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Metastasis in renal cell carcinoma:Biology and implications for therapy

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Asian Journal of Urology 2016年第4期3卷 286-292页

作者： Jun Gong Manuel Caitano Maia Nazli Dizman Ameish Govindarajan sumanta k.pal Department of Medical Oncology&Experimental Therapeutics City of Hope Comprehensive Cancer CenterDuarteCAUSA Division of Medical Oncology Instituto Hemomed de Oncologia e Hematologia.Av.Arnolfo de Azevedo121-Cerqueira Ce´sar-CEP 01248-040Sao PauloBrazil Department of Internal Medicine Istanbul Medeniyet University Goztepe Research and Training HospitalIstanbulTurkey

Although multiple advances have been made in systemic therapy for renal cell carcinoma(RCC),metastatic RCC remains *** the current review,we focus on the underlying biology of RCC and plausible mechanisms of *** further outline evolving strategies to combat metastasis through adjuvant ***,we discuss clinical patterns of metastasis in RCC and how distinct systemic therapy approaches may be considered based on the anatomic location of metastasis.

关键词： Renal cell carcinoma Metastasis Vascular endothelial growth factor Mammalian target of rapamycin Hypoxia inducible factor

Dynamical behaviors of a constant prey refuge ratio-dependent prey-predator model with Allee and fear effects

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International Journal of Biomathematics 2024年第1期17卷 227-250页

作者： Soumitra pal Pijush Panday Nikhil pal A.k.Misra Joydev Chattopadhyays Department of Mathematics Institute of Science Banaras Hindu University Varanasi 221005India Department of Mathematical and Statistical Sciences University of Alberta EdmontonAB T6G 2G1Canada Department of Mathematics Visva-Bharati Santiniketan 731235India Agricultural and Ecological Research Unit Indian Statistical Institute 203 B.T.RoadKolkata 700108India

In this paper,we consider a nonlinear ratio-dependent prey-predator model with constant prey refuge in the prey *** Allee and fear phenomena are incorporated explicitly in the growth rate of the prey *** qualitative behaviors of the proposed model are investigated around the equilibrium points in *** bifurcation including its direction and stability for the model is also *** observe that fear of predation risk can have both stabilizing and destabilizing effects and induces bubbling phenomenon in the *** is also observed that for a fixed strength of fear,an increase in the Allee parameter makes the system unstable,whereas an increase in prey refuge drives the system toward ***,higher values of both the Allee and prey refuge parameters have negative impacts and the populations go to ***,we explore the variation of densities of the populations in different bi-parameter spaces,where the coexistence equilibrium point remains *** simulations are carried out to explore the dynamical behaviors of the system with the help of MATLAB software.

关键词： Predator-prey system Allee effect fear effect prey refuge bifurcation population density

Observation of Complex Organic Molecules Containing Peptide-like Bonds Toward Hot Core G358.93-0.03 MM1

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Research in Astronomy and Astrophysics 2024年第7期24卷 181-189页

作者： Arijit Manna Sabyasachi pal Department of Physics and Astronomy Midnapore City CollegePaschim MedinipurWest Bengal721129India

In star formation regions,the complex organic molecules(COMs)that contain peptide bonds(-NH-C(=O)-)play a major role in the metabolic process because-NH-C(=O)-is connected to amino acids(R-CHNH_2-COOH).Over the past few decades,many COMs containing peptide-like bonds have been detected in hot molecular cores(HMCs),hot corinos,and cold molecular clouds,however,their prebiotic chemistry is poorly *** present the first detection of the rotational emission lines of formamide(NH_2CHO)and isocyanic acid(HNCO),which contain peptide-like bonds toward the chemically rich HMC G358.93-0.03 MM1,using high-resolution and high-sensitivity Atacama Large Millimeter/submillimeter Array bands 6 and *** estimate that the column densities of NH_2CHO and HNCO toward G358.93-0.03 MM1 are(2.80±0.29)×10~(15)cm~(-2)and(1.80±0.42)×10~(16)cm~(-2)with excitation temperatures of 165±21 k and 170±32 k,*** fractional abundances of NH_2CHO and HNCO toward G358.93-0.03 MM1 are(9.03±1.44)×10~(-10)and(5.80±2.09)×10^(-9).We compare the estimated abundances of NH_2CHO and HNCO with the existing threephase warm-up chemical model abundance values and notice that the observed and modeled abundances are very *** conclude that NH_2CHO is produced by the reaction of NH_2and H_2CO in the gas phase toward G358.93-0.03 ***,HNCO is produced on the surface of grains by the reaction of NH and CO toward G358.93-0.03 *** also find that NH_2CHO and HNCO are chemically linked toward G358.93-0.03 MM1.

关键词： ISM individual objects(G358.93-0.03)-ISM abundances-ISM kinematics and dynamics-stars formation-astrochemistry

Analytical solutions fractional order partial differential equations arising in fluid dynamics

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 458-468页

作者： Sidheswar Behera Jasvinder Singh pal Virdi Department of Physics Veer Surendra Sai University of TechnologyOdishaIndia

This article describes the solution procedure of the fractional Pade-Ⅱ equation and generalized Zakharov equation(GSEs)using the sine-cosine ***-Ⅱ is an important nonlinear wave equation modeling unidirectional propagation of long-wave in dispersive media and GSEs are used to model the interaction between one-dimensional high,and low-frequency *** of trigonometric and hyperbolic function solutions in fractional calculus are *** simulations of the numerical solutions are flaunted by MATLAB.

关键词： the sine-cosine method He's fractional derivative analytical solution fractional Pade-Ⅱequation fractional generalized Zakharov equation

Analytical Verification of Performance of Deep Neural Network Based Time-synchronized Distribution System State Estimation

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1126-1134页

作者： Behrouz Azimian Shiva Moshtagh Anamitra pal Shanshan Ma School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85281USA the School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85281USA Quanta Technology RaleighNC 27607USA

Recently,we demonstrated the success of a time-synchronized state estimator using deep neural networks(DNNs)for real-time unobservable distribution *** this paper,we provide analytical bounds on the performance of the state estimator as a function of perturbations in the input *** has already been shown that evaluating perfor-mance based only on the test dataset might not effectively indi-cate the ability of a trained DNN to handle input *** such,we analytically verify the robustness and trustworthi-ness of DNNs to input perturbations by treating them as mixed-integer linear programming(MILP)*** ability of batch normalization in addressing the scalability limitations of the MILP formulation is also *** framework is val-idated by performing time-synchronized distribution system state estimation for a modified IEEE 34-node system and a real-world large distribution system,both of which are incompletely observed by micro-phasor measurement units.

关键词： Deep neural network(DNN) distribution system state estimation(DSSE) mixed-integer linear programming(MILP) robustness trustworthiness

Unraveling the role of dual Ti/Mg metals on the ignition and combustion behavior of HTPB-boron-based fuel

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Defence Technology（防务技术） 2024年第2期32卷 134-143页

作者： Arijit Debnath Yash pal Sri Nithya Mahottamananda Djalal Trache School of Aeronautical Science Hindustan Institute of Technology and ScienceChennai 603103India Department of Aerospace Engineering B S Abdur Rahman Crescent Institute of Science and TechnologyChennai 600048India Energetic Materials Laboratory(EMLab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj El-Bahri16046AlgiersAlgeria

Metal additives play an essential role in explosive and propellant formulations. Boron(B) is widely used in propellant applications owing to its high energetic content. The addition of B to explosives and propellants increases their energy density, making them more efficient and powerful. Nevertheless, B forms oxide layers on its surface during combustion, slowing down the combustion rate and reducing rocket motor efficiency. To overcome this issue, other metal additives such as aluminum(Al), magnesium(Mg),and titanium(Ti) are revealed to be effective in boosting the combustion rate of propellants. These additives may improve the combustion rate and therefore enhance the rocket motor’s performance. The present study focused on preparing and investigating the ignition and combustion behavior of pure hydroxyl-terminated polybutadiene(HTPB)-B fuel supplemented with nano-titanium and nanomagnesium. The burn rates of HTPB-B fuel samples were evaluated on the opposed flow burner(OFB)under a gaseous oxygen oxidizer, for which the mass flux ranges from 22 kg/(m^(2)·s) to 86 kg/(m^(2)·s). The addition of Ti and Mg exhibited higher regression rates, which were attributed to the improved oxidation reaction of B due to the synergetic metal combustion effect. The possible combustion/oxidation reaction mechanism of B-Mg and B-Ti by heating the fuel samples at 900℃ and 1100℃ was also examined in a Nabertherm burnout furnace under an oxygen atmosphere. The post-combustion products were collected and further subjected to X-ray diffraction(XRD) and field emission scanning electron microscopy(FE-SEM) analyses to inspect the combustion behavior of B-Ti and B-Mg. It has been observed that the B oxide layer at the interface between B-Ti(B-Mg) is removed at lower temperatures, hence facilitating oxygen transfer from the surroundings to the core B. Additionally, Ti and Mg decreased the ignition delay time of B, which improved its combustion performance.

关键词： Boron B_(2)O_(3) Opposed flow burner Combustion Magnesium

Study of Complex Nitrogen and Oxygen-bearing Molecules toward the High-mass Protostar IRAS 18089–1732

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Research in Astronomy and Astrophysics 2024年第6期24卷 81-93页

作者： Arijit Manna Sabyasachi pal Tapas Baug Sougata Mondal Department of Physics Midnapore City CollegePaschim MedinipurWest Bengal721129India S.N.Bose National Centre for Basic Sciences Block-JDSector-IIISalt Lake CityKolkata700106 India

The observation of oxygen(O)-and nitrogen(N)-bearing molecules gives an idea about the complex prebiotic chemistry in the interstellar *** millimeter and submillimeter wavelength observations have shown the presence of complex O-and N-bearing molecules in the star formation ***,the investigation of those molecules is crucial to understanding the chemical complexity in the star-forming *** this article,we present the identification of the rotational emission lines of N-bearing molecules ethyl cyanide(C_(2)H_(5)CN)and cyanoacetylene(HC_(3)N),and O-bearing molecule methyl formate(CH_(3)OCHO)toward high-mass protostar IRAS18089–1732 using the Atacama Compact *** also detected the emission lines of both the N-and O-bearing molecule formamide(NH_(2)CHO)in the envelope of IRAS 18089–*** have detected the v=0 and 1 state rotational emission lines of CH_(3)*** also detected the two vibrationally excited states of HC_(3)N(v7=1 and v7=2).The estimated fractional abundances of C_(2)H_(5)CN,HC_(3)N(v7=1),HC_(3)N(v7=2),and NH_(2)CHO toward IRAS 18089–1732 are(1.40±0.5)×10^(-10),(7.5±0.7)×10^(-11),(3.1±0.4)×10^(-11),and(6.25±0.82)×10^(-11)***,the estimated fractional abundances of CH_(3)OCHO(v=0)and CH_(3)OCHO(v=1)are(1.90±0.9)×10^(-9)and(8.90±0.8)×10^(-10),*** also created the integrated emission maps of the detected molecules,and the observed molecules may have originated from the extended envelope of the *** show that C_(2)H_(5)CNand HC_(3)N are most probably formed via the subsequential hydrogenation of the CH_(2)CHCNand the reaction between C_(2)H_(2)and CN on the grain surface of IRAS 18089–*** found that NH_(2)CHO is probably produced due to the reaction between NH_(2)and H_(2)CO in the gas ***,CH_(3)OCHO is possibly created via the reaction between radical CH_(3)O and radical HCO on the grain surface of IRAS 18089–1732.

关键词： ISM:individual objects(IRA 18089-1732)(except) ISM:abundances ISM:kinematics and dynamics stars:formation astrochemistry

Evaluating Ignition and Combustion Performance with Al-Metal- Organic Frameworks and Nano-Aluminum in HTPB Fuel

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火炸药学报 2024年第5期47卷 413-421,I0003页

作者： Sri Nithya Mahottamananda Yash pal Yarravarapu Sai Sriram Subha S Djalal Trache Department of Aerospace Engineering B S Abdur Rahman CrescentInstitute of Science and TechnologyChennai-600048India School of Aeronautical Science Hindustan Institute of Technologyand ScienceChennai-603103India Energetic Materials Laboratory(EMLab) Teaching and ResearchUnit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj El-Bahri16046AlgiersAlgeria

Incorporating aluminum metal-organic frameworks(Al-MOFs)as energetic additives for solid fuels presents a promising avenue for enhancing combustion *** study explores the potential benefits of Al-MOF(MIL-53(Al))energetic additive on the combustion performance of hydroxyl-terminated polybutadiene(HTPB)*** HTPB-MOF fuel samples were manufactured using the vacuum-casting technique,followed by a comprehensive evaluation of their ignition and combustion properties using an opposed flow burner(OFB)setup utilizing gaseous oxygen as an *** gauge the effectiveness of Al-MOFs as fuel additives,their impact is compared with that of nano-aluminum(nAl),another traditional additive in HTPB *** results indicate that the addition of 15%(mass fraction)nAl into HTPB resulted in the shortest ignition delay time(136 ms),demonstrating improved ignition performance compared to pure HTPB(273 ms).The incorporation of Al-MOF in HTPB also reduced ignition delay times to 227 ms and 189 ms,***,under high oxidizer mass flux conditions(79—81 kg/(m^(2)s)),HTPB fuel with 15%nAl exhibited a substantial 83.2%increase in regression rate compared to the baseline HTPB fuel,highlighting the positive influence of nAl on combustion *** contrast,HTPB-MOF with a 15%Al-MOF additive showed a 32.7%increase in regression rate compared to pure *** results suggest that HTPB-nAl outperforms HTPB-MOF in terms of regression rates,indicating a more vigorous and rapid burning behavior.

关键词： ignition combustion enhancement MOF HTPB regression rate

Enantioselective iridium-catalyzed allylic substitution with a Reformatsky reagent: direct construction of β-stereogenic homoallylic esters

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Science China Chemistry 2024年第11期67卷 3791-3797页

作者： Debasis pal kirana D.Veeranna Yuk Fai Wong P.Andrew Evans Department of Chemistry Queen's University Xiangya School of Pharmaceutical Sciences Central South University

The Reformatsky reagent derived from ethyl bromoacetate circumvents the challenge associated with the direct regio-and enantioselective iridium-catalyzed allylic alkylation with an unstabilized aliphatic ester enolate. Notably, this work represents the first example of using a Reformatsky reagent in a metal-allyl reaction, which permits the direct construction of enantioenriched β-stereogenic homoallylic esters without preactivation of the pronucleophile or post-reaction modification of the product(e.g., thermal decarboxylation of a 1,3-dicarbonyl). Moreover, the process allows the coupling of a broad range of sterically and electronically diverse electrophiles bearing aryl, heteroaryl and alkenyl derivatives, including the significantly more challenging alkyl-substituted allylic carbonates. The versatility of the ester product is exemplified by a series of functional group manipulations and the development of a concise and efficient enantioselective total synthesis of the natural product,(+)-descurainolide A. Finally, mechanistic studies indicate that the zinc enolate behaves as a soft nucleophile that undergoes outer-sphere alkylation.

关键词： allylic substitution asymmetric catalysis mechanistic studies natural product synthesis Reformatsky reagent