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Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 645-650页

作者： Angela J Umosen suleiman f ambali Joseph O Ayo Bisala Mohammed Chidiebere Uchendu Department of Veterinary Pharmacology Ahmadu Bello University Department of Veterinary Physiology Ahmadu Bello University Department of Veterinary Pathology Ahmadu Bello University

Objective:To evaluate the alleviating effects of melatonin on oxidative changes in the testes and pituitary gland induced by subacute chlopyrifos（CPf） exposure in ***:forty adult male Wistar rats divided into 4 groups of 10 animals were used for the *** I received soya oil（2 mL/kg） while group II was administered with melatonin（0.5 mg/kg）.Group III was administered CPf only(8.5 mg/kg l/10th of the LD50) while group Ⅳ was pretreated with melatonin（0.5 mg/kg） and then exposed to CPf（8.5 mg/kg）,10 min *** regimens were administered by gavage once daily for a period of 28 *** the end of the exposure period, the rats were sacrificed and the testicular tissues and pituitary glands were evaluated for the malonaldehyde（MDA） concentration and activities of superoxide dismutase（SOD） and catalase（CAT）.Results:CPf increased MDA concentrations and reduced the activities of SOD and CAT in the testes and pituitary *** pretreatment reduced the testicular and pituitary MDA concentrations and improves the SOD and CAT ***:the study showed that subacute CPf-induced oxidative stress in the testes and pituitary glands were alleviated by melatonin due to its antioxidant property.

关键词： Chlorpyrifos Oxidative stress Testes Pituitary glands Alleviation Melatonin

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Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub-chronic coadministration of chlorpyrifos and cypermethrin in male Wister rats

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 318-323页

作者： Idris Sherifat Banke ambali suleiman folorunsho Bisalla Mohammed suleiman Mohammed Musa Onukak Charles Ayo Joseph Olusegun Department of Pharmacology and Toxicology.faculty of Veterinary Medicine Usmanu Danfodiyo University Sokoto Department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversity of Ilorin Department of Pathology Faculty of Veterinary MedicineAhmadu Bello University Department of Pharmacology and Toxicology faculty of Veterinary Medicine Ahmadu Bello University Department of Pharmacology and Toxicology Faculty of Veterinary MedicineAhmadu Bello University

Objective:To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos(CPf)and cypermethrin(CYP)-evoked cognitive changes in male Wistar ***:fifty adult male Wistar rats,divided into five groups of ten rats each,were used for the ***ⅠandⅡwere given distilled water and soya oil(2 ml/kg)***Ⅲwas administered with melatonin at 0.5 mg/kg ***Ⅳwas administered with CPf[7.96 mg/kg(1/10th LD_(50))]and CYP[29.6 mg/kg(1/10th LD_(50))].and Group V was administered with CPf[7.96 mg/kg(1/10th LD_(50)]and CYP[29.6 mg/kg(1/10th LD_(50)]30 min after melatonin(0.5 mg/kg).The regimens were administered by gavage once daily for 12 ***,cognitive performances were determined and the brain was evaluated for malonaldehyde ***:CPf and CYP induced cognitive deficits and increased brain malonaldehyde concentration,which were all ameliorated by ***:Cognitive deficits elicited by CPf and CYP was mitigated by melatonin due to its antioxidant property.

关键词： Chlorpyrifos Cypermethrin Cognition Brain malondialdehyde Melatonin

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