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A Pilot Trial Testing the Feasibility of Using Molecular-Guided Therapy in Patients with Recurrent Neuroblastoma

Journal of Cancer Therapy 2012年第5期3卷 602-612页

作者： Giselle L. Saulnier Sholler William Ferguson Genevieve Bergendahl Erika Currier Shannon R. Lenox Jeffrey Bond Marni Slavik William Roberts Deanna Mitchell Don Eslin Jacqueline Kraveka Joel Kaplan Nehal Parikh suman malempati Gina Hanna Emily Eugster David Cherba Jeremy Miller Craig Webb Cardinal Glennon Children’s Hospital Saint Louis University School of Medicine St. Louis University St. Louis USA Center for Cancer Genomics and Computational Biology Pediatric Oncology Translational Research Program at the Van Andel Research Institute in Grand Rapids Grand Rapids USA Center for Children’s Cancer and Blood Disorders Arnold Palmer Hospital for Children MD Anderson Cancer Center Orlando Orlando USA Department of Pediatric Oncology Helen DeVos Children’s Hospital Michigan State University Grand Rapids USA Department of Pediatric Oncology Oregon Health Science University Portland USA Division of Hematology/Oncology 2J Connecticut Children’s Medical Center Hartford USA Pediatric Hematology/Oncology Medical University of South Carolina Charleston USA Pediatric Oncology Levine Children’s Hospital Charlotte USA Rady Children’s Hospital San Diego University of California San Diego School of Medicine at the University of California San Diego San Diego USA Vermont Cancer Center Department of Medicine University of Vermont Burlington USA

Background: Neuroblastoma is the most common extracranial solid tumor in children, and treatment options for recurrent neuroblastoma are limited. Using molecular profiling to target the molecular vulnerabilities of neuroblastoma with existing therapeutic agents may result in a rational, data-driven approach with potential to improve clinical outcomes. Methods: The primary objective of this pilot study was to evaluate the feasibility of supporting real-time treatment decisions through predictive modeling of genome-wide mRNA gene expression data from neuroblastoma tumor biopsies. Feasibility was defined as completion of tumor biopsy, histopathological evaluation, RNA extraction and quality control, gene expression profiling within a CLIA-certified laboratory, bioinformatic analysis, generation of a drug predicttion report, molecular tumor board review yielding a formulated treatment plan, and independent medical monitor review within a 2-week period. Results: Five patients with multiply relapsed or refractory neuroblastoma were enrolled between April and June 2010. All biopsies passed histopathology and RNA quality control. Generation of gene expression data and its analysis (3-7 days), reports which linked this data into medically actionable drug candidates (1-5 days), molecular tumor board (1-3 days) and independent medical monitor review (1 day) were all completed in real-time. The average time was 10.5 days for all patients. Conclusion: This study shows that it is feasible to create therapeutic treatment plans based on genomic profiling in less than 12 days. This warrants further testing in a Phase I study to determine safety of predicted treatments and evaluate whether the information obtained in these analyses would result in patient benefit.

关键词： Neuroblastoma Molecular Guided Therapy Predictive Therapies Molecular Profiling Genomic Profiling Pediatric Cancer

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Assessing the pomfret stock for setting catch limits in the northern Bay of Bengal,Bangladesh

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Aquaculture and Fisheries 2024年第2期9卷 324-335页

作者： Mohammed Shahidul Alam Qun Liu Md Mostafa Monwar Md Enamul Hoque suman Barua Md Leion Hassan Abdullah Munzer College of Fisheries Ocean University of ChinaQingdao266003China Department of Fisheries University of ChittagongChattogram4331Bangladesh Institute of Marine Sciences University of ChittagongChattogram4331Bangladesh Department of Oceanography University of ChittagongChattogram4331Bangladesh Department of Fisheries Ministry of Fisheries and LivestockDhaka1215Bangladesh

Pampus argenteus and Pampus chinensis form the high-value demersal Pomfret fishery of ***,due to a monotonic decline in catches over the last five years,it is essential to explore the current stock status concerning the removal rate to ensure the sustainability of this ***,given the reliability and minimal data requirements,this study employed an extended Bayesian State-Space Surplus Production Model,JABBA(Just Another Bayesian Biomass Assessment),to assess the stock *** results revealed that the stock biomass of the Pomfret fishery in the final year of the time series is significantly lower than BMSY,the biomass required to produce ***,this study recommends a yearly catch limit(TAC)of 10,000 metric tons to prevent further depletion of the stock ***,to avoid growth overfishing by allowing all immature fishes to reproduce at least once before being caught,this study also calculated the optimum length(Lopt)for catch for both species at which biologically maximum yield and revenue can be *** estimated Lopt is 25 cm for *** and 30 cm for ***,and not to capture fishes with lengths lower than these limits,this study further calculated the minimum mesh size limits for gill and set bag nets is 7.5 *** the mesh size regulation was estimated using length-based reference points derived from an empirical equation,this regulation can be used as an associate reference point when TAC is applied to assure the sustainability of this fishery.

关键词： Pomfret fishery Stock assessment JABBA TAC Lower length limits for catches Mesh size regulation

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Understanding factors affecting non-participants’interest in community-supported agriculture

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Regional Sustainability 2024年第3期5卷 69-80页

作者： Maula Fadhilata RAHMATIKA Agus suman Wildan SYAFITRI Sri MULJANINGSIH Faculty of Economics and Business Brawijaya UniversityMalang65145Indonesia

Community-supported agriculture(CSA)has emerged as a viable solution for addressing the agricultural challenges faced by countries like *** study uses the wellestablished unified theory of acceptance and use of technology(UTAUT2)model to examine the interest in CSA of potential customers in Indonesia.A standardized questionnaire was distributed to 1200 respondents,and the data were analyzed using structural equation model-partial least square(SEM-PLS)in SmartPLS 4.0 *** results capture potential CSA consumer interest and will help to improve CSA development strategies in *** model explains 44.4%of customers’intentions,and identifies performance expectancy as the decisive factor in customers’willingness to participate in *** expectancy(0.292),hedonic motivation(0.262),social influence(0.259),and facilitating conditions(0.086)positively influence customers’interest in participating in a CSA *** adoption of CSA programs by both farmers and customers could be increased by implementing regulations that provide tax incentives and subsidies,offering training on sustainable farming practices,facilitating the establishment of distribution channels,and establishing guidelines for fair price and quality *** study shows the high potential for the implementation of CSA in *** could also be used as a foundation for the development of new policies regarding sustainable agriculture markets in Indonesia.

关键词： Community-supported agriculture(CSA) Sustainable agriculture Behavioral intention Performance expectancy Unified theory of acceptance and use of technology model Indonesia

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Investigating computational models for diagnosis and prognosis of sepsis based on clinical parameters: Opportunities, challenges, and future research directions

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重症医学（英文） 2024年第4期04卷 468-477页

作者： Gupta Jyotirmoy Majumder Amit Kumar Sengupta Diganta Sultana Mahamuda Bhattacharya suman Department of Computer Science and Engineering (IOTCSBT) Future Institute of Technology Kolkata West Bengal India Department of Electronics and Communications Engineering Future Institute of Technology Kolkata West Bengal India Department of Computer Science and Engineering Heritage Institute of Technology Kolkata West Bengal India Department of Computer Science and Engineering Guru Nanak Institute of Technology Kolkata West Bengal India

This study investigates the use of computational frameworks for sepsis. We consider two dimensions for investigation - early diagnosis of sepsis (EDS) and mortality prediction rate for sepsis patients (MPS). We concentrate on the clinical parameters on which sepsis diagnosis and prognosis are currently done, including customized treatment plans based on historical data of the patient. We identify the most notable literature that uses computational models to address EDS and MPS based on those clinical parameters. In addition to the review of the computational models built upon the clinical parameters, we also provide details regarding the popular publicly available data sources. We provide brief reviews for each model in terms of prior art and present an analysis of their results, as claimed by the respective authors. With respect to the use of machine learning models, we have provided avenues for model analysis in terms of model selection, model validation, model interpretation, and model comparison. We further present the challenges and limitations of the use of computational models, providing future research directions. This study intends to serve as a benchmark for first-hand impressions on the use of computational models for EDS and MPS of sepsis, along with the details regarding which model has been the most promising to date. We have provided details regarding all the ML models that have been used to date for EDS and MPS of sepsis.

关键词： Sepsis Computing methodologies Early prediction of sepsis Mortality prediction of sepsis Machine learning Artificial intelligence

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Stock appraisal for Atlantic tripletail(Lobotes surinamensis;Bloch, 1790) in the Bay of Bengal, Bangladesh

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Journal of Oceanology and Limnology 2024年第05期 1683-1694页

作者： suman BARUA Qun LIU Ahmed Fazley RABBY Md.Abdullah AL-MAMUN Xu CHEN Rokeya SULTANA Aidah BALOCH College of Fisheries Ocean University of China Department of Fisheries Ministry of Fisheries and Livestock Bangladesh Fisheries Research Institute Directorate of Secondary and Higher Education Ministry of Education Gwadar Development Authority

The Atlantic tripletail (Lobotes surinamensis) is a high revenue-generating fish species predominantly caught by mechanized artisanal fishers community and the most available member of its family in *** is a ground work of fish stock assessment study in the Bay of Bengal region to explore the life history parameters and associated biomass of this species,using three length-based approaches of TropFishR,the length-based Bayesian biomass estimation (LBB),and Froese’s lengthbased indicators (LBIs).An almost homogenous body growth pattern (b=3.07;R2=0.98) was observed in the length-weight relationship of *** life history parameters for tripletail,as determined by the von Bertalanffy Growth Function (VBGF) model,were L∞=113.36 cm and k=0.51/*** length converted catch curve (LCCC) yielded an estimation of the total mortality (Z=1.77/a),with the natural mortality estimated at (M=0.53/a) and the fishing mortality estimated at (F=1.24/a).But,the ratio of mortality(F/M=0.15) by LBB captured the non-fully exploited status of biomass (B/BMSY=2.1).LBI analysis indicated that the tripletail fishery’s spawning stock biomass is greater than the target and limit reference points,indicating a healthy state of biomass.

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在关系化与类别化之间:鄂西武陵山区返乡农民工的创业实践及社会网络重构

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原生态民族文化学刊 2024年第1期16卷 97-106,155页

作者：解素蔓中央民族大学民族学与社会学学院北京100081

本文通过对鄂西武陵山区农村的田野调查发现,熟人社会网络主要依靠传统儒家伦理来维持,呈现出关系化的社会网络状态,这种社会网络呈现单一和发展规模有限等特点。随着人口城乡流动剧增,特别是大批农民工进城以及返乡以后,原本相对单一... 详细信息

本文通过对鄂西武陵山区农村的田野调查发现,熟人社会网络主要依靠传统儒家伦理来维持,呈现出关系化的社会网络状态,这种社会网络呈现单一和发展规模有限等特点。随着人口城乡流动剧增,特别是大批农民工进城以及返乡以后,原本相对单一的重构方式趋于多元化,并呈现着关系化和类别化等多重社会网络并置的状况。多重社会网络并置现象既是城乡流动的体现,也是不同人群基于生存选择而将乡土性和城市性编入日常生活实践的结果。其生成对于重新理解国家、社会和个人的关系,以及进一步理解中国社会转型过程中的差序格局及公私边界等问题有着重要启示意义。

关键词：返乡农民工社会网络关系化类别化并置

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High Strain-Rate and Shock Response of Carbon SupercompositeTM

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Open Journal of Composite Materials 2024年第3期14卷 132-145页

作者： suman Babu Ukyam Raju P. Mantena Damian L. Stoddard Arunachalam M. Rajendran Department of Mechanical Engineering University of Mississippi Mississippi USA

This study focuses on assessing the dynamic behaviors of carbon SupercompositeTM laminates when subjected to high strain-rates and air blast loads, using a shock tube for testing. The investigation aims to understand the response of these advanced materials under extreme conditions, which is crucial for applications in aerospace, military, and other high-performance industries. SupercompositeTM (CZE) prepreg, made up of a 3K plain weave carbon fabric with milled carbon fibers as interlaminar reinforcements impregnated with epoxy, is used to create SupercompositeTM (CZE) laminates. A woven carbon composite (CBE) laminate was also created using 3K plain weave Carbon/Epoxy (CBE) prepreg. Both types of laminates were designed and fabricated using the autoclave process. The dynamic behaviors of CZE and CBE laminate under transverse compression loads were evaluated using a modified Split Hopkinson Pressure Bar (SHPB). The study found that the 3D reinforcement with milled carbon fibers significantly affected the dynamic behavior of the CZE laminate. Stereo imaging videos, captured using two SHIMADZU high-speed video cameras in shock tube experiments, recorded the time history of back surface deflection. The plate specimens exhibited low deflections without any visible damage. The experimentally observed center point deflections of the CZE plates decayed sooner than those of the CBE laminates, indicating an improvement in damping due to the presence of 3D reinforced milled carbon fibers. This research shows that optimized utilization of milled carbon fibers as 3D reinforcement can withstand high stress in the thickness direction and higher energy absorption when subjected to impact and high strain-rate loading.

关键词： SupercompositeTM GOM Software 3D Reinforcement Milled Carbon Fibers Split Hopkinson Pressure Bar (SHPB) Air-Blast Loads

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A Pilot Trial Testing the Feasibility of Using Molecular-Guided Therapy in Patients with Recurrent Neuroblastoma

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Journal of Cancer Therapy（癌症治疗） 2012年第5期

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布南色林联合经颅磁刺激对女性精神分裂症患者的临床研究

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四川医学 2024年第2期45卷 151-154页

作者：程素满重庆市精神卫生中心重庆401147

目的探讨布南色林联合经颅磁刺激(TMS)对女性精神分裂症患者的临床疗效。方法选取2022年1月至2022年10月我中心收治的60例女性精神分裂症患者,分为对照组(单独服用布南色林)和观察组(布南色林联合TMS),每组各30例,治疗8周。观察患者治... 详细信息

目的探讨布南色林联合经颅磁刺激(TMS)对女性精神分裂症患者的临床疗效。方法选取2022年1月至2022年10月我中心收治的60例女性精神分裂症患者,分为对照组(单独服用布南色林)和观察组(布南色林联合TMS),每组各30例,治疗8周。观察患者治疗前后血清中催乳素(PRL)、促甲状腺激素(TSH)、游离三碘甲状腺素(FT3)、游离甲状腺素(FT4)水平变化。采用阳性与阴性症状量表(PANSS)评价临床症状,简易精神状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)评价认知功能的变化。结果与对照组比较,观察组在治疗后血清中性激素(PRL、TSH)和甲状腺激素(TSH、FT3、FT4)水平变化显著,PANSS总分、阴性症状评分和一般精神病理评分均降低,MMSE评分和MoCA评分增高,两组比较显示观察组优于对照组,差异有统计学意义(P<0.05)。结论TMS调控血清中激素水平,对精神分裂症患者的阴性症状和认知功能均具有改善作用,布南色林联合TMS治疗精神分裂症效果更好,值得临床推广和应用。

关键词：精神分裂症布南色林经颅磁刺激激素认知功能

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Impact of selection of DC base values and DC link control strategies on sequential AC-DC power-flow convergence

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Frontiers in Energy 2015年第4期9卷 399-412页

作者： Shagufla KHAN suman BHOWMICK Department of Electrical Engineering Delhi Technological University Delhi 110042 India

This paper demonstrates the convergence of the integrated AC-DC power-flow algorithm as affected by the selection of different base values for the DC quantities and adoption of different control strategies for the DC link. For power-flow modeling of integrated AC-DC systems, the base values of the various DC quantities can be defined in several ways, giving rise to different sets of per-unit system equations. It is observed that different per-unit system models affect the convergence of the power-flow algorithm differently. In a similar manner, the control strategy adopted for the DC link also affects the power- flow convergence. The sequential method is used to solve the DC variables in the Newton Raphson （NR） power flow model, where AC and DC systems are solved separately and are coupled by injecting an equivalent amount of real and reactive power at the terminal AC buses. Now, for a majority of the possible control strategies, the equivalent real and reactive power injections at the concerned buses can be computed a-priori and are independent of the NR iterative loop. However, for a few of the control strategies, the equivalent reactive power injections cannot be computed a-priori and need to be computed in every NR iteration. This affects the performance of the iterative process. Two different per-unit system models and six typical control strategies are taken into consideration. This is validated by numerous case studies conducted on the IEEE 118-bus and 300-bus test systems.

关键词： AC-DC power-flow Newton-Raphsonmethod high voltage direct current (HVDC) controlstrategy

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