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B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and hybrid immunity

Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente Thomas h.Winkler Matthias Tenbusch Institut für klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech communities to investigate infection-and vaccine-induced immune responses in the context of this pathogen.B-cell and antibody responses are at the center of these investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and the primary target of SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics for scientists and health policy *** recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of infection-and vaccine-induced *** also provided an opportunity to explore new vaccine platforms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** with the technological advances of recent years,this situation has provided detailed mechanistic insights into the development of B-cell and antibody responses but also revealed some unexpected *** this review,we summarize the key findings of the last 2.5 years regarding infection-and vaccine-induced B-cell immunity,which we believe are of significant value not only in the context of SARS-CoV-2 but also for future vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

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Microbial,immune and antioxidant responses of Nile tilapia with dietary nano-curcumin supplements under chronic low temperatures

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Aquaculture and fisheries 2024年第1期9卷 57-65页

作者： Mohammed f.El Basuini Mohamed A.A.Zaki Abdelaziz M.El-hais Mohamed G.Elhanafy Emad h.El-Bilawy Amr I.Zaineldin Mohamed f.A.Abdel-Aziz Ibrahim A.Abouelsaad Ibrahim TEl-Ratel Kumbukani Mzengereza Ronick S.Shadrack Islam I.Teiba faculty of Agriculture Tanta UniversityTanta31527Egypt King Salman International University South Sinai46618Egypt faculty of Agriculture Alexandria UniversityAlexandria21526Egypt Animal health Research Institute(AhRI-DOKI) Agriculture Research CenterGiza12619Egypt fish Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt horticulture Department Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Department of Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of Aquatic Animal Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Department of Aquatic and fisheries Science Mzuzu UniversityMzuzuPrivate Bag 201Malawi faculty of Aquaculture and Marine fisheries Arish UniversityArish45516Egypt

A 56-day feeding period was performed to investigate the possible impacts of dietary nano curcumin(0,50,100,150,and 200 ppm)on the growth,nutrient utilization,non-specific immune parameters,antioxidants in Nile tilapia under chronic low temperature(21.02±0.11◦C).fishes(n=225;Initial weight=4.39±0.08 g/fish)were randomly stocked at 15 fish/tank for five experimental groups in *** low-temperature circumstances,dietary curcumin in nano form showed no notable alteration in growth variable,nutrient efficiency,digestive enzymes efficiency,biometric indices,survival rates,and hematological ***,the serum of fishes with nano curcumin diets under low-temperature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol compared with the control ***,fish fed nano curcumin diets displayed higher lysozyme and bactericidal activities compared to the control group and the best performance was found at dietary nano curcumin level of≥100 ***,groups fed the basal diet demonstrated the poorest antioxidant capacity,and the best superoxide dismutase(SOD)and glutathione peroxidase(GPx)existed in fish with nano curcumin diets while the best catalase(CAT)efficiency occurred at higher nano curcumin levels≥100 *** addition,higher counts of intestinal microbiota in terms of total bacterial count(TBC),total yeast and molds count(TYMC),and coliform were noticed in fish consumed the basal diet compared to groups fed on nano curcumin *** conclusion,incorporating nano curcumin at a level of≥100 mg/kg diet(particularly at 150 mg/kg)improved a non-specific immune response,antioxidant,and healthier gastrointestinal microbiota in Nile tilapia under chronic low-temperature stress.

关键词： Nano curcumin Gastrointestinal microbiota Antioxidants Non-specific immune responses Temperature stress

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Scalable orthogonal delay-division multiplexed OEO artificial neural network trained for TI-ADC equalization

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Photonics Research 2024年第1期12卷 85-105页

作者： ANDREA ZAZZI ARKA DIPTA DAS LUKAS hüSSEN RENATO NEGRA JEREMY WITZENS Institute of Integrated Photonics RWTH Aachen University52074 AachenGermany Chair of high-frequency Electronics RWTH Aachen University52074 AachenGermany

We propose a new signaling scheme for on-chip optical-electrical-optical artificial neural networks that utilizes orthogonal delay-division multiplexing and pilot-tone-based self-homodyne *** scheme offers a more efficient scaling of the optical power budget with increasing network *** simulations,based on220 nm silicon-on-insulator silicon photonics technology,suggest that the network can support 31×31 neurons,with 961 links and freely programmable weights,using a single 500 m W optical comb and a signal-to-noise ratio of 21.3 d B per ***,it features a low sensitivity to temperature fluctuations,ensuring that it can be operated outside of a laboratory *** demonstrate the network’s effectiveness in nonlinear equalization tasks by training it to equalize a time-interleaved analog-to-digital converter(ADC)architecture,achieving an effective number of bits over 4 over the entire 75 Ghz ADC *** anticipate that this network architecture will enable broadband and low latency nonlinear signal processing in practical settings such as ultra-broadband data converters and real-time control systems.

关键词： network delay artificial

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All-electron basis sets for h to Xe specific for ZORA calculations:Applications in atoms and molecules

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Chinese Physics B 2024年第8期33卷 238-246页

作者： C.S.Gomes f.E.Jorge A.Canal Neto Departamento de fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for h through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-CCSD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–hess hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from h to Xe CCSD(T)method atomic and molecular properties

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Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month follow-up questionnaire study

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World Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abdullah M Alhammad Namareq f Aldardeer Abdulaziz Alqahtani Mohammad h Aljawadi Bushra Alnefaie Raghad Alonazi Mansour Almuqbil Abdulrahman Alsaadon Rakan M Alqahtani Rashid Alballaa Bader Alshehri Mohammed I Alarifi fahad D Alosaimi Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Department of Pharmacy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Department of Pharmacy Services King Saud University Medical CityRiyadh 12372Saudi Arabia College of Pharmacy King Saud UniversityRiyadh 12372Saudi Arabia Department of Critical Care Medicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Psychiatry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological ***,few studies have examined those who recovered from coronavirus disease 2019(COVID-19).There is a paucity of data from the Middle East assessing the post-ICU discharge mental health status of patients who had *** To evaluate anxiety and depression among patients who had severe *** This is a prospective single-center follow-up questionnaire-based study of adults who were admitted to the ICU or under ICU consultation for>24 h for *** patients were contacted via *** patient’s anxiety and depression six months after ICU discharge were assessed using the hospital Anxiety and Depression Scale(hADS).The primary outcome was the mean hADS *** secondary outcomes were risk factors of anxiety and/or *** Patients who were admitted to the ICU because of COVID-19 were screened(n=518).Of these,48 completed the *** mean age was 56.3±17.2 *** patients(62.5%)were *** main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)*** mean overall hADS score for anxiety and depression at 6 months post-ICU discharge was 11.4(SD±8.5).A hADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),*** from the multivariable ordered logistic regression demonstrated that vasopressor use was associated with the development of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;Phs after ICU discharge,30% of patients who had COVID-19 demonstrated a hADS score that confirmed anxiety and *** compare the psychological status of patients following an ICU admission(with vs without COVID-19),further studies are warranted.

关键词： COVID-19 Critically ill Anxiety Depression hADS Saudi Arabia

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ITPK1 is an InsP/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.harmel Philipp Gaugler Verena Gaugler Michael frei Mohammad-Reza hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea fiedler henning J.Jessen Gabriel Schaaf Ricardo f.h.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects figures 2D,3C,4C,and 7D and figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

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Pre-activated macrophage membrane-encased aggregationinduced emission featuring nanoparticles:a novel possibility for tuberculosis treatment

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao Tian Quazi T.h.Shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Department of human Anatomy and histology and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Institute of Chemistry University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent study published in Nature Nanotechnology,Li et *** the synthesis of a novel photosensitizer with unique aggregation-induced emission(AIE)characteristics.1 They microencapsulated this photosensitizer inside engineered nanoparticles(NPs)coated with pre-activated macrophage cell membranes(CMs),an innovative approach marking a significant leap in nanomedicine by offering a pathway to potent tuberculosis(TB)treatments that bypass antibiotic resistance with unparalleled precision.

关键词： tuberculosis macrophage aggregation

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STCf conceptual design report (Volume 1): Physics & detector

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frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu f.M.Cai h.Cai J.J.Cao Q.h.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen h.Chen h.X.Chen J.f.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.f.Chen X.R.Chen Y.Chen Y.Q.Chen h.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.h.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.fan S.S.fang Z.J.fang G.fedotovich C.Q.feng X.feng Y.T.feng J.L.fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo f.K.Guo J.C.Guo J.Guo Y.P.Guo Z.h.Guo A.Guskov K.L.han L.han M.han X.Q.hao J.B.he S.Q.he X.G.he Y.L.he Z.B.he Z.X.heng B.L.hou T.J.hou Y.R.hou C.Y.hu h.M.hu K.hu R.J.hu W.h.hu X.h.hu Y.C.hu J.hua G.S.huang J.S.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.J.huang Y.B.huang Y.S.huang N.hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.h.Li C.Li D.Y.Li f.Li G.Li G.Li h.B.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li S.Li T.Li W.J.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li Z.J.Li h.Liang J.h.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu f.Liu G.M.Liu h.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.f.Lü Y.Lu Y.Lu Z.Lu P.Lukin f.J.Luo T.Luo X.f.Luo Y.h.Luo h.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma f.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.f.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.f.Redmer h.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique fédérale de Lausanne(EPfL) LausanneSwitzerland fudan University Shanghai 200433China Goethe University frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of Science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCf)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCf will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCf project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCf,describes conceptual designs of the STCf detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCf detector conceptual design

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Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.Lugata Sawadi f.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta Knop János Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary faculty of Agriculture and food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—commercial layer hybrid and hungarian Partridge colored hen breed(hPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Phe *** DLM group had significantly reduced crypt depth,glutathione(GSh)content,glutathione S-transferase 3 alpha(GST3),occludin(OCLN)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group(Phe hPC genotype has overexpressed insulin-like growth factor 1(IGf1)gene,tricellulin(MD2),occludin(OCLN),superoxide dismutase 1(SOD1),and GST3 genes than the TSL genotype(Phese findings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

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Layered Potassium Titanium Niobate/Reduced Graphene Oxide Nanocomposite as a Potassium‑Ion Battery Anode

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Nano-Micro Letters 2024年第1期16卷 1-16页

作者： Charlie A.f.Nason Ajay Piriya Vijaya Kumar Saroja Yi Lu Runzhe Wei Yupei han Yang Xu Department of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUK

With graphite currently leading as the most viable anode for potassium-ion batteries(KIBs),other materials have been left relatively *** metal oxides are among these,with many positive attributes such as synthetic maturity,longterm cycling stability and fast redox ***,to address this research deficiency we report herein a layered potassium titanium niobate KTiNbO5(KTNO)and its rGO nanocomposite(KTNO/rGO)synthesised via solvothermal methods as a high-performance anode for *** effective distribution across the electrically conductive rGO,the electrochemical performance of the KTNO nanoparticles was *** potassium storage performance of the KTNO/rGO was demonstrated by its first charge capacity of 128.1 mAh g^(−1) and reversible capacity of 97.5 mAh g^(−1) after 500 cycles at 20 mA g^(−1),retaining 76.1%of the initial capacity,with an exceptional rate performance of 54.2 mAh g^(−1)at 1 A g^(−1).furthermore,to investigate the attributes of KTNO in-situ XRD was performed,indicating a low-strain ***-situ X-ray photoelectron spectra further investigated the mechanism of charge storage,with the titanium showing greater redox reversibility than the *** work suggests this lowstrain nature is a highly advantageous property and well worth regarding KTNO as a promising anode for future high-performance KIBs.

关键词： Potassium-ion batteries Intercalation Transition metal oxides Anodes Nanocomposite

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