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Management of localized prostate cancer： the pendulum swings （back to the middle）

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Asian Journal of Andrology 2014年第4期16卷 570-571页

Herein, we discuss 18-year follow-up data from the Scandinavian ProstateCancer Group-4 （SPCG-4） trial, a randomized study comparing observation and radical prostatectomy （RP） in patients with localized prostate cancer. The results of this study are contrasted with another study employing a similar randomization, the Prostate Cancer Intervention Versus Observation Trial （PIVOT）. We highlight several key differences in study eligibility and enrollment that may account for distinct results, and describe how these datasets impact the complex landscape of therapy for localized prostate cancer.

关键词： RADICAL PROSTATECTOMY

The role of peroxisome proliferator-activated receptor gamma in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 238-243页

作者： Catherine Elix sumanta k pal Jeremy O Jones Department of Medical Oncology City of Hope National Medical Center Duarte CA91010 USA.

Despite great progress in the detection and treatment of prostate cancer, this disease remains an incredible health and economic burden. Although androgen receptor （AR） signaling plays a key role in the development and progression of prostate cancer, aberrations in other molecular pathways also contribute to the disease, making it essential to identify and develop drugs against novel targets, both for the prevention and treatment of prostate cancer. One promising target is the peroxisome proliferator-activated receptor gamma （PPARy） protein. PPARy was originally thought to act as a tumor suppressor in prostate cells because agonist ligands inhibited the growth of prostate cancer cells; however, additional studies found that PPARy agonists inhibit cell growth independent of PPARy. Furthermore, PPARy expression increases with cancer grade/stage, which would suggest that it is not a tumor suppressor but instead that PPARy activity may play a role in prostate cancer development and/or progression. Indeed, two new studies, taking vastly different, unbiased approaches, have identified PPARy as a target in prostate cancer and suggest that PPARy inhibition might be useful in prostate cancer prevention and treatment. These findings could lead to a new therapeutic weapon in the fight against prostate cancer.

关键词： androgen receptor PPAR gamma prevention prostate cancer warfarin

Renal cell carcinoma:An update for the practicing urologist

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Asian Journal of Urology 2015年第1期2卷 19-25页

作者： sumanta k.pal Paulo Bergerot Robert A.Figlin Department of Medical Oncology&Experimental Therapeutics City of Hope Comprehensive Cancer CenterDuarteCAUSA Health Department of Federal District(SES)e HRAN BrasiliaBrazil Department of Medicine Cedars-Sinai Medical CenterLos AngelesCAUSA

Systemic therapy for metastatic renal cell carcinoma(mRCC)has evolved drastically,with agents targeting vascular endothelial growth factor(VEGF)and the mammalian target of rapamycin(mTOR)now representing a standard of *** present paper is to review the current status of relevant clinical trials that were either recently completed or ongoing.(1)Though observation remains a standard of care following resection of localized disease,multiple trials are underway to assess VEGF-and mTOR-directed therapies in this setting.(2)While the preponderance of retrospective data favors cytoreductive nephrectomy in the context of targeted agents,prospective data to support this approach is still forthcoming.(3)The first-line management of mRCC may change substantially with multiple studies exploring vaccines,immune checkpoint inhibitors,and novel targeted agents currently *** general,prospective studies that will report within the next several years will be critical in defining the role of adjuvant therapy and cytoreductive *** the same span of time,the current treatment paradigm for first-line therapy may evolve.

关键词： Renal cell carcinoma Sdjuvant therapy Cytoreductive nephrectomy Vaccines Immunotherapy PD-1 Cabozantinib

Metastasis in renal cell carcinoma:Biology and implications for therapy

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Asian Journal of Urology 2016年第4期3卷 286-292页

作者： Jun Gong Manuel Caitano Maia Nazli Dizman Ameish Govindarajan sumanta k.pal Department of Medical Oncology&Experimental Therapeutics City of Hope Comprehensive Cancer CenterDuarteCAUSA Division of Medical Oncology Instituto Hemomed de Oncologia e Hematologia.Av.Arnolfo de Azevedo121-Cerqueira Ce´sar-CEP 01248-040Sao PauloBrazil Department of Internal Medicine Istanbul Medeniyet University Goztepe Research and Training HospitalIstanbulTurkey

Although multiple advances have been made in systemic therapy for renal cell carcinoma(RCC),metastatic RCC remains *** the current review,we focus on the underlying biology of RCC and plausible mechanisms of *** further outline evolving strategies to combat metastasis through adjuvant ***,we discuss clinical patterns of metastasis in RCC and how distinct systemic therapy approaches may be considered based on the anatomic location of metastasis.

关键词： Renal cell carcinoma Metastasis Vascular endothelial growth factor Mammalian target of rapamycin Hypoxia inducible factor

Dynamical behaviors of a constant prey refuge ratio-dependent prey-predator model with Allee and fear effects

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International Journal of Biomathematics 2024年第1期17卷 227-250页

作者： Soumitra pal Pijush Panday Nikhil pal A.k.Misra Joydev Chattopadhyays Department of Mathematics Institute of Science Banaras Hindu University Varanasi 221005India Department of Mathematical and Statistical Sciences University of Alberta EdmontonAB T6G 2G1Canada Department of Mathematics Visva-Bharati Santiniketan 731235India Agricultural and Ecological Research Unit Indian Statistical Institute 203 B.T.RoadKolkata 700108India

In this paper,we consider a nonlinear ratio-dependent prey-predator model with constant prey refuge in the prey *** Allee and fear phenomena are incorporated explicitly in the growth rate of the prey *** qualitative behaviors of the proposed model are investigated around the equilibrium points in *** bifurcation including its direction and stability for the model is also *** observe that fear of predation risk can have both stabilizing and destabilizing effects and induces bubbling phenomenon in the *** is also observed that for a fixed strength of fear,an increase in the Allee parameter makes the system unstable,whereas an increase in prey refuge drives the system toward ***,higher values of both the Allee and prey refuge parameters have negative impacts and the populations go to ***,we explore the variation of densities of the populations in different bi-parameter spaces,where the coexistence equilibrium point remains *** simulations are carried out to explore the dynamical behaviors of the system with the help of MATLAB software.

关键词： Predator-prey system Allee effect fear effect prey refuge bifurcation population density

Observation of Complex Organic Molecules Containing Peptide-like Bonds Toward Hot Core G358.93-0.03 MM1

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Research in Astronomy and Astrophysics 2024年第7期24卷 181-189页

作者： Arijit Manna Sabyasachi pal Department of Physics and Astronomy Midnapore City CollegePaschim MedinipurWest Bengal721129India

In star formation regions,the complex organic molecules(COMs)that contain peptide bonds(-NH-C(=O)-)play a major role in the metabolic process because-NH-C(=O)-is connected to amino acids(R-CHNH_2-COOH).Over the past few decades,many COMs containing peptide-like bonds have been detected in hot molecular cores(HMCs),hot corinos,and cold molecular clouds,however,their prebiotic chemistry is poorly *** present the first detection of the rotational emission lines of formamide(NH_2CHO)and isocyanic acid(HNCO),which contain peptide-like bonds toward the chemically rich HMC G358.93-0.03 MM1,using high-resolution and high-sensitivity Atacama Large Millimeter/submillimeter Array bands 6 and *** estimate that the column densities of NH_2CHO and HNCO toward G358.93-0.03 MM1 are(2.80±0.29)×10~(15)cm~(-2)and(1.80±0.42)×10~(16)cm~(-2)with excitation temperatures of 165±21 k and 170±32 k,*** fractional abundances of NH_2CHO and HNCO toward G358.93-0.03 MM1 are(9.03±1.44)×10~(-10)and(5.80±2.09)×10^(-9).We compare the estimated abundances of NH_2CHO and HNCO with the existing threephase warm-up chemical model abundance values and notice that the observed and modeled abundances are very *** conclude that NH_2CHO is produced by the reaction of NH_2and H_2CO in the gas phase toward G358.93-0.03 ***,HNCO is produced on the surface of grains by the reaction of NH and CO toward G358.93-0.03 *** also find that NH_2CHO and HNCO are chemically linked toward G358.93-0.03 MM1.

关键词： ISM individual objects(G358.93-0.03)-ISM abundances-ISM kinematics and dynamics-stars formation-astrochemistry

Assessment of soil erosion in the Irga watershed on the eastern edge of the Chota Nagpur Plateau,India

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Regional Sustainability 2024年第1期5卷 54-68页

作者： Ratan pal Buddhadev HEMBRAM Narayan Chandra JANA Department of Geography the University of BurdwanWest Bengal-713104India

Human activities to improve the quality of life have accelerated the natural rate of soil *** turn,these natural disasters have taken a great impact on *** activities,particularly the conversion of vegetated land into agricultural land and built-up area,stand out as primary contributors to soil *** present study investigated the risk of soil erosion in the Irga watershed located on the eastern fringe of the Chota Nagpur Plateau in Jharkhand,India,which is dominated by sandy loam and sandy clay loam soil with low soil organic carbon(SOC)*** study used the Revised Universal Soil Loss Equation(RUSLE)and Geographical Information System(GIS)technique to determine the rate of soil *** five parameters(rainfall-runoff erosivity(R)factor,soil erodibility(k)factor,slope length and steepness(LS)factor,cover-management(C)factor,and support practice(P)factor)of the RUSLE were applied to present a more accurate distribution characteristic of soil erosion in the Irga *** result shows that the R factor is positively correlated with rainfall and follows the same distribution pattern as the *** k factor values in the northern part of the study area are relatively low,while they are relatively high in the southern *** mean value of the LS factor is 2.74,which is low due to the flat terrain of the Irga *** is a negative linear correlation between Normalized Difference Vegetation Index(NDVI)and the C factor,and the high values of the C factor are observed in places with low *** mean value of the P factor is 0.210,with a range from 0.000 to *** calculating all parameters,we obtained the average soil erosion rate of 1.43 t/(hm^(2)•a),with the highest rate reaching as high as 32.71 t/(hm^(2)•a).Therefore,the study area faces a low risk of soil ***,preventative measures are essential to avoid future damage to productive and constructive activities caused by soil *** study also ident

关键词： Soil erosion Soil organic carbon Rainfall-runoff erosivity factor Soil erodibility factor Slope length and steepness factor Cover-management factor Support practice factor Irga watershed

Influence of Heat Input on Martensite Formation and Impact Property of Ferritic-Austenitic Dissimilar Weld Metals

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Journal of Materials Science & Technology 2012年第4期28卷 343-352页

作者： M. Mukherjee T.k. pal Welding Technology Centre Metallurgical and Material Engineering Department Jadavpur University

The effect of heat input on martensite formation and impact properties of gas metal arc welded modified ferritic stainless steel （409M） sheets （as received） with thickness of 4 mm was described in detail in this work. The welded joints were prepared under three heat input conditions, i.e. 0.4, 0.5 and 0.6 kJ/mm using two different austenitic filler wires （308L and 316L） and shielding gas composition of Ar ＋ 5% CO2. The welded joints were evaluated by microstructure and charpy impact toughness. The dependence of weld metal microstructure on heat input and filler wires were determined by dilution calculation, Creq/Nieq ratio, stacking fault energy （SFE）, optical microscopy （OM） and transmission electron microscopy （TEM）. It was observed that the microstructure as well as impact property of weld metal was significantly affected by the heat input and filler wire. Weld metals prepared by high heat input exhibited higher amount of martensite laths and toughness compared with those prepared by medium and low heat inputs, which was true for both the filler wires. Furthermore, 308L weld metals in general provided higher amount of martensite laths and toughness than 316L weld metals.

关键词： Heat input Ferritic-austenitic dissimilar weld Martensite Grain size Toughness

Hybrid fuzzy-grey-Taguchi based multi weld quality optimization of Al/Cu dissimilar friction stir welded joints

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Advances in Manufacturing 2016年第3期4卷 237-247页

作者： Prakash kumar Sahu kanchan kumari Sukhomay pal Surjya k. pal Department of Mechanical Engineering Indian Institute of Technology Guwahati Guwahati Assam 781039 India Department of Mechanical Engineering Indian Institute of Technology Kharagpur Kharagpur West Bengal 721302India

Nowadays aluminum alloys substitute copper in various applications for weight reduction and cost savings. This paper presents fuzzy-grey Taguchi technique for optimization of friction stir welding condition with seven weld quality attributes of dissimilar A1/Cu joints with the minimum number of experiments for effective productivity and product quality. Taguchi＇s L16 orthogonal array was used to conduct the experiments. Fuzzy inference system was adapted to convert the multi quality characteristics into an equivalent single quality parameter which was opti- mized by Taguchi approach. Four parameters namely, rotational speed of the tool, welding speed, plunging depth and tool pin offset were varied in four levels for investi- gating the effects on the process output like tensile strength, compressive strength, percentage of elongation, bending angle, weld bead thickness and average hardness at the nugget zone. The hardness profile is consistent with the variation of the structure within the nugget zone （NZ）. Confirmation experiment was conducted using predicted optimum parameter setting and it showed that the proposed approach could efficiently optimize weld quality parame- ters. The microstructural analyses were also performed for all the zones of the joints at both Al and Cu sides. It revealed the finer grain size at the NZ compared to the base material due to dynamic recrystallization.

关键词： Dissimilar friction stir welding - Grey relational analysis. Fuzzy inference system Multi-response optimization Mechanical properties Microstructural analysis