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Modern Research in Inflammation 2013年第4期2卷 75-81页

作者： Shamim Ahmed S.K. Barbhuiya sumana chakraborty Mahuya Sengupta Department of Biotechnology Assam University Silchar India

Immune infertility has gained impetus in recent years. Various scientific studies have been carried out on the toxic effects of lead on immune function;however, uncertainties still persist. The present study addresses the immunomodulatory effects of testicular macrophages caused due to lead exposure (in-vivo). In mice, lead has a primary effect on the testes, and acts at all levels of the reproductive as well as the testicular immune response. The study was undertaken to investigate the effects of lead acetate on immune system in Swiss albino mice and the underlying mechanism of pro-inflammatory cytokine action. The immunomodulatory effects of lead are complex and appear to involve multiple pathways, not all of which are fully understood. Testicular macrophage dysfunctions by lead was studied by calculating morphological alteration and associated cell functions of innate immunity followed by estimation of pro-inflammatory cytokine release (TNF-α). The present work shows that lead is responsible for a significant morphological alteration, reducing cell function in testicular macrophages probably by increasing oxidative damage whereas increase in TNF-α release was also observed which increased inflammation. Results demonstrated that lead intoxication leads to increase in pro-inflammatory response. TNF-α is probably unable to bind with the surface receptor in testicular macrophages because of altered morphology which reduces cell function and ultimately causes reproductive dysfunction.

关键词： Lead Phagocytosis Intracellular Killing Scanning Electron Microscopy Proinflammatory Cytokines

Effect of nitrofurazone on the reproductive organs in adult male mice

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Asian Journal of Andrology 2001年第1期3卷 39-44页

作者： Shio Kumar Singh sumana Chakravarty Department of Zoology Banaras Hindu University Varanasi IndiaDepartment of Zoology Banaras Hindu University Varanasi India

Aim: To study the effect of 5-nitro-2-fumldehyde semicarbazone (nitrofurazone), a derivative of nitrofuran, onmale reproductive organs of Parkes (P) swain mice. Methods: Mice were given nitrofurazone orally at a dose of 64mg/kg body weight per day, for 10 and 20 days, and were killed 24 h and/or 56 days after the last treatment. Histo-logical appearance of testis, motility and number of spermatozoa in cauda epididymidis, and biochemical indices in epi-didymis and seminal vesicle were evaluated. Results: Histologically, testis showed marked regressive changes inthe seminiferous tubules in mice treated with nitrofurazone. Ten days after treatment, there was much depletion of germcells in the seminiferous tubules, and the germinal epithelium was lined mainly with Sertoli cells, spermatogonia, sper-matocytes, and a few round spermatids; intraepithelial vacuoles and multinucleated giant cells were also observed intubules. By 20 days, regressive changes in the seminiferous tubules were further pronounced, and pachytene spermato-cytes were the most advanced germ cells noticed in the tubules. In severe cases, the tubules were lined with a thin layerof Sertoli cells and spermatogonia. The treatment also caused marked reductions in the motility and number of sperma-tozoa in the cauda epididymidis, in weight and the level of fructose in the seminal vesicle, and in sialic acid level in theepididymis. Fifty six days after drag withdrawal, the alterations induced in the reproductive organs returned to controllevels. Conclusion: Our results suggest that nitrofurazone treatment in P mice induces marked alterations in themale reproductive organs, and that the alterations are reversible following cessation of treatment.(Asian J Androl 2001 Mar; 3: 39-44)

关键词： nitrofurazone testis epididymis seminal vesicles sperm fructose sialic acids

Variation and dispersal of PM_(10) and PM_(2.5) during COVID-19 lockdown over Kolkata metropolitan city,India investigated through HYSPLIT model

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Geoscience Frontiers 2022年第1期13卷 285-296页

作者： Biswajit Bera sumana Bhattacharjee Nairita Sengupta Soumik Saha Department of Geography Sidho-Kanho-Birsha UniversityRanchi RoadP.O.Purulia Sainik School723104India Department of Geography Jogesh Chandra Chaudhuri College(University of Calcutta)30Prince Anwar Shah RoadKolkata 700033India Department of Geography Diamond Harbour Women’s UniversitySarisha 743368India M.A. Independent ScholarDepartment of GeographyUniversity of Calcutta35Ballygunge Circular RoadKolkata 700019India

The higher concentration of PM_(10) and PM_(2.5) in the lower atmosphere is severely harmful for human health and it also makes visibility diminution along with weather and climate *** main objective is to find out the spatiotemporal variation and dispersal of PM_(10) and PM_(2.5) along with COVID-19 infection in the dusty city *** consecutive two years PM_(10) and PM_(2.5) data of different stations have been obtained from State Pollution Control Board,*** West *** trajectory analysis has been done through HYSPLIT(Hybrid Single Particle Lagrangian Integrated Trajectory)model to find the path and direction of air *** result showed that the various meteorological or environmental factors(such as temperature,relative humidity,wind,wind speed,pressure and gusty wind)and geographical location regulate the spatiotemporal variation of PM_(10) and PM_(2.5).These factors like high temperature with relative humidity and strong wind influence to disperse the particulate matters from north to south direction from city to outside during summer in Kolkata metropolitan *** summer(both pre and lockdown years),the height of particles is extended up to 1000 m owing to active atmospheric ventilation whereas in winter it is confined within 100 *** HYSPLIT model clearly specified that the particles dispersed from south,south-west to north and north east direction due to strong *** constant magnification of PM_(10) and PM_(2.5) in the lower atmosphere leads to greater frequency of COVID-19 infections and *** Kolkata,the one of the crucial reasons of high infection and deaths(COVID-19)is co-morbidity of people.

关键词： COVID-19 Lockdown Variation Dispersal HYSPLIT model

Ethnobotanical survey of folklore plants used in treatment of snakebite in Paschim Medinipur district,West Bengal

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Asian Pacific Journal of Tropical Biomedicine 2014年第5期4卷 416-420页

作者： sumana Sarkhel Department of Human Physiology with Community Health Vidyasagar University

Objective:To investigate and collect information from traditional health healers/tribal communities on the use of medicinal plants for treatment of ***:The ethno-medicinal study was conducted in 8 villages of the Paschim Medinipur district of West Bengal in 2012-2013 through questionnaire and personal *** the method of Martin,information about medicinal plants used in snake bite,precise plant parts used,methods of treatment and administration was enquired from the tribal communities(Santhals,Mundas,Lodhas,Bhumijs,Oram Kherias) of the ***:The present study enumerates 20 ethnomedicinal plant species belonging to 16 families used by the tribal communities and medicinal healers of Paschim Medinipur district,West Bengal in treatment of *** plant species has been listed alphabetically according to its botanical name,family,vernacular name,part(s) used,mode of preparation/***:The importance of traditional medicinal system among the tribal communities of Paschim Medinipur district of West Bengal has been highlighted in the present study.

关键词： Traditional medicinal system Snakebite Paschim Medinipur district

Network approach to understanding the organization of and the consequence of targeted leader removal on an end-oriented task

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Current Zoology 2017年第3期63卷 269-277页

作者： sumana ANNAGIRI Swetashree KOLAY Bishwarup PAUL Chandan SONA Behaviour & Ecology Lab Department of Biological Sciences Indian Institute of Science Education and Research Kolkata Mohanpur West Bengal 741246 India Department of Pharmacology CSIR-CDRI Jankipurm Vistar Lucknow Uttar Pradesh 226021 India

Relocation is an important event in the lives of several social insects whereby all colony members have to be transferred to a new nest when conditions in the old nest become unfavorable. In the current study, network tools were used to examine the organization of this goal-oriented task in the Indian queenless ant Diacamma indicum Which relocate their colonies by means of tandem running. Individual ants were used as nodes and tandem runs as directed edges to construct unweighted networks. Network parameters were characterized in control relocations （CRs） and in relocations where the node with the highest outdegree, that is, the Maximum tandem leader （Max TL） was experimentally removed. These were then compared to 1） randomized networks, 2） simu- lated networks in which Max TL was removed, and 3） simulated networks with removal of a random leader. Not only was there complete recovery of the task, but the manner in which it was organized when Max TL was removed was comparable to CRs. The results obtained from our empirical study were significantly different from the results predicted by simulations of leader removal. At an individual level, the Max TL had a significantly higher outdegree than expected by chance alone and in her absence the substitute Max TL did comparable work. In addition, the position of the Max TL in the pathway of information flow was conserved in control and experimentally manipulated conditions. Understanding the organization of this critical event as more than the sum of individual interactions using network parameters allows us to appreciate the dynamic response of groups to perturbations.

关键词： Diacamma indicum division of labor networks relocation tandem running

Sum-connectivity index of a graph

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Frontiers of Mathematics in China 2016年第1期11卷 47-54页

作者： Kinkar Ch. DAS sumana DAS Bo ZHOU Department of Mathematics Sungkyunkwan University Suwon 440-746 Korea School of Information and Communication Engineering Sungkyunkwan UniversitySuwon 440-746 Korea Department of Mathematics South China Normal University Guangzhou 510631 China

Let G be a simple connected graph, and let di be the degree of its i-th vertex. The sure,connectivity index of the graph G is defined as χ（G） =∑vivj∈E（G）（di＋dj）-1/*** discuss the effect onχ（G）of inserting... 详细信息

关键词： Graph Randid index sum-connectivity index minimum degree

Intranasal ketamine for the treatment of patients with acute pain in the emergency department

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World Journal of Emergency Medicine 2016年第1期7卷 19-24页

作者： Roshana Shrestha Samita Pant Ashis Shrestha Kabita Hada Batajoo Rashmi Thapa sumana Vaidya Department of General Practice and Emergency Medicine Manmohan Medical College and Teaching Hospital Department of General Practice and Emergency Medicine Patan Academy of Health Sciences Department of General Practice and Emergency Medicine KIST Medical College Hospital Department of General Practice and Emergency Medicine KMC Medical College Hospital

BACKGROUND:Pain in the emergency department(ED)is common but *** objective of this study was to examine the efficacy and safety of intranasal(IN)ketamine used as an analgesic for patients with acute injury with moderate to severe ***:This study was a cross sectional,observational study of patients more than 8 years old experiencing moderate to severe pain[visual analog score(VAS)>50 mm].The initial dose of IN ketamine was 0.7 mg/kg with an additional dose of 0.3 mg/kg if VAS was more than 50 mm after *** scores and vital signs were recorded at 0,15,30 and 60 ***-effects,sedation level and patient's satisfaction were also *** primary outcome was the number of patients achieving≥20 mm reductions in VAS at 15 *** secondary outcome measures were median reduction in VAS at 15,30 and 60 minutes,changes of vital signs,adverse events,satisfaction of patients,and need for additional ***:Thirty-four patients with a median age of 29.5 years(IQR 17.5–38)were enrolled,and they had an initial median VAS of 80 mm(IQR 67–90).The VAS decreased more than 20 mm at15 minutes in 27(80%)*** reduction of VAS from baseline to 40 mm(IQR 20–40),20 mm(IQR 14–20)and 20 mm(IQR 10–20)respectively at 15,30 and 60 minutes(P<0.001).No critical changes of vital signs were noted and adverse effects were mild and ***:This study showed that IN ketamine is an analgesic choice for patients with acute injury in moderate to severe pain in an overcrowded and resource limited ED.

关键词： Analgesia Intranasal Ketamine Pain Visual analog score

Siwalik plant megafossil diversity in the Eastern Himalayas: A review

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Plant Diversity 2023年第3期45卷 243-264页

作者： Mahasin Ali Khan sumana Mahato Robert A.Spicer Teresa E.V.Spicer Ashif Ali Taposhi Hazra Subir Bera Palaeobotany and Palynology Laboratory Department of BotanySidho-Kanho-Birsha UniversityRanchi RoadPurulia 723104India CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303PR China School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton KeynesMK76AAUK Centre of Advanced Study Department of BotanyUniversity of Calcutta35B.C.RoadKolkata 700019India

The Eastern Himalayas are renowned for their high plant *** understand how this modern botanical richness formed,it is critical to investigate past plant biodiversity preserved as fossils throughout the eastern Himalayan Siwalik succession(middle Miocene-early Pleistocene).Here,we present a summary of plant diversity records that document Neogene floristic and climate *** do this by compiling published records of megafossil plant remains,because these offer better spatial and temporal resolution than do palynological *** of the Siwalik floral assemblages based on the distribution of the nearest living relative taxa suggest that a tropical wet evergreen forest was growing in a warm humid monsoonal climate at the deposition *** qualitative interpretation is also corroborated by published CLAMP(Climate Leaf Analysis Multivariate Program) ***,we also reconstruct the climate by applying a new common proxy WorldClim2 *** allows the detection of subtle climate differences between floral assemblages free of artefacts introduced by using different methodologies and climate *** analysis of the Siwalik floras indicates that there was a gradual change in floral *** lower Siwalik assemblages provide evidence of a predominance of evergreen *** increase in deciduous elements in the floral composition is noticed towards the close of the middle Siwalik and the beginning of the upper Siwalik *** change reflects a climatic difference between Miocene and Plio-Pleistocene *** review helps us to understand under what paleoenvironmental conditions plant diversity occurred and evolved in the eastern Himalayas throughout the Cenozoic.

关键词： Megafossils Siwalik MiocenePleistocene Palaeovegetation Palaeoenvironment Eastern Himalayas

Identification of speckle-type POZ protein somatic mutations in African American prostate cancer

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Asian Journal of Andrology 2014年第6期16卷 829-832页

作者： Eric Buckles Chiping Qian Andrew Tadros sumana Majumdar Jennifer Cvitanovic Jovanny Zabaleta John Estrada John Wilson Wanguo Liu Department of Biology School of Science Technology Engineering and Mathematics Dillard University New Orleans LA USA New Orleans LA USA Department of Genetics Louisiana State University Health Sciences Center New Orleans LA USA Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center New Orleans LA USA Biospecimen Core Laboratory Louisiana Cancer Research Consortium New Orleans LA USA Department of Pediatrics Louisiana State University Health Sciences Center New Orleans LA USA.

The speckle-type POZ protein （SPOP） is a tumor suppressor in prostate cancer （PCa）. SPOP somatic mutations have been reported in up to 15% of PCa of those of European descent. However, the genetic roles of SPOP in African American （AA）-PCa are currently unknown. We sequenced the SPOP gene to identify somatic mutations in 49 AA prostate tumors and identified three missense mutations （p.Y87C, p.F102S, and p.G111E） in five AA prostate tumors （10%） and one synonymous variant （p.11061） in one tumor. Intriguingly, all of mutations and variants clustered in exon six, and all of the mutations altered conserved amino acids. Moreover, two mutations （p.F102S and p.G111E） have only been identified in AA-PCa to date. Quantitative real-time polymerase chain reaction analysis showed a lower level of SPOP expression in tumors carrying SPOP mutations than their matched normal prostate tissues. In addition, SPOP mutations and novel variants were detected in 5 of 27 aggressive PCa and one of 22 less aggressive PCa （P 〈 0.05）. Further studies with increased sample size are needed to validate the clinicopathological significance of these SPOP mutations in AA-PCa.

关键词： African American mutation analysis prostate cancer speckle-type POZ protein

Thermal cycling behavior of alumina-graphite brazed joints in electron tube applications

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Transactions of Nonferrous Metals Society of China 2014年第6期24卷 1666-1673页

作者： Nadadulal DANDAPAT sumana GHOSH Kalyan Sundar PAL Someswar DATTA Bichitra Kumar GUHA Central Glass&Ceramic Research Institute Council of Scientific and Industrial Research Department of Physics Bengal Engineering&Science University Institute for Plasma Research

Alumina was joined with graphite by active metal brazing technique at 895,900,905,and 910 ℃ for 10 min in vacuum of0.67 mPa using Ti-Cu-Ag（68.8Ag-26.7Cu-4.5Ti;mass fraction,%） as filler *** brazed samples were thermal cycled between 30 and 600 ℃ and characterized.X-ray diffraction results show strong reaction between titanium and carbon as well as titanium and *** electron microscopy and helium leak tests show that the initial and thermal cycled brazed samples are devoid of cracks or anv other defects and hermeticity in *** strength of the joints is found to be satisfactory.

关键词： brazed joints thermal cycling brazing strength hermeticity