检索结果-南通市图书馆

Virological response and resistance mutations to NS3/4A inhibitors in hepatitis C virus-human immunodeficiency virus coinfection

引用

World Journal of Hepatology 2015年第18期7卷 2177-2183页

作者： Alissa naqvi Valérie Giordanengo Brigitte Dunais Francine de Salvador-Guillouet Isabelle Perbost Jacques Durant Pascal Pugliese Aline Joulié Pierre Marie Roger Eric Rosenthal Infectious Diseases Department Archet Hospital Centre Hospitalier Universitaire Virology Laboratory Archet Hospital Centre Hospitalier Universitaire Internal Medicine Department Archet Hospital Centre Hospitalier Universitaire

AIM: To evaluate virological response to telaprevir or boceprevir in combination with pegylated interferon and ribavirin and resistance mutations to NS3/4A inhibitors in hepatitis C virus-human immunodeficiency virus(HCV-HIV) coinfected patients in a real life setting. METHODS: Patients with HCV genotype 1-HIV coinfection followed in Nice University Hospital internal medicine and infectious diseases departments who initiated treatment including pegylated interferon and ribavirin(Peg IFN/RBV) + telaprevir or boceprevir, according to standard treatment protocols, between August 2011 and October 2013 entered this observational study. Patient data were extracted from an electronic database(Nadis®). Liver fibrosis was measured by elastometry(Fibroscan®) with the following cut-off values: F0-F1: < 7.1 k Pa, F2: 7.1-9.5 k Pa, F3: 9.5-14.5 k Pa, F4: ≥ 14.5 k Pa. The proportion of patients with sustained virological response(SVR) twelve weeks after completing treatment, frequency and type of adverse events, and NS3/4A protease inhibitor mutations were described. RESULTS: Forty-one patients were included: 13(31.7%) patients were HCV-treatment na?ve, 22(53.7%) had advanced liver fibrosis or cirrhosis(Fibroscan stage F3 and F4); none had decompensated cirrhosis or hepatocellular carcinoma; all were receiving antiretroviral treatment, consisting for most them(83%) in either a nucleoside reverse-transcriptase inhibitor/protease inhibitor or/integrase inhibitor combination; all patients had undetectable HIV-RNA. One patient was lost to follow-up. SVR was achieved by 52.5% of patients. Five patients experienced virological failure during treatment and four relapsed. Seven discontinued treatment due to adverse events. Main adverse events included severe anemia(88%) and rash(25%). NS3/4A protease mutations were analyzed at baseline and at the time of virological failure in the 9 patients experiencing non-response, breakthrough or relapse. No baseline resistance mutation cou

关键词： Telaprevir Boceprevir Hepatitis C virushuman immun

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervulina modulates the functions of chicken dendritic cells to boost Th1 type immune response and stimulates autologous CD4+T cells differentiation in-vitro

Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervu...

引用

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Shakeel Ahmed Lakho Muhammad Haseeb Jianmei Huang Zhang Yang Muhammad Waqqas Hasan Muhammad Tahir Aleem Muhammad Ali-Ul-Husnain naqvi Muhammad Ali Memon XiaoKai Song RuoFeng Yan Lixin Xu 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

Dendritic cells(DCs) play a pivotal role to amplify antigen-specific immune *** that sensitize T cells via antigen-presentation by DCs could enhance the capacity of host immunity to fight *** this study,we tested the immunogenic profiles of chicken DCs towards Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervulina(EaGAPDH).Immunoblot analysis showed that recombinant EaGAPDH(rEaGAPDH) protein was successfully recognized by rat sera generated against *** and internalisation of rEaGAPDH by chicken splenic-derived DCs(chSPDCs) was confirmed by immunofluorescence *** cytometry revealed that chSPDCs upregulated MHCII,CD 1.1,CD11 c,CD80,and CD86 cell-surface ***,mRNA expressions of DC maturation biomarkers(CCL5,CCR7,and CD83) and TLR signalling genes(TLR15 and MyD88) were also upregulated whereas those of Wnt signalling were non-significant compared to negative *** treatment induced IL-12 and IFN-γ secretion in chSPDCs but had no effect on IL-10 and TGF-β.Likewise,DC-T cell co-culture promoted IFN-γ secretion and the level of IL-4 was *** of T cells and their differentiation into CD3+/CD4+T cells were triggered in chSPDCs-T cells co-culture *** together,rEaGAPDH could promote Th1 polarization by activating both host DCs and T cells and sheds new light on the role of this important molecule which might contribute to the development of new DCs-based immunotherapeutic strategies against coccidiosis.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nanoparticles(PLGA and Chitosan)-Entrapped ADP-Ribosylation Factor 1 of Haemonchus contortus Enhances the Immune Responses in ICR Mice

Nanoparticles(PLGA and Chitosan)-Entrapped ADP-Ribosylation ...

引用

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Muhammad Waqqas Hasan Muhammad Haseeb Muhammad Ehsan Javaid Ali Gadahi Muhammad Ali-Ul-Husnain naqvi Qiang Qiang Wang Xinchao Liu Shakeel Ahmed Lakho Ruofeng Yan Lixin Xu Xiaokai Song 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

ADP-ribosylation factor 1(HcARF1) is one of the Haemonchus contortus(***)excretory/secretory proteins involved in modulating the immune response of goat peripheral blood mononuclear cells(PBMC).Here,we evaluated the immunogenic potential of recombinant HcARF1(rHcARF1) against *** infection in Institute of Cancer Research(ICR) ***,rHcARF1 was entrapped in poly(D,L-lactide-co-glycolide)(PLGA) and chitosan(CS)nanoparticles(NP) and injected into mice as a ***-six ICR mice were assigned randomly into seven groups,with eight animals in each group,and they were vaccinated *** the end of the experiment(14 th day),the blood and the spleen were collected from euthanized mice to detect lymphocyte proliferation,cytokine analysis,and the production of antigen-specific *** electron microscope was used to determine the size,morphology,and zeta potential of *** cytometry was performed,which presented the increase percentages of CD4+T cells(CD3 e+CD4+),CD8+T cells(CD3 e+CD8+) and dendritic cells(CD11 c+CD83+,CD11 c+CD86+) in mice vaccinated with rHcARF1+PLGA *** analysis show raised humoral(Immunoglobulin(Ig)G1,IgG2 a,IgM) and cell-mediated immune response(Interleukin(IL)-4,IL-12,and IL-17,and Interferon(IFN)-γ)induced by rHcARFl+PLGA *** groups that were treated with the antigen-loaded NP yield higher lymphocyte proliferation than the control *** on these results,we could propose that the rHcARF1 encapsulated in NP could stimulate a strong immune response in mice rather than administering alone against the infection of ***.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

霍莱纳拉西普尔片岩带的地质情况和地球化学及其在印度半岛演化历史中的地位

引用

华北地质 1981年第4期 17-30页

作者： S. M. naqvi S. Viswanathon M. N. Viswanatha 王俊连王伍云韩光徐文蒸国家地球物理研究所印度地质调查所原子矿物局印度海得拉巴印度海得拉巴印度海得拉巴

霍莱纳拉西普尔(HolenarasiPur)片岩带是印度达瓦尔克拉通中最关键、最复杂也是最老的(32～35亿年)上地壳层之一。角度不整合把地层划分为两个岩石地层单元,即萨格尔群(Sargur group)和达瓦尔群。萨格尔群是从基性一超基性岩的底部开始... 详细信息

霍莱纳拉西普尔(HolenarasiPur)片岩带是印度达瓦尔克拉通中最关键、最复杂也是最老的(32～35亿年)上地壳层之一。角度不整合把地层划分为两个岩石地层单元,即萨格尔群(Sargur group)和达瓦尔群。萨格尔群是从基性一超基性岩的底部开始的,上面被各种成分的沉积变质岩覆盖,然而达瓦尔群则由底砾岩开始向上发育有角闪岩、石英岩和条带状磁铁石英岩系。达瓦尔群作为一个整体变质程度为角闪岩相,而萨格尔群显示了更高级的变质(兰晶石带)。平卧褶皱、等斜褶皱和迭加的倾伏褶皱普遍存在,并且就整个地区而言以向北倾伏的褶皱为主。与达瓦尔群不同,在萨格尔群的底部或层序中都不存在砾岩。萨格尔群的变超镁铁质/镁铁质岩在各处均与铬云母石英岩互层,而且见有变形的枕状熔岩和显微鬣刺结构。它们的成份类似于橄榄科马提岩、辉石科马提岩和玄武利马提岩。超镁铁岩中的斜长岩是富钙的(An97％)并且在许多方面类似于月球的斜长岩。变泥质岩中富含铝、镁、铁、钛、钙、镍、铬多,但硅、钾、铷和锶减少。萨格尔群的石英岩是成熟的砂岩。达瓦尔群的基性岩(角闪岩)是拉斑玄武质的。据我们的地球化学资料及与较年轻的吔层对比,我们认为霍莱纳拉西普尔片岩带的萨格尔群是由火山—沉积岩系组成的,但是这种层系大概在后来的地质时代里没有重复出现。把这种火山—沉积杂岩看作是地台型或地槽型的层序是困难的;.代之,这个带也许是在达瓦尔克拉通的“陆核阶段”形成的。在印度地盾的元占代时期地台和地槽是常见的现象,当时硅铝壳已成熟并趋于稳定。萨格尔后期广泛的英云闪长岩岩浆活动似乎已经提供中等程度的稳定性,从而在“陆核阶段”地层的顶部形成了薄而且范围较小的地台型沉积物。这些英云闪长岩与后来的花岗岩和伟晶岩一起似乎为其他岩石补充了硅、钾、铷和锶。

关键词：片岩变质岩角闪岩相斜长岩基性岩镁铁质岩镁铁岩萨格科马提岩火山岩超镁铁质岩超基性岩莱纳变质火山岩变火山岩绿岩带角闪石链状硅酸盐矿物云母层状硅酸盐矿物变泥质岩地球化学地球科学拉西地质情况地位

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Extending cardiomyocyte replicative capacity into adulthood improves outcomes after myocardial injury but repair is incomplete

Extending cardiomyocyte replicative capacity into adulthood ...

引用

作者： Ming Li Siiri E.Iismaa Nawazish naqvi Jianxin Wu Scott Kesteven Ahtesham ul Haq Andrea Y.Chan Sara R.Holman Amy Nicks Michael P.Feneley Ahsan Husain Robert M.Graham Cardiac Regeneration Research Institute Wenzhou Medical University Division of Molecular Cardiology and Biophysics Victor Chang Cardiac Research Institute St Vincent’s Clinical School University of New South Wales Department of Medicine Emory University School of Medicine

Aims:We have previously demonstrated that cardiomyocytes(CMs) of adult transgenic C57 BL/6 J mice with CM-restricted overexpression of the dominant negative Wv mutant(dn-c-kit-Tg) retain the ability to proliferate;a response normally restricted to fetal and early neonatal *** leads to a hyperplastic CM response to pressure overload with improved cardiac function and ***,we tested if this persistent CM proliferative competence allows complete,scar-less repair of the myocardium with normalization of cardiac morphology and function post-myocardial infarction(MI).Methods and *** to WT control non-transgenic littermates,dn-c-kit-Tg mice displayed i) persistent CM replicative capacity in adulthood,ii) a thicker left ventricular(LV) wall and a smaller LV cavity due to increased CM cell number,but no change in CM length,width,volume,pbidy or nucleation state,and iii) improved *** 24 hours after ligation of the left anterior descending coronary artery,infarct sizes were similar in adult(16 week old) WT and dn-c-kit-Tg *** weeks post-MI,infarct size in dn-c-kk-Tg was half that in WT hearts,but significant scarring was still *** infarct size in the dn-c-kit-Tg mice was associated with improved survival,increased CM cell cycle entry,attenuated left ventricular remodelling and improved cardiac ***:Extending CM replicative capacity into adulthood improves outcomes post-MI,but healing is structurally and functionally incomplete.

关键词： Cardiac regeneration cardiomyocyte proliferation myocardial infarct

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Upper Gastrointestinal Endoscopic Outcomes in Patients with Gastrointestinal Symptoms: Retrospective Analysis at a Tertiary Care Hospital

引用

Open Journal of Gastroenterology 2019年第8期9卷 141-157页

作者： Iftikhar Haider naqvi Abu Talib Muqadus Tabraze Omer Mustafa Siddiqui Maheen Fatima Hussaini Neha Saleem Paryani Rida Effendi Samrah lnam Siddiqui Syeda Zuhaa Hassan Maham Munawar Zaiya Waseem Ameer Ahmed Khan Zafir Zohab Hussain Khan S. Zain Naeem Rizvi Sofia Fatima Farooqui Misbah Munaf Hasan Obaid Faryal Khan Dow University of Health Sciences Department of Medicine Karachi Pakistan

Background: Endoscopic procedures are frequently performed to rule out any disease process which eventuates with either a positive or negative outcome. Association of patient demographics, clinical features with endoscopic outcomes are of paramount importance for better understanding and practice of endoscopy. Objectives: This study aimed to determine the frequency of positive endoscopic findings in patients with gastrointestinal symptoms compared to those with negative findings. As a secondary objective, the association between relevant demographics, symptoms, laboratory investigations and procedural outcomes of the participants and positive endoscopic findings were also assessed. Methods: A retrospective analysis of all the patients who underwent esophagogastroduodenoscopy from January 2017 to December 2017 was conducted. A total of 1066 endoscopy records were retrieved and using a convenience sampling technique, relevant data were manually entered to the questionnaires. Records with incomplete or inconsistent data were disregarded as per the exclusion criteria, resulting in 1011 patient records ultimately utilized for the study. All data were entered and analyzed using IBM SPSS 23.0. Results: The study comprised a total of 1011 patients where 52.2% were females and 47.8% males while the mean age of patients was 42.16 ± 15.45. Positive endoscopic findings were observed in 88.1%, where the most common finding was gastritis (49.1%). Approximately 14.5% had positive investigation findings for HBsAg and 23.1% were seropositive for anti-HCV antibody. P-values statistically significant were for age (p = 0.044), hematemesis (p = 0.002), betel quid addiction (p = 0.044), anti-HCV antibody (p = 0.043), HCV-RNA (p = 0.041) and “H. pylori” antigen (p = 0.032). Conclusion: Both genders were almost equally included where most patients presented between the 3rd and 5th decades of life. A high incidence of gastritis was noted. Positive endoscopic findings were associated with be

关键词： Esophagogastroduodenoscopy Endoscopy Gastritis Esophageal Varices

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

假牙与跛脚

引用

英国医学杂志中文版 2005年第6期8卷 375-375页

作者： Jason Raw Naseer naqvi 杨涛（译） Chorley and South Ribble District General Hospital Lancashire Teaching Hospitals Trust Chorley 不详

一名在街上流浪的老人被送进了医院.经过检查,发现他患有心肌梗死,于是收到病房,经治疗后患者病情逐渐好转,恢复得不错.但他总有些懵懵懂懂、辨不清方向,而且情绪低落.一天他在病房走路时明显地有些跛脚--腿部活动自如,但右脚却跛了.

关键词：假牙心肌梗死情绪低落治疗后病房

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole

引用

World Journal of Pharmacology 2023年第1期12卷 1-11页

作者： Syed Mujtaba Hussain naqvi Monil Yogesh Neena Gala Snehal Muchhala Anand Arumugam Dhananjay Panigrahi Dipak Patil Rahul Rathod Amey Mane Medical Affairs Dr Reddy’s LaboratoriesHyderabad 500016India Global Clinical Management Dr Reddy’s LaboratoriesHyderabad 500016India Formulation Development Dr Reddy’s LaboratoriesHyderabad 500016India

BACKGROUND Itraconazole is a broad-spectrum triazole antifungal inhibiting fungal growth by inhibiting ergosterol synthesis and exhibits a nonlinear pharmacokinetic *** absorption pattern with wide fluctuations in blood levels causes inconsistent and unpredictable clinical behaviour of this drug despite its low minimum inhibitory concentration(MIC)as compared to other antifungal *** To compare the oral bioavailability and bioequivalence of Fixtral SB(supra bioavailable itraconazole)with reference product R2(supra bioavailable 2×50 mg itraconazole).METHODS The study population consisted of 54 healthy volunteers,aged between 18-45 years and randomized to receive a single oral dose of either test[T;Fixtral SB(supra bioavailable itraconazole)100 mg]or reference product(R1;Sporanox 100 mg×2 capsules and R2;Lozanoc capsules 50 mg×2 capsules).Blood samples were taken pre-dose and post-dose up to 96 *** study evaluated bioequivalence by comparing the oral bioavailability of the test product with reference product *** pharmacodynamic characteristics of the drug were evaluated by comparing the test product with reference product ***(PK)-PD comparative analysis[area under the concentration-time curve(AUC)/minimum inhibitory concentration(MIC)>25]was performed for conventional itraconazole 100 mg and supra bioavailable itraconazole 50 *** events(AEs)assessments were performed in each study period and post-study *** Statistical analysis of primary PK variables revealed bioequivalence,with confidence intervals being completely inside the acceptance criteria of 80%-125%.The peak concentration levels of itraconazole were achieved at 10 h(T)and 8.5 h(R2),*** parameter assessment showed that AUC/MIC for R1 are comparable to Fixtral SB 100mg for MIC levels up to 16mcg/mL(P>0.05 and observed P=0.3196).Six AEs were observed that were mild to moderate in severity and *** severe AE was reported.

关键词： Supra-Bioavailable itraconazole Conventional itraconazole Oral bioavailability Pharmacodynamics Efficacy Adverse events

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：