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Nano Research 2018年第10期11卷 5219-5239页

作者： Rimpei Kamegawa Mitsuru naito Kanjiro Miyata Department of Materials Engineering Graduate School of Engineering The University of Tokyo Tokyo 113-8656 Japan Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo Tokyo 113-0033 Japan

Silica nanoparticles （SiNPs） have been widely engineered for biomedical applications, such as bioimaging and drug delivery, because of their high tunability, which allows them to perform specific functions. In this review, we discuss the functionalization and performance of SiNPs for nucleic acid delivery. Nucleic acids, including plasmid DNA （pDNA） and small interfering RNA （siRNA）, constitute the next generation molecular drugs for the treatment of intractable diseases. However, their low bioavailability requires delivery systems that can circumvent nuclease attack and kidney filtration to ensure efficient access to the target cell cytoplasm or nucleus. First, we discussed the biological significance of nucleic acids and the parameters required for their successful delivery. Next, we reviewed SiNP designing for nucleic acid delivery with respect to nucleic acid loading and release, cellular uptake, endosomal escape, and biocompatibility. In addition, we discussed the co-delivery potential of SiNPs. Finally, we analyzed the current challenges and future directions of SiNPs for advanced nucleic acid delivery.

关键词： silica nanoparticle mesoporous silica silica coating nucleic acid drug delivery

Safety of pancreatic surgery with special reference to antithrombotic therapy:A systematic review of the literature

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World Journal of Clinical Cases 2021年第23期9卷 6747-6758页

作者： Takahisa Fujikawa Shigetoshi naito Department of Surgery Kokura Memorial HospitalKitakyushu 802-8555Japan

BACKGROUND Postpancreatectomy hemorrhage(PPH)is the most severe type of complication after pancreatic surgery,although the effect of antithrombotic therapy(ATT)on PPH is largely *** safety and efficacy of chemical thromboprophylaxis for venous thromboembolism(VTE)remains *** To elucidate the effect of ATT on *** Published articles between 2013 and 2020 were searched from PubMed and Google Scholar,and after careful reviewing of all studies,studies concerning ATT and pancreatic surgery were *** such as study design,type of surgical procedures,type of antithrombotic drugs,and surgical outcome were extracted from the *** Nineteen published articles with a total of 37863 patients who underwent pancreatic surgery were included in the systematic *** were cohort studies,with only three being prospective in *** studies demonstrated that in patients receiving chronic ATT,which were mostly managed by heparin bridging,the risk of PPH was higher compared with those without ATT,and one study showed that patients with direct-acting oral anticoagulants managed by heparin bridging had significantly higher postoperative bleeding rates than *** remaining six studies reported that pancreatic surgery can be safely performed in patients receiving chronic ATT,even under preoperative aspirin *** chemical thromboprophylaxis for VTE,most studies have shown a potentially high risk of PPH in patients undergoing chemical thromboprophylaxis;however,its effectiveness against VTE has not been statistically demonstrated,particularly among Asian *** Pancreatic surgery in chronically ATT-received patients can be safely performed without an increase in the occurrence of PPH,although the safety and efficacy of chemical thromboprophylaxis for VTE during pancreatic surgery is still *** investigation using reliable studies with good design is required to establish definite pr

关键词： Antithrombotic therapy Pancreatic surgery Perioperative management Antiplatelet therapy Anticoagulation therapy Pancreaticoduodenectomy

Comparison of the effects of cold water and ice ingestion on endurance cycling capacity in the heat

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Journal of Sport and Health Science 2017年第1期6卷 111-117页

作者： Takashi naito Tetsuro Ogaki Graduate School of Human-Environment Studies Kyushu UniversityFukuoka 40218Japan

Purpose: The purpose of this study was to examine the effects of pre-cooling and fluid replacement with either crushed ice or cold ***: On 2 separate occasions, in a counterbalanced order, 9 recreationally-trained males ingested 1.25 g/kg(80–100 g) of either crushed ice(0.5℃)or cold water(4℃) every 5 min for 30 min before exercise. They also ingested 2.0 g/kg(130–160 g) of the same treatment drink at 15 min, 30 min, and45 min after the commencement of cycling to exhaustion at 60%VO_(2max) until voluntary exhaustion in a hot environment(35℃ and 30% relative humidity).Results: The cycling time to exhaustion in the crushed ice trial(50.0 ± 12.2 min) was longer than the cold water trial(42.2 ± 10.1 min; p = 0.02).Although the rectal temperature fell by 0.37℃± 0.03℃(p = 0.01) at the end of the resting period after the crushed ice ingestion, the rates of rise in rectal temperature during the exercise period were not significantly different between these 2 conditions(crushed ice: 0.23℃± 0.07℃, 5 min;cold water: 0.22℃± 0.07℃, 5 min; p = 0.94).Conclusion: Crushed ice ingestion before and during exercise in a hot environment may be a preferred and effective approach for minimizing thermal strain, and for improving endurance performance as compared with cold water ingestion.

关键词： Cold water ingestion Pre-cooling Rectal temperature Thermoregulation

Liquid Immiscibility of Boninite in Xiangcheng, Southwestern China, and Its implication to Genetic Relationship between Boninite and Komatiitic Basalt

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Acta Geologica Sinica(English Edition) 2001年第1期75卷 74-93页

作者： Tetusro Urabe Takagi naito Geological Survey of Japan Ibaraki 305 JapanGeological Survey of Japan Ibaraki 305 JapanGeological Survey of Japan Ibaraki 305 Japan

Boninitic rocks and associated high-magnesian basalt and high-iron tholeiite in the Xiangcheng area constitute the basal horizon of the arc volcanic sequence in the Triassic Yidun Island-Arc, southwestern China. The boninite occurs as pillow, massive and ocellar lavas; the last one possesses well-developed globular structure and alternates with the former two. The boninite is characterized by the absence of phenocrysts of olivine and low-Ca pyroxenes and by low CaO/Al2O3 ratios (1000 ppm) and Ni (>250 ppm). The normalized abundance patterns (NAP) of trace elements to primitive mantle are similar to the NAP of low-Ca modern boninites and SHMB in the Archaean and Proterozoic.

关键词： boninite komatiitic basalt liquid immiscibility Xiangcheng area of Sichuan

Analysis of the Relationship between Eating and Swallowing Function and Lifestyle of the Elderly Living in the Community-A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第2期8卷 56-69页

作者： naito Tomoyoshi Yamada Masami Nakamura Mi Eiko Ojima Toshiyuki Hamamatsu Medical University Shizuoka 431-3125HamamatsuJapan Department of Nursing Faculty of Medical SciencesTeikyo University of Science and TechnologyTokyo 120-0045Japan Hamamatsu Medical University Department of Health and Social MedicineShizuoka 431-3125HamamatsuJapan

Objectives:The relationship between eating and swallowing function,and lifestyle among community-dwelling elderly people has not been extensively *** study aimed to analyze the characteristics of eating and swallowing function and their association with the lifestyle among the ***:A self-administered questionnaire survey was conducted on 419 elderly people who participated in the oral function improvement project operated by the Community Comprehensive Support Center.A total of 288 valid responses(58 males,230 females,average age 73.6 years)were *** survey items included basic demographics,health status,lifestyle,and eating and swallowing *** chi-square(χ2)test was used to compare for a difference in the risk of ***:72 patients(25.0%)were judged to be at risk for dysphagia,and 216(75.0%)were judged to be not at risk for dysphagia using the revised dysphagia risk assessment *** mean score for oral preparatory dysphagia was the highest,while the mean score for pharyngeal dysphagia was the *** group at risk of dysphagia had significant difficulty in chewing and had bad sleep quality as compared to the group that was not at ***:Concerning the risk of dysphagia,there is a need to maintain and improve masticatory *** addition,improving the swallowing function of the elderly may prevent insomnia and improve sleep quality.

关键词： Elderly living in the community Eating and swallowing function Lifestyle

Radical Reactions and Its Synthetic Application

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复旦学报（自然科学版） 2005年第5期44卷 758-759页

作者： Takeaki naito Medicinal Chemistry Laboratory Kobe Pharmaceutical University Kobe 658-8558 Japan

Strategies involving radical reactions have become preeminent tools in organic synthesis. Free radical-mediated cyclization has developed as a powerful method for preparing various types of cyclic compounds via carbon-carbon bond-forming processes. In order to develop effective and convenient methods for the synthesis of biologically active cyclic amines, we have focused our efforts on radical reactions using aldehydes, ketones,and C-C multiple bonds as a radical precursor and/or an oxime ether, hydrazone, and nitrone as a radical acceptor. In this lecture, I would like to talk on radical addition-cyclization of oxime ether and its application to the synthesis of martinellines.

关键词：自由基反应有机物合成环化过程循环化合物

Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis

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World Journal of Gastroenterology 2011年第4期17卷 409-418页

作者： Toshiyuki Ishiwata Yoko Matsuda Zenya naito Department of Pathology Integrative Oncological Pathology Nippon Medical School

Nestin is a class Ⅵ intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues. Under pathological conditions, nestin is expressed in repair processes in the CNS, muscle, liver, and infarcted myocardium. Furthermore, increased nestin expression has been reported in various tumor cells, including CNS tumors, gastrointestinal stromal tumors, pancreatic cancer, prostate cancer, breast cancer, malignant melanoma, dermatofibrosarcoma protuberances, and thyroid tumors. Nestin is reported to correlate with aggressive growth, metastasis, and poor prognosis in some tumors; however, the roles of nestin in cancer cells have not been well characterized. Furthermore, nestin is more specifically expressed in proliferating small-sized tumor vessels in glioblastoma and gastric, colorectal, and prostate cancers than are other tumor vessel markers. These findings indicate that nestin may be a marker for newly synthesized tumor vessels and a therapeutic target for tumor angiogenesis. It has received a lot of attention recently as a cancer stem cell marker in various cancer cells including brain tumors, malignant rhabdoid tumors, and uterine, cervical, prostate, bladder, head and neck, ovarian, testicular, and pancreatic cancers. The purpose of this review is to clarify the roles of nestin in cancer cells and in tumor angiogenesis, and to examine the association between nestin and cancer stem cells. Nestin has the potential to serve as a molecular target for cancers with nestin-positive cancer cells and nestin-positive tumor vasculature.

关键词： Cancer growth Intermediate filament protein Cancer invasion Tumor migration Nestin Stem cell marker Tumor angiogenesis

Usefulness and limitation of punched-out orchidometer in testicular volume measurement

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Asian Journal of Andrology 2005年第1期7卷 77-80,页

作者： Koji Shiraishi Hiroshi Takihara Yoriaki Kamiryo Katsusuke naito Department of Urology Saiseikai Shimonoseki General Hospital Yamaguchi Japan Department of Urology Onoda City Hospital Yamaguchi Japan Department of Urology Yamaguchi University School of Medicine Yamaguchi Japan

Aim: To determine the limitations of a punched-out orchidometer in practical use, we compared with a scrotal ultrasound (USG). Methods: A total of 281 testes from 142 males were examined using both a punched-out orchidometer and a USG. The volume differential between both methods was calculated and expressed as orchidometer/ USG volume (OAJ ratio). Distribution of the O/U ratio was determined and subdivided by clinical or pathological diagnosis. The correlations between the O/U ratio and patient age or orchidometer results were assessed. Results: There was a significant linear relationship between the results of orchidometer and USG (r = 0.94, P < 0.0001). The relationship between the O/U ratio and age or testicular volumes showed significant inverse correlations (r = 0.22, P = 0.0002, r = 0.45, P < 0.0001, respectively). Klinefelter's syndrome, ipsilateral detorted testes and hypogonadotropic hypogonadism comparatively showed a high O/U ratio. No incidental lesion was detected by USG necessitating treatment. Conclusion: The punched-out orchidometer gives estimates that correlated well with the USG measurements and provides enough information for routine andrological evaluation. We should be aware that the orchidometer often overestimates the testicular volume, especially for the patients with small testis or adolescents.

关键词： orchidometer testis ultrasonography

Exploring effects of tensor force and its strength via neutron drops

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Chinese Physics C 2021年第6期45卷 149-157页

作者： Zhiheng Wang Tomoya naito Haozhao Liang Wen Hui Long School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Department of Physics Graduate School of ScienceThe University of TokyoTokyo 113-0033Japan RIKEN Nishina Center Wako 351-0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

The tensor-force effects on the evolution of spin-orbit spittings in neutron drops are investigated within the framework of the relativistic Hartree-Fock *** a fair comparison on the pure mean-field level,the results of the relativistic Brueckner-Hartree-Fock calculation with the Bonn A interaction are adopted as *** a quantitative analysis,we certify that theπ-pscudovector(π-PV)coupling affects the evolutionary trend through the embedded tensor *** strength of the tensor force is explored by enlarging the strength fr of theπ-PV *** is found that weakening the density dependence of fn is slightly better than enlarging it with a *** thus provide a semiquantitative support for the renormalization persistency of the tensor force within the frame-work of density functional *** will serve as important guidance for further development of relativistic effective interactions with particular focus on the tensor force.

关键词： tensor force relativistic Hartree-Fock theory neutron drop tensor renormalization persistency