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Effect of Dietary Nitrate on Force Production and Sarcoplasmic Reticulum Ca<sup>2+</sup>Handling in Rat Fast-Twitch Muscles Following Eccentric Contraction

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Open Journal of Applied Sciences 2018年第12期8卷 607-618页

作者： Satoshi matsunaga Chihiro Aibara Daiki Watanabe Keita Kanzaki Yurie Morizaki sumiko matsunaga-futatsuki Masanobu Wada Faculty of Education University of Miyazaki Miyazaki Japan Graduate School of Integrated Arts and Sciences Hiroshima University Higashi-Hiroshima Japan Department of Engineering Science University of Electro-Communications Chofu Japan Faculty of Health Science and Technology Kawasaki University of Medical Welfare Kurashiki Japan Department of Communication and Liberal Arts Minami Kyushu Junior College Miyazaki Japan

Impaired excitation-contraction coupling occurs in eccentric contraction (ECC)-induced damaged muscles. It has been suggested that sarcoplasmic reticulum (SR) is susceptible to damage in the overstretched regions possibly marking the basis of excitation-contraction coupling damage. Recent studies have shown that dietary nitrate supplementation enhances SR function in fast-twitch muscles. In this study, we aimed to investigate whether dietary nitrate supplementation can alleviate a decline in muscle contractile properties and SR function following ECC. To this end, force production, Ca2+ uptake, Ca2+ release, and Ca2+-ATPase activity of the SR were examined in rat fast-twitch muscles immediately following ECC for 200 repetitions. In comparison with contralateral resting muscles, nitrate supplementation for up to 3 days resulted in an obvious decline in force production. However, there were no differences in terms of force production between 6-day nitrate-treated and contralateral muscles. Similar to the observations regarding force production, the SR Ca2+ release rate changed from an obvious decrease following the 0- and 3-day dietary nitrate supplementation to no difference following the 6-day nitrate supplementation. In contrast, ECC decreased the Ca2+-ATPase activity and Ca2+ uptake rate, irrespective of the period of dietary nitrate supplementation. Overall, these results indicate that dietary nitrate supplementation can alleviate ECC-related decreases in force production mediated through inhibited reductions in the SR Ca2+ release function.

关键词： Supplementation Ca2+-ATPase Activity Ca2+ Uptake Ca2+ Release

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