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Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： Jeffrey A Lowell Michael J Farber Keith sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy Combination therapy

Hereditary diffuse gastric cancer: One family's story

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World Journal of Clinical Cases 2018年第1期6卷 1-5页

作者： Haley M Zylberberg Keith sultan Steven Rubin Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Division of Gastroenterology Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Hereditary diffuse gastric cancer(HDGC) is an inherited form of gastric cancer that carries a poor prognosis. Most HDGCs are caused by an autosomal dominant genetic mutation in the CDH1 gene, which carries a 70%-80% lifetime risk of gastric cancer. Given its submucosal origin, endoscopic surveillance is an unreliable means of early detection, and prophylactic gastrectomy is recommended for CDH1 positive individuals older than age 20 years. We describe the case of a male with recurrent gastric cancer who was diagnosed with HDGC secondary to the CDH1 mutation, and we also describe the patient's pedigree and outcomes of recommended genetic testing.

关键词： Hereditary diffuse gastric cancer Genetic testing Genetic diseases Gastric cancer Lobular breast cancer Inheritable diseases

Characteristics of a plasma flow field produced by a metal array bridge foil explosion

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Plasma Science and Technology 2018年第7期20卷 127-138页

作者： Junying WU Long WANG Yase LI Lijun YANG Manzoor sultan Lang CHEN State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081People＇s Republic of China

To improve the energy utilization efficiency of metal bridge foil explosion, and increase the function range of plasmas, array bridge foil explosion experiments with different structures were performed. A Schlieren photographic measurement system with a double-pulse laser source was used to observe the flow field of a bridge foil explosion. The evolution laws of plasmas and shock waves generated by array bridge foil explosions of different structures were analyzed and compared. A multi-phase flow calculation model was established to simulate the electrical exploding process of a metal bridge foil. The plasma equation of state was determined by considering the effect of the changing number of particles and Coulomb interaction on the pressure and internal energy. The ionization degree of the plasma was calculated via the Saha-Eggert equation assuming conditions of local thermal equilibrium. The exploding process of array bridge foils was simulated, and the superposition processes of plasma beams were analyzed. The variation and distribution laws of the density, temperature, pressure, and other important parameters were obtained. The results show that the array bridge foil has a larger plasma jet diameter than the single bridge foil for an equal total area of the bridge foil. We also found that the temperature, pressure, and density of the plasma jet＇s center region sharply increase because of the superposition of plasma beams.

关键词： array bridge foil electrical exploding plasma shock wave numerical simulation

Transmission dynamics of Hand-Foot-Mouth Disease with partial immunity through non-integer derivative

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International Journal of Biomathematics 2023年第6期16卷 149-173页

作者： Rashid Jan Salah Boulaaras sultan alyobit Muhammad Jawad Department of Mathematics University of Swabi Swabi 23561Khyber PakhtunkhwaPakistan Department of Mathematics College of Sciences and Arts Qassim UniversityAr RassSaudi Arabia Department of Mathematics College of Science 8 Arts King Abdulaziz UniversityRabighSaudi Arabia

In this paper,we formulate the transmission phenomena of Hand-Foot-Mouth Disease(HFMD)through non-integer *** interrogate the biological meaningful results of the recommended system of *** basic reproduction number is determined through next generation method and the impact of different parameters on the reproduction number is examined with the help of partial rank correlation coeficient(PRCC)*** addition,we concentrated on qualitative analysis and dynamical behavior of HFMD ***'s and Schaefer's fixed-point theorems are used to analyze the uniqueness and existence of the solution of the proposed HFMD *** HFMD system's Ulam-Hyers stability has been confirmed to be *** highlight the impact of the parameters on the dynamics of HFMD,we performed several simulations through numerical scheme to conceptualize the transmission route of the *** be more specific,numerical simulations are used to visualize the effect of input parameters on the systems *** have shown the key input parameters of the system for the control of infection in the society.

关键词： Hand-Foot-Mouth Disease fractional derivatives mathematical model threshold parameter numerical scheme dynamical behavior

Innovative strategies toward challenges in PV-powered electrochemical CO_(2)reduction

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Journal of Energy Chemistry 2021年第9期30卷 410-416页

作者： Siraj sultan Jin Hyun Kim Seung Hyeon Kim Youngkook Kwon Jae Sung Lee Department of Energy Engineering School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919South Korea

The solar energy-driven electrochemical CO_(2)reduction to value-added fuels or chemicals is considered as an attractive path to store renewable energy in the form of chemical energy to close the carbon ***,CO_(2)reduction suffers from a number of challenges including slow reaction rates,low selectivity,and low energy conversion ***,innovative strategies have been developed to mitigate this *** the development of flow cell reactors with a gas diffusion electrode,ionic liquid electrolytes,and new electrocatalysts have dramatically improved the reaction rates and selectivity to desired *** this perspective,we highlight the key recent developments and challenges in PVpowered electrochemical CO_(2)reduction and propose effective strategies to improve the reaction kinetics,to minimize the electrical energy losses,and to tune the selectivity of the catalysts for desired products,and then suggest future direction of research and development.

关键词： Electrochemical CO_(2)reduction Photovoltaic cell Ionic liquid electrolytes Flow cell electrolyzers Gas diffusion electrode

Classification of hyperspectral images using fusion of CNN and MiniGCN with SVM

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International Journal of Digital Earth 2023年第1期16卷 3601-3617页

作者： Wenbing Wu Tariq Sadad Mejdl Safran sultan alfarhood Xiaojian Yuan Big Data College Fuzhou University of International Studies and TradeFuZhouPeople’s Republic of China Department of Computer Science University of Engineering&TechnologyMardanPakistan Department of Computer Science College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia

Convolutional neural networks(CNNs)have gained popularity for categorizing hyperspectral(HS)images due to their ability to capture representations of spatial-spectral ***,their ability to model relationships between data is *** convolutional networks(GCNs)have been introduced as an alternative,as they are effective in representing and analyzing irregular data beyond grid *** have *** computationally intensive,minibatch GCNs(miniGCNs)enable minibatch training of large-scale *** have improved the classification performance by using miniGCNs to infer out-of-sample data without retraining the *** addition,fuzing the capabilities of CNNs and GCNs,through concatenative fusion has been shown to improve performance compared to using CNNs or GCNs ***,support vector machine(SvM)is employed instead of softmax in the classification *** techniques were tested on two HS datasets and achieved an average accuracy of 92.80 using Indian Pines dataset,demonstrating the effectiveness of miniGCNs and fusion strategies.

关键词： CNN hyperspectral images MiniGCN SVM

Approach to solve multi-criteria group decision-making problems by exponential operational law in generalised spherical fuzzy environment

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CAAI Transactions on Intelligence Technology 2020年第2期5卷 106-114页

作者： Tipu sultan Haque Avishek Chakraborty Sankar Prasad Mondal Shariful alam Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpurIndia Department of Basic Science Narula Institute of TechnologyAgarparaKolkata-700109India Department of Applied Science Maulana Abul Kalam Azad University of TechnologyWest BengalIndia

The construction of generalised spherical fuzzy number(GSFN)is a reliable philosophy to design and understanding of vagueness and *** this study,at first,the authors have defined the generalised spherical fuzzy set and discussed its several ***,a new score and accuracy functions have been introduced in the generalised spherical fuzzy environment which leads to a new method of conversion of fuzzy number into a crisp *** exponential operational law has been defined for GSFNs where the bases are positive real numbers&components are GSFNs and its various algebraic properties have been studied *** this exponential operational law,a generalised spherical weighted exponential averaging operator has been proposed,which is used to develop a multi-criteria group decision-making(MCGDM)method in the generalised spherical fuzzy *** newly developed MCGDM has been demonstrated through a real-life problem and its effectiveness and rationality have been shown through sensitivity analysis.

关键词： properties. spherical exponential

Navigating Interoperability in Disaster Management:Insights of Current Trends and Challenges in Saudi Arabia

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International Journal of Disaster Risk Science 2023年第6期14卷 873-885页

作者： Zakaria Ahmed Mani Mohammed ali Salem sultan Virginia Plummer Krzysztof Goniewicz College of Nursing Jazan University45142 JazanSaudi Arabia Healthcare Transformation Model of CareRegional Health Directorate 66255 NajranSaudi Arabia 3 Institute of Health and Care SciencesSahlgrenska AcademyGothenburg University40530 GothenburgSweden Institute of Health and Wellbeing Federation University AustraliaBerwick 3806Australia Department of Security Studies Polish Air Force University08-521 DeblinPoland

In this rapid review,we critically scrutinize the disaster management infrastructure in Saudi Arabia,illuminating pivotal issues of interoperability,global cooperation,established procedures,community readiness,and the integration of cuttingedge *** exploration uncovers a significant convergence with international benchmarks,while pinpointing areas primed for *** recognize that continual commitments to infrastructural progression and technology adoption are ***,we underscore the value of robust community involvement and cross-border collaborations as key factors in bolstering disaster response ***,we spotlight the transformative influence of emerging technologies,such as artificial intelligence and the Internet of Things,in elevating the effectiveness of disaster management *** review champions in all-encompassing approach to disaster management,which entails harnessing innovative technologies,nurturing resilient communities,and promoting comprehensive disaster management strategies,encapsulating planning,preparedness,response,and *** a result of our analysis,we provide actionable recommendations to advance Saudi Arabia's disaster management *** insights are timely and crucial,considering the escalating global focus on disaster response in the face of increasing disaster and humanitarian events.

关键词： Community preparedness Cooperation Disaster management Emergency response Healthcare Interoperability

Investigation of energy-efficient solid desiccant system for wheat drying

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International Journal of Agricultural and Biological Engineering 2019年第1期12卷 221-228页

作者： Shazia Hanif Muhammad sultan Takahiko Miyazaki Shigeru Koyama Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityFukuoka 816-8580Japan Department of Agricultural Engineering Bahauddin Zakariya UniversityMultan 60800Pakistan Faculty of Engineering Sciences Kyushu UniversityFukuoka 816-8580Japan International Institute for Carbon-Neutral Energy Research(WPI-I2CNER) Kyushu UniversityFukuoka 819-0395Japan

The study investigates the applicability of solid desiccant system for drying of freshly harvested wheat grains in order to reduce the moisture content to an optimum *** and low-temperature drying systems are required by today’s drying industries in order to provide economical and safe ***,comparison of desiccant drying has been made with the conventional method in terms of drying kinetics,allowable time for safe storage,the total time for drying cycle,and overall energy *** has been found that the air conditions of proposed desiccant drying system provides a high drying rate and longer allowable storage time for safe *** the desiccants possess water adsorbing ability by means of vapor pressure deficit,therefore,the desiccant system successfully provides low-temperature drying which ensures the quality of wheat *** energy consumption is estimated for both conventional hot air drying and desiccant drying *** has been found that the desiccant system requires less energy as drying is accomplished at minimum level of air flow and within allowable storage *** addition,the overall performance index of the desiccant system is higher at all *** study is useful for developing a low-cost and sustainable drying technology for various agricultural products.

关键词： desiccant solid desiccant system drying grain wheat performance evaluation