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Effect of mitomycin C on the corneal endothelial cells of Saudi patients with myopia after transepithelial photorefractive keratectomy:a two-armed cohort study

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 909-915页

作者： sult.n h alrashidi Department of Ophthalmology College of MedicineQassim UniversityBuraidah 51452Saudi Arabia

AIM:To study the effect of mitomycin C(MMC)applied during transepithelial photorefractive keratectomy(TPRK)on the corneal endothelium one week(W1)and three months(M3)after surgery and its ***:In this two-armed cohort study conducted in 2022,eyes treated with MMC during TPRK(group 1)were compared with eyes not treated with MMC(group 2).The corneal endothelial cell(EC)count,EC density(ECD;cells/mm2),average(μm2),standard deviation(μm2),coefficient of variation(CV%),ECmax,ECmin,and EC percentage of hexagonality were estimated at W1 and *** postoperative changes in the EC count in the two groups were compared and correlated with the other independent ***:Group 1 had 26 eyes,and group 2 had 78 *** TPRK indices were significantly higher for the eyes in group 1 than for those in group *** MMC usage was not a significant predictor of the change in ECD(P=0.644),change in CV(P=0.374),and change in the percentage of hexagonality of EC(P=0.164)at ***,the use of MMC was a significant predictor of changes in CV(P=0.014)and the change in the percentage of hexagonality of EC(P=0.039)at *** duration of laser exposure and the size of the optical zone influenced the correlation of MMC use with the changes in EC indices,***:The use of MMC doesn’t affect ECD,CV,and percentage of hexagonality at W1 if other surgical indices are *** M3 after operating myopic eyes by TPRK,MMC significantly influence the CV and percentage of *** duration of the laser application and the size of the optical zone should be considered when determining the effect of MMC on the EC indices.

关键词： transepithelial photorefractive keratectomy mitomycin-C corneal endothelium

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Watershed-based Image Segmentation with Region Merging and Edge Detection

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high Technology Letters 2003年第1期9卷 58-63页

作者： Salman n h Institute of Image Processing Pattern Recognition Shanghai Jiaotong University Shanghai P. R. China 200030

The clustering technique is used to examine each pixel in the image which assigned to one of the clusters depending on the minimum distance to obtain primary classified image into different intensity regions. A watershed transformation technique is then employes. This includes: gradient of the classified image, dividing the image into markers, checking the Marker Image to see if it has zero points (watershed lines). The watershed lines are then deleted in the Marker Image created by watershed algorithm. A Region Adjacency Graph (RAG) and Region Adjacency Boundary (RAB) are created between two regions from Marker Image. Finally region merging is done according to region average intensity and two edge strengths (T1, T2). The approach of the authors is tested on remote sensing and brain MR medical images. The final segmentation result is one closed boundary per actual region in the image.

关键词： image segmentation edge detection watershed K-means edge strength brain images remote sensing images region adjacency graph (RAG).

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Electrocardiographic interference and conductance volume measurements

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Journal of Biomedical Science and Engineering 2009年第7期2卷 491-498页

作者： Simon P. McGuirk Dan Ewert David J. Barron John h. Coote 不详

The conductance catheter technique enables continuous ventricular volume measurements based on the electrical conductance of blood within the ventricular cavity. however, ventricular excitation also produces a measurable electrical signal within the ventricular cavity. This study was undertaken to investigate the relationship between the ventricular electrogram and conductance volume measurements in a physical model of the left ventricle without parallel conductance. The ventricular electrogram was simulated with an ECG signal, ECGinput connected to two ring electrodes within the model ventricle. Conductance volume measurements were made with and without ECGinput. The difference between these measurements, GECG(t), represented the conductance volume due to ECGinput. GECG(t) varied as a function of the first-derivative of ECGinput with respect to time (r2=0.92, Phis primarily affected volume measurements during ventricular depolarisation;during this phase the volume measurement error varied widely between –12% and +9%. As a re-sult, end-diastole could not be reliably identified on the pressure-volume loop. The accuracy of conduc-tance volume measurements during late diastole and early isovolumic contraction are substantially affected by the ventricular electrogram. This may result in a significant error in end-diastolic volume estimates, which has important implications for the quantitative assessment of ventricular function including, in particular, the assessment of chamber compliance.

关键词： Volume Measurement Conductance Catheter Electrocardiogram Ventricular Electrogram

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猪丹毒氢氧化铝甲醛乳化菌苗研究

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畜牧兽医学报 1965年第2期 101-108页

作者：郑庆端王梦龄冯振群徐汉祥潘乃珍中国农业科学院江苏分院

一、引言猪丹毒在我国尚在部分地区流行,严重的危害养猪事业的发展。因此,消灭猪丹毒以保障生猪生产的顺利发展,实为当前兽医工作的重要任务之一。预防猪丹毒的菌苗虽有多种,但各有不同程度的缺点,例如:猪丹毒弱毒液体菌苗保存期不长,... 详细信息

一、引言猪丹毒在我国尚在部分地区流行,严重的危害养猪事业的发展。因此,消灭猪丹毒以保障生猪生产的顺利发展,实为当前兽医工作的重要任务之一。预防猪丹毒的菌苗虽有多种,但各有不同程度的缺点,例如:猪丹毒弱毒液体菌苗保存期不长,在使用上受到时同限制;猪丹毒弱毒冻干菌苗,限于设备条件,目前尚未

关键词：菌苗免疫力产生期免疫期弱毒疫苗猪丹毒打火印人畜共患病全苗甲醛脂肪族醛氢氧化铝氢氧化物

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医疗服务水平较低地区要坚持对低度细胞学异常的妇女随访

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 56-57页

作者： Benard V.B. Lawson h.W. Eheman C.R. 高雪莲 Epidemiology and A pplied Research Branch Division of Cancer Prevention and Control Mailstop K-5 5 4770 Buford Highway NE Atlanta GA 30341 United States Dr.

OBJECTIVE: To determine whether women in the national Breast and Cervical Ca nc er Early Detection Program (nBCCEDP) who had findings on a Papanicolaou (Pap) te st of atypical squamous cells of undetermined significance (ASC-US) or low-gra de squamous intraepithelial lesions (LSIL) were followed up in accordance with t he interim guidelines for management of abnormal cervical cytology. METhODS: For this study period, the guidelines for a Pap result of ASC-US or LSIL specified follow-up by Pap tests repeated every 4 to 6 months for 2 years. If a second r eport of ASC-US or LSIL was made, the patient was to have colposcopy. We analyz ed data from 10,004 women who had a result of ASC-US or LSIL followed by a seco nd ASC-US or LSIL from 1991-2000. REsultS: As judged by the guidelines, 44%of women who had 2 low-grade abnormalities were followed up appropriately with co lposcopy. Among women with 2 ASC-US results, those aged less than 30 years were more likely to receive colposcopy than the other age groups, while women who we re aged 60 years and olde r were more likely to be followed up with a third Pap test. For each of the 4 re sult groups, American Indian or Alaska native women had the highest percentages of a third Pap test, whereas Black or African-American women had a higher perce ntage of no follow-up. COnCLUSIOn: More than one half of the women studied were not followed up in accordance with the established guidelines for managing abno rmal cervical cytology. Factors such as age and race or ethnicity influence whet her women with cytologic abnormalities receive appropriate follow-up.

关键词：医疗服务水平细胞学异常宫颈涂片阴道镜检查非典型鳞状细胞早期筛查随访情况美国妇女本土人美国印第安人

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QT-GWAS:A novel method for unveiling biosynthetic loci affecting qualitative metabolic traits

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Molecular Plant 2023年第7期16卷 1212-1227页

作者： Marlies Brouckaert Meng Peng Renéhofer lias El houari Chiarina Darrah Veronique Storme Yvan Saeys Ruben Vanholme Geert Goeminne Vitaliy I.Timokhin John Ralph Kris Morreel Wout Boerjan Ghent University Department of Plant Biotechnology and Bioinformatics9000 GhentBelgium VIB Center for Plant Systems Biology 9052 GhentBelgium Ghent University Department of Applied MathematicsComputer Science and Statistics9000 GhentBelgium VIB Center for Inflammation Research 9052 GhentBelgium vIB Metabolomics Core 9052 GhentBelgium Department of Biochemistry and US Department of Energy Great Lakes Bioenergy Research CenterWisconsin Energy InstituteUniversity of Wisconsin-MadisonMadisonWI53706USA Ghent University Department of Applied MathematicsComputer Science and StatisticsGhentBelgium ViB Center for Inflammation Research GhentBelgium BionTech SE MainzRhineland-PalatinateGermany Eunomia Research&Consult.ng BristolUK VIB Agro-incubator NeveleBelgium Research Institute for Chromatography KortrijkBelgium

Although the plant kingdom provides an enormous diversity of metabolites with potentially beneficial applications for humankind,a large fraction of these metabolites and their biosynthetic pathways remain *** metabolite structures and their biosynthetic pathways is key to gaining biological understanding andto allow metabolic *** orderto retrieve novel biosynthetic genes involved in specialized metabolism,we developed a novel untargeted method designated as qualitative trait GWAs(QT-GWAS)that subjects qualitative metabolic traits to a genome-wide association study,while the conventional metabolite GWAS(mGWAS)mainly considers the quantitative variation of *** a proof of the validity of QT-GWAS,23 and 15of the retrieved associations identified in Arabidopsis thaliana by QTGWAS and mGWAS,respectively,were supported by previous ***,seven genemetabolite associations retrieved by QT-GWAS were confirmed in this study through reverse genetics combined with metabolomics and/or in vitro enzyme *** such,we established that CYTOChROME P450706A5(CYP706A5)is involved in the biosynthesis of chroman derivatives,UDP-GLYCOSYLTRAnSFERASE 76C3(UGT76C3)is able tohexosylate guanine in vitro and in planta,and SULFOTRAnSFERASE 202B1(sult202B1)catalyzes the sulfation of neolignans in ***,our study demonstrates that the untargeted QT-GWAS method can retrieve valid gene-metabolite associations at the level of enzyme-encoding genes,even new associations that cannot be found by the conventional mGwAs,providing a new approach for dissecting qualitative metabolic traits.

关键词： qualitative method proof

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