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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 253-256页

作者： Diganta Pan sumanta de Asit Kumar Bera Subhashis Bandyopadhyay Subrata Kumar Das debasis Bhattacharya Indian Veterinary Research Institute Eastern Regional Station37-Belgachia RoadKolkata-700 037West BengalIndia

Objective:To differentiate cryptic stage of Echinococcus granulosus(***) and Taenia by PCR-RFLP and sequence information of ***:DNA were isolated from metacestodes stage of Taenia and *** using DNA isolation kit(Q-BIOgene kit,USA), the amplified and purified DNA product was then cloned and sent for *** generating sequence information was used for amplicons ***:Out of 112 faecal and environmental samples,16 exhibited positive *** product size of amplicon positive for *** was 310 bp;whereas,for Taenia *** varied from 379 to 388 *** pr of ile of actinⅡwith Csp61 also differed Taenia *** ***:The result of the study indicated that,the primers were useful to differentiate cryptic stage of the two genera which is yet to be reported earlier.

关键词： Taenia solium Echinococcus granulosus Environmental samples PCR-RFLP

Intra-species sequence variability in 28s rRNA gene of Oesophagostomum venulosum isolated from goats of West Bengal,India.

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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 515-518页

作者： Subhasish Bandyopadhyay Asit Kumar Bera Sourav Sikdar sumanta de Subhashree Ghosh Tanmoy Rana Samiran Bandyopadhyay Premanshu Dandapat debasis Bhattacharya Eastern Regional Station of Indian Veterinary Research Institute 37 Belgachia Road.Kolkata-37West BengalIndia National Research Centre on Yak DirangArunachal Pradesh Eastern Regional Station of Indian Veterinary Research Institute.37 Belgachia Road.Kolkata-37 West BengalIndia

Objective:To identify genotypes of Oesophagostmum venulosum(***) prevailing in West Bengal,India by comparing variation of nucleotide sequences among 28S ***: PCR amplification of partial segment of 28 S rRNA sequence and analysis of sequence amplified product by single strand conformation polymorphism(SSCP).Results:Two distinct conformers among male and female parasites were identified by PCR-SSCP *** analysis among conformers revealed the presence of five single nucleotide polymorphisms(SNP) in codon 64,66,86,125 and *** RNA prediction structure showed that out of 5 SNPs,4 occurred at interior loop of RNA which confirmed evolutionary changes among isolates prevailing in this ***:SNPs occured in different isolates of *** might influence critical changes in rRNA folding pattern which influence evolutionary changes among isolates.

关键词： 28SrRNA PCR-SSCP Oesophagostomum SNP Secondary RNA structure

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Current paradigms and evolving concepts in metastatic castration-resistant prostate cancer

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Asian Journal of Andrology 2011年第5期13卷 683-689页

作者： sumanta Kumar Pal Oliver Sartor Division of Genitourinary Malignancies Department of Medical Oncology and Experimental Therapeutics City of Hope Comprehensive Cancer Center Los Angeles CA USA Tulane University School of Medicine New Orleans LA USA

Until recently, docetaxel-based therapy represented the only therapy shown to prolong survival in patients with metastatic castration-resistant prostate cancer （mCRPC）. The past year and a half has been marked by unprecedented progress in treatments for this disease. Three positive phase III clinical trials have emerged, each evaluating agents （sipuleuceI-T, cabazitaxel and abiraterone） with distinct mechanisms of action. Herein, the three pivotal trials are described alongside both past and current large phase III studies conducted in this mCRPC. The overall survival for patients with mCRPC treated in current clinical trials is considerably longer than noted in the past. We note that more recent trials with older agents have also shown improved survival and discuss potential non-therapeutic biases that influence this critical measure of outcome. The necessity for utilizing randomized trials when evaluating new therapeutics is emphasized given the changing prognosis in this mCRPC.

关键词： abiraterone bevacizumab cabazitaxel castrate resistant castration resistant docetaxel hormone refractory Jevtana Provenge prostate cancer sipuleuceI-T

Influence of dynamic soil-pile raft-structure interaction:an experimental approach

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Earthquake Engineering and Engineering Vibration 2015年第4期14卷 625-645页

作者： Rajib Saha sumanta Haldar Sekhar Chandra Dutta Civil Engineering department National Institute of Technology Agartala School of Infrastructure Indian Institute of Technolgy Bhubaneswar department of Civil Engineering Indian School of Mines

Traditionally seismic design of structures supported on piled raft foundation is performed by considering fixed base conditions, while the pile head is also considered to be fixed for the design of the pile foundation. Major drawback of this assumption is that it cannot capture soil-foundation-structure interaction due to flexibility of soil or the inertial interaction involving heavy foundation masses. Previous studies on this subject addressed mainly the intricacy in modelling of dynamic soil structure interaction (DSSI) but not the implication of such interaction on the distribution of forces at various elements of the pile foundation and supported structure. A recent numerical study by the authors showed significant change in response at different elements of the piled raft supported structure when DSSI effects are considered. The present study is a limited attempt in this direction, and it examines such observations through shake table tests. The effect of DSSI is examined by comparing dynamic responses from fixed base scaled down model structures and the overall systems. This study indicates the possibility of significant underestimation in design forces for both the column and pile if designed under fixed base assumption. Such underestimation in the design forces may have serious implication in the design of a foundation or structural element.

关键词： soil-foundation-structure interaction piled raft foundation base shear pile head shear model test

Management of localized prostate cancer： the pendulum swings （back to the middle）

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Asian Journal of Andrology 2014年第4期16卷 570-571页

作者： Winston Vuong Oliver Sartor sumanta K Pal department of Medical Oncology and Experimental Therapeutics City of Hope Comprehensive Cancer Center Duarte CA department of Medicine Tulane University School of Medicine New Orleans LA USA.

Herein, we discuss 18-year follow-up data from the Scandinavian ProstateCancer Group-4 （SPCG-4） trial, a randomized study comparing observation and radical prostatectomy （RP） in patients with localized prostate cancer. The results of this study are contrasted with another study employing a similar randomization, the Prostate Cancer Intervention Versus Observation Trial （PIVOT）. We highlight several key differences in study eligibility and enrollment that may account for distinct results, and describe how these datasets impact the complex landscape of therapy for localized prostate cancer.

关键词： @@

Radium-223 in metastatic castration resistant prostate cancer

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Asian Journal of Andrology 2014年第3期16卷 348-353页

In 2004, docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer （mCRPC）. For the next several years, there was a lull in drug approvals. However, from 2010 onwards, 5 additional therapies have been approved on the basis of showing a survival benefit in phase III studies. These agents include sipuleuceI-T, cabazitaxel, abiraterone, enzalutamide and （most recently） radium-223. Amongst radiopharmaceuticals currently used for advanced prostate cancer （e.g. samarium-153 and strontium-89）, radium-223 possesses several unique properties. As an alpha-emitting compound, the agent produces a high-energy output over a short range, facilitating selective destruction of tissue within the bone in the region of osteoblastic lesions while sparing surrounding normal tissue. The current review will outline biological rationale for radium-223 and also provide an overview of preclinical and clinical development of the agent. Rational sequencing of radium-223 and combinations, in the increasingly complex landscape of mCRPC will be discussed, along with factors influencing clinical implementation.

关键词： alpharadin bone metastases metastatic castration-resistant prostate cancer radiopharmaceuticals radium-223 Xofigo

A review on the current research on microwave processing techniques applied to graphene-based supercapacitor electrodes:An emerging approach beyond conventional heating

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Journal of Energy Chemistry 2022年第11期31卷 252-282,I0008页

作者： Rajesh Kumar sumanta Sahoo Ednan Joanni Rajesh Kumar Singh department of Mechanical Engineering Indian Institute of TechnologyKanpur 208016Uttar PradeshIndia School of Chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Centre for Information Technology Renato Archer(CTI) Campinas 13069-901Brazil School of Physical and Material Sciences Central University of Himachal Pradesh(CUHP)KangraDharamshala 176215HPIndia

The various methods for microwave processing of materials exhibit numerous advantages,such as short processing times,high yield,expanded reaction conditions,high reproducibility,and high purity of ***-assisted synthesis strategies have been widely adopted for the preparation of highperformance graphene-based materials for supercapacitor *** oxides,mixed metal oxides,metal hydroxides,layered double hydroxides,carbon nanotubes and conducting polymers are some of the main materials which have been added to graphene derivatives for advanced composite/hybrid *** review article first provides a brief introduction and an overview of microwave heating and its advantages for processing graphene-based electrode *** that,a systematic survey of recently published research on microwave irradiation-assisted processing is presented,focusing on:(i)transformation of graphite/graphite oxide into graphene/graphene oxide by exfoliation and reduction;(ii)formation of graphene derivatives in various liquid and gaseous media;(iii)modification of graphene derivatives with various metal oxides/hydroxides,carbon nanotubes,and conducting polymers for use in *** challenges and future perspectives for microwave-assisted processing of graphene-based materials for cutting-edge supercapacitor electrode applications are also summarized in the conclusion.

关键词： Microwave irradiation Graphene derivatives Reduction/Exfoliation Supercapacitor Energy

The role of peroxisome proliferator-activated receptor gamma in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 238-243页

作者： Catherine Elix sumanta K Pal Jeremy O Jones department of Medical Oncology City of Hope National Medical Center Duarte CA91010 USA.

despite great progress in the detection and treatment of prostate cancer, this disease remains an incredible health and economic burden. Although androgen receptor （AR） signaling plays a key role in the development and progression of prostate cancer, aberrations in other molecular pathways also contribute to the disease, making it essential to identify and develop drugs against novel targets, both for the prevention and treatment of prostate cancer. One promising target is the peroxisome proliferator-activated receptor gamma （PPARy） protein. PPARy was originally thought to act as a tumor suppressor in prostate cells because agonist ligands inhibited the growth of prostate cancer cells; however, additional studies found that PPARy agonists inhibit cell growth independent of PPARy. Furthermore, PPARy expression increases with cancer grade/stage, which would suggest that it is not a tumor suppressor but instead that PPARy activity may play a role in prostate cancer development and/or progression. Indeed, two new studies, taking vastly different, unbiased approaches, have identified PPARy as a target in prostate cancer and suggest that PPARy inhibition might be useful in prostate cancer prevention and treatment. These findings could lead to a new therapeutic weapon in the fight against prostate cancer.

关键词： androgen receptor PPAR gamma prevention prostate cancer warfarin

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao de-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response