Clinical Microbiology Division of Infection and ImmunityUniversity College Londonand UCL Hospitals NIHR Biomedical Research CentreLondonUK Department of Gastroenterology Changzheng HospitalSecond Military Medical UniversityShanghaiChina

Treatment of severe Coronavirus Disease 2019(COVID-19)is *** performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 *** this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung *** were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and *** primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day *** imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and *** all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two *** results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability.

关键词： damage patients double

Flexible Copper‑Doped Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti‑inflammatory Effects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Fiber Materials 2024年第1期6卷 278-296页

作者： Jie Cui Yuchen Cai Xiao Yu Yihong Shen tianyi Zhou Binbin sun Pengfei Cai Zhengchao Yuan Muhammad Shafiq Mohamed EL‑Newehy Hany EL‑Hamshary Xingping Zhou yao Fu Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011People’s Republic of China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011People’s Republic of China Innovation Center of NanoMedicine Kawasaki Institute of Industrial Promotion3‑25‑14 Tono‑machiKawasaki‑kuKanagawa 210‑0821Japan United Graduate School of Drug Discovery and Medical Information Sciences Gifu University1‑1 YanagidoGifu 501‑1193Japan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia

The conjunctiva is crucial in safeguarding the eye from harm or infection,thereby ensuring the preservation of the *** repair of infected conjunctival damage is *** objective of this study is to develop copper-doped flexible silica nanofibers(SiO_(2)@Cu NFs)with multifunctional antibacterial and anti-inflammatory *** continuous release of copper ions from electrospun membranes is shown to be effective to promote antibacterial and bioactive *** membranes also exhibit biocompatibility and promote cell growth,angiogenesis,and inflammation *** vivo evaluations further reveal the therapeutic efficacy of SiO_(2)@Cu NFs to promote the structural and the functional recoveries of the *** together,SiO_(2)@Cu NFs may hold significant promise for the fabrication of alterna-tive ocular bandage to suppress bacterial infection and promote repair of ocular tissues and may potential be also used for related disciplines.

关键词： Conjunctival reconstruction Inorganic nanofiber Bacterial infection Angiogenesis Anti-inflammation

A Potential Functional Cure in Chinese HBeAg-negative Chronic Hepatitis B Patients Treated with Peg-interferon Alpha-2a

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2019年第3期7卷 249-257页

作者： Xinyue Chen Qianguo Mao yao Xie Xiaoguang Dou Qing Xie Jifang Sheng Zhiliang Gao Xiaoling Zhou Yingxia Liu Huanwei Zheng Shuqin Zhang Shibo Li fusheng Zhu Yuqin Xu Mingxiang Zhang yaoren Hu Xiaoping Chen Yan Huang Hong Ren Jidong Jia International Medicine Ward Beijing YouAn HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases Xiamen Hospital of Traditional Chinese MedicineXiamenFujianChina Department of Liver Disease Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases Shengjing Hospital of China Medical UniversityShenyangLiaoningChina Department of Infectious Diseases Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiangChina Department of Infectious Diseases The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterology Liuzhou Traditional Chinese Medical HospitalLiuzhouGuangxiChina Department of Infectious Diseases Shenzhen Third People's HospitalShenzhenGuangdongChina Department of Infectious Diseases The Fifth Hospital of ShijiazhuangShijiazhuangHebeiChina Department of Infectious Diseases Hepatology Hospital of Jilin ProvinceChangchunJilinChina Department of Infectious Diseases Zhoushan Hospital of Zhejiang ProvinceZhoushanZhejiangChina Department of Infectious Diseases General Hospital of Dagang OilfieldTianjinChina Department of Infectious Diseases The 211 Hospital of People's Liberation ArmyHarbinHeilongjiangChina Department of Integrated Traditional and Western Medicine on Liver Diseases The Sixth People's Hospital of ShenyangShenyangLiaoningChina Department of Liver Disease Ningbo No.2 Hospital of Zhejiang ProvinceNingboZhejiangChina Department of Infectious Diseases Guangdong General HospitalGuangzhouGuangdongChina Department of Medical Science Shanghai Roche Pharmaceuticals Ltd.ShanghaiChina Department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Liver Disease Beijing Friendship HospitalCapital Medical UniversityBeijing 100069China

Background and Aims:Data are limited on the use of pegylated-interferon alpha-2a(peg-IFNα)in Chinese patients with chronic hepatitis B virus(HBV)infection(CHB).We evaluated the effectiveness and safety of peg-IFNαin Chinese patients with hepatitis B envelope antigen-negative CHB in routine clinical ***:In this prospective,multicenter,observational,non-interventional cohort study,patients were assessed for up to 1 year after peg-IFNαtreatment *** physicians established the dosing and treatment duration according to Chinese clinical *** of peg-IFNαtreatment was measured by the percentage of:patients with HBV DNA<2000 IU/mL and loss of hepatitis B surface antigen(commonly known as HBsAg);HBV DNA level at end of treatment(EOT),and 6 months and 1 year posttreatment;and time course change in quantitative HBV DNA and ***:At EOT,6 months posttreatment,and 1 year posttreatment,the percentage of patients with HBV DNA<2000 IU/mL was 90.0%,81.8%,and 82.2%,and that of patients with HBsAg loss was 6.5%,9.4%,and 9.5%,*** HBV DNA level decreased from 5.61 log IU/mL at baseline to 2.48 log IU/mL at EOT and 2.67 log IU/mL at 1 year *** HBsAg level decreased from 3.08 log IU/mL at baseline to 2.24 log IU/mL at EOT and 2.10 log IU/mL at 1 year *** incidence of adverse events was 52.0%.Conclusions:Peg-IFNαhas the potential to provide functional cure(HBsAg loss)for CHB and is well tolerated in hepatitis B envelope antigen-negative CHB patients in routine clinical practice in China.

关键词： Chronic hepatitis B Prospective studies Observational study Interferon alpha