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Bile Cast Nephropathy in Patients with Acute Kidney Injury Due to Hepatorenal Syndrome:A Postmortem Kidney Biopsy Study

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 92-100页

作者： suman lata nayak Manoj Kumar Chhagan Bihari Archana Rastogi Department of Nephrology Institute of Liver and Biliary Sciences New Delhi India Department of Hepatology and Liver Transplatation Institute of Liver and Biliary Sciences New Delhi India Department of Pathology Institute of Liver and Biliary Sciences New Delhi India

Background and Aims:The role of bile cast nephropathy (BCN) in pathogenesis of hepatorenal syndrome (HRS) in decompensated cirrhosis and acute on chronic liver failure (ACLF) is *** study aimed to determine the frequency of BCN detected on postmortem renal biopsy among patients with decompensated cirrhosis and ACLF who had been admitted with acute kidney injury due to HRS (HRAAKI) and expired during that ***:One-hundred-twenty-seven postmortem renal biopsies with adequate size (>1 cm in length) were included for *** were obtained from 84 patients with decompensated cirrhosis and 43 patients with ***:BCN was detected in 57 of the total 127 (44.8%) renal biopsy *** with BCN had significantly higher levels of serum total bilirubin,total leukocyte count and model for end-stage liver disease score,as compared to those without *** was detected in 32/43 (74.4%) of the patients with ACLF,as compared to 25/84 (29.7%) of the patients with decompensated cirrhosis (p < 0.001).On multivariate analysis,direct bilirubin (OR (95% CI):1.27 (1121-1.698);p < 0.001)and presence of ACLF (OR (95% CI):2.603 (1.054-7.111);p =0.041) were found to be significant predictors of BCN on postmortem renal ***:BCN was found in 72.1% of patients with ACLF and 27.4% patients with decompensated cirrhosis who had been hospitalized with an admitting diagnosis of HRS-AKI and who expired during that hospitalization and underwent postmortem renal *** serum bilirubin and presence of ACLF were found to be significant predictors of BCN on postmortem renal biopsy.

关键词： Bile cast nephropathy Acute kidney injury Hepatorenal syndrome

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Omics Studies and Systems Biology Perspective towards Abiotic Stress Response in Plants

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American Journal of Plant Sciences 2020年第12期11卷 2172-2194页

作者： Jyoti Prakash Sahoo Laxmipreeya Behera Siddhartha Shankar Sharma Jannila Praveena suman Kumari nayak Kailash Chandra Samal Department of Agricultural Biotechnology Odisha University of Agriculture and Technology Bhubaneswar India Department of Genetics and Plant Breeding Uttar Banga Krishi Viswavidyalaya Cooch Behar India Department of Fruit Science and Horticulture Technology Odisha University of Agriculture and Technology Bhubaneswar India Department of Plant Physiology Odisha University of Agriculture and Technology Bhubaneswar India

Plant abiotic stress responses are vital yield-restricting aspect in agriculture. Recent technology in plant biology allows research of such stress responses at a molecular scale in plants. Network analysis provides in-depth knowledge regarding omics information visualisation as it reduces the intrinsic intricacy of such data. The use of integrated functional genomics helps to understand the relationship between the genomic profile and the phenotypic profile in different environmental conditions of an organism. Plants’ responses to abiotic stress are often considered as a complex process. Systems biology approaches allow visualising and understanding how plant life works to overcome abiotic stress. The combination of integrated functional genomics along with bioinformatics will put a hand in additional in-depth research knowledge on stress tolerance to plants by exploiting available genetic information and continuously improving techniques and strategies. Most of the omics technologies are high throughput with very rapid data generation rates and humongous outputs. These technologies have made noticeable contributions to the modern-day improvements in our knowledge of plant biology. So, in this review, omics studies and the system biology approach towards abiotic stress tolerance in plants are highlighted.

关键词： Genomics Proteomics Transcriptomics System Biology Abiotic Stress Plants

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