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The two sides of chromosomal instability:drivers and brakes in cancer

Signal Transduction and Targeted Therapy 2024年第4期9卷 1595-1624页

作者： Rendy Hosea Sharon Hillary sumera naqvi Shourong Wu Vivi Kasim Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400045China The 111 Project Laboratory of Biomechanics and Tissue Repair College of BioengineeringChongqing UniversityChongqing 400044China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing UniversityChongqing 400030China

Chromosomal instability(CIN)is a hallmark of cancer and is associated with tumor cell *** triggers a chain reaction in cells leading to chromosomal abnormalities,including deviations from the normal chromosome number or structural changes in *** arises from errors in DNA replication and chromosome segregation during cell division,leading to the formation of cells with abnormal number and/or structure of *** in DNA replication result from abnormal replication licensing as well as replication stress,such as double-strand breaks and stalled replication forks;meanwhile,errors in chromosome segregation stem from defects in chromosome segregation machinery,including centrosome amplification,erroneous microtubule-kinetochore attachments,spindle assembly checkpoint,or defective sister chromatids *** normal cells,CiN is deleterious and is associated with DNA damage,proteotoxic stress,metabolic alteration,cell cycle arrest,and ***,despite these negative consequences,CiN is one of the hallmarks of cancer found in over 90%of solid tumors and in blood ***,CiN could endow tumors with enhanced adaptation capabilities due to increased intratumor heterogeneity,thereby facilitating adaptive resistance to therapies;however,excessive CiN could induce tumor cells death,leading to the"just-right"model for CIN in *** the complex nature of CIN is crucial for understanding the dynamics of tumorigenesis and for developing effective anti-tumor *** review provides an overview of causes and consequences of CIN,as well as the paradox of CIN,a phenomenon that continues to perplex ***,this review explores the potential of CIN-based anti-tumor therapy.

关键词： chromosomal consequences thereby

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Recent advances in targeted fungicides and immune elicitors for rice blast management

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Plant Communications 2024年第9期5卷 5-7页

作者： Huanbin Shi Naweed I.naqvi Yanjun Kou State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Temasek Life Sciences Laboratory and Department of Biological Sciences Research LinkNational University of SingaporeSingapore 117604Singapore

Blast disease,caused by the fungus Magnaporthe oryzae,wreaks havoc on crops worldwide,resulting in an approximate loss of 20%-30%of the annual rice yield(He et al.,2020;Liu et al.,2024).*** heads the top 10 list of the most devastating phytopathogens and serves as a model system for investigating fungal diseases in plants,thus offering insights relevant to disease control in important agricultural crops.

关键词： crops offering insight

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A Dual Source Power Based EV Wireless Charging System

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第S1期41卷 35-42页

作者： naqvi Syed Zohair Raza XIAO Lan JIANG Menghan College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China

Recently,there has been a huge increase in the usage of fuel resources for automobiles which is severely affecting the climate and causing global *** use of electric vehicle(EV)is an effective way to protect the environment and reduce travel ***,the EV charging system has a single charging source,and the charging rate is *** this paper,an EV wireless charging system based on dual source power supply has been *** realizes intelligent switching between 12 V photovoltaic output and 220 V AC dual source power,and has wireless transmission *** on the proposed power supply architecture,the micro wireless charging model is built,which enables the EV model to store power and realize static and mobile control through the wireless induction charging system.

关键词： renewable energy inductive coupling inductive charging converters automatic changeover auto cutoff circuit

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Potential of eNose Technology for Monitoring Biological CO2 Conversion Processes

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Transactions of Tianjin University 2024年第5期30卷 381-394页

作者： Muhammad Awais Syed Muhammad Zaigham Abbas naqvi Sami Ullah Khan M.Ijaz Khan Sherzod Abdullaev Junfeng Wu Wei Zhang Jiandong Hu Department of Electrical Engineering Henan Agricultural University Henan International Joint Laboratory of Laser Technology in Agriculture Sciences State Key Laboratory of Wheat and Maize Crop Science Department of Mathematics Namal University Department of Mechanical Engineering Prince Mohammad Bin Fahd University Faculty of Chemical Engineering New Uzbekistan University Scientific and Innovation Department Tashkent State Pedagogical University

Electronic nose（eNose） is a modern bioelectronic sensor for monitoring biological processes that convert CO2into valueadded products, such as products formed during photosynthesis and microbial fermentation. eNose technology uses an array of sensors to detect and quantify gases, including CO2, in the air. This study briefly introduces the concept of eNose technology and potential applications thereof in monitoring CO2conversion processes. It also provides background information on biological CO2conversion processes. Furthermore, the working principles of eNose technology vis-à-vis gas detection are discussed along with its advantages and limitations versus traditional monitoring methods. This study also provides case studies that have used this technology for monitoring biological CO2conversion processes. eNose-predicted measurements were observed to be completely aligned with biological parameters for R2values of 0.864, 0.808, 0.802, and 0.948. We test eNose technology in a variety of biological settings, such as algae farms or bioreactors, to determine its effectiveness in monitoring CO2conversion processes. We also explore the potential benefits of employing this technology vis-à-vis monitoring biological CO2conversion processes, such as increased reaction efficiency and reduced costs versus traditional monitoring methods. Moreover, future directions and challenges of using this technology in CO2capture and conversion have been discussed. Overall, we believe this study would contribute to developing new and innovative methods for monitoring biological CO2conversion processes and mitigating climate change.

关键词： Bioelectronic nose Biological monitoring CO2 conversion Electronic nose (eNose) Gas detection

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Plant Nitrogen Metabolism: Balancing Resilience to Nutritional Stress andAbiotic Challenges

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 581-609页

作者： Muhammad Farhan Manda Sathish Rafia Kiran Aroosa Mushtaq Alaa Baazeem Ammarah Hasnain Fahad Hakim Syed Atif Hasan naqvi Mustansar Mubeen Yasir Iftikhar Aqleem Abbas Muhammad Zeeshan Hassan Mahmoud Moustafa Department of Plant Pathology Faculty of Agricultural Sciences&TechnologyBahauddin Zakariya UniversityMultan60800Pakistan Centro de Investigación de Estudios Avanzados del Maule(CIEAM) Vicerrectoría de Investigación y PostgradoUniversidad Católica del MauleTalca3460000Chile College of Food Science and Nutritional Engineering China Agricultural UniversityBeijingChina Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Biotechnology Faculty of Biological SciencesLahore University of Biological and Applied SciencesLahorePakistan Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan Department of Agriculture and Food Technology Karakorum International UniversityGilgitPakistan Department of Biology Faculty of ScienceKing Khalid UniversityAbhaSaudi Arabia

Plant growth and resilience to abiotic stresses,such as soil salinity and drought,depend intricately on nitrogen *** review explores nitrogen’s regulatory role in plant responses to these challenges,unveiling a dynamic interplay between nitrogen availability and abiotic *** the context of soil salinity,a nuanced rela-tionship emerges,featuring both antagonistic and synergistic interactions between salinity and nitrogen ***-induced chlorophyll depletion in plants can be alleviated by optimal nitrogen supplementation;however,excessive nitrogen can exacerbate salinity *** delve into the complexities of this interaction and its agri-cultural ***,a vital element within essential plant structures like chloroplasts,elicits diverse responses based on its *** review comprehensively examines manifestations of nitrogen deﬁciency and toxicity across various crop types,including cereals,vegetables,legumes,and ***,we explore the broader consequences of nitrogen products,such as N_(2)O,NO_(2),and ammonia,on human ***-ing the intricate relationship between nitrogen and salinity,especially chloride accumulation in nitrate-fed plants and sodium buildup in ammonium-fed plants,is pivotal for optimizing crop nitrogen ***,prudent nitrogen use is essential,as overapplication can exacerbate nitrogen-related *** Use Efﬁ-ciency(NUE)is of paramount importance in addressing salinity challenges and enhancing sustainable crop *** this goal requires advancements in crop varieties with efﬁcient nitrogen utilization,pre-cise timing and placement of nitrogen fertilizer application,and thoughtful nitrogen source selection to mitigate losses,particularly urea-based fertilizer *** review article delves into the multifaceted world of plant nitrogen metabolism and its pivotal role in enabling plant resilience to nutritional stress and abiotic chall

关键词： Synthetic nitrogen nitrogen signaling sustainable agriculture eutrophication ammonium nitrate

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Multifunctional MXene/Carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments

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Nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail Hassan Aamir Iqbal Byungkwon Yoo Jun Young Jo Nilufer Cakmakci Shabbir Madad naqvi Hyerim Kim Sungmin Jung Noushad Hussain Ujala Zafar Soo Yeong Cho Seunghwan Jeong Jaewoo Kim Jung Min Oh Sangwoon Park Youngjin Jeong Chong Min Koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D Center INNOMXENE Co. Ltd.Daejeon 34365Republic of Korea School of Chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust thin films capable of operating in demanding harsh temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating highly-crystalline Ti_(3)C_(2)T_(x) MXene and mechanically-robust carbon nanotube(CNT)film through strong hydrogen *** hybrid film not only exhibits high electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mechanical strength and durability in both extremely low and high temperature environments,showing exceptional resistance to thermal *** hybrid Janus film of 15μm thickness reveals remarkable multifunctionality,including efficient electromagnetic shielding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)shielding capability with an average emissivity of 0.09(a minimal value of 0.02),superior thermal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in the radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resistance when exposed to 250 W IR *** multifunctional MXene/CNT Janus film offers a feasible solution for electromagnetic shielding and IR shielding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference shielding Infrared shielding Thermal camouflage Infrared detection

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Hydrodynamic metasurface for programming electromagnetic beam scanning on the Azimuth and elevation planes

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Microsystems & Nanoengineering 2022年第2期8卷 217-225页

作者： Aqeel Hussain naqvi Sungjoon Lim School of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 06974Republic of Korea

The development of multifunctional and reconfigurable metasurfaces capable of manipulating electromagnetic waves has created new opportunities for various exciting *** efforts have been applied to exploiting active metasurfaces with properties that can be controlled by externally controlling active ***,previous approaches have poor switch isolation,power handling limitations due to nonlinear effects,and complex biasing ***,dynamically tunable metasurfaces have become a burgeoning field in many research *** paper reports a hydrodynamic metasurface(HMS)that can be programmed to realize electromagnetic beam scanning on the azimuth and elevation *** proposed HMS platform incorporates four micropumps,each controlling four metasurface elements via microfluidic channels,built into the HMS *** proposed platform regulates microfluidic flow through micropumps,causing irregularities in incident wave transmission *** HMS was built as a proof of concept,and far-field scanning experiments were *** and experimental results verify the feasibility of electromagnetic beam scanning using a hydrodynamic *** work advances metasurface research,with very high potential for wide-ranging application and a promising route for replacing bulky cascading active components.

关键词： surface. beam programming

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Hepatic expression and cellular distribution of the glucose transporter family

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World Journal of Gastroenterology 2012年第46期18卷 6771-6781页

作者： sumera Karim David H Adams Patricia F Lalor Centre for Liver Research and NIHR Biomedical Research Unit Institute of Biomedical Research University of Birmingham

Glucose and other carbohydrates are transported into cells using members of a family of integral membrane glucose transporter (GLUT) molecules. To date 14 members of this family, also called the solute carrier 2A proteins have been identified which are divided on the basis of transport characteristics and sequence similarities into several families (Classes 1 to 3). The expression of these different receptor subtypes varies between different species, tissues and cellular subtypes and each has differential sensitivities to stimuli such as insulin. The liver is a contributor to metabolic carbohydrate homeostasis and is a major site for synthesis, storage and redistribution of carbohydrates. Situations in which the balance of glucose homeostasis is upset such as diabetes or the metabolic syndrome can lead metabolic disturbances that drive chronic organ damage and failure, confirming the importance of understanding the molecular regulation of hepatic glucose homeostasis. There is a considerable literature describing the expression and function of receptors that regulate glucose uptake and release by hepatocytes, the most import cells in glucose regulation and glycogen storage. However there is less appreciation of the roles of GLUTs expressed by non parenchymal cell types within the liver, all of which require carbohydrate to function. A better understanding of the detailed cellular distribution of GLUTs in human liver tissue may shed light on mechanisms underlying disease pathogenesis. This review summarises the available literature on hepatocellular expression of GLUTs in health and disease and highlights areas where further investigation is required.

关键词： Hepatic Liver Glucose transporters Glucose Transport Hepatocyte

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Ultrasonic Study of Basic αr-Amino Acids in Different Acetate Salt Solutions at Different Temperatures

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Chinese Journal of Chemistry 2011年第4期29卷 669-678页

作者： Siddique Jamal Akhter naqvi, Saeeda Department of Chemistry Aligarh Muslim University Aligarh 202002 ( U.P.) India

The ultrasonic velocity （U）, has been measured for three a-amino acids, namely L-lysine monohydrochloride, L-arginine and L-histidine in solutions （1 mol/L aqueous） of sodium acetate （SA）, potassium acetate （PA） and calcium acetate （CA） at different temperatures （303.15, 308.15, 313.15, 318.15 and 323.15 K）. With the help of these results various ultrasonic derived parameters, viz. isentropic compressibility （Ks）, change in isentropic compressibility （△K5）, relative change in isentropic compressibility （△Kr）, specific acoustic impedance （Z）, relative association （RA）, and apparent molal compressibility （Фks） have been estimated. The results have been interpreted in the light of intermolecular interactions between solute and solvent.

关键词： ultrasonic velocity (U) amino acid salt effect isentropic compressibility organic salt

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Promoting the production of salinized cotton field by optimizing water and nitrogen use efficiency under drip irrigation

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Journal of Arid Land 2021年第7期13卷 699-716页

作者： LIN En LIU Hongguang LI Xinxin LI Ling sumera ANWAR College of Water Conservancy&Architectural Engineering Shihezi UniversityShihezi 832000China Xinjiang Production&Construction Group Key Laboratory of Modern Water-Saving Irrigation Shihezi 832000China Institute of Molecular Biologyand Biotechnology The University of LahoreLahore 54660Pakistan

Cotton is the main economically important crop in Xinjiang,China,but soil salinization and shortage of water and nutrients have restricted its production.A field experiment was carried out in the salinity-affected arid area of Northwest China from 2018 to 2019 to explore the effects of nitrogen and water regulation on physiological growth,yield,water and nitrogen use efficiencies,and economic benefit of *** salinity levels were 7.7(SL)and 12.5 dS/m(SM).Drip irrigation was used with low,medium and adequate irrigation levels representing 60%,80%and 100%of cotton crop water demand,respectively,and three nitrogen applications,i.e.,206,275 and 343 kg/hm^(2),accounting for 75%,100%and 125%of local N application,respectively were *** multi-objective optimization based on spatial analysis showed that,at SL salinity,water use efficiency(WUE),nitrogen use efficiency(NUE),economic benefit and yield simultaneously reached more than 85%of their maxima at 379.18-398.32 mm irrigation and 256.69-308.87 kg/hm^(2).At SM salinity,WUE,yield and economic benefit simultaneously reached more than 85%of their maxima when irrigation was 351.24-376.30 mm and nitrogen application was 230.18-289.89 kg/hm^(2).NUE,yield and economic benefit simultaneously reached their maxima at 428.01-337.72 mm irrigation,and nitrogen application range was 222.14-293.93 kg/hm^(2).The plants at SL salinity had 21.58%-46.59%higher WUE rates,14.91%-34.35%higher NUE rates and 20.71%-35.34%higher yields than those at SM *** results are of great importance for the nutrient and water management in cotton field in the arid saline area.

关键词： cotton growth multi-objective optimization soil salinization water and nitrogen regulation spatial analysis

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