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Correlation of tumor-associated macrophage density and proportion of M2 subtypes with the pathological stage of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1878-1889页

作者： Fouzia Fazal Muhammad Arsalan Khan sum.yya shawana Rahma Rashid Muhammed Mubarak Department of Pathology Jinnah Medical and Dental CollegeKarachi 74800SindhPakistan Department of General Surgery Sindh Institute of Urology&Transplantation(SIUT)Karachi 74200SindhPakistan Department of Pathology Bahria University of Health SciencesKarachi 74400SindhPakistan Department of Pathology SIUTKarachi 74200SindhPakistan

BACKGROUND Colorectal cancer(CRC)is a prevalent global malignancy with complex prognostic ***-associated macrophages(TAMs)have shown paradoxical associations with CRC survival,particularly concerning the M2 *** We aimed to establish a simplified protocol for quantifying M2-like TAMs and explore their correlation with clinicopathological *** A cross-sectional study included histopathological assessment of paraffinembedded tissue blocks obtained from 43 CRC *** CD68 and CD163 immunohistochemistry,we quantified TAMs in tumor stroma and front,focusing on M2 ***,histopathological,and clinical parameters were *** TAM density was significantly higher at the tumor front,with the M2 proportion three times greater in both *** tumor front had a higher M2 proportion,which correlated significantly with advanced tumor stage(P=0.04),pathological nodal involvement(P=0.04),and lymphovascular invasion(LVI,P=0.01).However,no significant association was found between the M2 proportion in the tumor stroma and clinicopathological *** Our study introduces a simplified protocol for quantifying M2-like TAMs in CRC tissue *** demonstrated a significant correlation between an increased M2 proportion at the tumor front and advanced tumor stage,nodal involvement,and *** suggests that M2-like TAMs might serve as potential indicators of disease progression in CRC,warranting further investigation and potential clinical application.

关键词： Colorectal cancer Macrophages Tumor stroma M2 subset Tumor front Tumor stage Lymphovascular invasion Prognosis Tumor-associated macrophages Immunohistochemistry

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Reassessing the contributions of terrestrial waters to sea level variations in the South China Sea and its response to alternating ENSO events

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Science China Earth Sciences 2024年第7期67卷 2253-2267页

作者： Pengfei YANG Hok sum FOK Zhongtian MA MOE Key Laboratory of Geospace Environment and Geodesy&MNR Key Laboratory of Geophysical Geodesy School of Geodesy and GeomaticsWuhan UniversityWuhan 430079China Hubei Luojia Laboratory Wuhan 730079China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong 999077China

Regional sea level variability is linked to regional terrestrial water and the El Ni?o-Southern Oscillation(ENSO).This study assessed the relationships between the sea level variations in the South China Sea(SCS)and ENSO,the impact of terrestrial water storage(TWS)on non-steric sea level(NSSL),and the contributions of steric sea level(SSL)and NSSL to sea level anomaly(SLA),*** 2003 to 2015,the SLAs exhibited a long-term trend of 6.65±0.78 mm/yr,which was primarily attributed to the ***,during 2003-2015,ENSO events alternating with varying intensities might also be responsible for the unusually high SLA *** to the SSLs,the NSSLs contributed the seasonal signals to the SLAs,while the NSSLs changes were largely explained by the TWS in the Mekong River Basin at the seasonal scale and in the Pearl River Basin and Red River Basin at other time *** contrast to the TWS,the contributions of precipitation and evapotranspiration were relatively minor.A negative correlation between the sea level variations and ENSO was also found,with cross-correlation coefficients between the oceanic Ni?o index and SLAs/SSLs/NSSLs of -0.36/-0.37/-0.62 with lags of 2/3/2 months,*** findings systematically reassessed the contributions of different components to the sea level *** study provided a benchmark for in-depth analysis of the impacts of terrestrial water and other potential causes on sea level rise in the SCS.

关键词： South China Sea Sea level variations Terrestrial water storage ENSO

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Nonlinear Absorption and Low-threshold Two-photon Pumped Amplified Stimulated Emission from FAPbBr_(3) Nanocrystals

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发光学报 2024年第8期45卷 1281-1291页

作者： WANG Yajuan TAY Yong Kang Eugene WANG Fang YU Sheng sum Tze Chien LIU Wei School of Materials and Chemical Engineering Ningbo University of TechnologyNingbo 315211China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China

Formamidinium lead bromide(FAPbBr_(3))nanocrystals(NCs)have been considered to be a good optoelectronic material due to their pure green emission,excellent stability and superior carrier transport ***,two-photon pumped amplified spontaneous emission(ASE)and the corresponding nonlinear optical properties of FAPbBr_(3) NCs are scarcely ***,we synthesized colloidal FAPbBr_(3) NCs with different sizes by changing the molar ratio of FABr/PbBr_(2) in the precursor solution,using ligand assisted precipitation(LARP)technology at room ***(PL)and time resolved photoluminescence(TRPL)spectroscopy were measured to characterize their ASE *** their nonlinear optical properties were studied through the Zscan technique and the two-photon excited fluorescence *** stimulated emission properties including oneand two-photon pumped ASE have been realized from FAPbBr_(3) *** large two-photon absorption coefficient(0.27 cm/GW)and high non-linear absorption cross-section(7.52×10^(5) GM),ASE with threshold as low as 9.8μJ/cm^(2) and 487μJ/cm^(2) have been obtained from colloidal FAPbBr_(3) NCs using one-and two-photon *** results indicate that as a new possible green-emitting frequency-upconversion material with low thresholds,FAPbBr_(3) NCs hold great potential in the development of high-performance two-photon pump lasers.

关键词： perovskites formamidinium lead bromide nanocrystals nonlinear optical gain amplified spontaneous emission

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On a non-abelian invariant on complex surfaces of general type Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第12期49卷 1897-1900页

作者： CHEUNG Wing-sum WONG Bun Department of Mathematics University of Hong Kong Department of Mathematics University of California at Riverside

In this paper,we give certain homotopy and diffeomorphism versions as a generalization to an earlier result due to ***,Bun Wong and Stephen *** concerning a local rigidity problem of the tangent bundle over compact su... 详细信息

关键词： Chern numbers complex surfaces of general type coholomogy group local moduli local deformation space Miyaoka-Yau inequality Yau's global rigidity theorem Yau's uniformization theorem.

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SOME DISCRETE NONLINEAR INEQUALITIES AND APPLICATIONS TO DIFFERENCE EQUATIONS

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Acta Mathematica Scientia 2008年第2期28卷 417-430页

作者： Cheung Wing-sum Ma Qing-Hua Josip Pecaric Department of Mathematics University of Hong Kong Hong Kong Faculty of Information Science and Technology Guangdong University of Foreign Studies Guangzhou 510420 China Faculty of Textile Technology University of Zagreb Pierottijeva 6 1000 Zagreb Croatia

In this article, the authors establish some new nonlinear difference inequalities in two independent variables, which generalize some existing results and can be used as handy tools in the study of qualitative as well... 详细信息

关键词： Discrete Gronwll-Bellman-Ou-Iang type inequalities a Priori bound difference equation boundary value problems

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Remarks on two theorems of Qi-Keng Lu

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Science China Mathematics 2008年第4期51卷 773-776页

作者： CHEUNG Wing-sum WONG Bun Department of Mathematics University of Hong Kong Department of Mathematics University of California

Two alternate arguments in the framework of intrinsic metrics and measures respectively of part of the proof of a famous theorem due to Qi-Keng Lu on Bergman metric with constant negative holomorphic sectional curvature are presented.A relationship between the Lu constant and the holo- morphic sectional curvature of the Bergman metric is *** recent progress of the Yau’s porblem on the characterization of domain of holomorphy on which the Bergman metric is K(?)hler-Einstein is described.

关键词： Bergman metric holomorphic sectional curvature intrinsic metrics and measures Qi-Keng Lu theorem 32F45 32Q05 32W20

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TNFAIP3表达水平对MRL/lpr小鼠B淋巴细胞功能及其炎症反应的影响

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皮肤病与性病 2024年第4期46卷 205-209页

作者：栾春艳孙艺萱李晓岚昆明医科大学第二附属医院皮肤性病科云南昆明650101 河南大学淮河医院河南开封475000

目的探讨肿瘤坏死因子α诱导蛋白3(TNFAIP3)对MRL/lpr小鼠B淋巴细胞功能的影响,进一步探索其在免疫及炎症反应中发挥功能的具体作用机制,为系统性红斑狼疮(SLE)的临床研究提供实验依据。方法采用腺相关病毒(AAV)感染提高MRL/lpr小鼠TNFA... 详细信息

目的探讨肿瘤坏死因子α诱导蛋白3(TNFAIP3)对MRL/lpr小鼠B淋巴细胞功能的影响,进一步探索其在免疫及炎症反应中发挥功能的具体作用机制,为系统性红斑狼疮(SLE)的临床研究提供实验依据。方法采用腺相关病毒(AAV)感染提高MRL/lpr小鼠TNFAIP3的表达,RT-qPCR及Western blot检测B淋巴细胞中TNFAIP3、Toll样受体7(TLR7)、Toll样受体9(TLR9)基因及蛋白表达水平,ELISA法检测血清抗ds-DNA抗体、TNF-α和IL-6的水平,分析TNFAIP3与TLR7/TLR9之间的关系。结果成功过表达MRL/lpr小鼠B淋巴细胞的TNFAIP3后,该组小鼠血清中抗ds-DNA抗体、TNF-α和IL-6的水平与对照组相比明显降低(P<0.05)。Western blot及RT-qPCR检测显示TLR7、TLR9蛋白及mRNA水平与对照组相比明显降低(P<0.05)。结论TNFAIP3可能通过抑制B淋巴细胞中TLR7/TLR9蛋白及mRNA表达水平,抑制MRL/lpr小鼠体内自身抗体和炎症因子的产生,从而缓解MRL/lpr小鼠的病情进展。

关键词：系统性红斑狼疮肿瘤坏死因子α诱导蛋白3 B淋巴细胞 Toll样受体

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Why Hong Kong Ranks Highest in Life Expectancy: Looking for Answers from Data Science and Social Sciences

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Journal of Social Computing 2022年第3期3卷 250-261页

作者： Ting Xu Ming-sum Tsui Dah Ming Chiu the Department of Information Engineering Chinese University of Hong KongHong Kong 999077China Felizberta Lo Padilla Tong School of Social Sciences Caritas Institute of Higher EducationHong Kong 999077China Department of Information Engineering Chinese University of Hong Kongand also with Data Science Research CenterCaritas Institute of Higher EducationHong Kong 999077China

In trying to explain why Hong Kong of China ranks highest in life expectancy in the world,we review what various experts are hypothesizing,and how data science methods may be used to provide more evidence-based *** more data become available,we find some data analysis studies were too simplistic,while others too overwhelming in answering this challenging *** find the approach that analyzes life expectancy related data(mortality causes and rate for different cohorts)inspiring,and use this approach to study a carefully selected set of targets for *** discussing the factors that matter,we argue that it is more reasonable to try to identify a set of factors that together explain the phenomenon.

关键词： life expectancy data science social science population

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Topological feature engineering for machine learning based halide perovskite materials design

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npj Computational Materials 2022年第1期8卷 1943-1950页

作者： D.Vijay Anand Qiang Xu JunJie Wee Kelin Xia Tze Chien sum Division of Mathematical Sciences School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore Division of Physics&Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore

Accelerated materials development with machine learning(ML)assisted screening and high throughput experimentation for new photovoltaic materials holds the key to addressing our grand energy ***-driven ML is envisaged as a decisive enabler for new perovskite materials ***,its full potential can be severely curtailed by poorly represented molecular descriptors(or fingerprints).Optimal descriptors are essential for establishing effective mathematical representations of quantitative structure-property *** we reveal that our persistent functions(PFs)based learning models offer significant accuracy advantages over traditional descriptor based models in organic-inorganic halide perovskite(OIHP)materials design and have similar performance as deep learning *** multiscale simplicial complex approach not only provides a more precise representation for OIHP structures and underlying interactions,but also has better transferability to ML *** results demonstrate that advanced geometrical and topological invariants are highly efficient feature engineering approaches that can markedly improve the performance of learning models for molecular data ***,new structure-property relationships can be established between our invariants and *** anticipate that our molecular representations and featurization models will transcend the limitations of conventional approaches and lead to breakthroughs in perovskite materials design and discovery.

关键词： perovskite halide invariants

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Origins of the long-range exciton diffusion in perovskite nanocrystal films: photon recycling vs exciton hopping

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Light(Science & Applications) 2021年第1期10卷 41-49页

作者： David Giovanni Marcello Righetto Qiannan Zhang Jia Wei Melvin Lim Sankaran Ramesh Tze Chien sum Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University(NTU)21 Nanyang LinkSingapore 637371Singapore Energy Research Institute@NTU(ERI@N) Interdisciplinary Graduate SchoolNanyang Technological University50 Nanyang AvenueS2-B3a-01Singapore 639798Singapore

The outstanding optoelectronic performance of lead halide perovskites lies in their exceptional carrier diffusion *** the perovskite material dimensionality is reduced to exploit the quantum confinement effects,the disruption to the perovskite lattice,often with insulating organic ligands,raises new questions on the charge diffusion ***,we report direct imaging of>1μm exciton diffusion lengths in CH3NH3PbBr3 perovskite nanocrystal(PNC)***,the resulting exciton mobilities in these PNC films can reach 10±2cm^(2)V^(-1) s^(-1),,which is counterintuitively several times higher than the carrier mobility in 3D perovskite *** show that this ultralong exciton diffusion originates from both efficient inter-NC exciton hopping(via Forster energy transfer)and the photon recycling process with a smaller yet significant ***,our study not only sheds new light on the highly debated origins of the excellent exciton diffusion in PNC films but also highlights the potential of PNCs for optoelearonic applications.

关键词： properties. perovskite diffusion

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