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Growing Economic Interdependence of China and the Gulf Cooperation Council

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China & World Economy 2008年第2期16卷 109-124页

作者： Michael Thorpe sumit Mitra College of Graduate Studies University of WollongongDubaiUnited Arab Emirates College of Graduate Studies University of WollongongDubaiUAE

The six nations of the Gulf Cooperation Council （GCC） have approximately 40percent of total proven oil reserves as well as 23 percent of the world＇s gas reserves. Although rising oil revenues have led to greater outward investment flows, there is also a growing need for significant expansion of the domestic energy sector＇s capacity. Meanwhile, China＇s sustained economic boom has resulted in China emerging as the world＇s second largest consumer and importer o foil, with close to 40percent of its import demand presently sourced from the GCC. This share will grow significantly in the future. Commercial relations between the GCC and China have to date been dominated by energy-related bilateral investment flows and China＇s oil imports. Although this will continue to be a central feature, trade and investment links in non-energy areas will further broaden and deepen the relationship. China ＇s relationship with the USA in terms of energy is also emerging as a major issue. Rather than being competitors, a mutual dependence on stable and secure supplies from the GCC highlights the need for a cooperative relationship.

关键词： China Gulf Cooperation Council economic interdependence oil

Differential methylation landscape of pancreatic ductal adenocarcinoma and its precancerous lesions

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 205-217页

作者： Akash Bararia Subhankar Dey sumit Gulati Supriyo Ghatak Shibajyoti Ghosh Sudeep Banerjee Nilabja Sikdar Human Genetics Unit Indian Statistical InstituteKolkataIndia Department of Zoology New Alipore CollegeUniversity of CalcuttaKolkataIndia Department of Gastroenterological Surgery Calcutta Medical Research InstituteKolkataIndia Department of General Surgery Medical College and HospitalKolkataIndia Department of Gastrointestinal Surgery Tata Medical CenterRajarhatKolkataIndia

Background:Pancreatic cancer is one of the most lethal diseases with an incidence almost equal to the *** addition to having genetic causes,cancer can also be considered an epigenetic *** methylation is the premier epigenetic modification and patterns of aberrant DNA methylation are recognized to be a common hallmark of human *** the multistage carcinogenesis of pancreas starting from precancerous lesions to pancreatic ductal adenocarcinoma(PDAC),the epigenetic changes play a significant *** sources:Relevant studies for this review were derived via an extensive literature search in Pub Med via using various keywords such as pancreatic ductal adenocarcinoma,precancerous lesions,methylation profile,epigenetic biomarkers that are relevant directly or closely associated with the concerned area of our *** literature search was intensively done considering a time frame of 20 years(1998–2018).Result:In this review we have highlighted the hypermethylation and hypomethylation of the precancerous PDAC lesions(pancreatic intra-epithelial neoplasia,intraductal papillary mucinous neoplasm,mucinous cystic neoplasm and chronic pancreatitis)and PDAC along with the potential *** have also achieved the early epigenetic driver that leads to progression from precancerous lesions to PDAC.A bunch of epigenetic driver genes leads to progression of precancerous lesions to PDAC(pp ENK,APC,p14/5/16/17,h MLH1 and MGMT)are also *** summarized the importance of these observations in therapeutics and diagnosis of PDAC hence identifying the potential use of epigenetic biomarkers in epigenetic targeted *** inactivation occurs by hypermethylation of Cp G islands in the promoter regions of tumor suppressor *** listed all hyper-and hypomethylation of Cp G islands of several genes in PDAC including its precancerous ***:The concept of the review would help to understand their biological effects,and to determine

关键词： Pancreatic cancer Methylation CpG islands Epigenetic Biomarkers Precancerous lesions

Tiletamine/zolazepam and dexmedetomidine with tramadol provide effective general anesthesia in rats

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Animal Models and Experimental Medicine 2021年第1期4卷 40-46页

作者： Vudhiporn Limprasutr Patrick Sharp Katechan Jampachaisri Cholawat Pacharinsak sumit Durongphongtorn Department of Pharmacology and Physiology Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkokThailand Research Clusters:Preclinical Toxicity and Efficacy Assessment of Medicines and Chemicals Chulalongkorn UniversityBangkokThailand Animal Resources Centre MurdochWAAustralia Department of Mathematics Faculty of SciencesNaresuan UniversityPhitsanulokThailand Department of Comparative Medicine School of MedicineStanford UniversityStanfordCAUSA Department of Veterinary Surgery Faculty of Veterinary ScienceChulalongkorn UniversityBangkokThailand

Background:Tiletamine/zolazepam is a dissociative anesthetic combination commonly used in small animals but information is limited in *** alpha-2 agonist,dexmedetomidine,has gained popularity in laboratory animal *** is a weak opioid mu *** aim of this study was to assess whether the tiletamine/zolazepam/dexmedetomidine(ZD)combination effectively provides a surgical anesthesia plane comparable to tiletamine/zolazepam/dexmedetomidine with tramadol(ZDT)in a minor procedure in ***:Rats were induced with ZD or *** the loss of paw withdrawal,a small incision was made on the rats’left thighs as a surgical *** were maintained under a surgical anesthesia plane by assessing the loss of the paw withdrawal reflex for 45 minutes,then atipamezole was *** anesthesia parameters included:(a)physiological parameters-pulse rate(PR),respiratory rate(RR),tissue oxygen saturation(%SpO 2),and body temperature;(b)duration parameters-induction time,onset and duration of surgical anesthesia plane,onset of recovery,and recovery ***:PR was significantly lower at 10 minutes in ZD and 5 minutes in ZDT *** difference was observed for RR,%SpO 2,and body ***,there were no differences for duration parameters:induction time was less than 3 minutes;onset and duration of surgical anesthesia plane were approximately 5 and 45 minutes,respectively;onset of recovery(time to move)was 51 minutes;and recovery time was 52 minutes,***:These data suggest the ZD combination provides a surgical anesthesia plane comparable to ZDT in a rat incisional pain model.

关键词： anesthesia dexmedetomidine rats tiletamine tramadol

Savings,investment,and growth in Nepal:an empirical analysis

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Financial Innovation 2019年第1期5卷 679-691页

作者： Aadersh Joshi sumit Pradhan Jagadish Prasad Bist Global College International affiliated to Midwestern University KathmanduNepal Uniglobe College affiliated to Pokhara University KathmanduNepal The British College affiliated to University of the West of England BristolUKKathmanduNepal

This study analyzes the relationship between savings,investment,and economic growth in Nepal over 1975–*** structural breaks in the variables have been accounted for using the(Zivot and Andrews’s,J Bus Econ Stat 10:251–2701992)unit root test along with(Gregory and Hansen’s,Oxf Bull Econ Stat 58:555–560,1996)cointegration *** ARDL approach to cointegration in the presence of structural breaks has also been utilized to analyze the long-and short-run dynamics of savings,investment,and growth in *** results show structural breaks in the real GDP per capita during 2001 when the Royal Massacre and a state of emergency have taken place in *** allowing for this structural break,evidence of a cointegration relationship amongst savings,investment,and economic growth was *** estimates of the ARDL approach suggest that investment has a significant and positive impact on economic ***,gross domestic savings have a negative impact on growth in the long *** results clearly show weaknesses of the economy in mobilizing savings into productive sectors.

关键词： Savings Investment Economic Growth Structural Break ARDL Model

Anti-thymocyte globulin for treatment of T-cell-mediated allograft rejection

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World Journal of Transplantation 2023年第6期13卷 299-308页

作者： sumit Acharya Suraj Lama Durga Anil Kanigicherla Department of Nephrology Shahid Dharmabhakta National Transplant CenterBhaktapur 44800Nepal Department of Renal Medicine Manchester University NHS Foundation TrustManchester M139WLUnited Kingdom

Anti-thymocyte globulin(ATG)is a pivotal immunosuppressive therapy utilized in the management of T-cell-mediated rejection and steroid-resistant rejection among renal transplant *** available as Thymoglobulin(rabbit-derived,Sanofi,United States),ATG-Fresenius S(rabbit-derived),and ATGAM(equine-derived,Pfizer,United States),these formulations share a common mechanism of action centered on their interaction with cell surface markers of immune cells,imparting immunosuppressive *** the prevailing mechanism predominantly involves T-cell depletion via the complement-mediated pathway,alternate mechanisms have been *** dosing and treatment duration of ATG have exhibited variance across randomised trials and clinical reports,rendering the establishment of standardized guidelines a *** spectrum of risks associated with ATG administration spans from transient adverse effects such as fever,chills,and skin rash in the acute phase to long-term concerns related to immunosuppression,including susceptibility to infections and *** comprehensive review aims to provide a thorough exploration of the current understanding of ATG,encompassing its mechanism of action,clinical utility in the treatment of acute renal graft rejections,specifically steroid-resistant cases,efficacy in rejection episode reversal,and a synthesis of findings from different eras of maintenance ***,it delves into the adverse effects associated with ATG therapy and its impact on long-term graft ***,the review underscores the existing gaps in evidence,particularly in the context of the Banff classification of rejections,and highlights the challenges faced by clinicians when navigating the available literature to strike the optimal balance between the risks and benefits of ATG utilization in renal transplantation.

关键词： Anti-thymocyte globulin T-cell-mediated rejection Steroid-resistant rejection Biopsy confirmed acute rejection

Activity of Angiogenesis Inhibitors in Metastatic Epithelioid Hemangioendothelioma:A Case Report

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Clinical oncology and cancer researeh 2012年第2期9卷 133-136页

作者： sumit Gaur Alireza Torabi Thomas I O'Neill Divisions of Hematology-Oncology Texas Tech University Health Science Center Divisions of Pathology Texas Tech University Health Science Center Divisions of Radiology Texas Tech University Health Science Center

This report describes a patient with metastatic epithelioid hemangioendothelioma treated with bevacizumab and nanoparticle albumin-bound *** treatment was well tolerated and led to the stabilization of an aggressive variant of the disease. This case report is the first one that describes the activity of the combination of chemotherapy and bevacizumab in epithelioid *** describing the activity of bevacizumab and other agents(thalidomide,lenalidomide,and interferon) believed to possess anti-angiogenic activities is also reviewed.

关键词： hemangioendothelioma angiogenesis inhibitors nab-paclitaxel bevacizumab

Monitoring permeable paver runoff with an open-innovation geospatial sensor network

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International Journal of Digital Earth 2016年第1期9卷 30-46页

作者： Andrew J.Rettig sumit Khanna Richard A.Beck Quinn Wojcik Carmen A.McCane Department of Geography University of CincinnatiCincinnatiOHUSA College of Engineering and Computer Science University of Tennessee at ChattanoogaChattanoogaTNUSA

Sensor networks are an essential tool for environmental *** scientists and engineers are beginning to utilize these new methods and devices in their fieldwork,they need to be actively involved in the future of sensor-networking *** sensor network innovation is important for improved standardization,affordability,and *** article uses a storm water case study to outline an end-to-end open-innovation sensor *** innovation by scientists,engineers,and entities is the collaborative process of creating value for this project in permeable paver runoff data and advances within sensor *** article focuses on the technical implementation of the near–real-time location and temporally aware sensor *** are streamed in near–real-time with subliter precision to the cloud using common off-the-shelf *** sensors use Maxim’s 1-wire™protocol,and the unique digital serial numbers confirm the *** data retrieved compare residence times within the permeable paver catchment basins and the control *** network advances are made by bridging the gap between sensor protocols and communication *** advances enable the development of open-source representational state transfer web *** successful implementation serves as an example for others to study and expand upon for a variety of monitoring solutions.

关键词： sensor networks Internet of things open geospatial consortium open innovation permeable pavers

Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula:A narrative review

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1089-1106页

作者： Nadya Rykina-Tameeva Jaswinder S Samra sumit Sahni Anubhav Mittal Northern Clinical School University of SydneySt Leonards 2065Australia

Clinically relevant postoperative pancreatic fistula(CR-POPF)has continued to compromise patient recovery post-pancreatectomy despite decades of research seeking to improve risk prediction and *** current diagnostic criteria for CR-POPF requires elevated drain fluid amylase to present alongside POPFrelated complications including infection,haemorrhage and organ *** worrying sequelae necessitate earlier and easily obtainable biomarkers capable of reflecting evolving *** fluid has recently emerged as a promising source of biomarkers as it is derived from the pancreas and hence,capable of reflecting its postoperative *** present review aims to summarise the current knowledge of CR-POPF drain fluid biomarkers and identify gaps in the field to invigorate future research in this critical area of clinical *** findings may provide robust diagnostic alternatives for CR-POPF and hence,to clarify their clinical utility require further reports detailing their diagnostic and/or predictive accuracy.

关键词： Biomarkers Clinically relevant postoperative pancreatic fistula Diagnosis Drain fluid Prediction

Bilateral choroidal detachment and exudative retinal detachment following laser peripheral iridotomy in a case of ocular Vogt-Koyanagi-Harada’s disease

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 630-632页

作者： Arijit Mitra Arnab Das sumit Choudhury Suchand Sar Debarpita Chaudhury Department of Glaucoma Disha Eye Hospitals Pvt.Ltd.BarrackporeKolkata 700120West BengalIndia

Dear Editor,We present a case of bilateral choroidal detachment(CD)and exudative retinal detachment(ERD)following laser peripheral iridotomy(LPI)in a patient of ocular Vogt-Koyanagi-Harada’s disease(VKHD).A 42 yearold-lady presented to us with the complaint of sudden onset of pain,redness,and dimness of vision in her right eye for past two *** best-corrected visual acuity(BCVA)was 20/40 and 20/30 in right and left eye respectively.

关键词： laser choroidal Koyanagi